DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1fb

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_021333942.1 Gene:cacna1fb / 559964 ZFINID:ZDB-GENE-031104-1 Length:2068 Species:Danio rerio


Alignment Length:1866 Identity:790/1866 - (42%)
Similarity:1082/1866 - (57%) Gaps:258/1866 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY 79
            |.:|:.|..:||||:....::||.||:..:||.|.||||.|.:.:..|..|.......||:.|..
Zfish    92 PRALYCLKLNNPIRRAALHLVEWKPFDIFILLAIFANCVALGVSKPFPEDDSNATNHDLEQVEYV 156

  Fly    80 FLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM---------------TQYPQIG 129
            ||.||.:|..|||||.|||:|..||:||.||::||.:|:.|..               :..|...
Zfish   157 FLIIFTIETFLKILAYGLVMHPSSYIRNGWNLLDFVIVIVGLFSVVLETVTHKSGETTSHTPGKP 221

  Fly   130 PEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGA 194
            ..:|::.|||.||||||:||||:||||:||.||:|||.|||.|.|||||.|:|:||||||.:.|.
Zfish   222 GGLDVKALRAFRVLRPLRLVSGVPSLQIVLNSIMKAMVPLLHISLLVLFVIIIYAIIGLELFIGR 286

  Fly   195 LHKTC-------YSLEDPNKLVKEGESETPCNTDNILEKATGSFV-----CNNTTSMCLEKWEGP 247
            :|:||       |:.:||          .||           :|.     |....|.|..|||||
Zfish   287 MHRTCFFIGTDNYADDDP----------LPC-----------AFAGHGRQCYVNGSECRGKWEGP 330

  Fly   248 NSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVL 312
            |.|||:|||..||||||||||||||||.:|||.|||:|....|:|||.|::.||||:||||||||
Zfish   331 NGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMNDAIGFELPWVYFVSLVIFGSFFVLNLVLGVL 395

  Fly   313 SGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRN 377
            ||||:|||||.:.|.:|.|||.:||:|.:|.||::||.:||::...:|.......:       |:
Zfish   396 SGEFSKEREKAKARGDFQKLREKQQMEEDLCGYMDWITQAEDIDEFDEDGNRRVTL-------RD 453

  Fly   378 AAKRKKLK------------SLGKSKSTDTEEEEAEEDYGD-DGYLKTRSKPQGSCTGFWRAEKR 429
            .|.:|:.|            ||..|::.....|..:|::.| ......|......|....|..:.
Zfish   454 LADKKRGKFGWFSHSNETHASLPASETASENTENIDEEHTDCCAACCARIMKIPCCRALRRWNRC 518

  Fly   430 FRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYA 494
            .|...|..||:..|||.|::||||||...|.|||.||.:||:....|..:.|.||..||.:|||:
Zfish   519 IRRNCRTAVKSVTFYWLVLILVFLNTALSASEHYNQPEWLTDVQDIANKVLLSLFTVEMLLKMYS 583

  Fly   495 LGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GGSFGLSVLRALRLLRIFKVTKYWSSLRNLVI 558
            ||.::||.:.||||||.|:.|.|.|.:..|:: ....|:||||.:|||||||||::|::|.|||.
Zfish   584 LGLQVYFVAFFNRFDCFVVCGGILETVLVEMEIMPPLGISVLRCVRLLRIFKVTRHWTALSNLVA 648

  Fly   559 SLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL-PGGTPETNFNTFPIALLTVFQILTGED 622
            ||||||:||.|||.|||||::||||||||||||:||. ...|..:.|::||.||||.||||||||
Zfish   649 SLLNSMKSIASLLLLLFLFLIIFALLGMQLFGGKFNFDETQTKRSTFDSFPQALLTCFQILTGED 713

  Fly   623 WNEVMYQGIISQGG-AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEE 686
            ||.|||.||::.|| ...|||..:||::|.:.|||.||||||||||||||...    .:.::.||
Zfish   714 WNVVMYDGIMAYGGPVFPGMIVCLYFVILFICGNYILLNVFLAIAVDNLAGGD----GDNKKNEE 774

  Fly   687 DKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEG------------ 739
            .||.:.:..|:            |||:..|        ..:||.:||||..||            
Zfish   775 KKEGEAEPAEE------------ENGEVKV--------DMDEEYEEEEEPEEGDDEEGKIQLNVA 819

  Fly   740 ----PK----PMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENS 796
                ||    |:...|:.|.||.|||||.|.|.:::...|...|:|.|.:|||:||||||:|.:|
Zfish   820 DFAPPKEKILPIPEGSAFFCLSKTNPIRVGCHTLIHHHIFTNLILVFIILSSISLAAEDPIRAHS 884

  Fly   797 RRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSS 861
            .||.:|.|.|||||.:||:|:|||:...|..||.||:.|.::|::|.:||..:.|||....|.  
Zfish   885 FRNNVLGYADYAFTSIFTVEILLKMTVHGAFLHEGSFCRNWFNLLDLLVVSVSLVSFFLHSSA-- 947

  Fly   862 AGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLF 926
                :|.:|.||||||||||:.|.|...||.|..||..:::.:.||:||..|.||:|:.||||||
Zfish   948 ----ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLF 1008

  Fly   927 NGKFFYCTDESKHTSAECQGSYFKYEEDELL-PKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEG 990
            .|||:.||||:|:|..:|:|::..|::.::. |....|:|....|::|||...|:.||.|.|.||
Zfish  1009 KGKFYRCTDEAKNTPEQCKGTFVVYKDGDVSHPMVRERIWLNSDFNFDNVLMGMMALFTVSTFEG 1073

  Fly   991 WPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGE 1055
            ||.:|..::.|..|:.|||.|:|:|:|||:|||.|:..||.:||||..:||||:||||||.::.|
Zfish  1074 WPALLYKAIDANGENHGPIYNYRVEISIFFIVYIIIIAFFMMNIFVGFVIITFREQGEAEFKNCE 1138

  Fly  1056 IDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQG 1120
            :||||:.|:::.:.|:||:.|:||  |..:||.|.|:.||.|||.:.:||:.||:.|.:::::|.
Zfish  1139 LDKNQRQCVEYALKAQPLKLYIPK--NPVQYKFWSIINSTGFEYVMFVLILLNTVTLAVQHYDQS 1201

  Fly  1121 DMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS-- 1183
            ..:.:.:..:||.|||:|:||.::|::...::::|.|.||.||.:.|:||:||.:..||.|:.  
Zfish  1202 KFFSQVMDILNMVFTGLFTVEMIIKLMALRLRHYFVDAWNSFDALIVVGSVVDIVVTEFSSSEDS 1266

  Fly  1184 --INVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1246
              :::.|.||||..||:|||.:|..||.||||||:|.:|||||.|||||:|||||:||||.||.|
Zfish  1267 SRVSITFFRLFRVMRLVKLLSKGEGIRTLLWTFVKSLQALPYVALLIAMIFFIYAVIGMQTFGKI 1331

  Fly  1247 KLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGE--YCGSTL 1309
            .:.. ...|.|:||||:|.|.|:|||||||||||..||||.|.||.||.:::..|||  .|||.:
Zfish  1332 AMQD-HTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGKRCDAESDFEPGEEFSCGSNI 1395

  Fly  1310 AYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTE 1374
            |..||:||...|:||::|||||||||||||||||.||||.||||||.|||:||||.|.|:|.:.:
Zfish  1396 AIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLD 1460

  Fly  1375 MYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMD 1439
            :..:|:.:.||||||..||:|:|.|:|:.|||||:.:..|.|..|||||:|  .::|::.....|
Zfish  1461 VVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNADGTVTFNATLFALVR--TALKIKTDGNPD 1523

  Fly  1440 QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMP 1504
            |.:.|||..|..||.....|:|:.::||..:   .:::|||.||.|||.:.:|..|..:...|:.
Zfish  1524 QENEELRIIIKKIWKRTKPKVLDEVIPPPAE---EEVTVGKFYATFLIQDYFRKFRKRKEKVGLE 1585

  Fly  1505 MLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDI 1569
                ::.:.:|:...|..|....|         ....|.:|     ||            ::.|:
Zfish  1586 ----EEGNGNPTALQLCQAGLRTL---------QELGPEMR-----LA------------MNEDL 1620

  Fly  1570 -----GFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQL 1629
                 |..:      |..::..|.::.|.:         |.|.|            ||||:|:.|
Zfish  1621 EEEEEGLDE------EQEEDDAHYKNENGY---------AHTEP------------LSRSRRSSL 1658

  Fly  1630 PYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRR--LPPT 1692
            .....|         :|.|..          |.||..|                |:|||  |..|
Zfish  1659 ATTPIG---------APVPVP----------GDGILNG----------------GLGRRSSLAKT 1688

  Fly  1693 PSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSV-HSLPHHRDLLRDPRDMYYSSRERERDRERL 1756
            |:....|:    |.||.:.::..:..|:...:.| ..||        .|..||....|:      
Zfish  1689 PNGNGALE----NENFRRRDSMRSSIHYQHKNGVIDQLP--------KRPSYYKYPRRD------ 1735

  Fly  1757 RDRDRDRDRDRLHEYDLRYEYRDRERELYERERDREREVERERLEY 1802
               .|||....|...:...||...:| .|.::.|.|..:.|||..|
Zfish  1736 ---SRDRFSSPLSRREEGGEYPGEQR-FYGKDEDSESVISRERHGY 1777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 157/313 (50%)
Ion_trans 441..677 CDD:334124 139/238 (58%)
Ion_trans 769..1050 CDD:334124 135/281 (48%)
Ion_trans 1094..1345 CDD:334124 136/256 (53%)
GPHH 1346..1416 CDD:339854 38/69 (55%)
Ca_chan_IQ 1418..1492 CDD:337190 27/73 (37%)
cacna1fbXP_021333942.1 Ion_trans 114..407 CDD:306908 157/313 (50%)
Ion_trans 532..763 CDD:306908 137/230 (60%)
Ion_trans 856..1093 CDD:306908 110/242 (45%)
Ion_trans 1178..1431 CDD:306908 134/253 (53%)
GPHH 1432..1502 CDD:318993 38/69 (55%)
Ca_chan_IQ 1504..1575 CDD:312334 28/75 (37%)
CAC1F_C 1601..2067 CDD:318975 59/287 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.720

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