DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and Scn8a

DIOPT Version :10

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_062139.2 Gene:Scn8a / 29710 RGDID:3638 Length:1978 Species:Rattus norvegicus


Alignment Length:1926 Identity:475/1926 - (24%)
Similarity:804/1926 - (41%) Gaps:502/1926 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|:||:..|.||:....|:....|...::.||:.|||.:.. .:.|...|.|        |..|.
  Rat   111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTF-SNPPEWSKNV--------EYTFT 166

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||:|.|..:...::||:.||.:||.|::..::|::..:|   ::..||..||||.|
  Rat   167 GIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLG---NVSALRTFRVLRAL 228

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|.           
  Rat   229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV----------- 282

  Fly   212 GESETPCN-TDNILEKATGSF----------------------VCNNTTS--------MCLEKWE 245
               ..|.| .::.||..|..|                      :|.|::.        .|::...
  Rat   283 ---VWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGR 344

  Fly   246 GPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLG 310
            .||.|.||||...:|.|.:|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:|.
  Rat   345 NPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTY-MIFFVLVIFVGSFYLVNLILA 408

  Fly   311 VLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILA----------EERTTEE 365
            |::..:.::.:..        |...:|.|.|....:|.:.|.:|...|          .|...||
  Rat   409 VVAMAYEEQNQAT--------LEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEE 465

  Fly   366 E---------------KMHIMEAR-RRNAAKRKKLKSLG------------KSKSTD-------- 394
            |               |:....|: |||..|::|.|.|.            ||:|.|        
  Rat   466 EGEDGVGSPRSSSELSKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFR 530

  Fly   395 ------------------------------------------------TEEEEAEEDYG------ 405
                                                            :|.|.|::::.      
  Rat   531 LPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESE 595

  Fly   406 ---DDGYLKTRSKPQGSC----TGFWRAEKRFRFW--IRHTVKTQ-------------------- 441
               |..::..|::.:.|.    :|:.:..:..|.:  :|.:||..                    
  Rat   596 GRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGPGSHIGR 660

  Fly   442 ------------------------------------------------------------WF--- 443
                                                                        |:   
  Rat   661 LLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFA 725

  Fly   444 ----------YWF------------------VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIF 480
                      ||.                  :.:.:.|||:.:|:||:.........|.....:|
  Rat   726 NTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVF 790

  Fly   481 LGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFK 545
            .|:|.:|||:|:.|:.|..||:..:|.||..::|.|:.|:..::|:    ||||||:.||||:||
  Rat   791 TGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVE----GLSVLRSFRLLRVFK 851

  Fly   546 VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETN 603
            :.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:       |.....|..:
  Rat   852 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQECKLPRWH 916

  Fly   604 FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAI--- 665
            .|.|..:.|.||::|.|| |.|.|:..:...|.|    :..|.|:::::.||..:||:|||:   
  Rat   917 MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQA----MCLIVFMMVMVIGNLVVLNLFLALLLS 976

  Fly   666 --AVDNLANAQE---------------------------LTAAEEEQVEEDKEKQLQEL-EKEME 700
              :.||||...:                           ...|..:|.|.|:.|.|.|| ||:..
  Rat   977 SFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKVKVHAFMQAHFKQREADEVKPLDELYEKKAN 1041

  Fly   701 A--------LQADGVHVENGDGAVA---------------------------------------- 717
            .        :..:|...:||:|..:                                        
  Rat  1042 CIANHTGVDIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENL 1106

  Fly   718 ----------PSKSKGKKKE---------EEKKEEEEV-TEGPKPMLPYSSMFILSPTNPIRR-- 760
                      |..||.|..:         :.|.|.||| .|.|:..|...:.|   ....::|  
  Rat  1107 NTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACF---TEGCVQRFK 1168

  Fly   761 ----------GAHW---------VVNLPYFDFFIMVVISMSSIALAAED-PVRENSRRNKILNYF 805
                      |..|         :|...:|:.||:.:|.:||.|||.|| .:.:......||.|.
  Rat  1169 CCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYA 1233

  Fly   806 DYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIK 870
            |..||.:|.:|||||....|.:    .:....|..:|.::|..:.||...:..|.|   .|..||
  Rat  1234 DKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYS---ELGAIK 1291

  Fly   871 SLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTD 935
            |||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..|||::||.||.||:.||.:
  Rat  1292 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFN 1356

  Fly   936 ESKHTSAECQGSYFKYEEDELLP--KQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHS 998
            |:.....|......|.:.::|:.  ..|:| ||....::|||.|..|.|..|.|.:||..::..:
  Rat  1357 ETSEIRFEIDIVNNKTDCEKLMEGNSTEIR-WKNVKINFDNVGAGYLALLQVATFKGWMDIMYAA 1420

  Fly   999 MAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQ-----GEAELQDGEIDK 1058
            :.:...|..|.....|.|.|:::::.|...||.:|:|:.:||..|.:|     |    ||..:.:
  Rat  1421 VDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG----QDIFMTE 1481

  Fly  1059 NQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGD 1121
            .||...:.  .:|::..::.:|:..|..:..|:..|....|:..|||||..|.:.:|::...|..
  Rat  1482 EQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSK 1546

  Fly  1122 MYEKSLKYINMGFTGMFSVETVLKIIGFGVKN-FFKDPWNIFDLITVLGSIV-----DALWMEFG 1180
            ..|..|.:||:.|...|:.|.|||:  |.::: :|...|||||.:.|:.|||     |.:...|.
  Rat  1547 QMENILYWINLVFVIFFTCECVLKM--FALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFV 1609

  Fly  1181 SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1245
            |.:: ...:||.|..|:::|::....||.||:..:.|..||..:.||:.::.||::|.||..|..
  Rat  1610 SPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAY 1673

  Fly  1246 IKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACL-KGKACDDDAEKAPGE----YC 1305
            :|   .|..|....||::|...::.||:..|...|..::|..| :...|..|.|. ||.    .|
  Rat  1674 VK---HEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEH-PGSGFKGDC 1734

  Fly  1306 GS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATG 1368
            |: ::...:|||:|.....:::|:::|:|::||...|.:|: .|.....:.|..||.::||:||.
  Rat  1735 GNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1799

  Fly  1369 KIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMR 1433
            .|.|.::.|....::.||....  ||.:   :||.|::|:....|:.....|||..:..|.    
  Rat  1800 FIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFTKRVLG---- 1855

  Fly  1434 APEEMD--QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRF 1496
            ...|:|  :..||.|...:|...:..:.:...|....::::...|.  :.|.|.|       .|.
  Rat  1856 DSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQ--RAYRGHL-------ARR 1911

  Fly  1497 GQLDSGMPMLELQDASRH-------------PSQESLTGAD 1524
            |.:...|...:|::...|             ||.:|:|..|
  Rat  1912 GFICRKMASNKLENGGTHRDKKESTPSTASLPSYDSVTKPD 1952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:459842 85/317 (27%)
Ion_trans 441..677 CDD:459842 85/385 (22%)
Ion_trans 769..1050 CDD:459842 94/288 (33%)
Ion_trans 1094..1345 CDD:459842 82/262 (31%)
GPHH 1354..1407 CDD:465306 17/52 (33%)
Ca_chan_IQ 1417..1496 CDD:462591 15/80 (19%)
AF-4 <1512..>1704 CDD:461550 6/26 (23%)
Scn8aNP_062139.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62
I. /evidence=ECO:0000305 114..442 96/362 (27%)
Ion_trans 131..421 CDD:459842 85/316 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 18/83 (22%)
Na_trans_cytopl 546..700 CDD:463401 11/153 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..597 3/20 (15%)
II. /evidence=ECO:0000305 733..1005 84/280 (30%)
Ion_trans 750..963 CDD:459842 71/221 (32%)
Na_trans_assoc 989..1190 CDD:461936 30/203 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1146 9/40 (23%)
III. /evidence=ECO:0000305 1178..1493 101/326 (31%)
Ion_trans 1195..1471 CDD:459842 93/283 (33%)
Na_channel_gate 1463..1515 CDD:240441 11/55 (20%)
IV. /evidence=ECO:0000305 1502..1799 94/303 (31%)
Ion_trans 1520..1774 CDD:459842 82/260 (32%)
IQ 1892..1913 CDD:197470 5/29 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1923..1978 7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

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