DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1ba

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_009299772.1 Gene:cacna1ba / 555941 ZFINID:ZDB-GENE-060531-44 Length:2378 Species:Danio rerio


Alignment Length:2482 Identity:1059/2482 - (42%)
Similarity:1332/2482 - (53%) Gaps:606/2482 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GPKKEENPPGG------------------GP-----------TSLFILTEDNPIRKYTRFIIEWP 38
            |..::..||||                  .|           .||||.:|||.||||.:.|.|||
Zfish    26 GATRQPGPPGGPRVYKQTMAQRARTMAIYNPIPVKQNCLTVNRSLFIFSEDNIIRKYAKKITEWP 90

  Fly    39 PFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHS 103
            ||||.:|.||||||:||.||:|||..|||.::::|:.||.||:.|||.||.:||:|||...||.|
Zfish    91 PFEYMILATIIANCIVLGLEQHLPALDKTPMSKRLDDTEPYFIGIFCFEAGIKIIALGFAFHKGS 155

  Fly   104 YLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAP 168
            ||||.||:|||.||:||.:|   .:||:.|||||||:||||||||||||||||||||||:|||.|
Zfish   156 YLRNGWNVMDFVVVLTGILT---IVGPDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVP 217

  Fly   169 LLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVC 233
            |||||||:.|||::||||||:||.|..|:||:..:     ..|...|.||..:      :.::.|
Zfish   218 LLQIGLLLFFAILMFAIIGLDFYMGKFHRTCFRTD-----TGEQVDEFPCGLE------SPAWTC 271

  Fly   234 NNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIV 298
            .|.|. |.|.|.|||.|||:||||.||:||||||||||||..|||..|||.|:.:||:||:|||:
Zfish   272 ENGTE-CREYWIGPNFGITNFDNILFAVLTVFQCITMEGWVDILYNANDASGNTWNWLYFIPLII 335

  Fly   299 IGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTT 363
            |||||||||||||||||||||||:||.||||||||||||:||||.||:|||||||||:||||...
Zfish   336 IGSFFMLNLVLGVLSGEFAKERERVEKRQEFLKLRRQQQIERELTGYLEWICKAEEVMLAEEDKN 400

  Fly   364 EEEKMHIMEARRRNAAKRKKLKSLG------------KSKSTDTEEEEAEEDYGDDGYLKTRSKP 416
            .|:|..:...:|:........:|||            |||:.....||.|:.:.|...:    .|
Zfish   401 AEDKDDVAWYKRKCNNPGGFTRSLGADFGLPVLKRAKKSKNDLINAEEGEDHFTDISSV----AP 461

  Fly   417 QG--------------SCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPS 467
            ||              |.:.|.|.||||||:||..||.|.|||.|:.:|.|||:|||:.||.||.
Zfish   462 QGSPFTRTSVKSSKIESLSYFRRKEKRFRFFIRRMVKAQSFYWTVLCIVGLNTLCVAIVHYDQPE 526

  Fly   468 FLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GGSFG 531
            :||..||.|||:|||||:.||.:|||.||||.||.||||.||..||.||||||||:.|| |.|||
Zfish   527 WLTYALYLAEFVFLGLFLIEMSLKMYGLGPRTYFHSSFNCFDFGVIVGSIFEVIWAAVKPGASFG 591

  Fly   532 LSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLP 596
            :||||||||||||||||||:||||||:||||||:|||||||||||||::||||||||||||||..
Zfish   592 ISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFE 656

  Fly   597 GGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNV 661
            ..||.|||:|||.|:|||||||||||||.|||.||.||||..:||..|:|||||.||||||||||
Zfish   657 DETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVHRGMFCSVYFIVLTLFGNYTLLNV 721

  Fly   662 FLAIAVDNLANAQELTAAEEEQVEE-------DKEKQLQE------------------------- 694
            ||||||||||||||||..||||.|.       .|.|:::|                         
Zfish   722 FLAIAVDNLANAQELTKDEEEQEEAISKKLALQKAKEVKEVSPMSAANISITAFIRPNPGALSCS 786

  Fly   695 ----------------------------LEKEMEA------------------------------ 701
                                        :.|.|.|                              
Zfish   787 SSNSSSHSPKEQQRSLKMMSVWEQRTTQIRKHMLASSEALYQEELNPRLMSNLPLRTDIKTHLDR 851

  Fly   702 -----------------------LQADGV------------------------------------ 707
                                   ||.:|.                                    
Zfish   852 PLVVEPRCDGPISPHSGWDKPQDLQGEGSTPEERVPPVFEPPQSHPPRKHHRHRERLSNETNENG 916

  Fly   708 ----------------------------------------------------------------- 707
                                                                             
Zfish   917 DTGHAKEGRHHVHHSRSKEHDGTRCKEGKGDRSRSREGGRRHHHQSSVDEGVGGGEREHRHHHSH 981

  Fly   708 -HVENGDGAVA----------------------------------------PSKSK--------- 722
             |...|:|.|:                                        |..||         
Zfish   982 RHNREGNGVVSAGGKSERRSRQKEGSRSGTREGERCSRGENGGNGGRRRHRPRTSKAQSTLEGEE 1046

  Fly   723 --------GKKKEE-------------------------EKKEEEE------------------V 736
                    ||.:..                         ||.|:.:                  |
Zfish  1047 QHVNGEEEGKSQSHRHMDMGGDSMAVNPHQPSVGSRWCLEKPEDSDNKRNIGQTGGMSTHIPVTV 1111

  Fly   737 TEGP-------------------------------KPMLPYSSMFILSPTNPIRRGAHWVVNLPY 770
            |..|                               :|:||:|||||.:||||:||..|::|:|.|
Zfish  1112 TSPPGETTLIPMNSIDSETVPMTEKNLEDLNQSSIRPILPFSSMFIFNPTNPVRRLCHYIVSLRY 1176

  Fly   771 FDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLR 835
            |:..|:|||:||||||||||||:.|:.||.:|.|.||.||||||.||::|:||||:|||||||.|
Zfish  1177 FEMCILVVIAMSSIALAAEDPVQANAPRNNVLKYLDYVFTGVFTFEMVIKMVDLGLILHPGSYFR 1241

  Fly   836 EFWNIMDAVVVICAAVSFGF--------DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKA 892
            :.|||:|.:||..|.|:|.|        .::..:.|:::||||||||||||||||||||:|||||
Zfish  1242 DLWNILDFIVVSGALVAFAFSSFMGSHQSVNRGTKGKDISTIKSLRVLRVLRPLKTIKRLPKLKA 1306

  Fly   893 VFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELL 957
            ||||||||||||:|||||||||.|||:||.||||.|||||||||||....:|:|.:..|::|::.
Zfish  1307 VFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFYCTDESKGLEKDCRGLFLDYDKDDVT 1371

  Fly   958 PKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIV 1022
            .:.  |.||...||||||..|.||||.|.||||||.||:||:.||:||:||...:||||||||:|
Zfish  1372 AQP--REWKKYEFHYDNVLWAFLTLFTVSTGEGWPTVLKHSVDATFEDQGPSPGYRIEMSIFYVV 1434

  Fly  1023 YFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYK 1087
            ||:||||||||||||||||||||||:..|.:..::||:::||||.|.|:||.||||:|:.:|:|:
Zfish  1435 YFVVFPFFFVNIFVALIIITFQEQGDKVLSECSLEKNERACIDFAINAKPLTRYMPQNQQSFQYR 1499

  Fly  1088 VWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVK 1152
            :|:.|||.||||.||::|..||::||||:|...|.||..|||:|:.||.:||:|.:||||.||..
Zfish  1500 LWKFVVSPPFEYSIMIMIALNTVVLMMKFHGAPDFYEAMLKYLNIVFTVLFSLECILKIIAFGPL 1564

  Fly  1153 NFFKDPWNIFDLITVLGSIVDALWMEFGS--NSINVGFLRLFRAARLIKLLRQGYTIRILLWTFV 1215
            |:.||.||:||.:||||||.|.|..|..:  ..:|..||||||||||||||||||||||||||||
Zfish  1565 NYLKDAWNVFDFVTVLGSITDILVTEINTTERQLNFSFLRLFRAARLIKLLRQGYTIRILLWTFV 1629

  Fly  1216 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAW 1280
            |||||||||||||||||||||||||||||||.|.. :.:|.|||||::|:|.:|||||.||||||
Zfish  1630 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIDLND-DTAINRHNNFRTFLQALMLLFRSATGEAW 1693

  Fly  1281 PNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS 1345
            .:|||:||..:.||..:... |:.|||..||.|||||||.|||||||||||||||||:|||||||
Zfish  1694 HDIMLSCLSERTCDPSSGTL-GKECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSS 1757

  Fly  1346 ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDD 1410
            |||.||||||:|:||||||.|.|:|.|.:||:||.:|.||||.|.|||.|:|||:|::||||:.|
Zfish  1758 ILGPHHLDEFIRVWAEYDPAACGRIKYLDMYEMLLHMSPPLGLGKKCPPRIAYKRLVKMNMPIAD 1822

  Fly  1411 ELRVQFTTTLFALIRENLSIKMRAPEEMDQ-ADMELRETITNIWPLQAKKMLNLLVPPSDQLNKG 1474
            :..|.||:||.||||..|.||:.:.....: :|.||::.::.:||..::|.::|||.|.   ...
Zfish  1823 DNSVHFTSTLMALIRTALEIKLASGMVAQRLSDAELKKELSTVWPNLSQKTMDLLVTPH---KPN 1884

  Fly  1475 KLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDAS----------------RHPSQESLTGA 1523
            :|:|||:||..:|.:.::..|..:|......|:.|...                .|...:.:.|.
Zfish  1885 ELTVGKVYAALMIFDYYKQNRAKRLQMQQQQLKEQAGPGSQNKVSALLEPILPLTHMQDQPVNGV 1949

  Fly  1524 DA-----GHLHPGHSYMNGHRRSPSLRHNGSPLARSPS----------PRRRGHQYIHHDIGFSD 1573
            |:     ....|..:.:|..|.:......||....|..          |..||..   .|...::
Zfish  1950 DSASECQAQTRPSSTTLNNGRTTLDNTIKGSSSWASEKSKEVQKSKRRPMSRGQS---EDASNAN 2011

  Fly  1574 TVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTS 1638
            |....|||.|...                ||:|..:        ||...:.:...:|    ...:
Zfish  2012 TAQESVEMRKMEN----------------SANTVTS--------GGLEGQGRAASMP----KLNA 2048

  Fly  1639 LCQRSRS-PSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLK 1702
            ..|||.| .||..|.|           .:..:.::.|..|.|             |.:|..:.|.
Zfish  2049 EMQRSHSRQSPGTLLE-----------PIPDSPMRRSASTFA-------------PQRPHEVNLN 2089

  Fly  1703 PTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDR 1767
            ...:..|   ....|.||...|..|   |.||..:..|.:..|.....:......|...:|..||
Zfish  2090 DYILEKP---VQERHHHHHHHHRCH---HRRDRDKKQRSLDRSPTGHHKTTGTATDSVEERAHDR 2148

  Fly  1768 LHEYDLRYEYRDRERELY---ERERDREREVERERLEYIA--PLSFEQA-LAMGRTGRVLPSPVL 1826
            ...::.::.....|::.|   :|...||....:..:...|  |...::| |....:|....||||
Zfish  2149 GRSHERKHHSSSGEKQRYYSCDRYASREHCSSKSAVASCATSPSETQEANLNKQGSGWAKGSPVL 2213

  Fly  1827 ---------NGFK--PKSGLNPRHSDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPN-- 1878
                     .|.:  |::.|.||.|           :..|:.|...   |...|..:||..|:  
Zfish  2214 LTSGASTPSRGRRQLPQTPLTPRPS-----------VAYRTANSSP---VQLLATTTSLLPPSPG 2264

  Fly  1879 ------LDHN----FDTIRHSYQIPEHLQNLPYLCPPVHQHQHQHQTQTQNQRQHQDQHLYQRYG 1933
                  .:||    ..:|..|......:.:.|:|.||.|....|.:.             :..:.
Zfish  2265 RLSRGLSEHNALLLSGSISSSPAPVSRINSEPFLGPPDHPAGLQPEA-------------FAVFQ 2316

  Fly  1934 TNVSTPKLGTTISDIKLAGVSLQELSPNRQPQSQQKQEQQLHQDGWLRWYRQSGPYGSPVMASLP 1998
            .|.| |::|.:...:.:..|::    |...||..::.....|        ..:||     .||..
Zfish  2317 ENPS-PQMGRSPQTVGMPFVAI----PPPPPQQFRRVPNGYH--------FSTGP-----SASRG 2363

  Fly  1999 ETRATSPHSDIE 2010
            ..:...|.:::|
Zfish  2364 RAQQYYPEAEVE 2375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 183/286 (64%)
Ion_trans 441..677 CDD:334124 181/236 (77%)
Ion_trans 769..1050 CDD:334124 191/288 (66%)
Ion_trans 1094..1345 CDD:334124 171/252 (68%)
GPHH 1346..1416 CDD:339854 44/69 (64%)
Ca_chan_IQ 1418..1492 CDD:337190 26/74 (35%)
cacna1baXP_009299772.1 Ion_trans 132..361 CDD:278921 156/243 (64%)
Ion_trans 517..738 CDD:278921 172/220 (78%)
Ion_trans 1192..1416 CDD:278921 143/225 (64%)
Ion_trans 1524..1757 CDD:278921 161/234 (69%)
GPHH 1765..1828 CDD:293510 38/62 (61%)
Ca_chan_IQ 1830..1904 CDD:285917 26/76 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 376 1.000 Domainoid score I822
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20184
Inparanoid 1 1.050 1778 1.000 Inparanoid score I66
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - LDO PTHR45628
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X841
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1211.830

Return to query results.
Submit another query.