DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and scn8a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_031751845.1 Gene:scn8a / 549640 XenbaseID:XB-GENE-1011299 Length:1987 Species:Xenopus tropicalis


Alignment Length:1934 Identity:477/1934 - (24%)
Similarity:813/1934 - (42%) Gaps:513/1934 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|:||:..||:||:...|:....|...::.||:.|||.:.. .:.|...|.|        |..|.
 Frog   111 ALYILSPFNPLRKFAIKILIHSLFSMIIMCTILTNCVFMTF-SNPPEWSKQV--------EYTFT 166

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||:|.|..:...::||:.||.:||.|::..::|::..:|   ::..||..||||.|
 Frog   167 GIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLG---NVSALRTFRVLRAL 228

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC------------ 199
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|.:.|            
 Frog   229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRRKCVAWPVDMDQMYL 293

  Fly   200 -----------YSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTS--------MCLEKWE 245
                       |.:.|.|.....|              |....:|.|.:.        .|::...
 Frog   294 ANGSKGFDFDEYIMNDTNFFKVHG--------------AIDPLLCGNGSDAGQCPEGYTCMKAGR 344

  Fly   246 GPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLG 310
            .||.|.||||...:|.|.:|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:|.
 Frog   345 NPNYGYTSFDTFSWAFLALFRLMTQDFWENLYQLTLRASGKTY-MIFFVLVIFVGSFYLVNLILA 408

  Fly   311 VLSGEF-------AKEREKVENRQEFLKL-----RRQQQLERELN----GYVEWICKAEEVILAE 359
            |::..:       .:|.|:.||  ||..:     |.|::.:...|    |.|     .|:.:..|
 Frog   409 VVAMAYEEQNQATLEEAERKEN--EFKAMLEQMKRMQEEAQAAANATSAGTV-----TEDAVEDE 466

  Fly   360 E-------RTTEEEKMHIMEAR-RRNAAKRKKLKSLG------------KSKSTD---------- 394
            :       .::|..|.....|: |||..|::|.|.|.            ||:|.|          
 Frog   467 DGEARMSHTSSEFSKPSSKSAKERRNRRKKRKQKELSEGEEKGDSEKVYKSESEDGVKRRGFWYP 531

  Fly   395 --------------------------------------------TEEEEAEEDY----------- 404
                                                        :|.|.|::::           
 Frog   532 DNRLGRRFSIMNQSLLSIPGSPYLSRHNSKSSIFSFRGRFRDPVSENEFADDEHSTVEESEGRRD 596

  Fly   405 -------GDD-------GY---------------------------------------------- 409
                   |.|       ||                                              
 Frog   597 SLFIPVRGHDRRNSYNSGYSQGSRSSRILQNLRRNPKRNSTVDCNGVVSLIGGPGSNIPGGRLLP 661

  Fly   410 ----------------LKTRSKPQGS--------------------------------------C 420
                            ::.:.||.||                                      |
 Frog   662 EVKIDKAATDDSPTTEVEVKRKPSGSLRVSMDQLTASFGRKRANSILSVVTQTLVEELEESQRKC 726

  Fly   421 TGFWRAEKRFRF------------WIRHTVKT--------QWFYWFVIVLVFLNTVCVAVEHYGQ 465
            ...|     ::|            |||  :||        .:....:.:.:.|||:.:|:|||..
 Frog   727 PPCW-----YKFADTYLIWTCCPLWIR--IKTIVNMIVMDPFVDLTITICIVLNTLFMAMEHYPM 784

  Fly   466 PSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSF 530
            .......|.....:|.|:|.:|||:|:.|:.|..||:..:|.||..::|.|:.|:...:|:    
 Frog   785 TPHFENVLVVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELGLQDVE---- 845

  Fly   531 GLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-- 593
            ||||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:  
 Frog   846 GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKD 910

  Fly   594 -----NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLF 653
                 |.....|..:.|.|..:.|.||::|.|| |.|.|:..:...|.|    :..|.|:::::.
 Frog   911 CVCKINPECVLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQA----MCIIVFMMVMVI 970

  Fly   654 GNYTLLNVFLAI-----AVDNLA---------------------------NAQELTAAEEEQVEE 686
            ||..:||:|||:     :.||||                           .|.:......::.:.
 Frog   971 GNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGIAWIKLKAHDFMQKHFKKKDA 1035

  Fly   687 DKEKQLQEL-EKEMEAL--------QADGVHVENGDG---------------------------- 714
            |:.|.|.|: ||:|..|        ..|..:.:||:|                            
 Frog  1036 DEVKPLDEMYEKKMNCLANNTGADIHRDMDYPKNGNGTTSGIGSSVEKYMIDEDHMSFIHNPNLT 1100

  Fly   715 -----AVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMF---------------------ILS 753
                 ||..|..:....|:.....:|  ||.|..|..:|..                     .|.
 Frog  1101 VKVPIAVGESDFENLNTEDFSSASDE--EGSKDKLDDTSSSEGSTIDIKPEAEEVPVEQPEEYLD 1163

  Fly   754 PTN--------------------------PIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP- 791
            |.|                          .:|:....:|...:|:.||:.:|.:||.|||.||. 
 Frog  1164 PDNCFTEGCVARFKCCQVSVEEGLGKSWWTLRKTCFLIVEHNWFETFIIFMILLSSGALAFEDVY 1228

  Fly   792 VRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFD 856
            :.:......||.|.|..||.:|.:|||||.:..|.:    .:....|..:|.::|..:.||...:
 Frog  1229 IEQRKTIRTILEYADKVFTYIFILEMLLKWLAYGFV----KFFTNAWCWLDFLIVDVSLVSLIAN 1289

  Fly   857 MSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVI 921
            ..|.|   .|..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..|||::
 Frog  1290 ALGYS---ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM 1351

  Fly   922 GVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRV-WKPRAFHYDNVAAAMLTLFAV 985
            ||.||.||::||.:|:.....|.:....:.:..:|:......| ||....::|||.|..|.|..|
 Frog  1352 GVNLFAGKYYYCYNETAEGMFEIEDVENETQCFDLIGNNYTEVRWKNVKINFDNVGAGYLALLQV 1416

  Fly   986 QTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF----PFFFVNIFVALIIITFQEQ 1046
            .|.:||..:    |.|..:.|...|..:.|.:|:..:||::|    .||.:|:|:.:||..|.:|
 Frog  1417 ATFKGWMDI----MYAAVDSRKVHQQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1477

  Fly  1047 -----GEAELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMML 1104
                 |    ||..:.:.||...:.  .:|::..::.:|:..|.|:..::.|:....|:..||:|
 Frog  1478 KKKFGG----QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGAIFDIITQQAFDIVIMIL 1538

  Fly  1105 IVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLG 1169
            |..|.:.:|::..:|.|..:..|.:||:.|...|:.|.|||:.... ..:|...|||||.:.|:.
 Frog  1539 ICLNMVTMMVETDDQSDYTDNVLYWINVVFIVFFTTECVLKLCALR-HYYFTIGWNIFDFVVVIL 1602

  Fly  1170 SIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1229
            |||     |.:...|.|.:: ...:||.|..|:::|::....||.||:..:.|..||..:.||:.
 Frog  1603 SIVGMFLADLITKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLF 1666

  Fly  1230 MLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACD 1294
            ::.||::|.||..|..:|   .|..|....||::|...::.||:..|...|..::|..| .:..|
 Frog  1667 LVMFIFSIFGMSNFAYVK---KEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPIL-NRPPD 1727

  Fly  1295 DDAEKA-PGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHL 1352
            .||.|. ||..    ||: ::...:|||:|.....:::|:::|:|::||...|.:|: .|.....
 Frog  1728 CDAHKENPGSQVKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDF 1792

  Fly  1353 DEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFT 1417
            :.|..||.::||:||..|.::::.|....::.||....  ||.:   :||.|::|:....|:...
 Frog  1793 ETFYEIWEKFDPDATQFIQFSKLPDFADALEHPLRIPK--PNTI---ELIAMDLPMVSGDRIHCL 1852

  Fly  1418 TTLFALIRENLSIKMRAPEEMD--QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGK 1480
            ..|||..:..|.    ...|:|  :..||.|...:|...:..:.:...|....:.::  .:.:.:
 Frog  1853 DILFAFTKRVLG----ESGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEDVS--AVVIQQ 1911

  Fly  1481 IYAGFLILESW----RSTRFGQLDSGMPMLELQDASRHPSQESLTGADA 1525
            .|...|:...:    |||  |::::|...::.::.:  ||..||...|:
 Frog  1912 AYRRHLVKRGFISRKRST--GKMENGGTNMDKKEGT--PSTASLPSYDS 1956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 86/324 (27%)
Ion_trans 441..677 CDD:334124 84/274 (31%)
Ion_trans 769..1050 CDD:334124 95/291 (33%)
Ion_trans 1094..1345 CDD:334124 81/261 (31%)
GPHH 1346..1416 CDD:339854 19/69 (28%)
Ca_chan_IQ 1418..1492 CDD:337190 13/79 (16%)
scn8aXP_031751845.1 Ion_trans 131..421 CDD:395416 84/316 (27%)
Na_trans_cytopl 503..709 CDD:403218 15/205 (7%)
Ion_trans 759..972 CDD:395416 72/221 (33%)
Na_trans_assoc 998..1199 CDD:399489 27/202 (13%)
Ion_trans 1204..1480 CDD:395416 94/286 (33%)
Na_channel_gate 1472..1524 CDD:240441 11/55 (20%)
Ion_trans 1529..1783 CDD:395416 81/259 (31%)
GPHH 1795..1842 CDD:407139 16/51 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

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