DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and cacna1ha

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_021330381.1 Gene:cacna1ha / 560875 ZFINID:ZDB-GENE-130103-1 Length:2198 Species:Danio rerio


Alignment Length:2360 Identity:567/2360 - (24%)
Similarity:949/2360 - (40%) Gaps:732/2360 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI---FCVEASLKILALGLVLHKHSYLR 106
            :|.|:.|||.|.:  :.|..|....::.....:|:..||   |.||..:|::||| :...:.||.
Zfish     1 MLVILLNCVTLGM--YQPCEDLKCQSEWCIVLQAFDDCIFAFFAVEMVIKMIALG-IFGINGYLG 62

  Fly   107 NIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQ 171
            :.||.:|||:|:.|.| :|...|....|..:|.:||||||:.::.:||:::::..::..:..|..
Zfish    63 DTWNRLDFFIVMAGMM-EYSLDGHNASLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGN 126

  Fly   172 IGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNK-----------LVKEGE--SETP--CNT- 220
            :.||..|...||.|:|::.::|.|...|:.   |:|           |..|.|  .:.|  |:: 
Zfish   127 VLLLCFFVFFIFGIVGVQLWAGLLRNRCFM---PSKVRDQYNLSYMSLYYENEDGEDNPFICSSS 188

  Fly   221 -DNILEK----------------------------ATGSFVC---NNTTSMCLEKWEGPNSGITS 253
             ||.:::                            .||::.|   |...|.|......|:.|..:
Zfish   189 KDNGMKRCSAVPPLKEGVECTLNASFLGHVYSGLSGTGNYSCVNWNQYYSECKPGDLNPHKGAVN 253

  Fly   254 FDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA- 317
            |||||:|.:.:||.||:|||..|:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|| 
Zfish   254 FDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFAE 317

  Fly   318 -KEREKV---ENR--------------------QEFLKL---------RR--------QQQLERE 341
             |:||.:   |.|                    :|.||.         ||        |.:..::
Zfish   318 TKQRENMLMKEQRARYRSNDSTLASYSEPGSCYEEMLKYVSHLYRKVKRRLSRIYNSWQSKRRKK 382

  Fly   342 LN----------------GYVEWICKAEEVILAEER----------------------------- 361
            :|                ||..|:.....:|...:|                             
Zfish   383 VNPNTGAGGGANGHSRHRGYGHWVQSIHSLIQQHQRQHCHLSNGSPSPVATTGSSEALEMRSITA 447

  Fly   362 ----------------TTEEEKMH-IMEARRRNAAKRKK---------------------LKSL- 387
                            ::..:.:| |.:...|.|.:.:.                     |.|| 
Zfish   448 GQQLTVSSQPTATHNLSSSTQSVHSIYQGDFREAPQERTPTNVAVPALSRLNGGMNYPTILPSLI 512

  Fly   388 -------------GKSKSTDTEE------------------------------------------ 397
                         |||.:....|                                          
Zfish   513 CNYSGGGSLGKERGKSDANTGHEVIQDFDKLHQQIEAHSHSRVLLQMAGVVPTQLLLEVMSCPYC 577

  Fly   398 ---------EEAEEDYG------------DDGYLKTRS------KPQGSCTGFWRAEKRFRFWIR 435
                     |..:.||.            |.|::..||      :.|.....||   :.||..:.
Zfish   578 VRALESMDLEIGDSDYPRSEGDMVYEFSYDAGFITGRSAHHKMQEKQNRLVQFW---EDFRERLT 639

  Fly   436 HTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIY 500
            ..|.:::|...:::.:.:||:.:.:|::.||..||..|..:..:|..:|:.||..|:.|.|...|
Zfish   640 RIVDSKYFNRGIMIAILINTLSMGIEYHEQPEELTNILEISNIVFTSMFVLEMLFKLLAFGIFGY 704

  Fly   501 FESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMR 565
            ..:.:|.||.|::..|::|:| ....|   ||||||..||||:.|:.::..:||..::.|:.:|.
Zfish   705 IRNPYNIFDGVIVVISVWEII-GHADG---GLSVLRTFRLLRVLKLVRFLPALRRQLLVLMKTMD 765

  Fly   566 SIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPET-----NFNTFPIALLTVFQILTGEDWNE 625
            ::.:...||.|||..|::|||.|||.:|:|.....:|     ||::...|::|||||||.||||.
Zfish   766 NVATFCMLLMLFIFTFSILGMHLFGCKFSLKMENGDTIPDRKNFDSLLWAIVTVFQILTQEDWNV 830

  Fly   626 VMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNL-----ANAQELTAAEEEQVE 685
            |:|.|:     |......::||:.|:.||||.|.|:.:||.|:..     ||..:   .:||:..
Zfish   831 VLYNGM-----ASTSPWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANKSD---GDEEKTS 887

  Fly   686 EDKEKQLQELEKEME-------------ALQADGVHVE--------------------------- 710
            .:.|:::::|:....             .|.|:| ||:                           
Zfish   888 VNSEEKMEQLQSSEPLSISDPDLKFYSLMLSANG-HVDPCGTLPPPIIMRTAATPMPTPKSSLGP 951

  Fly   711 -------------------------------------NGDGA-------------VAPS----KS 721
                                                 .|.|:             .|||    .:
Zfish   952 ESVFDLTESRRGSAVSIDPNAFDQKSLSSPRRSPCHPRGSGSNWGSRRSSWNSLGRAPSLKRKDT 1016

  Fly   722 KGKKK-----------EEEKKEEEEVT-------EGPK----PMLPYS----------------- 747
            .|:::           |::..|.|::|       :.|.    |.||..                 
Zfish  1017 SGERESLLSGEGRGSFEDDDIEAEKLTNISGGSLQHPSSLDIPELPQMGEYLDCNGRSQHILADL 1081

  Fly   748 -----------------------------------------SMFILSPTNPIRRGAHWVVNLPYF 771
                                                     |:::.||.|..|.....:::...|
Zfish  1082 SASLNKEDSIAEEDLDDSFCFRLRRTLAAYKPKWCKDHEEWSLYLFSPHNKFRMMCQKLISHKMF 1146

  Fly   772 DFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLRE 836
            |:.::|.|.::.|.:|.|.|..:.|.|..:| ..:|.||.:|..||.:|:|.||......|||:.
Zfish  1147 DYVVLVFIFLNCITIALERPHIQQSERLFLL-VSNYVFTVIFVAEMTVKVVALGFYSGNQSYLKS 1210

  Fly   837 FWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSL 901
            .||::|.|:|..:.:.....::. :..:....::.||:||.||||:.|.|.|.||.|.:.::.||
Zfish  1211 TWNVLDGVLVFVSLIDILVSLAW-TGNRIFGILRVLRLLRTLRPLRVISRAPGLKLVVETLITSL 1274

  Fly   902 KNVVNILIVYILFQFIFSVIGVQLFNGKFFYCT--DESKHTS-AECQGSYFKYEEDELLPKQELR 963
            :.:.||:::...|..:|.::|||||.||||:|.  |....|: ::|..:..|             
Zfish  1275 RPIGNIVLICCAFFIVFGILGVQLFKGKFFHCEGGDTRNITNKSDCLQANLK------------- 1326

  Fly   964 VWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFP 1028
             |..|.:::||:..|:::||.:...:||..::...:.|...|:.|.:|....|.:::|.:.::..
Zfish  1327 -WIRRKYNFDNLGQALMSLFVLSCKDGWVNIMYDGLDAVGVDQQPERNHNPWMLLYFISFLLIVS 1390

  Fly  1029 FFFVNIFVALIIITF------QEQGEAELQDGEIDK-------NQKSCIDFTIGARPLERYMPKN 1080
            ||.:|:||.:::..|      ||:.||.|.:.:..|       ::::|     |:..|.|....:
Zfish  1391 FFVLNMFVGVVVENFHKCRQDQEEVEARLLELKRQKLMEKKRRSKENC-----GSEALRRPYYAD 1450

  Fly  1081 RNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLK 1145
            .:..:..:..:..:...:.||..:|..|.:.:.:::.||....:::|||.|..||.:|.:|.:||
Zfish  1451 YSPARLYIHTLCTNHYLDLFITGIICINVVTMSIEHFNQPSYLDEALKYCNYVFTIIFIIEALLK 1515

  Fly  1146 IIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS---IN---VGFLRLFRAARLIKLLRQG 1204
            ::.||::.||||.||..||..||.||:.....|...|:   ||   :..:|:.|.||::|||:..
Zfish  1516 LVAFGIRRFFKDRWNQLDLAIVLLSIMGITLEEIKMNAALPINPTIIRIMRVLRIARVLKLLKMA 1580

  Fly  1205 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENS----ITRHNNFQSFI 1265
            ..:|.||.|.:|:...:..:.||..:||||||.:|:::||  ||...||:    ::.|..|::|.
Zfish  1581 TGMRSLLDTVMQALPQVGNLGLLFMLLFFIYAALGVELFG--KLECTENNPCEGLSPHATFENFG 1643

  Fly  1266 QGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGE-YCGSTLAYA---YFVSFIFFCSFLML 1326
            ...:.|||.:||:.|..||...|:        |..|.| .|.|.|.:.   |||:|:....|:::
Zfish  1644 MAFLTLFRVSTGDNWNGIMKDTLR--------ECLPSETQCLSYLPWVSPIYFVTFVLMAQFVLV 1700

  Fly  1327 NLFVAVIMDNFDYLTRDS-------SILGAHHLDEFVRIWAEYDPNAT----GKIHYTEMYDMLK 1380
            |:.|||:|.:.:...:::       :.:....|.|..|: :....:||    |:..|.|.:....
Zfish  1701 NVVVAVLMKHLEESNKEAKEDAEMDAAIKLAILKETRRL-STISASATAGPEGRATYIEPHPDSP 1764

  Fly  1381 NMDPPLGFGNKCPNRLAYKKL--IRM-NMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQAD 1442
            ..|.  |......|.|:.:|:  .|| ::|.|        :.:|..:|     ...||..:::.:
Zfish  1765 EQDE--GMQRTQGNLLSPRKMSVSRMHSLPND--------SYMFRPVR-----PASAPYPLEEVE 1814

  Fly  1443 -----MELRETITNIWPLQAKKMLNLL----VPPSDQLNKGKLSVGKI--------YAGFLILES 1490
                 :|| .:||::.. |..:.|:||    |||..|.|    .:.||        ::...||..
Zfish  1815 TCQDYLEL-GSITSVHS-QPCESLSLLQVPGVPPHSQFN----CLPKIPPPMPSPTHSIDRILRR 1873

  Fly  1491 WRSTRFGQLD--------------------------------SGMPMLELQDASRHPSQESLTGA 1523
            .|:.:...:|                                .|.|:|..:..|.|..|:.    
Zfish  1874 QRAIKNDSIDMHNFDSKENVERQKGITTGSFKLHVPQITGISQGSPLLPPRGPSVHTFQQP---- 1934

  Fly  1524 DAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHP 1588
                    ||..|...|.|||..:    :||.||  .|..:        |:.....|.|      
Zfish  1935 --------HSQHNISSRPPSLASS----SRSTSP--SGSMF--------DSADPTDEEV------ 1971

  Fly  1589 RHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRS-RSPS---PA 1649
            ||.||..|.    |....:.|||.|.|.|.     :..|.||.|....:|....: :.|.   ..
Zfish  1972 RHINSTARL----WIGVHAEARSHSLSPYS-----TSGTLLPIPVKNCSSAANLTIKDPKKCFSV 2027

  Fly  1650 RLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGI-GRRL---PPTPSKPSTLQL-KPTNINFP 1709
            ..:...||.   |..|   .|.:||....:|...|: |:.|   ...|::..:|.: :.|.::.|
Zfish  2028 DTEGFLERP---YASD---DHRRHSIEICSSGDDGLFGQELCEKRHVPTRGKSLHIPRKTKMSPP 2086

  Fly  1710 KLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLR 1774
            .::..|              |..:|:  .|.   ::|.::..|...|        |.|...|||.
Zfish  2087 CISIEP--------------PFEKDV--SPS---HASMKKLSDSMLL--------RRRTPSYDLA 2124

  Fly  1775 YEYRDRERELYERERDREREVERER-----LEYIAPLSFEQALAMGRTGRVLPSPVLNGFKPKSG 1834
            .: || ..:|.|.:...:..::.||     .||::                ||.|.     |.||
Zfish  2125 LQ-RD-SLDLPENQLSTQPLIKVERHPSHCAEYLS----------------LPHPA-----PMSG 2166

  Fly  1835 L--------NPRHSDSDEED 1846
            |        .|...||..|:
Zfish  2167 LAGVLCESTQPPPFDSRYEE 2186

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 106/334 (32%)
Ion_trans 441..677 CDD:334124 87/245 (36%)
Ion_trans 769..1050 CDD:334124 87/289 (30%)
Ion_trans 1094..1345 CDD:334124 89/271 (33%)
GPHH 1346..1416 CDD:339854 17/76 (22%)
Ca_chan_IQ 1418..1492 CDD:337190 21/90 (23%)
cacna1haXP_021330381.1 Ion_trans 1..323 CDD:306908 105/329 (32%)
Ion_trans 644..871 CDD:306908 85/235 (36%)
Ion_trans 1143..1413 CDD:306908 84/285 (29%)
Ion_trans 1464..1695 CDD:306908 83/240 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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