DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and trpl

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster

Alignment Length:	1253	Identity:	215/1253 - (17%)
Similarity:	395/1253 - (31%)	Gaps:	412/1253 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   740 PKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNY 804
            |:|:|.....|:|:    :.||     ::|.....:...:....|.:...||:...:....|.|.
  Fly    35 PQPLLLEEKKFLLA----VERG-----DMPNVRRILQKALRHQHININCMDPLGRRALTLAIDNE 90

  Fly   805 FDYAFTGVFTIEMLLKIVDLGV-----ILHPGSYLREFWNIMDAVVVICAAVSFGF--------- 855
                     .:||:..:|.:||     :||  :...||   ::||.::.......:
  Fly    91 ---------NLEMVELLVVMGVETKDALLH--AINAEF---VEAVELLLEHEELIYKEGEPYSWQ 141

  Fly   856 --DMSGSSAGQNLSTI------KSLRVLRVLRPLKTIKRVP-----------KLKAVFDCVVNSL 901
              |::.:....:::.:      .:..:||:|........||           :|.|. |.:.:||
  Fly   142 KVDINTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAE-DSLRHSL 205

  Fly   902 KNVVNI--------LI-------VYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKY 951
            .. |||        ||       :...||..:.:..:.|              |..||:..|...
  Fly   206 SR-VNIYRALCSPSLICLTSNDPIITAFQLSWELRNLAL--------------TEQECKSEYMDL 255

  Fly   952 EE----------DELLPKQELRV---WKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHS----- 998
            ..          |:.....||.:   :.|:...|:......||...........:.:.||
  Fly   256 RRQCQKFAVDLLDQTRTSNELAIILNYDPQMSSYEPGDRMSLTRLVQAISYKQKKFVAHSNIQQL 320

  Fly   999 MAATYEDRGPIQNFR----IEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKN 1059
            :::.:.|..|  .||    ::..|......::||.:.:....|
  Fly   321 LSSIWYDGLP--GFRRKSIVDKVICIAQVAVLFPLYCLIYMCA---------------------- 361

  Fly  1060 QKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLI------------VFNTL-- 1110
             .:|....:..:|..::              ::.::.:.:|:.:||            :|.|.
  Fly   362 -PNCRTGQLMRKPFMKF--------------LIHASSYLFFLFILILVSQRADDDFVRIFGTTRM 411

  Fly  1111 ---LLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLI------- 1165
               |...:...:|....| |:.|.:.:...|..|.|.:|...|:|::.::.||..|.:
  Fly   412 KKELAEQELRQRGQTPSK-LELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVS 475

  Fly  1166 -------------------TVLGSIVDALWMEFGSNSINVGFLRLFRAARLIKLLRQGY------ 1205
                               ..:..|....|.:|....|..|   ||.||.:...|:..:
  Fly   476 VMCLRAFAYIQQATEIARDPQMAYIPREKWHDFDPQLIAEG---LFAAANVFSALKLVHLFSINP 537

  Fly  1206 ------------TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF----GNIKLGTVENS 1254
                        .|.|:.:.|:.:.....:.|.|..:|::..|:...:.:    |....|:..:|
  Fly   538 HLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSKCYVLPGGEADWGSHGDS 602

  Fly  1255 ITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIF 1319
            ..:...|.:..:....||       |.:..:..|      ||.|      .....:|..|...:.
  Fly   603 CMKWRRFGNLFESSQSLF-------WASFGMVGL------DDFE------LSGIKSYTRFWGLLM 648

  Fly  1320 FCSF------LMLNLFVAVIMDNFDYLTRDSSILGAHHLDEF----VRIWAEY-DPNATGKIHYT 1373
            |.|:      ::|||.:|::.:::       :::..|...|:    .::|..| :.:||
  Fly   649 FGSYSVINVIVLLNLLIAMMSNSY-------AMIDEHSDTEWKFARTKLWMSYFEDSAT------ 700

  Fly  1374 EMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEM 1438
                    :.||.   |..|:.....::.|.:....|..|               |.|.:..|:.
  Fly   701 --------LPPPF---NVLPSVKWVIRIFRKSSKTIDRQR---------------SKKRKEQEQF 739

  Fly  1439 DQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKI-YAGFLILESWRSTRFGQLDSG 1502
            .:.|..:|..:........:|..|..| ..|.:|:.|..:..: |....|.|          :||
  Fly   740 SEYDNIMRSLVWRYVAAMHRKFENNPV-SEDDINEVKSEINTMRYEMLEIFE----------NSG 793

  Fly  1503 MPMLELQDASRHP--------SQESLTGADAGHLHPG-----HSYMNGHRRSPSLRHNGSPLARS 1554
            |.:.......|.|        .:..:.|.....:..|     ...:||......::....|...:
  Fly   794 MDVSSANKKERQPRPRRIKVWERRLMKGFQVAPVQNGCELDAFGNVNGQGEMQEIKVESIPSKPA 858

  Fly  1555 PSPRRRGHQYIHHDIGFSDTVS--NVV-------EMVKETRHPRH-----GNSHPRYPR------ 1599
            ....:...|.:...:....|..  |||       ::.:.|::.|.     |.:.....|
  Fly   859 KETAKERFQRVARTVLLQSTTHKWNVVLRAAKDSQIGRCTKNERKSLQNLGRAIEEAKRLIMLNP 923

  Fly  1600 GSWSASTSPARSPSP-----------SRYGGHLSRSKRTQL------PYPTY--------GTTSL 1639
            |..|...||.|....           ::....:|.|::.::      |..|.        .|.||
  Fly   924 GCPSGRESPIRIEFEDEKTSTLLELLNQISAEISDSEKPKIRPIWRPPLKTVPARAMAANNTRSL 988

  Fly  1640 ------CQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSK--- 1695
                  ..|..||:|....            ..||:|.     .|:..|   .|.||..|||
  Fly   989 TAPELKISRKSSPAPTPTP------------TPGVSHT-----ALSQFR---NRELPLCPSKLIA 1033

  Fly  1696 ---PSTLQLKPTNINFPKLNA--SPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRER 1755
               ||.    ||..  ||.:|  :||.|:..|.|:             |..:...:||..|..:.
  Fly  1034 NSAPSA----PTAP--PKKSAPTAPTPTYKPTTHA-------------PFSVEGGNRENTRASDG 1079

  Fly  1756 LRDRDRDRDRDRLHEYDL 1773
            :|..:.:.|   :|..||
  Fly  1080 VRSDNSNFD---IHVVDL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124	57/350 (16%)
		Ion_trans	1094..1345	CDD:334124	55/321 (17%)
		GPHH	1346..1416	CDD:339854	13/74 (18%)
		Ca_chan_IQ	1418..1492	CDD:337190	14/74 (19%)
trpl	NP_476895.1	trp	48..784	CDD:273311	140/876 (16%)
		ANK	48..195	CDD:238125	25/169 (15%)
		ANK repeat	78..114	CDD:293786	9/46 (20%)
		ANK repeat	134..177	CDD:293786	4/42 (10%)
		TRP_2	187..246	CDD:285535	14/74 (19%)
		DUF2031	<706..>805	CDD:299055	22/124 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910