DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and tpcn3

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_001170916.1	Gene:	tpcn3 / 557460	ZFINID:	ZDB-GENE-141215-16	Length:	773	Species:	Danio rerio

Alignment Length:	717	Identity:	150/717 - (20%)
Similarity:	302/717 - (42%)	Gaps:	209/717 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 YWFVIVLVF---------------------------LNTVCVAVEHYGQPSFLTEFLYYAEFIFL 481
            :||:..||:                           :.|:|::       :|....::||:.|..
Zfish    71 HWFMQTLVYVFIIINLALALFEDPAVVPLPIWATSTIETICLS-------AFTVRIIHYAKVIPK 128

  Fly   482 GLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFE-VIWSEVKG-GSFGLSVLRALRLLRIF 544
            ..|..:         |:       |....::::.|..: ||:..:|. |.:|:...|.||.|.:.
Zfish   129 DKFWKD---------PK-------NICIIIIVTLSFIDMVIYGALKATGHYGIRWSRVLRPLLLV 177

  Fly   545 KVTKYWSSLRNLVISLLNSMRSIISLLFLLFLF-ILIFALLGMQLFGGQFNLP-GGTPETNFNTF 607
            .||: ...||....|:.|::.. ||.:|.||:| :|:|:|:.::|||.:..|. .|:|  .|..:
Zfish   178 NVTE-GRQLRRAFRSIRNALPQ-ISYVFFLFMFSVLVFSLMALKLFGKRGLLTINGSP--YFTDY 238

  Fly   608 PIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLAN 672
            ...:..::.::|..:..:||.....|      .:.::|:||:.::...||.::.|||:..:|.
Zfish   239 MDIVFDLYVLVTTANSPDVMMPAYNS------SVYFTIFFILYIVINTYTFMSFFLAVVYNNY-- 295

  Fly   673 AQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVEN-GDGA---------------VAPSKS 721
                     ::..:::.:||.: .|.::..:|..:..|| |:|.               |.|..|
Zfish   296 ---------KKYLKEEVRQLVK-AKRIKMCRAFSLLQENRGEGGEPVVTQANWNHLVKLVKPKIS 350

  Fly   722 KGKKK------EEEKK-----------------EEEEVTEGPKPM-LPYSSMFILSPTNPIRRGA 762
            ...::      :::.|                 :...|.....|: :.:.|::...|:..||:..
Zfish   351 TAHRELLWSVLDDQNKGHIGKFAFVQLADLLSIQVITVKSQAHPIQICFPSLYNSLPSRFIRQMV 415

  Fly   763 HWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVI 827
            |..|.:..:|  ::::::...|.|..|:||..|:         ::.|..::.:|:|||:    ..
Zfish   416 HHRVFVYAYD--LIILVNAVFIGLDEENPVVSNA---------EWGFLALYMLEILLKL----YA 465

  Fly   828 LHPGSYL--REFWNIMDAVVVICAAVSFGFDMS-------GSSAGQNLSTIKSLRVLRVLRPLKT 883
            ..|.::.  .:|||..|.::|:.|.  ||..::       |.::.|.|..:..|||||::|.:.:
Zfish   466 TEPRAFFARHQFWNWFDTIIVVSAL--FGTIINSALKHSGGYTSRQVLDIVFILRVLRLIRVVDS 528

  Fly   884 IKRVPKLKAVFDCVVNSLKNV--------VNILIVYILFQFIFSVIGVQLFNGK--FF------- 931
            |||       |..::|:|..:        ..||:||    :||:::|::||.||  ||
Zfish   529 IKR-------FRAIINTLIKIGPTILTFGQLILVVY----YIFAMVGMELFKGKIQFFEPNSTSP 582

  Fly   932 ---YCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQ 993
               ||.:....:::..:.:|.|.                   ::::|.::.:.|..:.....|..
Zfish   583 DREYCGNPLLKSTSFAKLNYCKN-------------------NFNDVISSFILLLELTVVNQWHV 628

  Fly   994 VLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDK 1058
            :.....|.|:          :...:|::::.||.....:|||||.|:       ||.|.:..:||
Zfish   629 LTSGFTAVTH----------VSARLFFVIFHIVVVIIIINIFVAFIL-------EAFLVEYTVDK 676

  Fly  1059 NQ 1060
            ::
Zfish   677 SE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124	58/263 (22%)
		Ion_trans	769..1050	CDD:334124	68/309 (22%)
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
tpcn3	NP_001170916.1	Ion_trans	73..295	CDD:395416	56/254 (22%)
tpcn3	NP_001170916.1	Ion_trans	417..>571	CDD:395416	46/181 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810