DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1f

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_062528.2 Gene:Cacna1f / 54652 MGIID:1859639 Length:1984 Species:Mus musculus


Alignment Length:1910 Identity:817/1910 - (42%)
Similarity:1089/1910 - (57%) Gaps:271/1910 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY 79
            |.:||.||..||||:....|:||.||:..:||||.||||.|.:....|..|.......||:.|..
Mouse    69 PRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYV 133

  Fly    80 FLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGP-------------- 130
            ||.||.||..|||:|.|||||..:|:||.||::||.:||.|..:...:.||              
Mouse   134 FLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG 198

  Fly   131 EVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 195
            ..|::.|||.||||||:||||:|||.:||.||:||:.|||.|.|||||.|:|:||||||.:.|.:
Mouse   199 GFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRM 263

  Fly   196 HKTCYSL-------EDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITS 253
            |||||.|       |||:.....|...:                |....:.|..:|.|||.|||:
Mouse   264 HKTCYFLGSDMEAEEDPSPCASSGSGRS----------------CTLNHTECRGRWPGPNGGITN 312

  Fly   254 FDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAK 318
            |||..||||||||||||||||.:|||..||:|....|:|||.|::.||||:||||||||||||:|
Mouse   313 FDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSK 377

  Fly   319 EREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEV------------ILAEE-RTTEEEKMHI 370
            ||||.:.|.:|.|||.:||:|.:|.||::||.:|||:            .|||| |.....::..
Mouse   378 EREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSE 442

  Fly   371 MEARRR--------------NAAKRKKLKSLGKSKSTDTEEEEAEEDYGD--------DGYLKTR 413
            :..|||              :.:....|.:......|||..:|.||: |.        :..:|||
Mouse   443 LTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTDTPGDEDEEE-GTMASCTRCLNKIMKTR 506

  Fly   414 SKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEF 478
                 .|..|.||.:..|...|..||:...||.|::||||||:.:|.||:|||.:||:...||..
Mouse   507 -----ICRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPLWLTQTQEYANK 566

  Fly   479 IFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGS---FGLSVLRALRL 540
            :.|.||..||.:|:|.|||.:|..|.||||||.|:.|.|.|....||  |:   .|:||||.:||
Mouse   567 VLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEV--GAMQPLGISVLRCVRL 629

  Fly   541 LRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL-PGGTPETNF 604
            |||||||::|:||.|||.||||||:||.|||.||||||:||:|||||||||:||. ...|..:.|
Mouse   630 LRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTF 694

  Fly   605 NTFPIALLTVFQILTGEDWNEVMYQGIISQGGA-QKGMIYSIYFIVLVLFGNYTLLNVFLAIAVD 668
            :|||.|||||||||||||||.|||.||::.||. ..||:..:|||:|.:.|||.|||||||||||
Mouse   695 DTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVD 759

  Fly   669 NLANAQELTAAE---EEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEK 730
            |||:....||.:   |:..|.:..|:.:.|....|...|.|...|   || ||...:.:::|||:
Mouse   760 NLASGDAGTAKDKGREKSSEGNPPKENKVLVPGGENEDAKGARSE---GA-APGMEEEEEEEEEE 820

  Fly   731 KEEEEVTEG-----------PK----PMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVIS 780
            :||||...|           ||    |:...|:.|.||.|||:|:..|.:::...|...|:|.|.
Mouse   821 EEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHIFTSLILVFII 885

  Fly   781 MSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVV 845
            :||::||||||:|.:|.||.||.|||||||.:||:|:|||:...|..||.||:.|.::|::|.:|
Mouse   886 LSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNLLDLLV 950

  Fly   846 VICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIV 910
            |..:.:|||...|.      :|.:|.||||||||||:.|.|...||.|..||..:::.:.||:||
Mouse   951 VSVSLISFGIHSSA------ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIV 1009

  Fly   911 YILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE-DELLPKQELRVWKPRAFHYDN 974
            ..|.||:|:.||||||.|||:.||||:|||..||:||:..|.: |...|....|:|....|::||
Mouse  1010 TTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNSDFNFDN 1074

  Fly   975 VAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALI 1039
            |.:||:.||.|.|.||||.:|..::.|..||.|||.|:.:|:|:|:|||.|:..||.:||||..:
Mouse  1075 VLSAMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFV 1139

  Fly  1040 IITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMML 1104
            ||||:.|||.|.|:.|:||||:.|:::.:.|:||.||:|||.:  :|:||..|.|..|||.:.:|
Mouse  1140 IITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPH--QYRVWATVNSAAFEYLMFLL 1202

  Fly  1105 IVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLG 1169
            |:.||:.|.|:::.|...:..::..:||.|||:|::|.|||||.|..|::|.|.||.||.:.|:|
Mouse  1203 ILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFADAWNTFDALIVVG 1267

  Fly  1170 SIVDALWMEFG-----------SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPY 1223
            |:||....|..           |:.|::.|.||||..||:|||.:|..||.|||||::||:||||
Mouse  1268 SVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPY 1332

  Fly  1224 VCLLIAMLFFIYAIIGMQVFGNIKL--GTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLA 1286
            |.|||||:|||||:||||:||.:.|  ||   .|.|:||||:|.|.|:|||||||||||..||||
Mouse  1333 VALLIAMIFFIYAVIGMQMFGKVALQDGT---QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLA 1394

  Fly  1287 CLKGKACDDDAEKAPGE--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGA 1349
            .|.|..||.:::..|||  .|||:.|..||:||...|:||::|||||||||||||||||.||||.
Mouse  1395 SLPGNRCDPESDFGPGEEFTCGSSFAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGP 1459

  Fly  1350 HHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRV 1414
            ||||||.|||:||||.|.|:|.:.::..:|:.:.||||||..||:|:|.|:|:.||:||:.:..|
Mouse  1460 HHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTV 1524

  Fly  1415 QFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVG 1479
            .|..|||||:|.:|.||...  .:|||:.|||..|..||....:|:|:.::||.|:   .:::||
Mouse  1525 TFNATLFALVRTSLKIKTEG--NLDQANQELRMVIKKIWKRIKQKLLDEVIPPPDE---EEVTVG 1584

  Fly  1480 KIYAGFLILESWRSTR-------FGQ---------LDSGMPMLE----------LQDASRHPSQE 1518
            |.||.|||.:.:|..|       .|:         |.:|:..|:          ..|......:|
Mouse  1585 KFYATFLIQDYFRKFRRRKEKGLLGREAPTSTSSALQAGLRSLQDLGPEIRQALTYDTEEEEEEE 1649

  Fly  1519 SLTGADAGHLHPGHS---YMNGHRRSPSLRHNG--------------------------SPLARS 1554
            ...|.:|......::   |.:.....|..|.|.                          :|.:|.
Mouse  1650 EAVGQEAEEEEAENNPEPYKDSIDSQPQSRWNSRISVSLPVKEKLPDSLSTGPSDDDGLAPNSRQ 1714

  Fly  1555 PS-------PRRR---------------------GHQYIHHDIGFSDTVSNVVEMVKETRHP--- 1588
            ||       |.||                     |....:.:....|...::.|......:|   
Mouse  1715 PSVIQAGSQPHRRSSGVFMFTIPEEGSIQLKGTQGQDNQNEEQEVPDWTPDLDEQAGTPSNPVLL 1779

  Fly  1589 ------RHGNSHPRYPRGSWSASTSPARSPS-----PSRYGGHLSRSKRTQLPYP-TYGTTSLCQ 1641
                  :|.|.| ..||......|...|.||     ..|.|      ....||.| ||      .
Mouse  1780 PPHWSQQHVNGH-HVPRRRLLPPTPAGRKPSFTIQCLQRQG------SCEDLPIPGTY------H 1831

  Fly  1642 RSRSPSPARLQ----EMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLK 1702
            |.|:..|:|.|    ...::.||.|.            |.|....:.:|.........|    |:
Mouse  1832 RGRTSGPSRAQGSWAAPPQKGRLLYA------------PLLLVEESTVGEGYLGKLGGP----LR 1880

  Fly  1703 P-TNINFPKLNASPTHTHHSTPHSV 1726
            . |.:..|..:.:|:|....:..|:
Mouse  1881 TFTCLQVPGAHPNPSHRKRGSADSL 1905

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 155/307 (50%)
Ion_trans 441..677 CDD:334124 144/240 (60%)
Ion_trans 769..1050 CDD:334124 139/281 (49%)
Ion_trans 1094..1345 CDD:334124 142/265 (54%)
GPHH 1346..1416 CDD:339854 37/69 (54%)
Ca_chan_IQ 1418..1492 CDD:337190 31/73 (42%)
Cacna1fNP_062528.2 Ion_trans 109..383 CDD:278921 144/289 (50%)
Ion_trans 546..763 CDD:278921 134/218 (61%)
Ion_trans 891..1110 CDD:278921 111/224 (50%)
Ion_trans 1210..1455 CDD:278921 134/247 (54%)
GPHH 1463..1526 CDD:293510 31/62 (50%)
Ca_chan_IQ 1528..1599 CDD:285917 32/75 (43%)
CAC1F_C 1623..1981 CDD:293490 55/312 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.720

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