DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1sb

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_999891.1 Gene:cacna1sb / 405791 ZFINID:ZDB-GENE-051227-1 Length:1847 Species:Danio rerio


Alignment Length:1906 Identity:766/1906 - (40%)
Similarity:1052/1906 - (55%) Gaps:325/1906 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 GGG---PTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKL 73
            ||.   |.:||.....||.||....|:||.|||..:||||.||||.||:...:|..|.......|
Zfish    45 GGNPRPPRTLFFFKLRNPFRKACTNIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTL 109

  Fly    74 EKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMT-----------QYPQ 127
            |..|..||.||.:|..|||:|.||:.|:.:||||.|||:||.:|..|..|           ...:
Zfish   110 ESLEYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQKE 174

  Fly   128 IGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYS 192
            .|...|::.|||.||||||:||||:||||||:.|::|:|.||..|.|||.|.:.|:||:|||.:.
Zfish   175 KGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAIMGLELFK 239

  Fly   193 GALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNI 257
            ..:|||||........::|.|..:||      .:|.....|....:.|.:.|.|||.|||.|||.
Zfish   240 CKMHKTCYYQGTNIIALRENEKPSPC------AQAGNGRRCTINGTECRDGWPGPNFGITHFDNF 298

  Fly   258 GFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREK 322
            ||||||||||||.|.||.:|||.|||:|:.:.||||:.||::||||:||||||||||||.|||||
Zfish   299 GFAMLTVFQCITTESWTDVLYWINDAMGNDWPWIYFLSLIMLGSFFILNLVLGVLSGEFTKEREK 363

  Fly   323 VENRQEFLKLRRQQQLERELNGYVEWICKAE--------EVILAEERTTEEEKMHIME------- 372
            ..:|.|:..||.:||::.:|.||:|||..||        .::|.::..:|.:.::.||       
Zfish   364 SRSRGEWQVLRERQQMDEDLKGYMEWITHAEVMDGDSDAMLLLRKDTGSETDSLYKMEGINKVVY 428

  Fly   373 ----ARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFW 433
                |||.|...|:|                                    |.|          |
Zfish   429 FYRLARRWNIVIRRK------------------------------------CHG----------W 447

  Fly   434 IRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPR 498
                ||::.|.|:|:::|.|||:.:|.||:.|...||.|...|..|.|..|..||.:||||.|||
Zfish   448 ----VKSKSFNWWVLIVVLLNTLVIATEHHNQTEGLTNFQDTANVILLACFTIEMIMKMYAFGPR 508

  Fly   499 IYFESSFNRFDCVVISGSIFEVIWSEVKGG---SFGLSVLRALRLLRIFKVTKYWSSLRNLVISL 560
            .||.|.||||||.|::..|.|:|.  |..|   ..|:||:|.:||||:||:||||:||.|||:||
Zfish   509 SYFMSIFNRFDCFVVTIGILEIIL--VGSGIMTPLGISVMRCIRLLRLFKLTKYWTSLNNLVVSL 571

  Fly   561 LNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPG-GTPETNFNTFPIALLTVFQILTGEDWN 624
            |||::||.|||.||||||:||||||||:|||:||.|. ....:||:.||.||::|||:||||:|:
Zfish   572 LNSVKSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDRPIQRSNFDNFPQALISVFQVLTGEEWD 636

  Fly   625 EVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDK 688
            .:||.||::.||.:. |::.|||||:|.:.||:.||||||||||||||.|:.|.||::|:.||..
Zfish   637 TIMYNGIMAHGGPKSPGILVSIYFIILYVCGNFVLLNVFLAIAVDNLAEAESLAAAQKERAEERA 701

  Fly   689 EKQLQ----ELEKEMEALQADGVHVENGDGAVAPSKSKGKKKE-------------------EEK 730
            .|:|.    |..:|.:||.|..:..........|:.:|.|..|                   :::
Zfish   702 RKKLMKPLPEKTEEEKALMAKRLMESRQKTEGMPTTAKLKIDEFESNVNEVKDPFPPADFPGDDE 766

  Fly   731 KEEEEVTEGPK--------------PMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISM 781
            :||.|:...|:              ||...||.||..|.|..|:..|.::|...|...|::.|.:
Zfish   767 EEEPEIPISPRPRPMADLQLKETVVPMPEASSFFIFGPQNKFRKLCHRIINHTTFTNIILLFILL 831

  Fly   782 SSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVV 846
            |||:||||||:..:|.|||:|.|.|..||.|||||::||:...|..|||||:.|..:||:|.:||
Zfish   832 SSISLAAEDPIDPHSFRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHPGSFCRNSFNILDLIVV 896

  Fly   847 ICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVY 911
            ..:.:|.|.:.|      .:|.:|.||||||||||:.|.|...||.|..|:..::|.:.||::|.
Zfish   897 AVSLLSMGMESS------TISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLVT 955

  Fly   912 ILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQ-ELRVWKPRAFHYDNV 975
            :|..|:||.||||||.|..|||||..:.|:.:|||::.|:.::.|...: ..|.|....|::|||
Zfish   956 MLLDFMFSCIGVQLFKGTLFYCTDPLQKTAEQCQGTFLKHVQNSLHDTEIHQRRWVNSDFNFDNV 1020

  Fly   976 AAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALII 1040
            ...||.||.:.|.||||::|..::.:...|.||:.|.|:.:|||:|:|.|:..||.:||||..:|
Zfish  1021 LNGMLALFTISTFEGWPEILYKAIDSYDVDTGPLYNNRVGISIFFIIYIIIIAFFMMNIFVGFVI 1085

  Fly  1041 ITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLI 1105
            :|||.|||.|.::.|:||||:.|:.:.:.||||:.|:|:|.:  :|:||.:|.|..|||.:..||
Zfish  1086 VTFQRQGEQEYKNCELDKNQRQCVQYALKARPLKCYIPENPH--QYRVWYLVTSCYFEYLMFFLI 1148

  Fly  1106 VFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGS 1170
            :.|||.|.|:|.||.....|....:|:.||.:|:.|.::|:|.|..|.:|.||||:||.:.|:||
Zfish  1149 MLNTLSLGMQYCNQPFYITKLSDNLNVIFTVLFTGEMIVKLIAFKAKGYFGDPWNVFDFVIVIGS 1213

  Fly  1171 IVD--------------ALWMEFGSNSI--------------NVGFLRLFRAARLIKLLRQGYTI 1207
            |||              .||...|.:.:              ::.|.||||..||||||.:...|
Zfish  1214 IVDVVLSEVDRTLEASGGLWCLHGCSEVDPMQAIAEAENVKLSITFFRLFRVLRLIKLLNRSEGI 1278

  Fly  1208 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL--GTVENSITRHNNFQSFIQGVML 1270
            |.|||||::||:|||:|.|||.|||||||:||||:||.|.|  ||   .|.|:||||:|.|.|:|
Zfish  1279 RNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMFGKIALVDGT---EINRNNNFQTFPQAVLL 1340

  Fly  1271 LFRCATGEAWPNIMLACLKGKACDDDAEKAPGE--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVI 1333
            |||.||||.||.||||.:.||.||..::..|||  .|||::|..||:||...|:||::|||||:|
Zfish  1341 LFRVATGEQWPKIMLASMYGKLCDPKSDYGPGEEYTCGSSIAVCYFLSFYMLCAFLVINLFVAII 1405

  Fly  1334 MDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAY 1398
            ||||||||.|.||||.||||||.:||.||||.|||:|.:.::..:|:.:.||||||..||:..|.
Zfish  1406 MDNFDYLTHDWSILGPHHLDEFKKIWGEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHHAAC 1470

  Fly  1399 KKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNL 1463
            |:||.|||||:.:..|.|..|||||:|..|.||...  ..:||:.|||..|.:||...:.|:|:.
Zfish  1471 KRLISMNMPLNSDGTVTFNATLFALVRTALKIKTEG--NFEQANEELRAIIKSIWKRTSMKLLDQ 1533

  Fly  1464 LVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHL 1528
            ::||   :.:.:::|||.||.|||.|.:|  :|.|                 .||.|.|      
Zfish  1534 VIPP---IGEDEVTVGKFYATFLIQEHFR--KFMQ-----------------RQEELYG------ 1570

  Fly  1529 HPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHG-- 1591
                 |....:.:..::.....:....:|..  |:.|..|:...|.:...:|..:|..:.|.|  
Zfish  1571 -----YRPTKKNADEIKAGLRSIEEEAAPEL--HRAISGDLIAEDEMERAMESGEEGIYRRTGGL 1628

  Fly  1592 --------NSHPRYPRGSWSASTSP----------ARSP-------------------------- 1612
                    :|.|..|..:...|..|          |.||                          
Zfish  1629 FGLNADPFSSEPSSPLSTQVTSQRPLQFAENRPEDAGSPPDSVFLPNTEFFPDNMPTTSNTNNNA 1693

  Fly  1613 -------------SPSR------------YGGHLS------------RSKRTQLPYPTYGTTSLC 1640
                         |.||            |.|..|            ::..||.||......|..
Zfish  1694 NFIEEFTFESESLSASRNYSYEDIRDSSLYVGGASNVNDRRLSDFNVKTNSTQFPYNPSCEESKN 1758

  Fly  1641 QRS---RSPSPARL--QEMRE----------------RDRLGYGIDMGVTHVQHSYPTLASRRAG 1684
            |||   .||:..:|  |.:|:                |..|...:::|:..::.....:.:.::|
Zfish  1759 QRSAAEASPATDKLIQQALRDGGLESLAEDPQFVSVTRKELAEAVNIGLQDIESVAQGIVNGQSG 1823

  Fly  1685 -IGRR------LPPTPSKPST 1698
             :.:|      :||:.:|.:|
Zfish  1824 KVTKRKRRPIPVPPSKTKEAT 1844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 151/297 (51%)
Ion_trans 441..677 CDD:334124 135/240 (56%)
Ion_trans 769..1050 CDD:334124 127/281 (45%)
Ion_trans 1094..1345 CDD:334124 140/282 (50%)
GPHH 1346..1416 CDD:339854 38/69 (55%)
Ca_chan_IQ 1418..1492 CDD:337190 30/73 (41%)
cacna1sbNP_999891.1 Ion_trans 91..365 CDD:278921 139/279 (50%)
Ion_trans 468..682 CDD:278921 123/215 (57%)
Ion_trans 836..1095 CDD:278921 121/264 (46%)
Ion_trans 1155..1417 CDD:278921 131/264 (50%)
GPHH 1425..1488 CDD:293510 32/62 (52%)
Ca_chan_IQ 1490..1561 CDD:285917 31/77 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG56527
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.730

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