DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and AgaP_AGAP012433

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_024667089.1	Gene:	AgaP_AGAP012433 / 4578508	VectorBaseID:	AGAP012433	Length:	912	Species:	Anopheles gambiae

Alignment Length:	1016	Identity:	371/1016 - (36%)
Similarity:	511/1016 - (50%)	Gaps:	206/1016 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   928 GKFFYCTDESKHTSAECQGSYFKYEEDEL-LPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGW 991
            ||||.|:|.||...:||.|:|..||:..: .|..:.|.|....||:|:|:.||||||.|.|.|||
Mosquito     1 GKFFSCSDGSKMQESECHGTYLVYEDGNVDKPVSKERYWSRNRFHFDDVSKAMLTLFTVSTFEGW 65

  Fly   992 PQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEI 1056
            |.:|..|:.:..||.|||.|||..::.:||:|.|:..||.|||||..:|:|||.:||.|.::.::
Mosquito    66 PGLLYVSIDSHEEDSGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDL 130

  Fly  1057 DKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGD 1121
            ||||::||:|.:.|:|:.||:||:|  .:||||..|.|.||||.|.:||:.||:.|.||::.|.:
Mosquito   131 DKNQRNCIEFALKAKPIRRYIPKHR--IQYKVWWFVTSQPFEYMIFVLIMINTITLSMKFYRQPE 193

  Fly  1122 MYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWME-------- 1178
            :|.:.|..:|:.||.:|::|.|.|:..|..||:|.|.||:||.|.||||.:|.::.|
Mosquito   194 IYTEVLDLLNLIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEQRNEGTLV 258

  Fly  1179 ----------------FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1227
                            .||:.|::.|.||||..||:|||.:|..||.|||||::||:|||||.||
Mosquito   259 NILKIYLIYEIISSQCGGSSIISINFFRLFRVMRLVKLLARGEGIRTLLWTFIKSFQALPYVALL 323

  Fly  1228 IAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLK--G 1290
            |.|||||||:|||||||.|.:.. |.||.|:||||:|.|.|::|||.||||||.:|||.|..  |
Mosquito   324 IVMLFFIYAVIGMQVFGKIAMDD-ETSIHRNNNFQTFPQAVLVLFRSATGEAWQDIMLDCSSRPG 387

  Fly  1291 KA-CD---DDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHH 1351
            :. ||   |||....|  |||.:|:.||:||...||||::|||||||||||||||||.||||.||
Mosquito   388 EVNCDAKSDDAGSPEG--CGSNIAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHH 450

  Fly  1352 LDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQF 1416
            ||||||:|:||||:|.|:|.:.::..:|:.:.||||||..||:|:|.|:|:.|||||:.:..|.|
Mosquito   451 LDEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVLF 515

  Fly  1417 TTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPP---SDQLNKGKLSV 1478
            ..||||::|.:|.||...  .:|.|:.|||.||..||.....|:|:.:|||   .|:     ::|
Mosquito   516 NATLFAVVRTSLKIKTEG--NIDDANAELRNTIKQIWKRTNPKLLDQVVPPPGVDDE-----VTV 573

  Fly  1479 GKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPS 1543
            ||.||.|||.:.:|  ||               .:....:|...:|           ...||:.:
Mosquito   574 GKFYATFLIQDYFR--RF---------------KKRKENDSKLNSD-----------QNKRRTMT 610

  Fly  1544 LR------HNGSP-LARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGS 1601
            |:      |...| |.|:.|                   .|:.|:..:...|.|..:|..:  |:
Mosquito   611 LQAGLRTLHEAGPELKRAIS-------------------GNLEEIGDDNPEPSHRRNHTLF--GN 654

  Fly  1602 -WSASTSPARSPSPSRYGGH----------LSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMR 1655
             ||:...|....|..::..:          .|.:..|.|..|..|::   |....|....:....
Mosquito   655 VWSSIRRPGPFGSKQKWNSNNNKMSATSMAASAAMHTVLSGPNDGSS---QTEMKPKQNCVNSSN 716

  Fly  1656 ERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRL------PPTPSKPSTLQ----LKPTN----- 1705
            ..:.:...|    .|..|..|  ..|..|.|..:      ...|.:|..|.    ||..|
Mosquito   717 TYNHVAESI----LHAVHDEP--IGRNYGNGLNIGNAGHTGEIPLRPLVLDDSSILKRANAKDLI 775

  Fly  1706 -----INFPK----------------LNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRER 1749
                 |...|                .|.......||||.|             |::.:..|.|.
Mosquito   776 VLGSSIGLYKSIFMSIVDYIYSYNQVANFEEDRLIHSTPSS-------------PQETHKLSAEV 827

  Fly  1750 ERDRERLRDR-------DRDRDRDRLH----EYDLRYEYRDRERELYERERDREREVERERLEYI 1803
            ....|.|..|       .:..|.|.:|    |.....:....|.:|...|...|   ||.:.:..
Mosquito   828 IGSAESLVGRVLAQQGLGKYCDLDLVHCAQMEMQEALDMTQEEMDLAAHELMLE---ERFKRKNC 889

  Fly  1804 APLSFEQALAMGRTGRVLPSPVLNGFKPKSGLNPRHSDSDE 1844
            |||..:                     ||.|.|.|.:.:.:
Mosquito   890 APLKGQ---------------------PKRGTNTRKNKNQQ 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124	60/122 (49%)
		Ion_trans	1094..1345	CDD:334124	145/280 (52%)
		GPHH	1346..1416	CDD:339854	38/69 (55%)
		Ca_chan_IQ	1418..1492	CDD:337190	31/76 (41%)
AgaP_AGAP012433	XP_024667089.1	Ion_trans	<42..124	CDD:306908	43/81 (53%)
		Ion_trans	166..444	CDD:306908	145/280 (52%)
		GPHH	445..515	CDD:318993	38/69 (55%)
		Ca_chan_IQ	517..589	CDD:312334	32/80 (40%)
		CAC1F_C	<812..879	CDD:318975	17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820