DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and AgaP_AGAP002577

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_563586.4	Gene:	AgaP_AGAP002577 / 3290639	VectorBaseID:	AGAP002577	Length:	1813	Species:	Anopheles gambiae

Alignment Length:	1870	Identity:	1320/1870 - (70%)
Similarity:	1480/1870 - (79%)	Gaps:	134/1870 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GGPKKEENPPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDK 66
            |.|:....||..||:||||..|||.|||.|:||||||||||||||||||||||||||||||.|||
Mosquito    55 GSPRHRTGPPPPGPSSLFIFAEDNFIRKATKFIIEWPPFEYAVLLTIIANCVVLALEEHLPKGDK 119

  Fly    67 TVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPE 131
            ||||||||.||:||||||.:||:|||:|||||||..||||||||:||||||.||.:|..| :..:
Mosquito   120 TVLAQKLELTESYFLCIFTIEAALKIVALGLVLHADSYLRNIWNMMDFFVVFTGLVTLLP-LPLD 183

  Fly   132 VDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALH 196
            |||||||:|
Mosquito   184 VDLRTLRSI-------------------------------------------------------- 192

  Fly   197 KTCYSLEDPNKLVKEGESETPCNTDN---ILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIG 258
                 ||    :::||:..|||..|:   ..|...|..:||:..|.|:|:|||||.|||:|||||
Mosquito   193 -----LE----IIEEGDLPTPCYDDDDTMNAELPAGVHLCNHNESACIEQWEGPNYGITNFDNIG 248

  Fly   259 FAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKV 323
            ||||||||||||||||:.:||||||:||.||||||||||:|||||||||||||||||||:|||||
Mosquito   249 FAMLTVFQCITMEGWTSTMYWTNDAIGSTFNWIYFVPLIIIGSFFMLNLVLGVLSGEFAREREKV 313

  Fly   324 ENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLG 388
            ||||||||||||||||:||||:|||||||||:||||:||||||:|:|||||::.||||||||:||
Mosquito   314 ENRQEFLKLRRQQQLEKELNGFVEWICKAEEIILAEDRTTEEERMYIMEARKKAAAKRKKLKNLG 378

  Fly   389 KSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFL 453
            ||||::|::|||..:.||:|.||...||..|  ||||||||||:.||||||||||||||||||||
Mosquito   379 KSKSSETDDEEATTESGDEGILKKEKKPAKS--GFWRAEKRFRYCIRHTVKTQWFYWFVIVLVFL 441

  Fly   454 NTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIF 518
            ||:||||||||||::|..|||||||:||||||.||.||:|||||||||||:||||||:||:||||
Mosquito   442 NTICVAVEHYGQPNWLALFLYYAEFVFLGLFMCEMLIKIYALGPRIYFESAFNRFDCIVIAGSIF 506

  Fly   519 EVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFAL 583
            ||:||..|.||||:|||||||||||||||||||||||||||||:|||||||||||||||||||||
Mosquito   507 EVVWSAYKEGSFGISVLRALRLLRIFKVTKYWSSLRNLVISLLSSMRSIISLLFLLFLFILIFAL 571

  Fly   584 LGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFI 648
            ||||||||||.||.|||.||||||.||||||||||||||||||||.||.||||.:.|||||:|||
Mosquito   572 LGMQLFGGQFILPEGTPPTNFNTFTIALLTVFQILTGEDWNEVMYLGINSQGGHESGMIYSLYFI 636

  Fly   649 VLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQ--ADGVHVEN 711
            :|.||||||||||||||||||||||||||||||:|.|.|||||..||||||||||  .||.....
Mosquito   637 ILTLFGNYTLLNVFLAIAVDNLANAQELTAAEEQQQERDKEKQQMELEKEMEALQKAKDGTPTTE 701

  Fly   712 GDGAVAPSKSKGKKKEEEKKE--EEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFF 774
             |......|.|..||||:|:|  |||..||||||||||.|||.|.|||:||.|||||||.|||||
Mosquito   702 -DAEAEKEKEKESKKEEKKEEEPEEEAPEGPKPMLPYSCMFIFSSTNPMRRAAHWVVNLRYFDFF 765

  Fly   775 IMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWN 839
            ||:|||:|||||||||||:|:|.|||:||..|||||.|||||||||::|||:||||||||||.||
Mosquito   766 IMIVISLSSIALAAEDPVQEDSPRNKVLNNLDYAFTCVFTIEMLLKVIDLGIILHPGSYLREIWN 830

  Fly   840 IMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNV 904
            |||||||.||.||.|||:|||.||.:|||||||||||||||||||||||||||||||||.|||||
Mosquito   831 IMDAVVVGCAVVSIGFDISGSDAGADLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVGSLKNV 895

  Fly   905 VNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRA 969
            :|||||||||||||:||.|||||||||||||:|||.|.:||||||.|.|.:.||:...|.||.:.
Mosquito   896 INILIVYILFQFIFAVIAVQLFNGKFFYCTDDSKHNSIDCQGSYFIYSEVDGLPRSAKREWKTQY 960

  Fly   970 FHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNI 1034
            |:|||||.|||||||||||||||||||:||||||||.||||||||||||||:|||:|||||||||
Mosquito   961 FNYDNVATAMLTLFAVQTGEGWPQVLQNSMAATYEDEGPIQNFRIEMSIFYVVYFVVFPFFFVNI 1025

  Fly  1035 FVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEY 1099
            ||||||||||||||||||||||||||||||||||||||||||:|...:.|||.||||:||.||||
Mosquito  1026 FVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYIPTKHSGFKYTVWRIIVSAPFEY 1090

  Fly  1100 FIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDL 1164
            |||.||||||||||||.|:|....|..:||:||.|||||||||||||||||.:|||||.||:|||
Mosquito  1091 FIMTLIVFNTLLLMMKCHDQNKKLENFMKYLNMIFTGMFSVETVLKIIGFGARNFFKDAWNVFDL 1155

  Fly  1165 ITVLGSIVDALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1229
            |||:|||||||.:....||.||||||||||||||||||||.||||||||||||||||||||||||
Mosquito  1156 ITVIGSIVDALILLLWENSFNVGFLRLFRAARLIKLLRQGDTIRILLWTFVQSFKALPYVCLLIA 1220

  Fly  1230 MLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACD 1294
            |||||||||||||||||:|.. :.:|:|||||:||:.|::    |||||:|||||||||||:.||
Mosquito  1221 MLFFIYAIIGMQVFGNIELDP-DTAISRHNNFRSFLDGLI----CATGESWPNIMLACLKGRPCD 1280

  Fly  1295 DDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIW 1359
            ..|.| |.|.|||||||.|||||||||||||||||||||||||||||||||||||||||||||||
Mosquito  1281 PRANK-PNETCGSTLAYGYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIW 1344

  Fly  1360 AEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALI 1424
            |||||:|:||:||||||||||||.||||||||||||||||||||||||:|:|.||.|||||||||
Mosquito  1345 AEYDPSASGKLHYTEMYDMLKNMAPPLGFGNKCPNRLAYKKLIRMNMPVDEEGRVGFTTTLFALI 1409

  Fly  1425 RENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILE 1489
            |||||||||..|||||||||||:||..|||:|||||::|||||::.||.||::|||||||.|:||
Mosquito  1410 RENLSIKMRPAEEMDQADMELRQTIRQIWPIQAKKMVDLLVPPNNVLNTGKMTVGKIYAGILMLE 1474

  Fly  1490 SWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARS 1554
            :||:.:..:.|...   |||:...|..||..  .|.|||||  ...|||.|||||: .||.|.||
Mosquito  1475 TWRNNKGARYDFEP---ELQEHKPHEIQEPY--IDDGHLHP--DQRNGHVRSPSLQ-RGSALERS 1531

  Fly  1555 PSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGG 1619
            ||||     ::|||||||:|||||||:.:..           :..||||.:|||||||||||...
Mosquito  1532 PSPR-----HLHHDIGFSETVSNVVEIARRD-----------HLIGSWSVATSPARSPSPSRLDT 1580

  Fly  1620 HLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGID-MGVTHVQHSYPTLASRRA 1683
            .:|...|.......||||||.|||||||||||||.|||:|..|..: :...::||:||.|.|.|
Mosquito  1581 QISAHHRCNRRIHPYGTTSLGQRSRSPSPARLQEWRERERDRYREEIVSRPYIQHTYPVLQSHR- 1644

  Fly  1684 GIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTH-------HSTPHSVHSLPHHR-DLLRDPR 1740
            ..||||||.|.||:|||||.||||||:||.||||.:       |:.|:||||||..| |:.||||
Mosquito  1645 DFGRRLPPRPIKPTTLQLKSTNINFPQLNTSPTHQNLHLALNTHTLPYSVHSLPGSRGDIPRDPR 1709

  Fly  1741 DMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELY------ERERDREREVERER 1799
            ..:::..||:|:|||||:|:||        |..||.:||.||||:      ||.||..|:.|.||
Mosquito  1710 IYHHTESERDRERERLRERERD--------YGSRYVFRDTERELFEIERELERARDSARDTEYER 1766

  Fly  1800 LEYIAPLSFEQALAMGRT-GRVLPSPVLNGFKPKSGLNPRHSDSDEEDWC 1848
            :|   |||:|....:||| |....|..|||:|||.|::..:|:|||.|||
Mosquito  1767 VE---PLSYEHLYTLGRTGGSSFGSSALNGYKPKVGMHSIYSESDEGDWC 1813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	168/289 (58%)
		Ion_trans	441..677	CDD:334124	205/235 (87%)
		Ion_trans	769..1050	CDD:334124	232/280 (83%)
		Ion_trans	1094..1345	CDD:334124	197/250 (79%)
		GPHH	1346..1416	CDD:339854	62/69 (90%)
		Ca_chan_IQ	1418..1492	CDD:337190	56/73 (77%)
AgaP_AGAP002577	XP_563586.4	Ion_trans	108..314	CDD:278921	150/271 (55%)
		Ion_trans	446..665	CDD:278921	189/218 (87%)
		Ion_trans	777..1000	CDD:278921	179/222 (81%)
		Ion_trans	1103..1330	CDD:278921	181/232 (78%)
		GPHH	1338..1401	CDD:293510	55/62 (89%)
		Ca_chan_IQ	1403..1479	CDD:285917	58/75 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	396	1.000	Domainoid score	I2208
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2632	1.000	Inparanoid score	I93
OMA	1	1.010	-	-		QHG56527
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	1	1.000	-	-		oto108065
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X841
TreeFam	1	0.960	-	-
	11	10.940