DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and scn1laa

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_956426.2 Gene:scn1laa / 393101 ZFINID:ZDB-GENE-040426-751 Length:1955 Species:Danio rerio


Alignment Length:1938 Identity:475/1938 - (24%)
Similarity:798/1938 - (41%) Gaps:525/1938 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKEENPPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVL 69
            ||:|........:|:|.:..|.:|:.:..|:....|.:.::.||:|||..:...: .|...|.| 
Zfish    96 KKKEIYRFNATPALYIFSSFNLLRRISIQILVHFLFNFIIICTILANCAFMVYTQ-TPDWAKNV- 158

  Fly    70 AQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDL 134
                   |..|..|:.:||.:||.|.|..:.:.::||:.||.:||.|:|..::|::..:|   .:
Zfish   159 -------EYVFTGIYTLEALVKITARGFCVGRFTFLRDPWNWLDFIVIVMAYVTEFVDLG---SV 213

  Fly   135 RTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC 199
            ..|||.||||.||.:|.:|.|:.::.::|:::..|..:.:|.||.:.:||::||:.:.|.|.:.|
Zfish   214 SALRAFRVLRALKTISVVPGLKTIVGALIQSVKKLSDVMILTLFCLSVFALVGLQLFMGILKQKC 278

  Fly   200 -YSLEDPNKLVKEGESETPC-----------NTDN--ILEKATGSFVCNNTTS--------MCLE 242
             ||       ....|::..|           |..|  .|.....:.:|.|::.        .||:
Zfish   279 VYS-------TSFTENKEACYKNKTCRDYINNPSNQYFLPGKKDALICGNSSDAGQCPEGYTCLK 336

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            ..:.|:.|.||||:.|:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||
Zfish   337 AGKNPDYGYTSFDSFGWAFLSLFRLMTQDFWENLYQQTLRAAGKTY-MIFFVLVIFLGSFYLVNL 400

  Fly   308 VLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVI-----------LAEER 361
            :|.|::  .|.:.:......|.||      .|.|.|..:|.|.:.|:..           |:.|:
Zfish   401 ILAVVA--MAYDEQNQATIDEALK------KEEEFNAMLEQITRQEQEAEAAAEQSKCEGLSGEK 457

  Fly   362 T---TEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEE------------------------- 398
            |   ::..|:....|:.|...|:|:.......|..|:.:|                         
Zfish   458 TDSSSDASKLSSKSAKERRNRKKKRQHQGESEKEEDSIKEGNDRKPNFTFAVDGKIRRSRDRSYT 522

  Fly   399 -------------------------------EAEEDYGDDG--------------YLKTR----- 413
                                           .::.:|.||.              :|.||     
Zfish   523 SPRQSPLSFQGSLLTPRRDSKASVFSFRGRIHSDNNYADDEQSMFEETGSRRDSLFLPTRPERLF 587

  Fly   414 ----------------------------------------------------------------- 413
                                                                             
Zfish   588 SNVSKSSLTPHLLLPSNGKARYVDDSNGMVMVTSGASAPNSPVIALNTPEVSRKRAMFDDTCADS 652

  Fly   414 --------------------------SKPQGS-------------CTGFWRAEKRFRF------- 432
                                      |...||             |..:|     |.|       
Zfish   653 DDERRSRCNSQNFSKAYRQSMRERALSVASGSNNPAECSEIFKQRCEEWW-----FEFAENYLIW 712

  Fly   433 -----WIR-----HTVKTQWFY-WFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMS 486
                 |:|     |.:....|. .|:.:.:.:|||.:|:|.|......:..|..|..:|:|:|.:
Zfish   713 DCSPTWLRIKEVVHMIVMDPFADLFITICIVINTVFMAMECYPMDGPYSSMLSTANVVFIGIFTA 777

  Fly   487 EMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWS 551
            ||..|:.||.|..||...:|.||.::::.|:.|:..:.|..   |:..||..||||:||:.|.|.
Zfish   778 EMIFKVIALDPYSYFLEGWNIFDSIIVTLSLMELCLANVLS---GIGFLRPFRLLRVFKLAKSWP 839

  Fly   552 SLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGG-----------TPETNFN 605
            :|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:    |           .|..:.|
Zfish   840 TLNMLIKIIGNSLGALSNLTLVLAIIVFIFAVVGMQLFGKSY----GECVCKISSDCMLPRWHMN 900

  Fly   606 TFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAI----- 665
            .|..:.|.||::|.|| |.|.|:..:...|   :.:..:::.:|:|: ||..:||:|||:     
Zfish   901 DFFHSFLIVFRVLCGE-WIETMWDCMEVAG---QPLCLTVFMMVMVI-GNLVVLNLFLALLLSSF 960

  Fly   666 AVDNLA---------------------------------------------------NAQE---- 675
            :.||||                                                   |.:|    
Zfish   961 SADNLAVSGEEDENNLQIAVRRIRKGFTFIKTCLQSFFRSGCLRKKKQKSADGNMIVNCKERKDS 1025

  Fly   676 -----------------------------LT-----AAEEEQVE----EDKEKQLQELEKEMEAL 702
                                         ||     ||||...|    ||......:||::.|.|
Zfish  1026 TNHTTIELVKSTGGTDLDSDTENFISNPSLTVSVPIAAEESDFECLNTEDFSSLSSDLEEDKEKL 1090

  Fly   703 QADGVHVENGDGAVAPSKSKGKKKEE--EKKEEEEVTEGPKPMLP------------------YS 747
              ..|.....:|:....:..||..|:  |...|||..  |:|...                  :.
Zfish  1091 --SDVASSFSEGSTVDLRPLGKDGEDALELVLEEEAY--PEPCFTAGCVRRFRCCQVDEEKGIWK 1151

  Fly   748 SMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILNYFDYAFTG 811
            ..::|      |:..:.:|...:|:.||:.:|.:||.|||.||...:..:..| ||.:.|..||.
Zfish  1152 KWWLL------RQTCYNIVEHSWFETFIVFMILLSSGALAFEDIYLDTRKSVKTILEFADKVFTY 1210

  Fly   812 VFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLR 876
            :|.:|||||.|..|.    ..|....|..:|.|:|..:.:|.   ::.:.....||.|||||.||
Zfish  1211 IFILEMLLKWVAYGF----AKYFTNLWCWLDFVIVDVSLISL---VANALNYSELSAIKSLRTLR 1268

  Fly   877 VLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---TDESK 938
            ..|||:.:.|...::.|.:.::.::.:::|:|:|.::|..|||::||..|.|||..|   |.|.:
Zfish  1269 AFRPLRALSRFDGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIVGVNFFAGKFSECINITTEQR 1333

  Fly   939 --------HTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVL 995
                    .|..|..|...:              |:....::|||....|.|..|.|.:||..: 
Zfish  1334 LPVSEVYNKTDCERMGKGVR--------------WRNVIINFDNVGNGYLALLQVATFKGWMPI- 1383

  Fly   996 QHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF----PFFFVNIFVALIIITFQEQ-----GEAEL 1051
               |.|..:.|.|.:....|::::..:||::|    .||.:|:|:.:||..|.:|     |    
Zfish  1384 ---MYAAVDSRNPEEQPEYEVNLYMYLYFVIFIILGAFFTLNLFIGVIIDNFNQQKKKFGG---- 1441

  Fly  1052 QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMM 1114
            ||..:.:.||...:.  .:|::..::.:|:.:|..:..::.:|....|:.|||:||..|.:.:|:
Zfish  1442 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPKNKIQGLIFDLVTKQAFDIFIMVLIWLNMVTMML 1506

  Fly  1115 KYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIV-----DA 1174
            :..:|.....::|.:||:.|..:|:.|.|||:|... ..||...||:||.|.|:.|||     :.
Zfish  1507 ETEDQSIEMTRALYWINVIFIVLFTTECVLKMIALR-HYFFTVGWNVFDFIVVILSIVGMSLTEV 1570

  Fly  1175 LWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1239
            :...|.|.:: ...:||.|..|:::|:|....||.||:..:.|..||..:.||:.::.|||||.|
Zfish  1571 IKKYFVSPTL-FRVIRLARIGRVLRLIRSAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFG 1634

  Fly  1240 MQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEK----- 1299
            |..|..:|...   .|....||::|...::.||:..|...|..::...|..|..|.|..|     
Zfish  1635 MSNFAYVKKTA---GIDDMFNFETFPNSMLCLFQITTSGGWDGLLAPMLNSKPPDCDPTKNFTGS 1696

  Fly  1300 -APGEYCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAE 1361
             ..|: ||: ::...:|||:|..|..:::|:::|||::||...|.:|: .|.....|.|..:|.:
Zfish  1697 SVVGD-CGNPSIGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFDRFYEVWEK 1760

  Fly  1362 YDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRE 1426
            :||.||..:.|.::.|...::||||....  |||.   :|:.|::|:....|:.....|||..:.
Zfish  1761 FDPKATQFMEYGKLSDFADSLDPPLRIPK--PNRF---QLMSMDLPMVTGDRIHCLDILFAFTKR 1820

  Fly  1427 NLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNK--GKLSVGKIYAGF---L 1486
            .|.    ...|||....::.:..     :|:....:...|.:..|.:  ..:|...|...|   |
Zfish  1821 VLG----EGGEMDMLHGQMEDRF-----MQSNPSKSSYEPITTTLRRKHEDMSAAVIQRAFRKHL 1876

  Fly  1487 ILESWRSTR---------FGQLDSGMPM-----LELQDA----SRHPSQESLT 1521
            :.:|.:..|         .|::.|...|     .|..||    |..||..|:|
Zfish  1877 VRDSMKKVRNFKKKNKHQNGKVPSNQSMDKDMCNEDSDATAATSSPPSYSSIT 1929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 90/308 (29%)
Ion_trans 441..677 CDD:334124 82/336 (24%)
Ion_trans 769..1050 CDD:334124 91/301 (30%)
Ion_trans 1094..1345 CDD:334124 84/262 (32%)
GPHH 1346..1416 CDD:339854 21/69 (30%)
Ca_chan_IQ 1418..1492 CDD:337190 15/78 (19%)
scn1laaNP_956426.2 Ion_trans 150..416 CDD:278921 84/287 (29%)
Na_trans_cytopl 483..594 CDD:288761 9/110 (8%)
Ion_trans 749..945 CDD:278921 64/207 (31%)
Na_trans_assoc 972..1161 CDD:284034 28/198 (14%)
Ion_trans 1184..1438 CDD:278921 83/278 (30%)
Na_channel_gate 1430..1482 CDD:240441 10/55 (18%)
Ion_trans 1504..1742 CDD:278921 77/243 (32%)
GPHH 1752..1801 CDD:293510 18/53 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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