DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and PKD1

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_024306066.1 Gene:PKD1 / 5310 HGNCID:9008 Length:4343 Species:Homo sapiens


Alignment Length:1414 Identity:262/1414 - (18%)
Similarity:444/1414 - (31%) Gaps:491/1414 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   429 RFRFWIRHTVK---TQWFYWFVIV--------LVFLNTVCVAVEHYGQPSFL-TEFLYYAEFIFL 481
            :.|.|  |..|   ..||...|||        ..||....::||.......: .|.|..::...|
Human  3221 KIRVW--HDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALL 3283

  Fly   482 ------------GLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIF---EVIWSEVKGGSFG 531
                        |.|...:::.::...||..| :...|..|.|:...:|   ..:|.    |:.|
Human  3284 RFRRLLVAELQRGFFDKHIWLSIWDRPPRSRF-TRIQRATCCVLLICLFLGANAVWY----GAVG 3343

  Fly   532 LSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLP 596
            .|......:.|:..:     |:..:.:.|::|:  ::..::|..||  :|.:...::.|.....|
Human  3344 DSAYSTGHVSRLSPL-----SVDTVAVGLVSSV--VVYPVYLAILF--LFRMSRSKVAGSPSPTP 3399

  Fly   597 GGTP-------------ETNFNTFPIALLTVFQILTGE-----------------------DWNE 625
            .|..             :::|.||  :.|...|...|:                       .|.:
Human  3400 AGQQVLDIDSCLDSSVLDSSFLTF--SGLHAEQAFVGQMKSDLFLDDSKSLVCWPSGEGTLSWPD 3462

  Fly   626 VMYQGII--------SQGGAQKGMIYSIYFIVLVLFG----NYTLLNVFLAIAVDNLANAQELTA 678
            ::....|        ::|.|..|:            |    .::|.:.:        :.|:..:|
Human  3463 LLSDPSIVGSNLRQLARGQAGHGL------------GPEEDGFSLASPY--------SPAKSFSA 3507

  Fly   679 AEEEQVEEDKEKQLQELEKEMEALQADGV---------HVENGDGAVAPSKSKGKKKEEEKKEEE 734
            ::|:.:::               :.|:||         |:|. |...:.|.:.|:|.|....:..
Human  3508 SDEDLIQQ---------------VLAEGVSSPAPTQDTHMET-DLLSSLSSTPGEKTETLALQRL 3556

  Fly   735 EVTEGPKPML----PYSSMFILSPTNPI-----RRGAHWVVNLPYFDFFIMVVISMS-------- 782
            .....|.|.|    |.::.  ||.|..:     |....|..:|.:....::|.::::        
Human  3557 GELGPPSPGLNWEQPQAAR--LSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGAS 3619

  Fly   783 -----SIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVI---LHPGSYLREFWN 839
                 |:|........           |..:|.|...:::||:.:...::   |||..       
Human  3620 FPPGVSVAWLLSSSAS-----------FLASFLGWEPLKVLLEALYFSLVAKRLHPDE------- 3666

  Fly   840 IMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDC-----VVN 899
              |..:|...||                |..|.||.||        |.|...|:|..     .|.
Human  3667 --DDTLVESPAV----------------TPVSARVPRV--------RPPHGFALFLAKEEARKVK 3705

  Fly   900 SLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRV 964
            .|..::..|:||:||..:                |..:.:..|.|.|..::.:.   ..||||. 
Human  3706 RLHGMLRSLLVYMLFLLV----------------TLLASYGDASCHGHAYRLQS---AIKQELH- 3750

  Fly   965 WKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPF 1029
              .|||           |...::.|.||.:..                            ::.|:
Human  3751 --SRAF-----------LAITRSEELWPWMAH----------------------------VLLPY 3774

  Fly  1030 FFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKV-WRIVV 1093
            ...|       .:..|.|...|:...:   |::......|.|..........:|..|.| |    
Human  3775 VHGN-------QSSPELGPPRLRQVRL---QEALYPDPPGPRVHTCSAAGGFSTSDYDVGW---- 3825

  Fly  1094 STPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKS----LKYINMGFTGMFSVETVLKIIGFGVKNF 1154
            .:|                    ||....:..|    |...:.|...::.....::.:|..::. 
Human  3826 ESP--------------------HNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEE- 3869

  Fly  1155 FKDPWNIFDLITVLGSIVDALWMEFGSNSINVGF-----LRL-FRAA--RLIKLLRQGYTIRILL 1211
            .:|......|...|.:...|:::|....|..||.     ||| |.||  .|..|..:.:.:|.| 
Human  3870 SRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRL- 3933

  Fly  1212 WTFVQSFKALPYVCLLIAMLFFIYA------------IIGMQVFGN---------------IKLG 1249
             :...|...|..||||:..:.|..|            ::.:..:..               .:||
Human  3934 -SAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLG 3997

  Fly  1250 TVENSITRH-----NNFQSFIQGVMLLFRCATGEAWPNIMLACLK--------------GKA-CD 1294
            ..:...||.     ..|.||.| |..|...|.|.|...:.|..:|              ||. | 
Human  3998 AADRQWTRFVRGRPRRFTSFDQ-VAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLC- 4060

  Fly  1295 DDAEKAPGEYCGSTL-------AYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHL 1352
                :|..|..|.||       |||.           :..|.|:..:|:                
Human  4061 ----RALPELLGVTLGLVVLGVAYAQ-----------LAILLVSSCVDS---------------- 4094

  Fly  1353 DEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAY-KKLIRMNMPLDDELRVQF 1416
                 :|:              :...|..:.|..|....||....: ..|:.:.:   ..||:..
Human  4095 -----LWS--------------VAQALLVLCPGTGLSTLCPAESWHLSPLLCVGL---WALRLWG 4137

  Fly  1417 TTTLFALI--------RENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNK 1473
            ...|.|:|        |..|......|::.:..::.||.  ..:|.               .|:|
Human  4138 ALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRR--LRLWM---------------GLSK 4185

  Fly  1474 GKLSVGKI-YAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNG 1537
            .|....|: :.|...|.| ||:|..::...:|         .||    .|:||.|.....|.::|
Human  4186 VKEFRHKVRFEGMEPLPS-RSSRGSKVSPDVP---------PPS----AGSDASHPSTSSSQLDG 4236

  Fly  1538 HRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSW 1602
              .|.||...|:.....||..:...:.:.......:..:..|..:::..|...|....|.|.|| 
Human  4237 --LSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGS- 4298

  Fly  1603 SASTSPARSPS-PSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPAR 1650
            |...||...|: |||    |:|:.|        |.......||:|..|:
Human  4299 SRGPSPGLRPALPSR----LARASR--------GVDLATGPSRTPLRAK 4335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124
Ion_trans 441..677 CDD:334124 50/307 (16%)
Ion_trans 769..1050 CDD:334124 51/301 (17%)
Ion_trans 1094..1345 CDD:334124 62/316 (20%)
GPHH 1346..1416 CDD:339854 9/70 (13%)
Ca_chan_IQ 1418..1492 CDD:337190 16/82 (20%)
PKD1XP_024306066.1 LRR <50..>126 CDD:227223
leucine-rich repeat 70..92 CDD:275378
leucine-rich repeat 93..116 CDD:275378
PCC 97..2768 CDD:188093
leucine-rich repeat 117..129 CDD:275378
GPS 3051..3100 CDD:197639
PLAT_polycystin 3158..3277 CDD:238850 15/57 (26%)
PKD_channel 3751..4153 CDD:332708 93/532 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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