DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and AgaP_AGAP012434

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_001231059.2	Gene:	AgaP_AGAP012434 / 4578503	VectorBaseID:	AGAP012434	Length:	980	Species:	Anopheles gambiae

Alignment Length:	991	Identity:	459/991 - (46%)
Similarity:	611/991 - (61%)	Gaps:	123/991 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGG------PKKEENPPGGGP------TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCV 53
            :||      |||.....|..|      .:||.||..||:||....|:||.||||.:||||.||||
Mosquito    11 IGGTTIPIAPKKPTRRAGVKPQPDRPMRALFCLTRTNPLRKLCIAIVEWKPFEYLILLTIFANCV 75

  Fly    54 VLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVV 118
            .||:....|..|.......|||.|..||.||..|..:|::|.|.:||..|||||.|||:||.:||
Mosquito    76 ALAVYTPFPNSDSNSTNAALEKIEYIFLVIFTAECIMKLIAYGFILHPGSYLRNGWNILDFTIVV 140

  Fly   119 TGFM-TQYPQIGPE-VDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIV 181
            .|.: |....:..| .|::.|||.||||||:||||:|||||||.||::||.|||.|.|||||.|:
Mosquito   141 IGMISTALSNLMKEGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILRAMVPLLHIALLVLFVII 205

  Fly   182 IFAIIGLEFYSGALHKTCYS------LEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTT--S 238
            |:||||||.:||.|||:|:.      ::||:          ||..|        .|.|:..:  .
Mosquito   206 IYAIIGLELFSGKLHKSCFHNETGEIMDDPH----------PCGED--------GFHCDTISPEM 252

  Fly   239 MCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFF 303
            :|...|||||.|||:|||.|.:|||||||:|:||||.:||:..||:||::.|:||:.::::|:||
Mosquito   253 VCRYYWEGPNFGITNFDNFGLSMLTVFQCVTLEGWTDMLYYIEDAMGSSWQWVYFISMVILGAFF 317

  Fly   304 MLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKM 368
            ::||:||||||||:|||.|.:||.:|.|||.:||:|.:|.||::||.:||::      ..:.:..
Mosquito   318 VMNLILGVLSGEFSKERTKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI------DPDNDAS 376

  Fly   369 HIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFW--------- 424
            .:.|.:.:|..                 |.::.::.|:||.::..|         |
Mosquito   377 GMQEGKMKNII-----------------ELDSSDNVGEDGEIQHES---------WVARKRKTID 415

  Fly   425 RAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMF 489
            |..:|.|...|..||:|.|||.:|:||||||..:|.|||.||.:|.:|..|....|:.||..||.
Mosquito   416 RINRRLRRACRKAVKSQAFYWLIIILVFLNTGVLATEHYRQPPWLDDFQEYTNMFFVALFTMEML 480

  Fly   490 IKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GGSFGLSVLRALRLLRIFKVTKYWSSL 553
            :|||:||.:.||.|.||||||.|:.|||.|:|.:..: ....|:||||.:||||:|||||||.||
Mosquito   481 LKMYSLGFQGYFVSLFNRFDCFVVIGSIGEMILTSTQIMPPLGVSVLRCVRLLRVFKVTKYWQSL 545

  Fly   554 RNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGT--PETNFNTFPIALLTVFQ 616
            .|||.|||||::||.|||.||||||:||||||||:|||:||.....  |.:||::|..:||||||
Mosquito   546 SNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFNSSVDKPRSNFDSFVQSLLTVFQ 610

  Fly   617 ILTGEDWNEVMYQGIISQGG-AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAE 680
            ||||||||.|||.||.:.|| |..|:|.|||||:|.:.|||.||||||||||||||:|..||..|
Mosquito   611 ILTGEDWNMVMYDGIQAYGGVASLGIIASIYFIILFICGNYILLNVFLAIAVDNLADADSLTTVE 675

  Fly   681 EEQVEE---DKEKQLQE-----------LEKEMEALQADGVHV---ENGDGAVAPSKSKGKKKEE 728
            :|:.:.   ::||...|           ::.:.:.|.:|...:   ::.||  ..|.:|....|:
Mosquito   676 KEEGDNPDGEEEKLSHEPTPTEHGDDGFMDHDKDNLDSDNDPMNISDDYDG--QDSDTKIPVAED 738

  Fly   729 EKKEEEEVTEG-PKPM---------LPY---SSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVIS 780
            ::..||:.|.| |:.|         ||.   |:.||||.||..|...||:.|...|...|:|.|.
Mosquito   739 DEGYEEQDTPGRPRRMSELNVINTILPIPDGSAFFILSKTNRFRIFCHWLCNHSTFGNIILVCIM 803

  Fly   781 MSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVV 845
            .||..||||||:..||.||:|||||||.||.|||||:|||:|..|.:.|.|::.|..:|::|.:|
Mosquito   804 FSSAMLAAEDPLNANSERNQILNYFDYFFTSVFTIELLLKLVSYGFLFHDGAFCRSAFNLLDLLV 868

  Fly   846 VICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIV 910
            |..:.:|..|. ||:     :|.||.||||||||||:.|.|...||.|..||:.::|.:.||::|
Mosquito   869 VCVSLISMFFS-SGA-----ISVIKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLV 927

  Fly   911 YILFQFIFSVIGVQLF 926
            ..|.||:|:||||||:
Mosquito   928 TCLLQFMFAVIGVQLY 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	152/296 (51%)
		Ion_trans	441..677	CDD:334124	147/239 (62%)
		Ion_trans	769..1050	CDD:334124	80/158 (51%)
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
AgaP_AGAP012434	XP_001231059.2	Ion_trans	77..338	CDD:278921	139/278 (50%)
		Ion_trans	449..672	CDD:278921	136/222 (61%)
		Ion_trans	809..>948	CDD:278921	74/141 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820