DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and Catsper2

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_001012220.1	Gene:	Catsper2 / 366174	RGDID:	1307620	Length:	584	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	94/417 - (22%)
Similarity:	170/417 - (40%)	Gaps:	87/417 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKT---VLAQKL 73
            ||.|          |:..:..::::...|...::..|..|..||.:|..|.....|   .|...|
  Rat    90 GGRP----------PLSLWAGWVLDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWPLKLAL 144

  Fly    74 EKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQY-PQIGPEVD---L 134
            |.|:.:.|..|.||..|..||...:     :.:|.|::.||.|.:...:.:: ..||...|   |
  Rat   145 EVTDWFILLSFIVEILLMWLASFFL-----FWKNAWSVFDFVVTMLSLLPEFVVLIGVSADSVWL 204

  Fly   135 RTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC 199
            :.||..||||.|||.:..|.::|:|.::::|:..:..:.:|:|....:||:.|:.|:......|.
  Rat   205 QLLRVSRVLRSLKLFARFPQIKVILLALVRALKSMTFLLMLLLIFFYVFAVAGVYFFKEYSRSTI 269

  Fly   200 YSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTV 264
            .:||                 .|:.                             |.::..:::||
  Rat   270 ENLE-----------------YNMF-----------------------------FSDLLNSLVTV 288

  Fly   265 FQCITMEGWTAIL--YWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQ 327
            |...|::.|.|:|  .|........|:.||.:..:::||....|:::.::...|...|.::....
  Rat   289 FILFTLDHWYAVLQDVWKVPEASRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRNELHEEM 353

  Fly   328 EFLK------------LRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAK 380
            ..|:            ::|:||.| .|.|..:.  |..|.|......|:|||....|:....:.:
  Rat   354 THLEVQYKADIFKRRIIQRRQQSE-SLRGTSQG--KVSEDITETSEATDEEKSEAEESEEEKSEE 415

  Fly   381 RKKLKSLGKSKSTDTEEEEAEEDYGDD 407
            .|  ..:.||.....:||:::|:..|:
  Rat   416 EK--SDVEKSDEEKNDEEKSDEEENDE 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	68/295 (23%)
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
Catsper2	NP_001012220.1	Ion_trans	138..348	CDD:278921	60/260 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..460		18/70 (26%)
		HSP90	419..>463	CDD:278607	6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900