DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and PKD2

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_000288.1	Gene:	PKD2 / 5311	HGNCID:	9009	Length:	968	Species:	Homo sapiens

Alignment Length:	844	Identity:	159/844 - (18%)
Similarity:	285/844 - (33%)	Gaps:	246/844 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   901 LKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---------------TDESKHTSAECQGSYFK 950
            ||:|:..|:.|:||..:..::...:.:...:|.               |:::...:......::|
Human   217 LKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWK 281

  Fly   951 YEEDELL--------PKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEG---WPQVLQHSMAATY- 1003
            :.|..||        |..:..........|:|:...:..:..::...|   .||.|:..:...|
Human   282 FTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYD 346

  Fly  1004 ------EDRGPI--QN-----FRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQG-------- 1047
                  |||.|.  :|     :..|..:....::             .||.|:...|
Human   347 VYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHW-------------GIIATYSGAGYYLDLSRT 398

  Fly  1048 --EAELQDGEIDKN-------QKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMM 1103
              |...|...:.||       :.:.|||::          .|.|...:.|.|::|..|....::.
Human   399 REETAAQVASLKKNVWLDRGTRATFIDFSV----------YNANINLFCVVRLLVEFPATGGVIP 453

  Fly  1104 LIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVL 1168
            ...|..|.| ::|....|.:..:.:.|...|...:.||.:|: |.....::|:..||..|::.|:
Human   454 SWQFQPLKL-IRYVTTFDFFLAACEIIFCFFIFYYVVEEILE-IRIHKLHYFRSFWNCLDVVIVV 516

  Fly  1169 GSIVD------------------------------ALW-MEFGSNSINVGFLRLFRA-ARLIKLL 1201
            .|:|.                              |.| ::|.    |:..:.:|.. .:|.|.:
Human   517 LSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFN----NIAAVTVFFVWIKLFKFI 577

  Fly  1202 RQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQ 1266
            ....|:..|..|..:..|.|....::..::|..||.:...|||           |:.::|.:|.:
Human   578 NFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFG-----------TQVDDFSTFQE 631

  Fly  1267 GVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVA 1331
            .:...||...|                  |...|..|.....|...||.:|:||..|::||:|:|
Human   632 CIFTQFRIILG------------------DINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLA 678

  Fly  1332 VIMDNFDYLTRDSSILGAH-HLDEFVR-------IWAEYDPNAT-----------GKIHYTEMYD 1377
            :|.|.:..:..|.:...|. .|.:.:|       :..:...|..           ||:::.|:..
Human   679 IINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQ 743

  Fly  1378 MLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFT---------TTLFALIRENLSIKMR 1433
            .||      |.|:                 .|.|:...||         .|      |:...:||
Human   744 DLK------GKGH-----------------TDAEIEAIFTKYDQDGDQELT------EHEHQQMR 779

  Fly  1434 APEEMDQADMEL-RETITNIWPLQAKKMLNLLVPPSD---------QLNKGKLSVGKIYAGFLIL 1488
            ...|.::.|::| ..::..  |:.::.....|....:         ...:|.:|.|..|..|.:|
Human   780 DDLEKEREDLDLDHSSLPR--PMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVL 842

  Fly  1489 -------ESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSL-R 1545
                   |....:...::|:.:..||:.:.::...:|.|     |.|..|.:......|...: |
Human   843 VRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVL-----GRLLDGVAEDERLGRDSEIHR 902

  Fly  1546 HNGSPLARSPSPRRRGH---QYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSAST 1606
            .....|.|....|....   ..|.|.:|              |....:|...||..|.|.|.||
Human   903 EQMERLVREELERWESDDAASQISHGLG--------------TPVGLNGQPRPRSSRPSSSQST 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124	32/198 (16%)
		Ion_trans	1094..1345	CDD:334124	60/282 (21%)
		GPHH	1346..1416	CDD:339854	13/88 (15%)
		Ca_chan_IQ	1418..1492	CDD:337190	16/90 (18%)
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..181
		PKD_channel	269..687	CDD:400395	93/475 (20%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:28092368	641..643		1/19 (5%)
		EFh_HEF	<724..792	CDD:355006	17/96 (18%)
		EF-hand motif	754..782	CDD:320075	7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..831		10/74 (14%)
		Linker. /evidence=ECO:0000305\|PubMed:18694932	803..822		1/18 (6%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269\|PubMed:15692563	810..821		0/10 (0%)
		Fer4_24	834..868	CDD:407943	5/33 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	917..968		12/50 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910