DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1d

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_017455544.1 Gene:Cacna1d / 29716 RGDID:70973 Length:2207 Species:Rattus norvegicus


Alignment Length:2323 Identity:893/2323 - (38%)
Similarity:1212/2323 - (52%) Gaps:459/2323 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKEENPPGGGPT-SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTV 68
            ||:.|.....|. :||.|:.:||||:....|::|.||:..:||.|.||||.||:....|..|...
  Rat    92 KKQGNSSNSRPARALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNS 156

  Fly    69 LAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTG-FMTQYPQIGPEV 132
            ....|||.|..||.||.||..|||:|.||:||.::|:||.||::||.:|:.| |.....|:..|.
  Rat   157 TNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 221

  Fly   133 -------------DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFA 184
                         |::.|||.||||||:||||:|||||||.||||||.|||.|.|||||.|:|:|
  Rat   222 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA 286

  Fly   185 IIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNS 249
            |||||.:.|.:||||:..:  :.:|.| |...||     .....|.....|.|. |...|.|||.
  Rat   287 IIGLELFIGKMHKTCFFAD--SDIVAE-EDPAPC-----AFSGNGRQCAANGTE-CRSGWVGPNG 342

  Fly   250 GITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSG 314
            |||:|||..||||||||||||||||.:|||.|||:|..:.|:|||.||::||||:||||||||||
  Rat   343 GITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407

  Fly   315 EFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAA 379
            ||:|||||.:.|.:|.|||.:||||.:|.||::||.:||::....|....||            .
  Rat   408 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE------------G 460

  Fly   380 KRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFW-------------------- 424
            ||.......:::|.:||....|            .:.||.|...|                    
  Rat   461 KRNTSMPTSETESVNTENVSGE------------GETQGCCGSLWCWWKRRGAAKTGPSGCRRWG 513

  Fly   425 ------RAEKRFRFW-------IRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYA 476
                  :..:|:|.|       .|..||:..|||.|||||||||:.::.|||.||.:||:....|
  Rat   514 QAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIA 578

  Fly   477 EFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGS-FGLSVLRALRL 540
            ..:.|.||..||.:|||:||.:.||.|.||||||.|:.|.|.|.|..|::..| .|:||.|.:||
  Rat   579 NKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRL 643

  Fly   541 LRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL-PGGTPETNF 604
            |||||||::|:||.|||.||||||:||.|||.||||||:||:|||||||||:||. ...|..:.|
  Rat   644 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTF 708

  Fly   605 NTFPIALLTVFQILTGEDWNEVMYQGIISQGG-AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVD 668
            :.||.|||||||||||||||.|||.||::.|| :..|||..||||:|.:.|||.|||||||||||
  Rat   709 DNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVD 773

  Fly   669 NLANAQELTAAEEEQVEEDKEKQL---QELEKEMEALQADGVHVENGDGAV--------APSKSK 722
            |||:|:.|..|::|:.||.:.|::   :.||.:... :.:...:.|.|..|        |..|..
  Rat   774 NLADAESLNTAQKEEAEEKERKKIARKESLENKKNN-KPEVNQIANSDNKVTIDDYQEEAEDKDP 837

  Fly   723 --------GKKKEEEKKEEEEVTEGPKPM-------------LPY-SSMFILSPTNPIRRGAHWV 765
                    |:::|||:::|.||..||:|.             :|. |:.||||.|||||.|.|.:
  Rat   838 YPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKL 902

  Fly   766 VNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHP 830
            :|...|...|:|.|.:||.|||||||:|.:|.||.||.|||||||.:||:|:|||:...|..||.
  Rat   903 INHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHK 967

  Fly   831 GSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFD 895
            |::.|.::|::|.:||..:.||||...|.      :|.:|.||||||||||:.|.|...||.|..
  Rat   968 GAFCRNYFNLLDMLVVGVSLVSFGIQSSA------ISVVKILRVLRVLRPLRAINRAKGLKHVVQ 1026

  Fly   896 CVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDEL-LPK 959
            ||..:::.:.||:||..|.||:|:.||||||.|||:.||||:|....||:|.:..|::.:: .|.
  Rat  1027 CVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPV 1091

  Fly   960 QELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYF 1024
            ...|:|:...|::|||.:||:.||.|.|.||||.:|..::.:..|:.||:.|:|:|:|||:|:|.
  Rat  1092 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYI 1156

  Fly  1025 IVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVW 1089
            |:..||.:||||..:|:|||||||.|.::.|:||||:.|:::.:.||||.||:||  |.::||.|
  Rat  1157 IIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPK--NPYQYKFW 1219

  Fly  1090 RIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNF 1154
            .:|.|:||||.:.:||:.|||.|.|:::.|..|:..::..:||.|||:|:||.|||:|.|..|.:
  Rat  1220 YVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGY 1284

  Fly  1155 FKDPWNIFDLITVLGSIVDA-----------LWMEFG---------------------------- 1180
            |.|.||.||.:.|:|||:|.           .|..|.                            
  Rat  1285 FSDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPSDSENIPLPT 1349

  Fly  1181 --------SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAI 1237
                    ||.|::.|.||||..||:|||.:|..||.|||||::||:|||||.|||||||||||:
  Rat  1350 ATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAV 1414

  Fly  1238 IGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPG 1302
            ||||:||.:.:.. .|.|.|:||||:|.|.|:|||||||||||..||||||.||.||.|::..||
  Rat  1415 IGMQMFGKVAMRD-NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPG 1478

  Fly  1303 E--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPN 1365
            |  .|||..|..||:||...|:||::|||||||||||||||||.||||.||||||.|||:||||.
  Rat  1479 EEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPE 1543

  Fly  1366 ATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSI 1430
            |.|:|.:.::..:|:.:.||||||..||:|:|.|:|:.|||||:.:..|.|..|||||:|..|.|
  Rat  1544 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI 1608

  Fly  1431 KMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTR 1495
            |...  .::||:.|||..|..||...:.|:|:.:|||:   ...:::|||.||.|||.:.:|..:
  Rat  1609 KTEG--NLEQANEELRAVIKKIWKKTSMKLLDQVVPPA---GDDEVTVGKFYATFLIQDYFRKFK 1668

  Fly  1496 FGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPS----------------- 1543
             .:.:.|:       ..::|::.:.....|| |...|......||:.|                 
  Rat  1669 -KRKEQGL-------VGKYPAKNTTIALQAG-LRTLHDIGPEIRRAISCDLQDDEPEDSKPEEED 1724

  Fly  1544 -LRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTS 1607
             .:.||:.|.          .|::|      ..|:..|.:::| :..|...|.:.|      |..
  Rat  1725 VFKRNGALLG----------NYVNH------VNSDRRESLQQT-NTTHRPLHVQRP------SIP 1766

  Fly  1608 PARSPSPSRYGGHLSRSKRTQLP-YPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHV 1671
            ||..               |:.| :|..| .|:|                             |.
  Rat  1767 PASD---------------TEKPLFPPAG-NSVC-----------------------------HN 1786

  Fly  1672 QHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPT---------HTHHSTPHSVH 1727
            .|::.:       ||:::|.:           ||.|....|.|..         ...|.:.:..:
  Rat  1787 HHNHNS-------IGKQVPTS-----------TNANLNNANMSKAAHGKRPSIGDLEHVSENGHY 1833

  Fly  1728 SLPHHRDLLRDPRDMYYSSRERERDRER-LRDRDRD-------RDRDRLHEYDLRYEYRD----R 1780
            |..|.|:|.|      .||.:|.|..|. :|....|       |:...:|.|     :||    .
  Rat  1834 SYKHDRELQR------RSSIKRTRYYETYIRSESGDEQLPTICREDPEIHGY-----FRDPRCFG 1887

  Fly  1781 ERELYERER----DREREVERERLEYI---------------------------APLSFEQALAM 1814
            |:|.:..|.    |......|:...|.                           :|:.::...:.
  Rat  1888 EQEYFSSEECCEDDSSPTWSRQNYSYYNRYPGSSMDFERPRGYHHPQGFLEDDDSPIGYDSRRSP 1952

  Fly  1815 GRTGRVL-PSPVLNGFKPKSGLNPRHSDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPN 1878
            .|  |:| |:|            |.|..|.....|     ||.:|.:|.:          |.:|.
  Rat  1953 RR--RLLPPTP------------PSHRRSSFNFEC-----LRRQNSQDDV----------LPSPA 1988

  Fly  1879 LDHNFDTIRHSYQIPEHLQNLPYLCPPVHQHQHQHQT----QTQNQRQHQDQHLYQRYGTNVSTP 1939
            |.|.                   ...|:|..|.|...    .:...:::...|..:.:.|..:||
  Rat  1989 LPHR-------------------AALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATP 2034

  Fly  1940 KLGTTISDIKLAGVSLQELSPNRQPQSQQKQEQ----------QLHQDGWLR-----WYRQSGPY 1989
                          ..::.:|...|..|..:.:          .||:..|..     .||...|.
  Rat  2035 --------------PYRDWTPCYTPLIQVDRSESMDQVNGSLPSLHRSSWYTDEPDISYRTFTPA 2085

  Fly  1990 GSPVMASLPETRATSPHSDIEFIRTMKRSE-TGTTAITPR---TTKTEAMILSVPITITSPLAIK 2050
            ...|.:|.....:....|....:..:..|| .|..|..|:   .||.|       |.....|.|.
  Rat  2086 SLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHE-------IADACDLTID 2143

  Fly  2051 KIYSDNDINYNTERGTDNDRV--DDAPAHHYHQPELTT--PDLQDEPP 2094
            ::.|......|   |:...|.  |..|..|....||..  |...||.|
  Rat  2144 EMESAASTLLN---GSVCPRANGDMGPISHRQDYELQDFGPGYSDEEP 2188

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 162/300 (54%)
Ion_trans 441..677 CDD:334124 147/238 (62%)
Ion_trans 769..1050 CDD:334124 135/281 (48%)
Ion_trans 1094..1345 CDD:334124 149/299 (50%)
GPHH 1346..1416 CDD:339854 38/69 (55%)
Ca_chan_IQ 1418..1492 CDD:337190 30/73 (41%)
Cacna1dXP_017455544.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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