DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and scn1lab

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001038360.2 Gene:scn1lab / 559447 ZFINID:ZDB-GENE-060906-1 Length:1996 Species:Danio rerio


Alignment Length:1935 Identity:471/1935 - (24%)
Similarity:819/1935 - (42%) Gaps:534/1935 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|:||:..||:|:.:..::....|.:.::.||:.||..:.| .:.|...|.|        |..|.
Zfish   109 ALYILSPFNPLRRISIRVLVHSLFSFVIMCTILTNCAFMTL-SNPPEWAKNV--------EYTFT 164

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||||.|..:.|.::||:.||.:||.|::..::|::..:|   ::..||..||||.|
Zfish   165 GIYTFESLIKILARGFCVGKFTFLRDPWNWLDFSVILMAYVTEFVNLG---NVSALRTFRVLRAL 226

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|.:.|..:.:.|.    
Zfish   227 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVKMPEVNV---- 287

  Fly   212 GESETPCNTDNILEKAT--------------------------GSFVCNNTTS--------MCLE 242
                    |||:.:.:|                          .:.:|.|::.        .|::
Zfish   288 --------TDNLTDYSTELHNSTFNWTEYISDSNNYYFIPGRRDALLCGNSSDAGQCPEGFTCIK 344

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            ....|:.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||
Zfish   345 AGRNPDYGYTSFDTFSWAFLSLFRLMTQDFWENLYQQTLRAAGKPY-MIFFVLVIFLGSFYLVNL 408

  Fly   308 VLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVI---------------- 356
            :|.|::..:.::.:..        :...||.|.|....:|.:.:.:|..                
Zfish   409 ILAVVAMAYDEQNQAT--------IEEAQQKEEEFQAMLEQLKRQQEEAQVAAAAATESGEYSGR 465

  Fly   357 --LAEERTTEEEKMHIMEAR-RRNAAKRKKLK---------SLGKSKSTDT-------------- 395
              |:||.::...::....|: |||..|::|.:         ...||.|.|:              
Zfish   466 GGLSEESSSGGSRLSSKSAKERRNRRKKRKQREEEEKADQEKFHKSASEDSIRRPGFRFSIDANR 530

  Fly   396 ---------------------------------------EEEEAEEDYGDDGY------------ 409
                                                   .:..:|.|:.||.:            
Zfish   531 LSYEKKCSTPNQSLLSIRGSLFSPRRNSRASLFSFRGRARDFGSENDFADDEHSTFEDSDSRRGS 595

  Fly   410 ------LKTRSK-----------------------------------------------PQGSCT 421
                  ::.||.                                               |:|:.|
Zfish   596 LFVPRCVERRSSTVSHCSLTAPRIMLPANGKMHCTVDCNGVVSLVGGTSVPTSPIGRLLPEGTTT 660

  Fly   422 GFWRAEKRF-----RFWIRHTVKTQ--------------------------WF------------ 443
            .....:||.     ..::..||..:                          |:            
Zfish   661 ESDVRKKRSGSHQPSDYLEETVARKRAMSVASILTNTMEELEESRQKCPPCWYKFANSFLIWDCS 725

  Fly   444 -YWF------------------VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMF 489
             .|.                  :.:.:.|||:.:|:|||...:..:..|.....:|.|:|.:||.
Zfish   726 PAWLKVKEIMNMIVMDPFVDLAITICIVLNTLFMAMEHYPMTTQFSHLLSVGNLVFTGIFTAEMC 790

  Fly   490 IKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLR 554
            :|:.||.|..||:..:|.||.:::|.|:.|:..:.|:    ||||||:.||||:||:.|.|.:|.
Zfish   791 LKVIALDPYYYFQEGWNIFDGIIVSLSLMELGLANVE----GLSVLRSFRLLRVFKLAKSWPTLN 851

  Fly   555 NLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-----------NLPGGTPETNFNTFP 608
            .|:..:.||:.::.:|..:|.:.:.|||::||||||..:           .||....:..|::| 
Zfish   852 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYRECVCKISESCELPRWHMDDFFHSF- 915

  Fly   609 IALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAI-----AVD 668
               |.||::|.|| |.|.|:..:...|   :.|...::.:|:|: ||..:||:|||:     :.|
Zfish   916 ---LIVFRVLCGE-WIETMWDCMEVAG---QSMCLIVFMMVMVI-GNLVVLNLFLALLLSSFSAD 972

  Fly   669 NLANA-------------------------------QELTAAEEEQVEEDKEKQLQELE------ 696
            |||..                               |.|..|..:....|:||.|.:|.      
Zfish   973 NLAATDDDSEMNNLQIAVGRIQKGIALVKSTLRQFLQSLFLAGSKPRSLDEEKPLDDLHSDGKEN 1037

  Fly   697 -----------------KEMEALQADGVH------VENGDG---------------AVAPSKSKG 723
                             ||......:||.      :|.||.               ||..|..:.
Zfish  1038 CLSNHAPVAVDLTKDYLKEGCVSPGNGVESHVKYGIEEGDYMSFIHNPSLTVTVPIAVGESDFEN 1102

  Fly   724 KKKEEEKKEEEEVTEGPKPMLPYSSMFILSPT-------NPIRRGAH------------------ 763
            ...|:...|..:| ||.|..||..:  :||.:       .|...||.                  
Zfish  1103 LNTEDFSSESSDV-EGSKEKLPVDT--VLSSSEGSTVDIRPPGEGAESVELEPEESLDPEACFTE 1164

  Fly   764 ---------------------W--------VVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRN 799
                                 |        :|...:|:.||:.:|.:||.|||.||...|..:..
Zfish  1165 GCVMRFQCCQVDVEKGKWKSWWILRKTCFIIVEHNWFESFIIFMILLSSGALAFEDIYIEQRKTI 1229

  Fly   800 K-ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAG 863
            | :|.|.|..||.:|.:|||||.|..|.    ..|....|..:|.::|..:.||...:..|.|  
Zfish  1230 KTVLEYADKVFTYIFILEMLLKWVAYGF----AKYFTNAWCWLDFLIVDVSLVSLVANALGYS-- 1288

  Fly   864 QNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNG 928
             .||.|||||.||.||||:.:.|...::.|.:.::.::.:::|:|:|.::|..|||::||.||.|
Zfish  1289 -ELSAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1352

  Fly   929 KFFYCTDESK---------HTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFA 984
            |::||.:.:.         :..::|..         |:...:...||....::|||.|..|.|..
Zfish  1353 KYYYCVNITNDELFPVSVVNNKSDCYA---------LIQNNDTARWKNVKINFDNVGAGYLALLQ 1408

  Fly   985 VQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEA 1049
            |.|.:||..::..::.:...::.|:....:.|.::::::.|...||.:|:|:.:||..|.:| :.
Zfish  1409 VATFKGWMDIMYAAVDSRDLEQQPVYETNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ-KK 1472

  Fly  1050 EL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTL 1110
            :|  ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:.::....|:..||:||..|.:
Zfish  1473 KLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGLVFDLITKQAFDIIIMILICLNMV 1537

  Fly  1111 LLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDAL 1175
            .:|::..:|.:..:..|.:||:.|..:|:.|.|||:|... ..||...||:||.:.|:.|||.. 
Zfish  1538 TMMVETDDQTEDMDNILYWINLVFIILFTGECVLKMISLR-HYFFTIGWNVFDFVVVILSIVGM- 1600

  Fly  1176 WMEFGSNSINVGF--------LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1232
               |.|..|...|        :||.|..|:::|::....||.||:..:.|..||..:.||:.::.
Zfish  1601 ---FLSEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1662

  Fly  1233 FIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDA 1297
            |||||.||..|..:|.   |..|....||::|...::.||:..|...|..::...|..:..|.|:
Zfish  1663 FIYAIFGMSNFAYVKR---EAGIDDMFNFETFGNSMLCLFQITTSAGWDGLLAPILNKQDPDCDS 1724

  Fly  1298 E-KAPGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEF 1355
            | :.||.:    ||: ::...:|||:|..|..:::|:::|||::||...|.:|: .|.....:.|
Zfish  1725 EMEHPGSFYRGNCGNPSVGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFEMF 1789

  Fly  1356 VRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTL 1420
            ..:|..:|||||..:.|.::.|....:||||....  ||::   :||.|::|:....|:.....|
Zfish  1790 YEVWERFDPNATQFVEYNKLSDFADALDPPLRIAK--PNKI---QLIAMDLPMVSGDRIHCLDIL 1849

  Fly  1421 FALIRENLSIKMRAPE-EMD--QADMELR-----------ETITNIWPLQAKKMLNLLVPPSDQL 1471
            ||     .::::...| |||  :..||.|           |.||.....:.::|..:::..:.:.
Zfish  1850 FA-----FTLRVLGEEGEMDALRGQMEDRFMASNPSKVSYEPITTTLRRKQEEMSAVVIQRAFRR 1909

  Fly  1472 NKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRH-PSQESL 1520
            ::.:.:|.|      ..|::|.             :|||...| |.:|.|
Zfish  1910 HRIRQTVKK------ASEAYRK-------------QLQDGGGHIPEKEVL 1940

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 85/320 (27%)
Ion_trans 441..677 CDD:334124 86/339 (25%)
Ion_trans 769..1050 CDD:334124 89/290 (31%)
Ion_trans 1094..1345 CDD:334124 84/264 (32%)
GPHH 1346..1416 CDD:339854 21/69 (30%)
Ca_chan_IQ 1418..1492 CDD:337190 17/87 (20%)
scn1labNP_001038360.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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