DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and CATSPER3

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_821138.1	Gene:	CATSPER3 / 347732	HGNCID:	20819	Length:	398	Species:	Homo sapiens

Alignment Length:	374	Identity:	80/374 - (21%)
Similarity:	165/374 - (44%)	Gaps:	52/374 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 GYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAV-EHYGQPSFLTE 471
            |:..|..|       |.|.:...|.:::..:.:::|...:|..|..|...:|: ..|.....|..
Human    24 GFCPTFKK-------FKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFR 81

  Fly   472 FLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFG-LSVL 535
            .|.::|..|:.:..||:.:|:| :.|..|:::.:|..|.::|..........::.|..|. |.:.
Human    82 LLEFSEIFFVSICTSELSMKVY-VDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIA 145

  Fly   536 RALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTP 600
            ..::.|||.|:..|...:|.|:.::..::.::.|:|.||||.:.|||:||..|||.    |....
Human   146 DGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGS----PDNGD 206

  Fly   601 ETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAI 665
            ..|:.....|..|:|.:.|.:.|.::.     .|...::..:...:.|:.:|..::..||:|:.:
Human   207 HDNWGNLAAAFFTLFSLATVDGWTDLQ-----KQLDNREFALSRAFTIIFILLASFIFLNMFVGV 266

  Fly   666 AVDNLANA-----QELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKK 725
            .:.:..::     :||...::|.:..:|:..||..::|:..|    :|::
Human   267 MIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRL----MHIQ--------------- 312

  Fly   726 KEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFF 774
            |..:.....|:.|..|..|.::...:|.         .:..:||:.|.:
Human   313 KNADCTSFSELVENFKKTLSHTDPMVLD---------DFGTSLPFIDIY 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124	57/242 (24%)
		Ion_trans	769..1050	CDD:334124	2/6 (33%)
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
CATSPER3	NP_821138.1	Ion_trans	72..269	CDD:278921	51/206 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900