DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1g

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_021336019.1 Gene:cacna1g / 563904 ZFINID:ZDB-GENE-090514-2 Length:2503 Species:Danio rerio


Alignment Length:2536 Identity:562/2536 - (22%)
Similarity:954/2536 - (37%) Gaps:802/2536 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GGPKKEENPPGG--------GPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALE 58
            ||..:|.:...|        .|...|.|.:....|.:...::..|.||.|.:|.|:.|||.|.:.
Zfish    56 GGAAEETSASDGEALPYPSLAPVVFFYLKQTTRPRSWCLKMVCNPWFERASMLVILLNCVTLGMF 120

  Fly    59 EHLPGGDKTVLAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTG 120
            .  |..|....:::   ||..:.:....|.||..:|::||| :..|..||.:.||.:|||:|:.|
Zfish   121 H--PCEDSHCDSERCKILEDFDDFIFAFFAVEMVIKMVALG-IFGKKCYLGDTWNRLDFFIVLAG 182

  Fly   121 FMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAI 185
             |.:|......|....:|.:||||||:.::.:||:::::..::..:..|..:.||..|...||.|
Zfish   183 -MLEYSLNLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 246

  Fly   186 IGLEFYSGALHKTCY---------SLEDPNKLVKEGESETP------------------------ 217
            :|::.::|.|...|:         |||.......|.:.|.|                        
Zfish   247 VGVQLWAGLLRNRCFLPENFSLPTSLELRKYYHTENDDENPFICSQPRENGMRLCTSVPTLHEEG 311

  Fly   218 --CNTDNILEKATGSFVC---NNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAIL 277
              |..|.....:|.:..|   |...:.|......|..|..:|||||:|.:.:||.||:|||..|:
Zfish   312 RQCQLDMASYNSTDNTTCVNWNKYYTNCSAGEANPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 376

  Fly   278 YWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KEREK---VENRQEF-------- 329
            |:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:  |:||.   .|.|..|        
Zfish   377 YFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMKEQRVRFRSNASTLN 440

  Fly   330 ----------------------------------------------------LKLRRQQQLEREL 342
                                                                .|.|||:|.:..:
Zfish   441 SYSEPGSCYDELLKYLVHVIRKGTRQIAHLIRAAGRRAGLRICASPPLEAPPTKRRRQKQRQGSI 505

  Fly   343 ------------------NGYVE---------------------------WICKAEEVILAEERT 362
                              ||.|.                           .|...::........
Zfish   506 RHIMHHHHHHLHHHYHLGNGSVRSDGGREVDNPSQSGIVNKSGNVNLMLPVIVPQQDAFSGSFGH 570

  Fly   363 TEEEKMH---------------------IMEARRRNAAK---------------------RKK-- 383
            :..|.:|                     ::.|.:||:..                     |::  
Zfish   571 SSAESVHSVYQVSGHLEPLRCGPSPSPTVLHAYKRNSVPFAAPVHKNYPTLQSSLALEQLRQRIL 635

  Fly   384 -----LKSL---------------------------------------------------GKSKS 392
                 |.||                                                   .||.:
Zfish   636 DPASVLTSLNIPPNPINTSQCLVETQGPPGKVISKDALMNCSSTNIDTALTYDPETCPYCAKSMA 700

  Fly   393 TDTEEEEAEE--DYGDDGYLKTR----------SKPQGSCTGFWRAEKRFRFW------IRHTVK 439
            .|:|..:..|  |...:|..:|:          .|.:....|. ||.|...||      .|..|.
Zfish   701 NDSEGIDGNETADSDSEGVYETQVAHYRDSRGPKKKKKFALGA-RATKVIDFWRLVCGTFRKIVD 764

  Fly   440 TQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESS 504
            :::|...:::.:.:||:.:.:|::.||..||..|..:..:|..||:.||.:|:...||..|.::.
Zfish   765 SKYFGQGIMIAILINTLSMGIEYHEQPDELTNALEISNIVFTSLFVLEMLLKLLVYGPFGYIKNP 829

  Fly   505 FNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIIS 569
            :|.||.:::..|::|::..:  ||  ||||||..||:|:.|:.::..:|:..::.|:.:|.::.:
Zfish   830 YNIFDGIIVVISVWEIVGQQ--GG--GLSVLRTFRLMRVLKLVRFMPALQRQLVVLMKTMDNVAT 890

  Fly   570 LLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVM 627
            ...||.|||.||::|||.|||.:|       .||   ...||::...|::|||||||.||||:|:
Zfish   891 FCMLLMLFIFIFSILGMHLFGCKFGSERDGDTLP---DRKNFDSLLWAIVTVFQILTQEDWNKVL 952

  Fly   628 YQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEE----------- 681
            |.|:     |....:.::|||.|:.||||.|.|:.:||.|:.. ..:|:|..::           
Zfish   953 YNGM-----ASTSPVAALYFIALMTFGNYVLFNLLVAILVEGF-QTEEITKRDDLHGQLSCIQLP 1011

  Fly   682 ------------------------------EQVEEDKE-----KQLQELEKEMEALQADGV---- 707
                                          :..:.|.|     :.|:::....:.:.|..|    
Zfish  1012 IDSGKGHVGVRIVKPNPDTMSTVLSSDLAGDASKSDSEADIYARSLEDVSGHKKDMSASSVVPIN 1076

  Fly   708 -HVE-------------------------NGDGAV------------------------------ 716
             ||:                         .||.|:                              
Zfish  1077 GHVDLKSSLTPPLITHTAATPMPIPKISGGGDSALSQESRRGSSVSMEPNGQDKSPSSARSSPNA 1141

  Fly   717 --------------------APSKSKGKKKEEEKK-----------EEEEVTE------------ 738
                                |||..:.|.:..|::           :|.:..|            
Zfish  1142 PLSSASSWNSRRSSWNSLGRAPSLKRQKHQSGERRSLLSGDGQSSSDEGDAGESMGGMSEGDDAS 1206

  Fly   739 -------GPKP---------------------MLPYS---------------------------- 747
                   |.:|                     .:||.                            
Zfish  1207 LARTDSLGQRPRHRRMESLETRSSFDLHPDTLQVPYPHRSGSIHSARPPNFLSNGKTSPSAATTQ 1271

  Fly   748 -------------------------------------------SMFILSPTNPIRRGAHWVVNLP 769
                                                       |:::..|.:..|...:.::...
Zfish  1272 LSLDEHHSEDDNADEEGNLSRRARLYRWLEHKQPEWCRQRVTWSLYLFPPESRFRVTCNKIITHK 1336

  Fly   770 YFDFFIMVVISMSSIALAAEDPVRENSRRNKI-LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSY 833
            .||..::|:|.::.|.:|.|.|..:.|...:| |...:|.||.:|..||.:|:|.||......:|
Zfish  1337 MFDHVVLVIIFLNCITIAMERPRIDPSSAERIFLTLSNYIFTAIFVTEMTIKVVALGFCFGEKTY 1401

  Fly   834 LREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVV 898
            |:..|||:|.::|:.:.:.....:..:|..:.|..::.||:||.||||:.|.|.|.||.|.:.::
Zfish  1402 LKSSWNILDGMLVMISVIDILVSLISNSGTKILGMLRVLRLLRTLRPLRVISRAPGLKLVVETLM 1466

  Fly   899 NSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC-TDESKH--TSAECQGSYFKYEEDELLPKQ 960
            :|||.:.||:::...|..||.::|||||.||||.| .|::::  ..::|..:.:|          
Zfish  1467 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCHGDDTRNITNKSDCLLANYK---------- 1521

  Fly   961 ELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFI 1025
                |....:::||:..|:::||.:.:.:||..::...:.|...|:.|:.|:...|.:::|.:.:
Zfish  1522 ----WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPVMNYNPWMLLYFISFLL 1582

  Fly  1026 VFPFFFVNIFVALIIITF------QEQGEAELQDGE----IDKNQKSCI---------DFTIGA- 1070
            :..||.:|:||.:::..|      ||:.||:.::.:    .||.:::.:         |.|..| 
Zfish  1583 IVAFFVLNMFVGVVVENFHKCRRNQEEEEAKRREAKRQKRRDKKRRNIMLTGVSWSSPDHTQEAQ 1647

  Fly  1071 -RPL-ERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMG 1133
             :|. ..|.|..|     .::.:..|...:.||.::|..|.:.:.|::::|..:...|||..|..
Zfish  1648 SKPFYSDYCPTRR-----LIYNMCKSQYLDLFITIVIALNVITMSMEHYHQPKVLSDSLKICNYI 1707

  Fly  1134 FTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS---IN---VGFLRLF 1192
            ||.:|.:|::.|::.||.:.||||.||..||..||.||:.....|...|:   ||   :..:|:.
Zfish  1708 FTVIFVLESIFKLVAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVL 1772

  Fly  1193 RAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI---KLGTVENS 1254
            |..|::|||:....:|.||.|.:|:...:..:.||..:||||:|.:|:::||::   :|...| .
Zfish  1773 RITRVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLICDELHPCE-G 1836

  Fly  1255 ITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIF 1319
            :.|:..|::|....:||||.:||:.|..||...|:.  |..|.    |....:.::..|||||:.
Zfish  1837 LGRYATFKNFGMAFLLLFRVSTGDNWNGIMKDTLRD--CSQDT----GICYNTVVSPIYFVSFVL 1895

  Fly  1320 FCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDP 1384
            ...|:::|:.:||:|.:.:...::     |...:....:..|.:..|.|:..     :|.:...|
Zfish  1896 TAQFVLVNVVIAVLMKHLEESNKE-----AKEAEAEAELELEQEMEALGRDR-----EMQRGHMP 1950

  Fly  1385 PLGFGN----------KCPNRLAYKKLIRMNMP-------LDDELRVQFTTTLFALIRENLSIKM 1432
            .||.|:          ...:|.....|..::.|       .:|.||......      .||...:
Zfish  1951 RLGSGDLGGPGGSPWISRDHRDLSGPLYPIDSPTADIRRDFEDHLRTDPDPP------PNLEPPL 2009

  Fly  1433 RAPEEMDQADMELRETITNIWPLQAKKMLNL---------LVP-PSDQLNKGKLSVGKIYAGFLI 1487
            ......|...:.::.::..    :...|.||         |.| |:....:.::.:.::.|  |.
Zfish  2010 ERRPMFDSVSLVIQGSLEG----ELSLMDNLSGSICHYYALPPLPNKHCTEKQIPLAEMEA--LS 2068

  Fly  1488 LESWRSTRFGQLDSGMP------MLELQDASR-------------HPSQESL-----TGADAGHL 1528
            |.|.:|......|..:|      :|..|:.:.             .|:.|.|     |.....|.
Zfish  2069 LASEKSWSLALTDDSVPDDFNPLLLTSQECNTTDPSDPPDTRQADEPTDEHLLSVKKTSVGRTHS 2133

  Fly  1529 HPGHSYM----------NGHRRSPSLRHNGSPLA-RSPSPRRRGHQYIHHDIGFSDTVSNVVEMV 1582
            .|..|||          :.|..||.|...||..: :|.:.....|..:..|:             
Zfish  2134 LPNDSYMFLPLQSNSNHSTHTTSPHLAQTGSTASVQSQTEEASQHLTVPSDL------------- 2185

  Fly  1583 KETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGH-LSRSKRTQLPYPTYGTTSL-CQRSRS 1645
                      ..|..|. |.|.|.|..|.|.|.|  .| |||:.|.|:........:| .:...:
Zfish  2186 ----------FRPISPH-SLSDSESIPRIPPPRR--AHTLSRTLRRQVAVSADSQETLYTEGGEA 2237

  Fly  1646 PSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPK 1710
            ..|..|:|:.:        .:.....||. |:|....|..|  ..|.||:||             
Zfish  2238 EGPLGLRELSD--------PLPPQQQQHQ-PSLFLVPATPG--ASPKPSRPS------------- 2278

  Fly  1711 LNASPTHTHHS--TPHSVHSLPHHRDLLRDPRDMY--------------------YSSRERERDR 1753
                 .||.|:  ..::|.|...|...:..|...|                    .:.|..:.:|
Zfish  2279 -----VHTQHNPYDQYNVFSRSSHSPPVPPPPPDYKKQEDVDSVDQEVSRIIRAGLTGRSDDVNR 2338

  Fly  1754 ERLRDRDRDRDRDRLHEYDLRYE-----------YRDRERELYERERDREREVERERLE--YI-- 1803
            |...|:...|...:.|..|.:.:           ..|..|...|.....|...:|..:.  ::  
Zfish  2339 EGTGDQCAKRQLKKYHSVDTQGQRALLLPRPLSWLDDPRRHSIEVCSSVESSPQRSSISSGFVSR 2403

  Fly  1804 APLSFEQALAMGRTGRVLP---------SPVL-NGFKPKSGLNPRHSDSDEEDWCXQRLXLRSRN 1858
            |....:|:...||..::.|         .|.| .||.|..|:.|....|  .|.|.:|....|.:
Zfish  2404 ADSLQQQSSPRGRKKKMSPPCISVDPPEDPELPGGFHPALGIVPPPLPS--RDTCLRRRAPSSES 2466

  Fly  1859 R 1859
            :
Zfish  2467 K 2467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 105/332 (32%)
Ion_trans 441..677 CDD:334124 86/242 (36%)
Ion_trans 769..1050 CDD:334124 88/290 (30%)
Ion_trans 1094..1345 CDD:334124 83/259 (32%)
GPHH 1346..1416 CDD:339854 15/86 (17%)
Ca_chan_IQ 1418..1492 CDD:337190 13/83 (16%)
cacna1gXP_021336019.1 Ion_trans 99..422 CDD:306908 104/327 (32%)
Ion_trans 765..998 CDD:306908 87/245 (36%)
Ion_trans 1335..1607 CDD:306908 85/285 (30%)
Ion_trans 1668..1910 CDD:306908 82/248 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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