DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and Cacna1e

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_038946935.1	Gene:	Cacna1e / 54234	RGDID:	2246	Length:	2465	Species:	Rattus norvegicus

Alignment Length:	2346	Identity:	1026/2346 - (43%)
Similarity:	1284/2346 - (54%)	Gaps:	598/2346 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ||||..|||.:|||.:.:|:||||||.:|.||||||:|||||:|||..|||.::::|||||.||:
  Rat   215 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFI 279

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPEVDLRTLRAIRVLRP 145
            .|||.||.:||:|||.:.||.|||||.||:|||.||::|.: |........||||||||:|||||
  Rat   280 GIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRP 344

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK 210
            |||||||||||:|||||:|||.||||||||:.|||::|||||||||||.||:.|:.   .|..:.
  Rat   345 LKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM---NNSGIL 406

  Fly   211 EG-ESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWT 274
            || :...||.    ::.....:.|.:        |.|||.|||.||||.||:|||||||||||||
  Rat   407 EGFDPPHPCG----VQGCPAGYECKD--------WIGPNDGITQFDNILFAVLTVFQCITMEGWT 459

  Fly   275 AILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLE 339
            .:||.||||||:.:||:||:|||:|||||:|||||||||||||||||:||||:.|:|||||||:|
  Rat   460 TVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIE 524

  Fly   340 RELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDY 404
            ||||||..||.|||||:||||  .:......:|..||...||.:.:::.:..|     :|...|.
  Rat   525 RELNGYRAWIDKAEEVMLAEE--NKNSGTSALEVLRRATIKRSRTEAMTRDSS-----DEHCVDI 582

  Fly   405 GDDGYLKTR-----SKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYG 464
            ...|....|     :|..|: :.|...|:..|..|||.||:|.|||.|:.:|.|||.|||:.|:.
  Rat   583 SSVGTPLARASIKSTKVDGA-SYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHN 646

  Fly   465 QPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GG 528
            ||.:||..||||||:|||||:.||.:|||.:|||:||.||||.||..|..||||||:|:..: |.
  Rat   647 QPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGT 711

  Fly   529 SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF 593
            |||:|||||||||||||:||||:||||||:||::||:|||||||||||||::|||||||||||:|
  Rat   712 SFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF 776

  Fly   594 NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658
            |...|||..||:|||.|::||||||||||||||||.||.||||...||..:||||||.|||||||
  Rat   777 NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTL 841

  Fly   659 LNVFLAIAVDNLANAQELTAAEEEQ--------------------------VEEDK--------- 688
            |||||||||||||||||||..|:|:                          :|.|:
  Rat   842 LNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMW 906

  Fly   689 -------------------EKQLQELEKEM-----EAL--------------------------- 702
                               |::..:|.:.|     |||
  Rat   907 EPRSSHLRERRRRHHMSVWEQRTSQLRRHMQMSSQEALNKEEAPPMNPLNPLNPLSPLNPLNAHP 971

  Fly   703 ----------------------------------------------------------------- 702

  Rat   972 SLYRRPRPIEGLALGLGLEKCEEERISRGGSLKGDIGGLTSVLDNQRSPLSLGKREPPWLPRSCH 1036

  Fly   703 ----------------------------------------------------------------- 702

  Rat  1037 GNCDPTQQETGGGETVVTFEDRARHRQSQRRSRHRRVRTEGKESASASRSRSASQERSLDEGVSI 1101

  Fly   703 ----------------------------------------------------------------- 702

  Rat  1102 DGEKEHEPQSSHRSKEPTIHEEERTQDLRRTNSLMVPRGSGLVGALDEAETPLVQPQPELEVGKD 1166

  Fly   703 ------QADG------------------------------------------------------- 706
                  :|:|
  Rat  1167 AALTEQEAEGSSEQALLADVQLDVGRGISQSEPDLSCMTTNMDKATTESTSVTVAIPDMDPLVDS 1231

  Fly   707 --VHVEN-GDGAVAPSKSKGKKKEEE----KKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHW 764
              |::.| .||..:|.|....|:|||    ||:::|..|..|.|:|:|||||.|.|||||:..|:
  Rat  1232 TVVNISNKTDGEASPLKEAETKEEEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRKACHY 1296

  Fly   765 VVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILH 829
            :|||.||:..|::||:.|||||||||||..||.|||:|.||||.||||||.||::|::|.|:||.
  Rat  1297 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQ 1361

  Fly   830 PGSYLREFWNIMDAVVVICAAVSFGF-DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAV 893
            .|||.|:.|||:|.|||:.|.|:|.. :..|::.|:::.|||||||||||||||||||:||||||
  Rat  1362 DGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAV 1426

  Fly   894 FDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLP 958
            |||||.|||||.||||||.||.|||:||.||||.||||||||.||.|..||.|:|..:|::::..
  Rat  1427 FDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEV 1491

  Fly   959 KQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVY 1023
            |.  |.||...|||||:..|:||||.|.||||||||||||:..|.|||||.::.|:||||||:||
  Rat  1492 KG--REWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVY 1554

  Fly  1024 FIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKV 1088
            |:||||||||||||||||||||||:..:::..::||:::||||.|.|:||.||||:||:||:|:|
  Rat  1555 FVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRV 1619

  Fly  1089 WRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN 1153
            |..|||..|||.||.:|..||::|||||::....||.:|||:|:.||.:||:|.|||:|.||..|
  Rat  1620 WHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPWTYELALKYLNIAFTMVFSLECVLKVIAFGFLN 1684

  Fly  1154 FFKDPWNIFDLITVLGSIVDALWME---FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFV 1215
            :|:|.|||||.|||:|||.:.:..:   ..::..|:.||:|||||||||||||||||||||||||
  Rat  1685 YFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFV 1749

  Fly  1216 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAW 1280
            |||||||||||||||||||||||||||||||||.. |:.|.|||||:||...:|||||.||||||
  Rat  1750 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDE-ESHINRHNNFRSFFGSLMLLFRSATGEAW 1813

  Fly  1281 PNIMLACLKGKACDDDAEKAPG----EYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLT 1341
            ..|||:||..|.|:.|.....|    |.||:.|||.|||||||||||||||||||||||||:|||
  Rat  1814 QEIMLSCLGEKGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLT 1878

  Fly  1342 RDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNM 1406
            |||||||.||||||||:|||||..|.|:|||||||:||..|.||||.|.:||:::|||:|:.|||
  Rat  1879 RDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNM 1943

  Fly  1407 PLDDELRVQFTTTLFALIRENLSIKM-RAPEEMDQADMELRETITNIWPLQAKKMLNLLVP---P 1467
            |:.:::.|.||:||.||||..|.||: :...:..|.|.||::....|||..::|||:||||   .
  Rat  1944 PVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKA 2008

  Fly  1468 SDQLNKGKLSVGKIYAGFLILESWRSTRF----GQLD--SGMPMLELQDASRHPSQESLTGADA- 1525
            ||      |:||||||..:|::.::.::.    .||:  ...||.:..:.|..| ||.::.|.|
  Rat  2009 SD------LTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLP-QEIISNAKAL 2066

  Fly  1526 GHLHPGH-SYMNGHRRSPSLRHNGSPLARSP---------SPRRRGHQYIHHDIGFSDTVSNV-- 1578
            .:|.... |.::|....||:    |||  ||         .|...|.        |.:..|.|
  Rat  2067 PYLQQDPVSGLSGRSGYPSM----SPL--SPQEIFQLACMDPADDGQ--------FQEQQSLVNE 2117

  Fly  1579 ----VEMVKETRHPRHGNSHP---RYPRGSWSASTSP--------ARSPSPSRYGGHLSRSKRTQ 1628
                |..:|..:...||...|   :...||..||:.|        ...||..|......|.||:.
  Rat  2118 REPEVSELKSVQSSNHGIYLPPDTQEHAGSGRASSMPRLTMDPQVVTDPSSMRRSFSTIRDKRSN 2182

  Fly  1629 LPYPTYGTTSLCQRSRSPSPARLQEM-RERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPT 1692
            ..:                   |:|. .||.               |..|..|||.
  Rat  2183 SSW-------------------LEEFSMERS---------------SENTYKSRRR--------- 2204

  Fly  1693 PSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLR 1757
             |..|:|:|....:|....:.|.||..                         ..|||.|.:||..
  Rat  2205 -SYHSSLRLSAHRLNSDSGHKSDTHRS-------------------------GGRERGRSKERKH 2243

  Fly  1758 ----DRDRDRDRDRLHEYDLRYEYRDRERELYE-RERDRERE--------------------VER 1797
                |..|....:|..:.|.....|.:.|...| |.:...|:                    ..|
  Rat  2244 LLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSISDTSTPRRSR 2308

  Fly  1798 ERLEYIAP-----LSFEQALAMGRTGRVLPSP-----------------------VLNGFKPKSG 1834
            .:|..:.|     ||:..  .|..||.:.|.|                       ..|...|:.|
  Rat  2309 RQLPPVPPKPRPLLSYSS--LMRHTGGISPPPDGSEGGSPLASQALESNSACLTESSNSLHPQQG 2371

  Fly  1835 LNPR------------HSDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPNLDHNFDTIR 1887
            .:|.            |.||...| |.:          ::......|:.:||...|...:...:|
  Rat  2372 QHPSPQHYISEPYLALHEDSHASD-CGE----------EETLTFEAAVATSLGRSNTIGSAPPLR 2425

  Fly  1888 HSYQIP 1893
            ||:|:|
  Rat  2426 HSWQMP 2431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	183/288 (64%)
		Ion_trans	441..677	CDD:334124	172/236 (73%)
		Ion_trans	769..1050	CDD:334124	188/281 (67%)
		Ion_trans	1094..1345	CDD:334124	171/257 (67%)
		GPHH	1346..1416	CDD:339854	44/69 (64%)
		Ca_chan_IQ	1418..1492	CDD:337190	33/77 (43%)
Cacna1e	XP_038946935.1	Ion_trans	235..509	CDD:395416	183/288 (64%)
		Ion_trans	622..861	CDD:395416	173/238 (73%)
		Ion_trans	1301..1535	CDD:395416	151/235 (64%)
		Ion_trans	1625..1882	CDD:395416	171/257 (67%)
		GPHH	1891..1944	CDD:407139	34/52 (65%)
		Ca_chan_IQ	1955..2028	CDD:400901	33/78 (42%)
		Atrophin-1	2170..>2429	CDD:397323	62/340 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I760
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1808	1.000	Inparanoid score	I58
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X841
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830