DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and CATSPER4

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens

Alignment Length:	469	Identity:	97/469 - (20%)
Similarity:	187/469 - (39%)	Gaps:	97/469 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1071 RPLERYMPKNRN-TFKYKVW------------RIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDM 1122
            ||.|:.:...:. |.|...|            :::....|:..:.:|:|.|.:.:.::.::
Human    55 RPEEQVLINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNS---- 115

  Fly  1123 YEKSLKYINMGFTGMFSV--ETVLKII----------GFGVKNFFKDPWNIFDLITVLGSIVDAL 1175
                  |::.....:||.  :.||.|:          ||.:  |:||.|||.:.|     ||..|
Human   116 ------YLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWI--FWKDGWNILNFI-----IVFIL 167

  Fly  1176 WMEFGSNSINVGFLR-LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1239
            .:.|..|.||:..:. ..||.||:.:......:..::...:||...:..:.:||.....::::.|
Human   168 LLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFG 232

  Fly  1240 MQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEY 1304
            :.:||..        :.:|  ||:....:..||.|.|.:.|.:|.        .|...||.  ||
Human   233 VTLFGAF--------VPKH--FQNIQVALYTLFICITQDGWVDIY--------SDFQTEKR--EY 277

  Fly  1305 CGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDS----------SILGAHHLDEFVRIW 1359
            ........||..||...:|:.:||||.|:..|.:.:.:..          |..||...:|..::
Human   278 AMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQL- 341

  Fly  1360 AEYDPNATGKIHYTEMYDMLKNMDPPLGFG-------NKCPNRLAYKKLIRMNMPLDDELRVQFT 1417
                |.....:..:|...:|:.   ||..|       |.|.|.....:.|:.|:....|:|.:
Human   342 ----PLVHCVVARSEKSGLLQE---PLAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDE-- 397

  Fly  1418 TTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIY 1482
              |..::.|..:|:..  :|.:...:..|.:.:......:.|.:..:....|.|: ..:|:.|::
Human   398 --LNMIVEEVRAIRFN--QEQESEVLNRRSSTSGSLETTSSKDIRQMSQQQDLLS-ALVSMEKVH 457

  Fly  1483 --AGFLILESWRST 1494
              :..::|:..:|:
Human   458 DSSSQILLKKHKSS 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124
		Ion_trans	1094..1345	CDD:334124	62/273 (23%)
		GPHH	1346..1416	CDD:339854	16/76 (21%)
		Ca_chan_IQ	1418..1492	CDD:337190	11/75 (15%)
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	62/258 (24%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438		2/21 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900