DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and cacna1bb

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_021324711.1	Gene:	cacna1bb / 562796	ZFINID:	ZDB-GENE-090514-4	Length:	2345	Species:	Danio rerio

Alignment Length:	2156	Identity:	1016/2156 - (47%)
Similarity:	1257/2156 - (58%)	Gaps:	471/2156 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ||||.:|||.||||.:.|.|||||||.:|.||||||:|||||:|||..|||.::::|:.||.||:
Zfish    67 SLFIFSEDNVIRKYAKRITEWPPFEYLILTTIIANCIVLALEQHLPALDKTPMSERLDDTEPYFI 131

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|||.||.:||:|||.|.||.|||||.||||||.|||||.:|   .:|.:.|||||||:||||||
Zfish   132 GIFCFEAGIKIIALGFVFHKDSYLRNGWNIMDFVVVVTGILT---TVGSQFDLRTLRAVRVLRPL 193

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            ||||||||||||||||:|||.||||||||:.||||:|||||:|||.|..|.||:.::...|.|
Zfish   194 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGVEFYMGKFHFTCFKVDTGEKAV-- 256

  Fly   212 GESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAI 276
               :.||..:      ..|..|...|: |.|.|:|||.|||:||||.||:|||||||||||||.:
Zfish   257 ---DYPCGAE------PPSRSCPVGTN-CTEYWKGPNFGITNFDNILFAILTVFQCITMEGWTDV 311

  Fly   277 LYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERE 341
            ||.||||.|:.:||:||:|||:|||||||||||||||||||||||:||.||||||||||||:|||
Zfish   312 LYHTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVEKRQEFLKLRRQQQIERE 376

  Fly   342 LNGYVEWICKAEEVILAEERTTEEEKMHIMEA---RRRNAAKRKKLKSLGKSKSTDTEEEEAEED 403
            |.||:|||||||||:||||....|||..:..|   |::|....|:.|| .|.::.....||.:|.
Zfish   377 LTGYLEWICKAEEVLLAEEDQNAEEKSPLDGAWYRRKQNNPVLKRTKS-RKGRNDLISAEEGDEH 440

  Fly   404 YGDDGYL----------KTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCV 458
            :.|...:          ..:|....|.:.|.|.|||.||:||..||.|.|||.|:.||.|||:||
Zfish   441 FTDISSVAPPGSPFARASLKSSKNDSSSYFRRKEKRIRFFIRRMVKAQSFYWIVLCLVGLNTMCV 505

  Fly   459 AVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWS 523
            |:.||.||.:||:.||.|||:|||||::||.:|||.||||.||.||||.||..||.||||||||:
Zfish   506 AIVHYDQPEWLTKALYLAEFVFLGLFLTEMTLKMYGLGPRNYFHSSFNCFDFGVIVGSIFEVIWA 570

  Fly   524 EVK-GGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQ 587
            .:: |.|||:||||||||||||||||||:||||||:||||||:|||||||||||||::|||||||
Zfish   571 AIQPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 635

  Fly   588 LFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVL 652
            |||||||....||.|||::||.|::||||||||||||.|||.||.||||.:.||..|:|||||.|
Zfish   636 LFGGQFNFEDETPTTNFDSFPAAIMTVFQILTGEDWNAVMYHGIESQGGVRGGMFSSVYFIVLTL 700

  Fly   653 FGNYTLLNVFLAIAVDNLANAQELTAAEEEQVE-------------------------------- 685
            |||||||||||||||||||||||||..||:|.|
Zfish   701 FGNYTLLNVFLAIAVDNLANAQELTKDEEQQEEAAKKSLALQKAMEVKEVSPMSAANISIAAFVK 765

  Fly   686 ------------------EDKEKQLQ--------------------------ELEKE-------- 698
                              :::::.||                          |||.|
Zfish   766 QNRDAISRRSSVCSVHSPKEQQRSLQKLSIWEQRTNQLRRHNLRSSSEALYNELEPEERLRVSSA 830

  Fly   699 ----------------------MEALQAD------------------------------------ 705
                                  ::.|::|
Zfish   831 LHLRPDMKTHHDRPLVVEHRDSVDNLRSDKDGDTSEGQPASNHQRKYHKCRGENGDTGEGRLHRH 895

  Fly   706 ---------------------------------GVHVE-----------------NGDGAV---- 716
                                             |:.:|                 ||:|.:
Zfish   896 HSQNRENQGGLERSNSQDGGQRNHHRSSGSPEEGIGIEEREHRHHHSRRPREVNGNGNGVIGNGG 960

  Fly   717 -----------------------------------------------------------APSKSK 722
                                                                       :||:.|
Zfish   961 RGERIRGHREGEGGNGERRRHRPRVKAQSTLDGDECRENGGKRRSRPTETDSLTTSPLQSPSEEK 1025

  Fly   723 GKKKE------------------------------------------EEKKEEEEVTE-GPKPML 744
            .:.|:                                          ||||:.:|:.: .||.:|
Zfish  1026 PEDKDNLKNSTRVGPSGVNIPVTITAPPGETTVIPMNNIDGDSLLLNEEKKDLDELNQNAPKHIL 1090

  Fly   745 PYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAF 809
            ||||||:..||||:||..|:||||.||:..|:.||:||||||||||||:.::.||.:|.|.||.|
Zfish  1091 PYSSMFVFGPTNPVRRLCHYVVNLRYFEMCILTVITMSSIALAAEDPVQAHAPRNDVLKYLDYVF 1155

  Fly   810 TGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGF--------DMSGSSAGQNL 866
            |||||.||::|::|||::||||||.|:.|||:|.:||..|.|:|..        .::..:.|:::
Zfish  1156 TGVFTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSSFMGSQQSVTRGTKGKDI 1220

  Fly   867 STIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFF 931
            :|||||||||||||||||||:|||||||||||||||||:|||||||||.|||:||.||||.||||
Zfish  1221 NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFF 1285

  Fly   932 YCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQ 996
            :||||||....:|:|.:.:|..|.:...|. |.||...||||||..|.||||.|.||||||.||:
Zfish  1286 HCTDESKALEKDCRGQFLEYGSDGVAMTQP-REWKKYDFHYDNVLWAFLTLFTVSTGEGWPLVLK 1349

  Fly   997 HSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQK 1061
            ||:.|||||:||...:|:|.||||:||||||||||||||||||||||||||:..:.:..::||::
Zfish  1350 HSVDATYEDQGPSPGYRMETSIFYVVYFIVFPFFFVNIFVALIIITFQEQGDKAMSECSLEKNER 1414

  Fly  1062 SCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKS 1126
            :||||.|.|:||.||||:::|:::||:|:.||||||||.|:.:|..||::||||:|.....||..
Zfish  1415 ACIDFAINAKPLTRYMPQDKNSYQYKMWKFVVSTPFEYSILTMIAINTVVLMMKFHGAPKPYEDM 1479

  Fly  1127 LKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS-INVGFLR 1190
            ||::|:.||.:|::|.|||:|.||..|:.|:.|||||.:||||||.|.|..|..::. ||:.|||
Zfish  1480 LKWLNIIFTALFTLECVLKVIAFGPLNYLKEAWNIFDFVTVLGSITDILVTEIKTDKRINLSFLR 1544

  Fly  1191 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSI 1255
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|...:::|
Zfish  1545 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALNNEDSAI 1609

  Fly  1256 TRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFF 1320
            ..||||::|.|.:|||||.||||||..||||||..:.||.::..: |:.|||..||.|||||||.
Zfish  1610 NIHNNFRTFFQALMLLFRSATGEAWHEIMLACLSERYCDIESGYS-GKECGSDFAYFYFVSFIFL 1673

  Fly  1321 CSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPP 1385
            |||||||||||||||||:|||||:||||.||||||:|:||||||.|.|::.|.:||:||::|.||
Zfish  1674 CSFLMLNLFVAVIMDNFEYLTRDASILGPHHLDEFIRVWAEYDPAACGRMSYLDMYEMLRHMSPP 1738

  Fly  1386 LGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQ--ADMELRET 1448
            ||.|.|||.|:|||:|:|||||:.::..|.||:||.||||..|.||: |...:.|  .|.|||:.
Zfish  1739 LGLGKKCPPRIAYKRLVRMNMPIAEDNTVHFTSTLMALIRTALEIKL-ASGVLAQRICDAELRKE 1802

  Fly  1449 ITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASR 1513
            |..|||..:.|.::|||.|.   ...:|:|||:||..:|.:.::..|         ...||....
Zfish  1803 INKIWPSLSSKTVDLLVTPH---KHNELTVGKVYAALMIFDYYKQNR---------AKRLQQQQA 1855

  Fly  1514 HPSQESLTGA------DAGHLHPGHSYMNGHRRSPSLRHNGSPLA-RSPSPRRRGHQYIHHDI-G 1570
            .|..:|..|.      ...||                 |:..||. :.|.|.       |.|| .
Zfish  1856 APGTQSKVGVLFRPMLPLTHL-----------------HDQEPLVPKGPPPS-------HLDITP 1896

  Fly  1571 FSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYG 1635
            .||.......:.                .|....|.|.|...|||  ||            |:..
Zfish  1897 QSDATPTSFHLT----------------NGDAVQSQSSAMKKSPS--GG------------PSQE 1931

  Fly  1636 TTS-----LCQRSRS---PSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASR---RAGI---- 1685
            .|.     ..||.:|   |:..|.||:.|...:....|:|..||...:...||.   .||.
Zfish  1932 VTQETNRRPIQRGQSEDVPNTYRSQELVEMTDMENDSDVGGYHVLEGHGRAASMPRLNAGFQRSH 1996

  Fly  1686 -----GRRLPP----TPSKPSTLQLKPT-----------NINFPKLNASPT--------HTHHST 1722
                 |..|.|    :|.:.||..|.|.           ::..|:::.|.|        ..||..
Zfish  1997 LRHTAGAYLAPIADVSPMRRSTSSLTPQRGAREVNLSEYDLERPRMSPSQTFAQDRERERVHHHH 2061

  Fly  1723 PHSVHSLPHHRDLLRDPRDMYYSSRE---------RERDRERLRDRDRDRDRDRLHEYDLRYEYR 1778
            .|..|.....||......|...|..:         ....|||.|:|||.|..:|.|......|
Zfish  2062 HHHHHRCQRRRDKKHKSLDRAISEEQPPPAADPNTESTPRERARERDRGRSHERKHHSSSAAE-- 2124

  Fly  1779 DRERELYERER 1789
             |::..|..:|
Zfish  2125 -RKQRYYSCDR 2134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	188/286 (66%)
		Ion_trans	441..677	CDD:334124	178/236 (75%)
		Ion_trans	769..1050	CDD:334124	185/288 (64%)
		Ion_trans	1094..1345	CDD:334124	169/251 (67%)
		GPHH	1346..1416	CDD:339854	43/69 (62%)
		Ca_chan_IQ	1418..1492	CDD:337190	31/75 (41%)
cacna1bb	XP_021324711.1	Ion_trans	87..359	CDD:306908	188/286 (66%)
		Ion_trans	487..726	CDD:306908	179/238 (75%)
		Ion_trans	1115..1404	CDD:306908	185/289 (64%)
		Ion_trans	1447..1698	CDD:306908	169/251 (67%)
		GPHH	1699..1769	CDD:318993	43/69 (62%)
		Ca_chan_IQ	1771..1845	CDD:312334	31/77 (40%)
		Transformer	<2074..>2135	CDD:253769	16/64 (25%)
		THRAP3_BCLAF1	2109..>2285	CDD:317794	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I748
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20184
Inparanoid	1	1.050	1778	1.000	Inparanoid score	I66
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	LDO	PTHR45628
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X841
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.830