Protein Alignment cac and nalcn

DIOPT Version :9

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: XP_005167755.1
• Gene: nalcn / 548345
• ZFINID: ZDB-GENE-050410-12
• Length: 1743
• Species: Danio rerio
• Alignment Length: 1818
• Identity: 393/1818 - (21%)
• Similarity: 712/1818 - (39%)
• Gaps: 504/1818 - (27%)

  Fly    37 WPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHK 101
            :||.:|          |..||:        |:|           :.::..|...|:...|::..:
Zfish    89 YPPLQY----------VTFALD--------TLL-----------MFLYTAEMIAKMHIRGIIKGE 124

  Fly   102 HSYLRNIWNIMDFFVVV---TGFMTQYPQIGPEVD-------LRTLRAIRVLRPLKLVSGIPSLQ 156
            :||:::.|.:.|.|:||   ...:.|..:|...||       ||..||:.::|..::.......:
Zfish   125 NSYVKDRWCMFDGFMVVFLWVSLVLQVFEIAELVDQMSPWGMLRIPRALIMIRVFRIYFRFELPR 189

  Fly   157 VVLKSIIKAMA-PLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGE---SETP 217
            ..:.:|:|... .:..:.:.:||.::::.|:|::.: |..:..|.:.|...:.|....   .:|.
Zfish   190 SRITNILKRSGEQIWSVTIFLLFFLLLYGILGVQMF-GTFNHHCVTNETEKEKVTWNSLAIPDTH 253

  Fly   218 CNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTND 282
            |:.:....:....|.|.:.....|.:.|   .|.:.|:.:|.::.||::..:.|||..|:|...|
Zfish   254 CSPNGEGYQCPVGFKCVDLEDYGLSRQE---LGYSGFNELGTSIFTVYEAASQEGWVFIMYRAID 315

  Fly   283 ALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVE 347
            :.....::.||:.||...::.:.|:.:.|:...||      |.|.:|      ||:
Zfish   316 SFPRWRSYFYFLTLIFFLAWLVKNVFIAVIIETFA------EIRVQF------QQM--------- 359

  Fly   348 WICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKT 412
            |                                      ..:|.:|.|...:...:....|:...
Zfish   360 W--------------------------------------GSRSSTTSTATTQMFHEDASGGWQLV 386

  Fly   413 R---SKPQG---SCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVE-HYGQPSFLT 470
            .   :||.|   :|             ::..:::..|:.|::.:|.::.:..|.. |.|......
Zfish   387 AVDVNKPHGRAPAC-------------LQQLMRSSVFHMFILSMVAVDVIVAASNYHRGDHKLTN 438

  Fly   471 EFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVL 535
            :..|.||..|..||..|..:|::.||...|..||.::|:.:::.|:... |:.::....|  :..
Zfish   439 DEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFESLLVVGTTLH-IYPDLYHSQF--TYF 500

  Fly   536 RALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTP 600
            :.||::|:.|::   .:|.:.|..:....:.:.||:......:::.:.:.:|:|....:|
Zfish   501 QVLRVVRLIKIS---PALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEDL----- 557

  Fly   601 ETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAI 665
             ..|.|||.|.:::|||||.|.|.:||.|.:::. |.....:.:||||:..||....||::|:|:
Zfish   558 -DRFTTFPRAFMSMFQILTQEGWVDVMDQTLVAV-GQMWAPVVAIYFILYHLFATLILLSLFVAV 620

  Fly   666 AVDNL----------------ANA----------------------------------------- 673
            .:|||                |||
Zfish   621 ILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPRIRESF 685

  Fly   674 ----------------QELTAAEEEQVEEDKEKQL-------QELEKEMEALQADGV-------- 707
                            :.|.:|.....:..|...:       |:|.|.:.:::|..:
Zfish   686 MKQFIDRQQQDPSCLFRRLPSASSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLMEKEITVN 750

  Fly   708 -------------------------------HVEN-----GDGAVAPSKSKGKKKE--------- 727
                                           |:..     ..|:.:...|:||..|
Zfish   751 KILRACTRQRMLSGSFEGQPTKERSILSVQHHIRQERRSLRHGSTSQRISRGKSLETLTQDHSST 815

  Fly   728 ----------------EEKKE---------EEEVTEG----PKPM--------------LPYSSM 749
                            :||||         |||:.|.    .||:              :...:.
Zfish   816 VRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRMIVRAR 880

  Fly   750 FILSPTNPIRRGA------HWVVNL----PYFDFFIMVVISMSSIALAAEDPVRENSRRNKI--L 802
            |..|.|:| ..||      |.:.:|    .|.|:.::||...|.|::..|.|.   :|...:  |
Zfish   881 FNASNTDP-NTGAVNSTKYHQLYDLLGLVTYLDWVMIVVTICSCISMMFESPF---TRVMHVPTL 941

  Fly   803 NYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGF---DMSGSSAGQ 864
            ...:|.|....:||:.|||:..|:...|.:.:|:|..:||..:.:.:.:...:   ::...|..|
Zfish   942 QIGEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWLPNNVPPESGAQ 1006

  Fly   865 NLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGK 929
                  .|.:||..|||:..|.||:::.|...|:...|.:..:.|:.:....:|:..|||||.||
Zfish  1007 ------LLMMLRCFRPLRIFKLVPQMRKVVREVLKGFKEIFLVSILLLTLMLVFATFGVQLFAGK 1065

  Fly   930 FFYCTDESKHTSAECQGSY-----------FKYEEDELLPKQEL-RVW-KPRAFHYDNVAAAMLT 981
            ...|.|....:..:|.|.:           .|.::.|..|...: ||| .||.|::|||..|||.
Zfish  1066 LAKCNDPHISSKDDCHGIFRINVSISKNLNLKLKDGEKKPGFWVPRVWANPRNFNFDNVGNAMLA 1130

  Fly   982 LFAVQTGEGWPQ---VLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPF----FFVNIFVALI 1039
            ||.|.:.:||.:   |:.|.:       |||..          :|..||.|    ..:.:||.::
Zfish  1131 LFEVLSLKGWVEVRDVIIHRV-------GPIHG----------IYIHVFVFLGCMIGLTLFVGVV 1178

  Fly  1040 IITFQE-QGEAELQDGEIDKNQ----KSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEY 1099
            |..|.| :|.|.|   .:|:.:    ||.:..   |:||..........|:.|::.|.....|:.
Zfish  1179 IANFNENKGTALL---TVDQRRWEDLKSRLKI---AQPLHLPPRPENGGFRAKMYDITQHPFFKR 1237

  Fly  1100 FIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFD- 1163
            .|.:|::..::||.:|:...|.: ...|..:::.||.:|.:|..:|:|......:::...|.:|
Zfish  1238 GIAVLVLAQSVLLSVKWDELGAV-TFPLATMSVVFTFIFVLEVTMKLIAMSPAGYWQSRRNRYDL 1301

  Fly  1164 LITVLGSIVDALW--MEFG-SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1225
            |:|.||.|    |  :.|. .|:............|...:..:..|:::||.|.|.|.....::.
Zfish  1302 LVTSLGLI----WIILHFALQNAYTYMMGTCVIVFRFFTICGKHVTLKMLLLTVVVSMYKSFFII 1362

  Fly  1226 LLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACL-K 1289
            :.:.:|...||..|:.:||.:|.|  || |.||.||.:..:.:.:|.|..|||.|..||..|: :
Zfish  1363 VGMFLLLLCYAFAGVVLFGTVKYG--EN-INRHANFSTAGKAITVLIRIVTGEDWNKIMHDCMVQ 1424

  Fly  1290 GKACDDDA----EKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFD--YLTRDSSILG 1348
            ...|..|.    |...|.|.|   |..||.||....:::||||.||:|::||.  |.|.:..:|.
Zfish  1425 PPFCTPDKHRYWETDCGNYAG---ALIYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLS 1486

  Fly  1349 AHHLDEFVRIWAEYDPNATGKIHYTEMYDMLK--------NMD-PPLGFGNKC------------ 1392
            .:.|..|..||...|....|.|..:.:..:|:        ::| ..|.|.:.|
Zfish  1487 YNDLRHFQIIWNMVDDKREGVIPTSRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDV 1551

  Fly  1393 -----PNRLAYKKL-IRMNMPLDDEL---RVQFT-------TTLFALIRENLSIKMRAPEEMD-Q 1440
                 .:.|:|:.: ||.::.|::.|   ::::|       .|:...:::.|. ::||.::.. .
Zfish  1552 TFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLK-RIRAKQQQSCS 1615

  Fly  1441 ADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPM 1505
            ..:.|||:       |.:.:..||.|||                              :::.:|.
Zfish  1616 IILSLRES-------QQQDLRRLLNPPS------------------------------IETTVPS 1643

  Fly  1506 LELQDASRH----PSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQY 1564
               :|.:.|    |:|..........|.|..|..:|:|:..:.|           |:|:..|:
Zfish  1644 ---EDTNTHNQDNPTQPEQNSGLQTLLSPTLSDRSGYRQDSADR-----------PQRKLGQW 1692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	62/300 (21%)
		Ion_trans	441..677	CDD:334124	66/309 (21%)
		Ion_trans	769..1050	CDD:334124	85/306 (28%)
		Ion_trans	1094..1345	CDD:334124	77/261 (30%)
		GPHH	1346..1416	CDD:339854	19/99 (19%)
		Ca_chan_IQ	1418..1492	CDD:337190	13/74 (18%)
nalcn	XP_005167755.1	Ion_trans	85..355	CDD:278921	64/304 (21%)
		Ion_trans	429..626	CDD:278921	58/209 (28%)
		Ion_trans	926..1184	CDD:278921	77/283 (27%)
		Ion_trans	1263..1481	CDD:278921	70/227 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850