DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1g

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_008766207.2 Gene:Cacna1g / 29717 RGDID:68942 Length:2388 Species:Rattus norvegicus


Alignment Length:2509 Identity:571/2509 - (22%)
Similarity:944/2509 - (37%) Gaps:816/2509 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GPKKEENPPGG-------------GPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVV 54
            ||...|..||.             .|...|.|::|:..|.:....:..|.||...:|.|:.|||.
  Rat    33 GPGSTEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVT 97

  Fly    55 LALEEHLPGGDKTVLAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFV 116
            |.:  ..|..|....:|:   |:..:.:....|.||..:|::||| :..|..||.:.||.:|||:
  Rat    98 LGM--FRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFI 159

  Fly   117 VVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIV 181
            |:.| |.:|......|....:|.:||||||:.::.:||:::::..::..:..|..:.||..|...
  Rat   160 VIAG-MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

  Fly   182 IFAIIGLEFYSGALHKTC-----YSL--------------EDPNKLV------------------ 209
            ||.|:|::.::|.|...|     :||              ||.:..:                  
  Rat   224 IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRENGMRSCRSVPTL 288

  Fly   210 -KEGESETPCNTDNILEKATGSFVC---NNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITM 270
             .||....||:.|.....::.:..|   |...:.|......|..|..:|||||:|.:.:||.||:
  Rat   289 RGEGGGGPPCSLDYETYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITL 353

  Fly   271 EGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KEREKV---ENRQEFL 330
            |||..|:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:  |:||..   |.|..||
  Rat   354 EGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFL 417

  Fly   331 K-----------------------------LRRQQQL---------------------------- 338
            .                             .||..|:                            
  Rat   418 SNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAIGVRAGLLSSPVARSGQEPQPSGSC 482

  Fly   339 ----------------------------------------ERELNG------------------- 344
                                                    :|:.||                   
  Rat   483 TRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRVPRASPEIQDRDANGSRRLMLPPPSTPTPSGGPP 547

  Fly   345 --------YVEWICKAEEV----------------------------------ILAEERTTEE-- 365
                    :....|..|.|                                  ||.::...|.  
  Rat   548 RGAESVHSFYHADCHLEPVRCQAPPPRCPSEASGRTVGSGKVYPTVHTSPPPEILKDKALVEVAP 612

  Fly   366 -----------------EKMH-IMEARRRNAAKRK-KLKS----------------------LGK 389
                             ..|| ::|.:...|.... |:.|                      .|:
  Rat   613 SPGPPTLTSFNIPPGPFSSMHKLLETQSTGACHSSCKISSPCSKADSGACGPDSCPYCARTGAGE 677

  Fly   390 SKSTD----TEEEEAEEDYGDDG--------YLKTRSKPQG------SCTGFWRAEKRFRFWIRH 436
            .:|.|    ..:.||..::..|.        :.:.|.:..|      |...|||.   .....|.
  Rat   678 PESADHVMPDSDSEAVYEFTQDAQHSDLRDPHSRRRQRSLGPDAEPSSVLAFWRL---ICDTFRK 739

  Fly   437 TVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYF 501
            .|.:::|...:::.:.:||:.:.:|::.||..||..|..:..:|..||..||.:|:...||..|.
  Rat   740 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYI 804

  Fly   502 ESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRS 566
            ::.:|.||.|::..|::|::..:  ||  ||||||..||:|:.|:.::..:|:..::.|:.:|.:
  Rat   805 KNPYNIFDGVIVVISVWEIVGQQ--GG--GLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDN 865

  Fly   567 IISLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETNFNTFPIALLTVFQILTGEDWN 624
            :.:...||.|||.||::|||.|||.:|       .||   ...||::...|::|||||||.||||
  Rat   866 VATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLP---DRKNFDSLLWAIVTVFQILTQEDWN 927

  Fly   625 EVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQEL------------- 676
            :|:|.|:.|.....     ::|||.|:.||||.|.|:.:||.|:.. .|:|:             
  Rat   928 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGF-QAEEIGKREDASGQLSCI 986

  Fly   677 ---------------------------------------------------------TAA----- 679
                                                                     |||     
  Rat   987 QLPVNSQGGDATKSESEPDFFSPSVDGDGDRKKRLALVALGEHAELRKSLLPPLIIHTAATPMSL 1051

  Fly   680 ----------------------------------------------------------------- 679
                                                                             
  Rat  1052 PKSSSTGVGEALGSGSRRTSSSGSAEPGAAHHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLG 1116

  Fly   680 ---------------------------EEEQVEEDK-------EKQLQELEKEM-------EALQ 703
                                       |||..|||:       .:....||:|.       :.||
  Rat  1117 RAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEDRASPAGSDHRHRGSLEREAKSSFDLPDTLQ 1181

  Fly   704 ADGVHVENGDGAVAPSKSK---GKKKE----------------EEKKEEEEVTEGP------KPM 743
            ..|:| ....|..:.|:.:   ||...                ::..:|..:::|.      :..
  Rat  1182 VPGLH-RTASGRSSASEHQDCNGKSASGRLARTLRTDDPQLDGDDDNDEGNLSKGERIQAWVRSR 1245

  Fly   744 LPYS-------SMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNK 800
            ||..       |.:|..|.:..|...|.::....||..::|:|.::.|.:|.|.| :..:|....
  Rat  1246 LPACCRERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI 1310

  Fly   801 ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQN 865
            .|...:|.||.||..||.:|:|.||......:|||..||::|.::|:.:.:.....|...|..:.
  Rat  1311 FLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKI 1375

  Fly   866 LSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKF 930
            |..::.||:||.||||:.|.|...||.|.:.:::|||.:.||:::...|..||.::|||||.|||
  Rat  1376 LGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1440

  Fly   931 FYCTDESKH---TSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWP 992
            |.|..|...   ..::|..:.::              |....:::||:..|:::||.:.:.:||.
  Rat  1441 FVCQGEDTRNITNKSDCAEASYR--------------WVRHKYNFDNLGQALMSLFVLASKDGWV 1491

  Fly   993 QVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITF------QEQGEAEL 1051
            .::...:.|...|:.||.|....|.:::|.:.::..||.:|:||.:::..|      ||:.||..
  Rat  1492 DIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1556

  Fly  1052 QDGE----IDKNQKS--------CIDFTIGA------------RPLERYMPKNRNTFKYKVWRIV 1092
            ::.:    ::|.::|        .:|..|.:            :|.  |...:|  |:..|..:.
  Rat  1557 REEKRLRRLEKKRRSKEKQMADLMLDDVIASGSSASAASEAQCKPY--YSDYSR--FRLLVHHLC 1617

  Fly  1093 VSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKD 1157
            .|...:.||..:|..|.:.:.|:::.|..:.:::||..|..||.:|..|:|.|::.||.:.||:|
  Rat  1618 TSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVFESVFKLVAFGFRRFFQD 1682

  Fly  1158 PWNIFDLITVLGSIVDALWMEFGSNS---IN---VGFLRLFRAARLIKLLRQGYTIRILLWTFVQ 1216
            .||..||..||.||:.....|...|:   ||   :..:|:.|.||::|||:....:|.||.|.:|
  Rat  1683 RWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQ 1747

  Fly  1217 SFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVE--NSITRHNNFQSFIQGVMLLFRCATGEA 1279
            :...:..:.||..:||||:|.:|:::||:::.....  ..:.||..|::|....:.|||.:||:.
  Rat  1748 ALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1812

  Fly  1280 WPNIMLACLKGKACDDDAEKAPGEYCGST-LAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRD 1343
            |..||...|:.  ||.::.      |.:| ::..|||||:....|:::|:.:||:|.:.:...::
  Rat  1813 WNGIMKDTLRD--CDQEST------CYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1869

  Fly  1344 SSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPL 1408
            :.        |...:.||.:         .||..:......|||      :...:..:..:|.|.
  Rat  1870 AK--------EEAELEAELE---------LEMKTLSPQPHSPLG------SPFLWPGVEGVNSPD 1911

  Fly  1409 DDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAK-----KMLNLLVPPS 1468
            ..:.....||   |.|.......:..|     .|.:|.:||:.:  :|..     |:::.|..|.
  Rat  1912 SPKPGAPHTT---AHIGAASGFSLEHP-----TDRQLFDTISLL--IQGSLEGELKLMDELAGPG 1966

  Fly  1469 DQL-----------NKGKLSVGKIYAGFLILE--SWRSTRFGQLDSGMP------MLELQDASRH 1514
            .|.           :..::.:.::.|..|..|  |..|......|..:|      :|...:::..
  Rat  1967 GQPSAFPSAPSLGDSDPQIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDTHTLLLSALESNMV 2031

  Fly  1515 PSQESL-------------TGADAGHLHPGHSYM--NGHRRSPSLRHNGSPLARSPSPRRRGHQY 1564
            |..|.:             :|....|..|..|||  ||.....||.|.|..|     |:.:....
  Rat  2032 PHPEEVPVPLGPDLLTVRKSGVSRTHSLPNDSYMCRNGSTAERSLGHRGWGL-----PKAQSGSI 2091

  Fly  1565 IHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQL 1629
            :......:|| |.::::.|:..:....:..|     :|.|.                     .:|
  Rat  2092 LSVHSQPADT-SCILQLPKDVHYLLQPHGAP-----TWGAI---------------------PKL 2129

  Fly  1630 PYPTYGTTSLCQRSRSPSPARLQEMRERDRL---GYGI--DM------------------GVTHV 1671
            |.|  |.:.|.||     |.|.|.....|.|   |.|.  |:                  |.:.:
  Rat  2130 PPP--GRSPLAQR-----PLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCPLTRSSSFWGGSSI 2187

  Fly  1672 QHSYPTLASRRAGIGR------RLP-PTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSL 1729
            |      ..:|:||..      ||| |.|.      |:|:....|             |.:..||
  Rat  2188 Q------VQQRSGIQSKVSKHIRLPAPCPG------LEPSWAKDP-------------PETRSSL 2227

  Fly  1730 PHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDRERE 1794
            ....:|.....|:..||:|     |.|..|            ||:..|.      .|.:..|.|.
  Rat  2228 ELDTELSWISGDLLPSSQE-----EPLSPR------------DLKKCYS------VETQSCRRRP 2269

  Fly  1795 ---VERERLEYIAPLSFEQALAMGRTGRVLPSPVL--------NGFKPKSGLNPRHSDSDEEDW- 1847
               ::.:|...||    ...|..|...|:.|||..        .|.:||..|:|.....|..:. 
  Rat  2270 GSWLDEQRRHSIA----VSCLDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQ 2330

  Fly  1848 -----CXQRLXLRSR----NRKDQIWVXHQAICSSLSAP 1877
                 | ..: ||.|    :.||          .|:|:|
  Rat  2331 GSRPPCSPGVCLRRRAPASDSKD----------PSVSSP 2359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 104/335 (31%)
Ion_trans 441..677 CDD:334124 88/312 (28%)
Ion_trans 769..1050 CDD:334124 88/290 (30%)
Ion_trans 1094..1345 CDD:334124 82/259 (32%)
GPHH 1346..1416 CDD:339854 10/69 (14%)
Ca_chan_IQ 1418..1492 CDD:337190 17/91 (19%)
Cacna1gXP_008766207.2 Ion_trans 80..406 CDD:395416 103/330 (31%)
Ion_trans 743..969 CDD:395416 86/238 (36%)
Ion_trans 1277..1549 CDD:395416 85/285 (30%)
Ion_trans 1619..1860 CDD:395416 81/248 (33%)
PHA03307 2119..>2370 CDD:223039 72/336 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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