DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and para

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2169 Identity:499/2169 - (23%)
Similarity:863/2169 - (39%) Gaps:655/2169 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ::::|...||||:...:|:..|.|...::.||:.||:::.:.          ....:|.||..|.
  Fly   132 AMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMP----------TTPTVESTEVIFT 186

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:::|::|.|.:|...:|||:.||.:||.|:...::|....:|   :|..||..||||.|
  Fly   187 GIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG---NLAALRTFRVLRAL 248

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC---YSLEDP-NK 207
            |.|:.:|.|:.::.::|:::..|..:.:|.:|::.:||::||:.|.|.|.:.|   :.|:.. ..
  Fly   249 KTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGN 313

  Fly   208 LVKEGESETPCNTDNILEKATG-SF-VCNNTTS--------MCLEKW-EGPNSGITSFDNIGFAM 261
            |..|.......|:.|...:..| || :|.|.:.        :||:.: ..||.|.||||:.|:|.
  Fly   314 LTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAF 378

  Fly   262 LTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENR 326
            |:.|:.:|.:.|..:......|.| .::.::|:.:|.:|||:::||:|.:::..:.:.::|.|..
  Fly   379 LSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEE 442

  Fly   327 Q----------EFLKLRRQQQLERELNGYVE----------------------WICKAEEVILAE 359
            :          |.....:..:||...|...:                      :.|.:.|:.:..
  Fly   443 EAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGG 507

  Fly   360 ERTTEE---EKM----------------------------------------------------- 368
            |:..::   |||                                                     
  Fly   508 EKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRS 572

  Fly   369 ---------------------------------HIMEARRRNA---------------------- 378
                                             |:..|...||                      
  Fly   573 SHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGS 637

  Fly   379 --------------------------------AKRKKLKSL-----------GKSKSTDTEEEEA 400
                                            .|..||::.           |.:...||..:..
  Fly   638 RHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLD 702

  Fly   401 EEDY-------GDDGYLK-----------------------------------TRSKPQG----- 418
            ..||       .:.|.:|                                   :|:..:|     
  Fly   703 HRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYY 767

  Fly   419 -------------------------------SCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVF 452
                                           .|...|   .:|:.|:...|...:...|:.:.:.
  Fly   768 FPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVW---LKFQEWVSLIVFDPFVELFITLCIV 829

  Fly   453 LNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSI 517
            :||:.:|::|:.....:...|....:.|...|..|..:|:.|:.|:.||:..:|.||.::::.|:
  Fly   830 VNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSL 894

  Fly   518 FEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLL-NSMRSIISLLFLLFLFILIF 581
            .|:....|:    ||||||:.||||:||:.|.|.:| ||:||:: .:|.::.:|.|:|.:.|.||
  Fly   895 LELGLEGVQ----GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIF 954

  Fly   582 ALLGMQLFGGQFN-----LP-GGTPETNFNTFPIALLTVFQILTGEDWNE----VMYQGIISQGG 636
            |::||||||..::     .| |..|..||..|..:.:.||::|.|| |.|    .||.|.:|   
  Fly   955 AVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYVGDVS--- 1015

  Fly   637 AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANA---------------------------- 673
                  ...:|:..|:.||..:||:|||:.:.|..::                            
  Fly  1016 ------CIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWV 1074

  Fly   674 ------------QELTAAEEEQVEEDKEKQL--------------------QELEKEMEALQADG 706
                        .:||....:|...::..|:                    .|||...:.:.|||
  Fly  1075 KRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHDEILADG 1139

  Fly   707 -----------VHVENGDGAV----------APSKSK---------------------------- 722
                       :.|..|||..          .|.|||                            
  Fly  1140 LIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDES 1204

  Fly   723 ---------GKKK----------EEEKKEEEEVTEGPK----------------------PMLPY 746
                     |::|          :||..||.|..|||.                      |...|
  Fly  1205 HKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYY 1269

  Fly   747 SSMFILS--PTNPIRRGAHW---------VVNLPYFDFFIMVVISMSSIALAAED------PVRE 794
            ....||:  ..:|..:|  |         ::...||:..::.:|.|||:|||.||      |:.:
  Fly  1270 KKFPILAGDDDSPFWQG--WGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQ 1332

  Fly   795 NSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSG 859
            :     ||.|.|..||.:|.:|||:|.:.||..:    |....|..:|.|:|:.:.::|...:.|
  Fly  1333 D-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMVSLINFVASLVG 1388

  Fly   860 SSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQ 924
            :.   .:...|::|.||.||||:.:.|:..::.|.:.:|.::.::.|:|:|.::|..||:::|||
  Fly  1389 AG---GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQ 1450

  Fly   925 LFNGKFFYCTDESKHTSAECQGSYFKYEEDELLP-----KQELRVWKPRAFHYDNVAAAMLTLFA 984
            ||.||:|.|.|        ..|:...:   |::|     :.|...|...|.::|:|..|.|.||.
  Fly  1451 LFAGKYFKCED--------MNGTKLSH---EIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQ 1504

  Fly   985 VQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF-PFFFVNIFVALIIITFQEQ-- 1046
            |.|.:||.|::..::.:...|:.||:...|.|.: |.|:||:| .||.:|:|:.:||..|.||  
  Fly  1505 VATFKGWIQIMNDAIDSREVDKQPIRETNIYMYL-YFVFFIIFGSFFTLNLFIGVIIDNFNEQKK 1568

  Fly  1047 ---GEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFN 1108
               |..|:...|..|...:.:......:|| :.:|:.|...:..|:.||....|:..||:.|..|
  Fly  1569 KAGGSLEMFMTEDQKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLN 1632

  Fly  1109 TLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVK-NFFKDPWNIFDLITVLGSIV 1172
            ...:.:..::..|.|...|.|:|..|..:||.|.:|||  |.:: ::|.:|||:||::.|:.||:
  Fly  1633 MFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI--FALRYHYFIEPWNLFDVVVVILSIL 1695

  Fly  1173 -----DALWMEFGSNSINVGFLRLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1229
                 |.:...|.|.::    ||:.|.|   |:::|::....||.||:....|..||..:|||:.
  Fly  1696 GLVLSDIIEKYFVSPTL----LRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLF 1756

  Fly  1230 MLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACD 1294
            ::.||:||.||..|.::|   .::.|....||::|.|.::|||:.:|...|..::.|.:..:|||
  Fly  1757 LVMFIFAIFGMSFFMHVK---EKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACD 1818

  Fly  1295 --DDAEKAPGEYCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRD-SSILGAHHLDEF 1355
              |:.:..||. ||| |:...:.:|::.....:::|:::|||::|:...|.| ...|.....|.:
  Fly  1819 PPDNDKGYPGN-CGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMY 1882

  Fly  1356 VRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTL 1420
            ..||.::||..|..|.|.::.:.|..::|||....  ||:.   |:|.|::|:.....:.....|
  Fly  1883 YEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIPICRGDLMYCVDIL 1942

  Fly  1421 FALIRENLSIKMRAPEEMDQ-------ADMELRETITN-IWPLQAKKMLNLLVPPSDQLNKGKLS 1477
            .||.::..:.|....||..:       .|.|..|.::: :|..:.:                   
  Fly  1943 DALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREE------------------- 1988

  Fly  1478 VGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSP 1542
                |...||..:||                    :|.::    |...|...|...:.:|     
  Fly  1989 ----YCARLIQHAWR--------------------KHKAR----GEGGGSFEPDTDHGDG----- 2020

  Fly  1543 SLRHNGSPLARSPSPRRRGHQYIHHD--IGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSAS 1605
                 |.|.|..|:|    .:....|  .|...:|:...|                   |:..|.
  Fly  2021 -----GDPDAGDPAP----DEATDGDAPAGGDGSVNGTAE-------------------GAADAD 2057

  Fly  1606 TSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTH 1670
            .|...||     |...:.:..........|||:........:..:...:.|.|  |:....|...
  Fly  2058 ESNVNSP-----GEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESD--GFVTKNGHKV 2115

  Fly  1671 VQHS-YPTLASRRAGIGRRLPPTP 1693
            |.|| .|::.||.|.: .|  |.|
  Fly  2116 VIHSRSPSITSRTADVXAR--PRP 2137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 86/301 (29%)
Ion_trans 441..677 CDD:334124 80/286 (28%)
Ion_trans 769..1050 CDD:334124 96/297 (32%)
Ion_trans 1094..1345 CDD:334124 83/263 (32%)
GPHH 1346..1416 CDD:339854 19/69 (28%)
Ca_chan_IQ 1418..1492 CDD:337190 13/81 (16%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 81/284 (29%)
Na_trans_cytopl 515..648 CDD:288761 7/132 (5%)
Ion_trans 835..1028 CDD:278921 69/207 (33%)
Na_trans_assoc 1054..1296 CDD:284034 35/243 (14%)
Ion_trans 1318..1571 CDD:278921 88/276 (32%)
Na_channel_gate 1561..1613 CDD:240441 11/52 (21%)
Ion_trans 1636..1871 CDD:278921 78/244 (32%)
GPHH 1880..1930 CDD:293510 17/54 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439103
Domainoid 1 1.000 73 1.000 Domainoid score I3264
eggNOG 1 0.900 - - E1_KOG2301
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
65.820

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