Protein Alignment cac and NaCP60E

DIOPT Version :9

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Alignment Length: 2760
• Identity: 537/2760 - (19%)
• Similarity: 917/2760 - (33%)
• Gaps: 1154/2760 - (41%)

  Fly    14 GPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEA 78
            |..|||:....:|.|:...:|.....|:|.|:.||:.||:.||:.|            .:|:.|.
  Fly   102 GTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTE------------TVEEAEY 154

  Fly    79 YFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEV-DLRTLRAIRV 142
            .||.|:.:|..:||:|.|.:|:|::||||.||.:||.|:.:|:.|    ||.|| :|..||..||
  Fly   155 IFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYAT----IGMEVGNLAGLRTFRV 215

  Fly   143 LRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNK 207
            ||.||.||.:|.|:.::.:::.:...|.::..|.:|.:::||:..|:.|.|.|...|.. :.|..
  Fly   216 LRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVR-QVPTD 279

  Fly   208 LVKEGESETPC---NTDN-ILEKATGSFVCNNTTS--------MCLEKWEGPNSGITSFDNIGFA 260
            ......::...   :||| :.::.....:|.|.|.        :||...|.||.|.|:|||..::
  Fly   280 WTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWS 344

  Fly   261 MLTVFQCITMEGWTAILYWTNDALGSAFNWI----------YFVPLIVIGSFFMLNLVLGVLSGE 315
            |||.||.||::      ||.|     .:|.:          :|..::..|||:::||:|.|::..
  Fly   345 MLTTFQLITLD------YWEN-----VYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALS 398

  Fly   316 FAKERE--KVENRQEFLKLRRQQQLE--------RELN-GYVEWICKAEEVILA---EERTT--- 363
            :.:|.|  ..|.:::.|..|......        ::|| ...:.|...:.|:||   :::|.
  Fly   399 YEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKK 463

  Fly   364 ------------------EEEKMH---------------------IMEARR--RNAAKRKKLKSL 387
                              ::.|.|                     .|:|::  :...::.||...
  Fly   464 TKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKS 528

  Fly   388 G-----------------------------------------------KSKSTDTEEEEAEEDYG 405
            |                                               .|.|:....|.:::|.|
  Fly   529 GSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSG 593

  Fly   406 ------------DDGYLKT--------------------RSK---------------------PQ 417
                        |.|::.|                    |.|                     |.
  Fly   594 VVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPD 658

  Fly   418 GSCTG--FWRAEKRFRFWIR------HTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLY 474
            .:|..  .|..:  :..|::      ..|:...|...:.:.:.|||..:|:||:|........|.
  Fly   659 RNCDRCVHWCTD--YESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721

  Fly   475 YAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALR 539
            ....:|..:|..|..:|:.||. :.:|...:|.||.::::.|:.::|:..|.    ||||||.||
  Fly   722 VGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD----GLSVLRGLR 781

  Fly   540 LLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL----PGGTP 600
            |||:.|:.:.|::::.|:..:::::.::.:|..:|.:.|.|||::|||||...:..    |...|
  Fly   782 LLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVP 846

  Fly   601 ETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAI 665
            ..|||.|..:.:.:|:||.|| |.|.::..:.::........::|:...||: ||:.:||:|||:
  Fly   847 RWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLAL 909

  Fly   666 AVDNLANAQELTAAEEEQVEEDK------------EKQLQELE--KE-----------MEALQA- 704
            .: |..|::||.:.:||..||.|            .|:.||.:  ||           ::|.||
  Fly   910 LL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAH 973

  Fly   705 ---------------------------------------------------DGVHV--------- 709
                                                               ||:|.
  Fly   974 AQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDD 1038

  Fly   710 ----------------------------------------ENGDGA---VAP------------- 718
                                                    .||:|.   :.|
  Fly  1039 TGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQIS 1103

  Fly   719 ----------------------------------------------------------------- 718
                                                                             
  Fly  1104 SGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHD 1168

  Fly   719 ------------------------SKSKGK------KKEEEK----------------------- 730
                                    |:|.|:      |.||.:
  Fly  1169 EAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQ 1233

  Fly   731 --------------------KEEEEVTEGPK---------------------------------- 741
                                :||||:.:|.|
  Fly  1234 QGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNI 1298

  Fly   742 ------------------------------------------------------------PMLPY 746
                                                                        |:.||
  Fly  1299 IQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPY 1363

  Fly   747 SSMFI-----------------------------------LSPTNPIRR---------------- 760
            .|..:                                   .|.:|.||:
  Fly  1364 DSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMA 1428

  Fly   761 ----------------------------------------------------------------- 760
                                                                             
  Fly  1429 VAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFL 1493

  Fly   761 ----------------------------------------------------------------- 760
                                                                             
  Fly  1494 HGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPP 1558

  Fly   761 ----------------------------------------------------------------- 760
                                                                             
  Fly  1559 LAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHS 1623

  Fly   761 ----------------------------------------------------------------- 760
                                                                             
  Fly  1624 SGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAY 1688

  Fly   761 ---------GA------------------------------------HW---------VVNLPYF 771
                     ||                                    ||         ||:.|.|
  Fly  1689 NDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAF 1753

  Fly   772 DFFIMVVISMSSIALAAED-PVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLR 835
            ::|::|:|..|||.|..|| .:.:|....::|.:.:::|..:|.:||:||.:.||.    ..|..
  Fly  1754 EWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFT 1814

  Fly   836 EFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNS 900
            .||.|:|.::|..:..|...:     ..:||..::|||.||.||||:.|.|...::.|.:.::.:
  Fly  1815 SFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYA 1874

  Fly   901 LKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELR-- 963
            :.::.|:|:|.::|..|||::|||.|.||||.|.:|.                .||||..|:.
  Fly  1875 IPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM----------------GELLPITEVNDK 1923

  Fly   964 --------VWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFY 1020
                    .|......:|:|....|.|..|.|.|||.:|:..::.|...|..|.:...:...|::
  Fly  1924 WDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYF 1988

  Fly  1021 IVYFIVFPFFFVNIFVALIIITFQ------EQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPK 1079
            :::.:...||.:|:|:.:||..|.      |.|..|:...|..|:..:.:. .:|.:..::.:.:
  Fly  1989 VIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMK-KLGRKKPQKVIKR 2052

  Fly  1080 NRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVL 1144
            ..|.|....:.:..|..||..|.:||..|.|.:.:::::|.......|:..|..||.:|.:|.::
  Fly  2053 PINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIV 2117

  Fly  1145 KIIGFGVKNFFKDPWNIFDLITVLGSI----VDALWMEFGSNSINVGFLRLFRAARLIKLLRQGY 1205
            ||:|... ::|..|||:||.:.||.||    ::.:.::...:...:..:|:||..|:::|::...
  Fly  2118 KIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAK 2181

  Fly  1206 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL-GTVENSITRHNNFQSFIQGVM 1269
            .||.||:..|.|..||..:..|:.::.|||||:||.:|||:|| |.:::.:    |||:|.:.:.
  Fly  2182 GIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV----NFQTFGRSMQ 2242

  Fly  1270 LLFRCATGEAWPNIMLA-CLKGKACDDDAEKAPGEYCG-STLAYAYFVSFIFFCSFLMLNLFVAV 1332
            ||||..|...|.:::.: .::...||..........|| ..||..||.|||.....:::|:::|:
  Fly  2243 LLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAI 2307

  Fly  1333 IMDNFDYLTRDSSI-LGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRL 1396
            |::||:...::..| :....|:.|...|::|||:||..||::::.|.:.::|||||...  ||.:
  Fly  2308 ILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNV 2370

  Fly  1397 AYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMD-------QADMELRE------- 1447
            |   |:..|:|:....::.....|.||::..|.    ..||.|       |.|::.::
  Fly  2371 A---LVSFNLPISKGNKIHCLDILHALVKHVLG----HVEETDNFKQLQEQMDVKFKKQFPTRKE 2428

  Fly  1448 ----TITNIWPLQAKKMLNLLVPPSDQL---------NKGKLSVGKIYAGFLILESWRSTRFGQL 1499
                :.|.||..|.|....:.....:.|         |.|..:......|     .|:|..
  Fly  2429 LEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPG-----GWQSKL---- 2484

  Fly  1500 DSGMPMLELQ-------DASRHPSQESLTGADAGHLHPGHSYMNG-------------------- 1537
             |.:....||       .:||..|::|...:||..|    |.:.|
  Fly  2485 -SALNFFHLQVSRRGTACSSRASSRKSSRASDASDL----SELAGPWLNLPLMLVSGADEVVKDI 2544

  Fly  1538 HRRSPSLRHNGSPLARSPSPRRRGHQY---IHHDIGFSDTV-SNVVEMVKETRHPRHGNSHPRYP 1598
            .:::..|...||....:|...||...|   :.|.....|:: |..|.......:..:..|:....
  Fly  2545 KQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSAST 2609

  Fly  1599 RGSWSA-STSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGY 1662
            .|:.|: :|:||....|:....  |.|.|.|    ..|..|...|.|:.|..|.:...||   |.
  Fly  2610 SGTASSTATAPATGCGPAATSA--SDSDRHQ----AVGGGSAPSRKRASSFIRKKPPLER---GL 2665

  Fly  1663 GIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSK---PSTLQLKPTNINFPKLNASPTHTHHSTPH 1724
            .....:...::::.:.||....|..|  |:|.:   |.:|.|:|.|...
  Fly  2666 SAQSALRVNKNAFVSEASAPEVIVTR--PSPEQQTHPHSLSLRPDNATL---------------- 2712

  Fly  1725 SVHSLPHHRDLLRDPRDMYYSSRERERDRE 1754
             ||.|.|               ||.|..:|
  Fly  2713 -VHVLVH---------------RESEEYKE 2726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	98/311 (32%)
		Ion_trans	441..677	CDD:334124	73/239 (31%)
		Ion_trans	769..1050	CDD:334124	88/297 (30%)
		Ion_trans	1094..1345	CDD:334124	81/257 (32%)
		GPHH	1346..1416	CDD:339854	23/70 (33%)
		Ca_chan_IQ	1418..1492	CDD:337190	18/100 (18%)
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	77/234 (33%)
		Ion_trans	705..902	CDD:278921	61/203 (30%)
		Ion_trans	1768..2019	CDD:278921	78/275 (28%)
		Na_channel_gate	2009..2063	CDD:240441	9/54 (17%)
		Ion_trans	2085..2320	CDD:278921	73/239 (31%)
		GPHH	2331..2386	CDD:293510	21/59 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439096
Domainoid	1	1.000	73	1.000	Domainoid score	I3264
eggNOG	1	0.900	-	-		E1_KOG2301
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I473
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.820