Protein Alignment cac and cacna1sb

DIOPT Version :10

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: NP_999891.1
• Gene: cacna1sb / 405791
• ZFINID: ZDB-GENE-051227-1
• Length: 1847
• Species: Danio rerio
• Alignment Length: 1906
• Identity: 766/1906 - (40%)
• Similarity: 1052/1906 - (55%)
• Gaps: 325/1906 - (17%)

  Fly    12 GGG---PTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKL 73
            ||.   |.:||.....||.||....|:||.|||..:||||.||||.||:...:|..|.......|
Zfish    45 GGNPRPPRTLFFFKLRNPFRKACTNIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTL 109

  Fly    74 EKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMT-----------QYPQ 127
            |..|..||.||.:|..|||:|.||:.|:.:||||.|||:||.:|..|..|           ...:
Zfish   110 ESLEYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQKE 174

  Fly   128 IGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYS 192
            .|...|::.|||.||||||:||||:||||||:.|::|:|.||..|.|||.|.:.|:||:|||.:.
Zfish   175 KGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAIMGLELFK 239

  Fly   193 GALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNI 257
            ..:|||||........::|.|..:||      .:|.....|....:.|.:.|.|||.|||.|||.
Zfish   240 CKMHKTCYYQGTNIIALRENEKPSPC------AQAGNGRRCTINGTECRDGWPGPNFGITHFDNF 298

  Fly   258 GFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREK 322
            ||||||||||||.|.||.:|||.|||:|:.:.||||:.||::||||:||||||||||||.|||||
Zfish   299 GFAMLTVFQCITTESWTDVLYWINDAMGNDWPWIYFLSLIMLGSFFILNLVLGVLSGEFTKEREK 363

  Fly   323 VENRQEFLKLRRQQQLERELNGYVEWICKAE--------EVILAEERTTEEEKMHIME------- 372
            ..:|.|:..||.:||::.:|.||:|||..||        .::|.::..:|.:.::.||
Zfish   364 SRSRGEWQVLRERQQMDEDLKGYMEWITHAEVMDGDSDAMLLLRKDTGSETDSLYKMEGINKVVY 428

  Fly   373 ----ARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFW 433
                |||.|...|:|                                    |.|          |
Zfish   429 FYRLARRWNIVIRRK------------------------------------CHG----------W 447

  Fly   434 IRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPR 498
                ||::.|.|:|:::|.|||:.:|.||:.|...||.|...|..|.|..|..||.:||||.|||
Zfish   448 ----VKSKSFNWWVLIVVLLNTLVIATEHHNQTEGLTNFQDTANVILLACFTIEMIMKMYAFGPR 508

  Fly   499 IYFESSFNRFDCVVISGSIFEVIWSEVKGG---SFGLSVLRALRLLRIFKVTKYWSSLRNLVISL 560
            .||.|.||||||.|::..|.|:|.  |..|   ..|:||:|.:||||:||:||||:||.|||:||
Zfish   509 SYFMSIFNRFDCFVVTIGILEIIL--VGSGIMTPLGISVMRCIRLLRLFKLTKYWTSLNNLVVSL 571

  Fly   561 LNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPG-GTPETNFNTFPIALLTVFQILTGEDWN 624
            |||::||.|||.||||||:||||||||:|||:||.|. ....:||:.||.||::|||:||||:|:
Zfish   572 LNSVKSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDRPIQRSNFDNFPQALISVFQVLTGEEWD 636

  Fly   625 EVMYQGIISQGGAQK-GMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDK 688
            .:||.||::.||.:. |::.|||||:|.:.||:.||||||||||||||.|:.|.||::|:.||..
Zfish   637 TIMYNGIMAHGGPKSPGILVSIYFIILYVCGNFVLLNVFLAIAVDNLAEAESLAAAQKERAEERA 701

  Fly   689 EKQLQ----ELEKEMEALQADGVHVENGDGAVAPSKSKGKKKE-------------------EEK 730
            .|:|.    |..:|.:||.|..:..........|:.:|.|..|                   :::
Zfish   702 RKKLMKPLPEKTEEEKALMAKRLMESRQKTEGMPTTAKLKIDEFESNVNEVKDPFPPADFPGDDE 766

  Fly   731 KEEEEVTEGPK--------------PMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISM 781
            :||.|:...|:              ||...||.||..|.|..|:..|.::|...|...|::.|.:
Zfish   767 EEEPEIPISPRPRPMADLQLKETVVPMPEASSFFIFGPQNKFRKLCHRIINHTTFTNIILLFILL 831

  Fly   782 SSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVV 846
            |||:||||||:..:|.|||:|.|.|..||.|||||::||:...|..|||||:.|..:||:|.:||
Zfish   832 SSISLAAEDPIDPHSFRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHPGSFCRNSFNILDLIVV 896

  Fly   847 ICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVY 911
            ..:.:|.|.:.|      .:|.:|.||||||||||:.|.|...||.|..|:..::|.:.||::|.
Zfish   897 AVSLLSMGMESS------TISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLVT 955

  Fly   912 ILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQ-ELRVWKPRAFHYDNV 975
            :|..|:||.||||||.|..|||||..:.|:.:|||::.|:.::.|...: ..|.|....|::|||
Zfish   956 MLLDFMFSCIGVQLFKGTLFYCTDPLQKTAEQCQGTFLKHVQNSLHDTEIHQRRWVNSDFNFDNV 1020

  Fly   976 AAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALII 1040
            ...||.||.:.|.||||::|..::.:...|.||:.|.|:.:|||:|:|.|:..||.:||||..:|
Zfish  1021 LNGMLALFTISTFEGWPEILYKAIDSYDVDTGPLYNNRVGISIFFIIYIIIIAFFMMNIFVGFVI 1085

  Fly  1041 ITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLI 1105
            :|||.|||.|.::.|:||||:.|:.:.:.||||:.|:|:|.:  :|:||.:|.|..|||.:..||
Zfish  1086 VTFQRQGEQEYKNCELDKNQRQCVQYALKARPLKCYIPENPH--QYRVWYLVTSCYFEYLMFFLI 1148

  Fly  1106 VFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGS 1170
            :.|||.|.|:|.||.....|....:|:.||.:|:.|.::|:|.|..|.:|.||||:||.:.|:||
Zfish  1149 MLNTLSLGMQYCNQPFYITKLSDNLNVIFTVLFTGEMIVKLIAFKAKGYFGDPWNVFDFVIVIGS 1213

  Fly  1171 IVD--------------ALWMEFGSNSI--------------NVGFLRLFRAARLIKLLRQGYTI 1207
            |||              .||...|.:.:              ::.|.||||..||||||.:...|
Zfish  1214 IVDVVLSEVDRTLEASGGLWCLHGCSEVDPMQAIAEAENVKLSITFFRLFRVLRLIKLLNRSEGI 1278

  Fly  1208 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL--GTVENSITRHNNFQSFIQGVML 1270
            |.|||||::||:|||:|.|||.|||||||:||||:||.|.|  ||   .|.|:||||:|.|.|:|
Zfish  1279 RNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMFGKIALVDGT---EINRNNNFQTFPQAVLL 1340

  Fly  1271 LFRCATGEAWPNIMLACLKGKACDDDAEKAPGE--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVI 1333
            |||.||||.||.||||.:.||.||..::..|||  .|||::|..||:||...|:||::|||||:|
Zfish  1341 LFRVATGEQWPKIMLASMYGKLCDPKSDYGPGEEYTCGSSIAVCYFLSFYMLCAFLVINLFVAII 1405

  Fly  1334 MDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAY 1398
            ||||||||.|.||||.||||||.:||.||||.|||:|.:.::..:|:.:.||||||..||:..|.
Zfish  1406 MDNFDYLTHDWSILGPHHLDEFKKIWGEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHHAAC 1470

  Fly  1399 KKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNL 1463
            |:||.|||||:.:..|.|..|||||:|..|.||...  ..:||:.|||..|.:||...:.|:|:.
Zfish  1471 KRLISMNMPLNSDGTVTFNATLFALVRTALKIKTEG--NFEQANEELRAIIKSIWKRTSMKLLDQ 1533

  Fly  1464 LVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHL 1528
            ::||   :.:.:::|||.||.|||.|.:|  :|.|                 .||.|.|
Zfish  1534 VIPP---IGEDEVTVGKFYATFLIQEHFR--KFMQ-----------------RQEELYG------ 1570

  Fly  1529 HPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHG-- 1591
                 |....:.:..::.....:....:|..  |:.|..|:...|.:...:|..:|..:.|.|
Zfish  1571 -----YRPTKKNADEIKAGLRSIEEEAAPEL--HRAISGDLIAEDEMERAMESGEEGIYRRTGGL 1628

  Fly  1592 --------NSHPRYPRGSWSASTSP----------ARSP-------------------------- 1612
                    :|.|..|..:...|..|          |.||
Zfish  1629 FGLNADPFSSEPSSPLSTQVTSQRPLQFAENRPEDAGSPPDSVFLPNTEFFPDNMPTTSNTNNNA 1693

  Fly  1613 -------------SPSR------------YGGHLS------------RSKRTQLPYPTYGTTSLC 1640
                         |.||            |.|..|            ::..||.||......|..
Zfish  1694 NFIEEFTFESESLSASRNYSYEDIRDSSLYVGGASNVNDRRLSDFNVKTNSTQFPYNPSCEESKN 1758

  Fly  1641 QRS---RSPSPARL--QEMRE----------------RDRLGYGIDMGVTHVQHSYPTLASRRAG 1684
            |||   .||:..:|  |.:|:                |..|...:::|:..::.....:.:.::|
Zfish  1759 QRSAAEASPATDKLIQQALRDGGLESLAEDPQFVSVTRKELAEAVNIGLQDIESVAQGIVNGQSG 1823

  Fly  1685 -IGRR------LPPTPSKPST 1698
             :.:|      :||:.:|.:|
Zfish  1824 KVTKRKRRPIPVPPSKTKEAT 1844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	151/297 (51%)
		Ion_trans	441..677	CDD:459842	135/240 (56%)
		Ion_trans	769..1050	CDD:459842	127/281 (45%)
		Ion_trans	1094..1345	CDD:459842	140/282 (50%)
		GPHH	1354..1407	CDD:465306	27/52 (52%)
		Ca_chan_IQ	1417..1496	CDD:462591	31/78 (40%)
		AF-4	<1512..>1704	CDD:461550	50/298 (17%)
cacna1sb	NP_999891.1	Ion_trans	73..365	CDD:459842	151/297 (51%)
		Ion_trans	450..682	CDD:459842	130/233 (56%)
		Ion_trans	818..1095	CDD:459842	127/282 (45%)
		Ion_trans	1139..1417	CDD:459842	139/280 (50%)
		GPHH	1426..1479	CDD:465306	27/52 (52%)
		Ca_chan_IQ	1489..1561	CDD:462591	31/78 (40%)