Protein Alignment cac and Ca-alpha1T

DIOPT Version :9

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Alignment Length: 3009
• Identity: 558/3009 - (18%)
• Similarity: 893/3009 - (29%)
• Gaps: 1413/3009 - (46%)

  Fly    11 PGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQK--- 72
            ||....|:..||:....|.:...:|..|.||...:|.|:.||:.|.:  :.|..|...:..:
  Fly   274 PGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGM--YQPCVDDACVTNRCKI 336

  Fly    73 LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTL 137
            |:..:......|.:|.::|::|:| :..|::||.:.||.:|||:|:.|.: :|......::|..:
  Fly   337 LQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLL-EYVMHVENLNLTAI 399

  Fly   138 RAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC--- 199
            |.|||||||:.::.|||:::::..::..:..|..:.||..|...||.|||::.:.|.|.:.|
  Fly   400 RTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLM 464

  Fly   200 ------YSLEDP---------NKLVK----EGESETPCNT---------DNILEKATGSFVCN-- 234
                  |.|..|         |.|.:    ..:.:..|:|         .|......||.|||
  Fly   465 RTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEE 529

  Fly   235 ----------NTT--------SMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTN 281
                      ||:        :.|.:..|.|..|..||||||.|.:.:|..|::||||.|:|:..
  Fly   530 AKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQ 594

  Fly   282 DALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KEREKVENRQE---------------- 328
            || .|.::|||||.|||||||||:||.|.|::.:|:  |:||....|||
  Fly   595 DA-HSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNN 658

  Fly   329 ------------------------------FLKLRRQQQLE------------------------ 339
                                          ..|.:|||:.|
  Fly   659 SEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCP 723

  Fly   340 ----------------------------------------------------------------- 339
                                                                             
  Fly   724 KYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAA 788

  Fly   340 --------RELNG---------------------------------------------------- 344
                    ..:||
  Fly   789 SCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGL 853

  Fly   345 ------------------------------YVEWICKAEEVIL---------------------A 358
                                          :.:.:..:|::||                     |
  Fly   854 PRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSA 918

  Fly   359 EER-------------------------------------------------------------- 361
            ..|
  Fly   919 SRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNG 983

  Fly   362 ----------TTEE------EKM------------------------------------------ 368
                      |||:      |||
  Fly   984 GASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELL 1048

  Fly   369 -----------------------------HIMEARRRNAAKRKKLKSLGKSKST----------- 393
                                         |..||.|  |..:.:....|::::|
  Fly  1049 AFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALR--AHHKPRSVPTGQNQTTPGAEGATVMVA 1111

  Fly   394 ----DT----------------------------------------------------------- 395
                ||
  Fly  1112 STAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSR 1176

  Fly   396 -EEEEAE-----EDYGD------------DGYLKTRSKPQGSCTGFWRAEKRFRFW----IRHTV 438
             .|..|.     |||..            |...:.||.........:|...|...|    ||..|
  Fly  1177 MREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLV 1241

  Fly   439 KTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFES 503
            :.::|...:::.:.:||:.:.:|::.||..||..:..:..:|.|:|..||.:|:.|.||..|..:
  Fly  1242 EHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIAN 1306

  Fly   504 SFNRFDCVVISGSIFEV----IWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSM 564
            .||.||.:::..|..|:    :.:...||..||||||..|||||.|:.::..:||..:..:|.:|
  Fly  1307 GFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTM 1371

  Fly   565 RSIISLLFLLFLFILIFALLGMQLFGGQF----------------NLPGGTPE-----TNFNTFP 608
            .::.....||.|||.||::|||.||||:|                .:....|:     .:||...
  Fly  1372 DNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNIL 1436

  Fly   609 IALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIY-SIYFIVLVLFGNYTLLNVFLAIAVD---- 668
            .|.:|||||||.||||.|::.|:      :|...: ::||:.|:.||||.|.|:.:||.|:
  Fly  1437 WATVTVFQILTQEDWNVVLFNGM------EKTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSS 1495

  Fly   669 ----------------------------------------------------------------- 668
                                                                             
  Fly  1496 ERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQD 1560

  Fly   669 ----------------------------------------------------------------- 668
                                                                             
  Fly  1561 SVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRD 1625

  Fly   669 ----------------------------------------------------------------- 668
                                                                             
  Fly  1626 RDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDS 1690

  Fly   669 --------------------------------------------------------------NLA 671
                                                                          |:.
  Fly  1691 PSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNIL 1755

  Fly   672 NAQEL----------------------------------------------TAAEEEQVE----- 685
            ||.:|                                              ||..:.|..
  Fly  1756 NASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDV 1820

  Fly   686 ----------------------------------------------------------------- 685
                                                                             
  Fly  1821 SVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALA 1885

  Fly   686 ----------EDKEKQLQELEKEMEALQADGVH---VENGDGAVAPS------------------ 719
                      :::.::.|:.|:|.:.|...|.:   :.|.:..|:.|
  Fly  1886 TDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRR 1950

  Fly   720 ----------------------------------------------------------------- 719
                                                                             
  Fly  1951 LSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEA 2015

  Fly   720 ------------------KSKG----------------------------KKKEEEK-------- 730
                              ||.|                            ||:.|||
  Fly  2016 NRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQL 2080

  Fly   731 ------------------------------KEEEEVTEGPKPMLP-----YS------------- 747
                                          |:::::...|..|:|     ||
  Fly  2081 HQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKH 2145

  Fly   748 --------SMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNKILN 803
                    |::|....|..|:...|.||..:||..:::.|:::.|.||.|.| :..:|.....|.
  Fly  2146 FTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLA 2210

  Fly   804 YFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLST 868
            ..:|.||.|||:||.:|:|..|:.....:|....|||||..:|..:.:.....:...|:.:....
  Fly  2211 TANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGI 2275

  Fly   869 IKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC 933
            ::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::|||||.|.|:||
  Fly  2276 LRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC 2340

  Fly   934 TDES---KHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVL 995
            ..|:   ...:.||:          .:|.   .||..|.:::|::..|:::||.:.:.:||..::
  Fly  2341 EGENIKGVRNADECR----------RIPG---NVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIM 2392

  Fly   996 QHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQ 1060
            ...:.|...|:.||.|:.....:::|.:.::..||.:|:||.:::..|....|.:.::.:|.:..
  Fly  2393 YTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAA 2457

  Fly  1061 KSCIDFTIGARPLE------RYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQ 1119
            |..:......|.:.      .|.|.     :..|..:|.|..|:..|..:|..|.:.:.|:|:..
  Fly  2458 KRALQMEKKRRRMHEPPYYTNYSPT-----RMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKM 2517

  Fly  1120 GDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS- 1183
            ....:.:||..|..||.:|.:|..:|::..|.|.:.||.||..|:..||.|||..:..|..:|:
  Fly  2518 PSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTH 2582

  Fly  1184 ----IN---VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQ 1241
                ||   :..:|:.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|.:|::
  Fly  2583 QIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVE 2647

  Fly  1242 VFGNIK---------LGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDA 1297
            :||.::         ||       .|.:|.:|....:.|||.|||:.|..||...|:.. |||.|
  Fly  2648 LFGRLECSDEIPCQGLG-------EHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-CDDAA 2704

  Fly  1298 EKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEY 1362
            :........|.:|..:||.|:....|:::|:.|||:|               .||:|
  Fly  2705 DCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE-------- 2746

  Fly  1363 DPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIREN 1427
                    .:.:|.|.|.                       |.:.|:.|           |:||
  Fly  2747 --------SHKQMEDELD-----------------------MEVELERE-----------LVRE- 2768

  Fly  1428 LSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWR 1492
                    :|..| :.:|.:.:       |:.......||........|....||
  Fly  2769 --------QEFAQ-EQKLCQQL-------AEAQSKAAAPPRPLAKVKSLPKNFIY---------- 2807

  Fly  1493 STRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSP 1557
            ||  ..||...|      |....:..|||.:.|.:|:...:..:|.....::     |......|
  Fly  2808 ST--PSLDKKFP------AVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAV-----PAGSGAGP 2859

  Fly  1558 RRRGHQYIHHDI-----GFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPS---- 1613
            ||:..||.....     |.|     :.|| ..|..|:...:....|.|....:.|..|..|
  Fly  2860 RRQTVQYFQQPPQSMLGGLS-----LAEM-GGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQI 2918

  Fly  1614 -PSRYGGHLSR---------------SKRTQLPYPTYGTTSL-CQRSRSPSPARLQEMRERDRLG 1661
             |.|..|.||:               :|||......:|..:| |:|      ..:.|..|.|..|
  Fly  2919 NPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRR------GTIFESLESDGGG 2977

  Fly  1662 Y----------GIDMGVTHVQHSYPTLASRRAGIGRR---------------------LPP---- 1691
            .          |:..||     ||...:.|.|.:|..                     |||
  Fly  2978 VGGGGSGGGGGGLGGGV-----SYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSL 3037

  Fly  1692 ---TP-SKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRE---R 1749
               || |.|:.||| |..:..|..:..|......:............||..||.|...||.   :
  Fly  3038 PIVTPTSTPTPLQL-PMPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGSTK 3101

  Fly  1750 ERDRERLRDRDRDRDRDRL 1768
            :..:::..|.|.|.|.:.|
  Fly  3102 QLFKQQALDEDADMDENSL 3120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	110/342 (32%)
		Ion_trans	441..677	CDD:334124	91/568 (16%)
		Ion_trans	769..1050	CDD:334124	84/284 (30%)
		Ion_trans	1094..1345	CDD:334124	84/267 (31%)
		GPHH	1346..1416	CDD:339854	9/69 (13%)
		Ca_chan_IQ	1418..1492	CDD:337190	12/73 (16%)
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	99/306 (32%)
		Ion_trans	1261..1495	CDD:278921	84/239 (35%)
		Ion_trans	2192..2448	CDD:278921	80/268 (30%)
		Ion_trans	2510..2728	CDD:278921	73/225 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439102
Domainoid	1	1.000	73	1.000	Domainoid score	I3264
eggNOG	1	0.900	-	-		E1_KOG2301
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I473
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800