DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn11a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_062138.1 Gene:Scn11a / 29701 RGDID:3630 Length:1765 Species:Rattus norvegicus


Alignment Length:1726 Identity:420/1726 - (24%)
Similarity:753/1726 - (43%) Gaps:406/1726 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKT----- 76
            :||||...||:|.....|.....|...::.|:|.||:              .:|..:|::     
  Rat   108 ALFILGPFNPLRSLMIRISVHSVFSMFIICTVIINCM--------------FMANSMERSFDNDI 158

  Fly    77 -EAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAI 140
             |..|:.|:.:||.:||||.|.::.:.|:||:.||.:||.|:.|...|.:|  |.:|:|..||..
  Rat   159 PEYVFIGIYILEAVIKILARGFIVDEFSFLRDPWNWLDFIVIGTAIATCFP--GSQVNLSALRTF 221

  Fly   141 RVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDP 205
            ||.|.||.:|.|..|:|::.::::::..|:.:.:|.||.:.|||::|.:.:.|.|::.|      
  Rat   222 RVFRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILNQKC------ 280

  Fly   206 NKLVKEGESETPCNTDNILEKA------------TGSFVCNNTTSMCLEKWEGPNSGITSFDNIG 258
               :|......|.:..:..||.            .||..|.| .|.|.:....|::..|.|||.|
  Rat   281 ---IKHNCGPNPASNKDCFEKEKDSEDFIMCGTWLGSRPCPN-GSTCDKTTLNPDNNYTKFDNFG 341

  Fly   259 FAMLTVFQCITMEGW---------TAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSG 314
            ::.|.:|:.:|.:.|         |:.:|:.          .:||.:|.:|||::|||.|.|::.
  Rat   342 WSFLAMFRVMTQDSWERLYRQILRTSGIYFV----------FFFVVVIFLGSFYLLNLTLAVVTM 396

  Fly   315 EFAKEREKV--ENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRN 377
            .:.::...|  |...:....:..|||.||          .:|.::|  ...:...::.::|...:
  Rat   397 AYEEQNRNVAAETEAKEKMFQEAQQLLRE----------EKEALVA--MGIDRSSLNSLQASSFS 449

  Fly   378 AAKRKKLKS-------LGKSKSTDTEEEEAEEDYGDDGYLKTRSK-------------------- 415
            ..|||...|       :..||:......::|:|...:..|..::|                    
  Rat   450 PKKRKFFGSKTRKSFFMRGSKTAQASASDSEDDASKNPQLLEQTKRLSQNLPVDLFDEHVDPLHR 514

  Fly   416 -------------------------PQG----------SCTGFWRAEKRFRFWIRHTVKTQWFYW 445
                                     |.|          .|:..|...|:    :..|:.|..|..
  Rat   515 QRALSAVSILTITMQEQEKFQEPCFPCGKNLASKYLVWDCSPQWLCIKK----VLRTIMTDPFTE 575

  Fly   446 FVI-VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFD 509
            ..| :.:.:|||.:||||:.....|...|....::|.|:|::||.:|:.||.|..||...:|.||
  Rat   576 LAITICIIINTVFLAVEHHNMDDNLKTILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNVFD 640

  Fly   510 CVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLL 574
            .:|...|:.:|:::.:...:  .|.|.:||:||:||:.|.|.:|..|:..:.:|:.::.:|..:|
  Rat   641 SIVALLSLADVLYNTLSDNN--RSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVL 703

  Fly   575 FLFILIFALLGMQLFGGQFNLPG-GTPET-----NFNTFPIALLTVFQILTGEDWNEVMYQGIIS 633
            .:.:.||:::||:|||.:||... .|.|.     :.:.|..:.|.||:||.|| |.|.|:..:..
  Rat   704 TIVVFIFSVVGMRLFGTKFNKTAYATQERPRRRWHMDNFYHSFLVVFRILCGE-WIENMWGCMQD 767

  Fly   634 QGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEE---------------- 682
            ..|:.   :..|.|:::::.|...:||:|:|:.:::.:|.::..:.|.|                
  Rat   768 MDGSP---LCIIVFVLIMVIGKLVVLNLFIALLLNSFSNEEKDGSLEGETRKTKVQLALDRFRRA 829

  Fly   683 ----------------------------------------------------------------- 682
                                                                             
  Rat   830 FSFMLHALQSFCCKKCRRKNSPKPKETTESFAGENKDSILPDARPWKEYDTDMALYTGQAGAPLA 894

  Fly   683 ---QVEEDKE--------------------------KQLQELEK---EMEALQADGVHVENGDGA 715
               :||:|.|                          |||...:.   |||....:.:|:    ..
  Rat   895 PLAEVEDDVEYCGEGGALPTSQHSAGVQAGDLPPETKQLTSPDDQGVEMEVFSEEDLHL----SI 955

  Fly   716 VAPSKSKG--------------------KKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNP--- 757
            .:|.|...                    :|....||:.:...  ||.:   |..|:...|:.   
  Rat   956 QSPRKKSDAVSMLSECSTIDLNDIFRNLQKTVSPKKQPDRCF--PKGL---SCHFLCHKTDKRKS 1015

  Fly   758 -------IRRGAHWVVNLPYFDFFIMVVISMSSIALAAED---PVRENSRRNKILNYFDYAFTGV 812
                   ||:..:.:|...:|:.||:.||.:||.||..||   |.|  .:..|:|...|..||.:
  Rat  1016 PWVLWWNIRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSR--PQVEKLLRCTDNIFTFI 1078

  Fly   813 FTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRV 877
            |.:||:||.|..|.    ..|....|..:|.::|:.:.:|.          .||.::||.|.||.
  Rat  1079 FLLEMILKWVAFGF----RRYFTSAWCWLDFLIVVVSVLSL----------MNLPSLKSFRTLRA 1129

  Fly   878 LRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---TDESKH 939
            ||||:.:.:...:|.|...:::::..::|:|:|.::|..:|.::||.||:|||..|   ||.:.:
  Rat  1130 LRPLRALSQFEGMKVVVYALISAIPAILNVLLVCLIFWLVFCILGVNLFSGKFGRCINGTDINMY 1194

  Fly   940 -------TSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQH 997
                   ..::|..|.:.              ||....::|||..|.|.|..|.|.:||.:::..
  Rat  1195 LDFTEVPNRSQCNISNYS--------------WKVPQVNFDNVGNAYLALLQVATYKGWLEIMNA 1245

  Fly   998 SMAATYEDRGPIQNFRIEMSIFYIVYFIVF----PFFFVNIFVALIIITF-QEQGEAELQDGEID 1057
            ::.:..:|..|    ..|.:::..:||:||    .||.:|:|:.:||..| |:|.:...||..:.
  Rat  1246 AVDSREKDEQP----DFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMT 1306

  Fly  1058 KNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQG 1120
            :.||...:.  .:|.:..::.:|:..|..:..|:.:|.|..|:..|:.|||.|.:::|.:..:|.
  Rat  1307 EEQKKYYNAMKKLGTKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVLNMIIMMAESADQP 1371

  Fly  1121 DMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNSIN 1185
            ...:|:...:|:.|..:|::|.::|:.... :::|.:.||:||.:.|:.||:..|......:.|:
  Rat  1372 KDVKKTFDILNIAFVVIFTIECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTLVSRLEDSDIS 1435

  Fly  1186 -----VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1245
                 ...:||.|..|:::|:|....||.||:..:.|..:|..:.||:.::.|||||.||..|..
  Rat  1436 FPPTLFRVVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMSWFSK 1500

  Fly  1246 IKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGST-- 1308
            :|.|:..:.|.   ||::|...::.||:..|...|..::...|:.|           |:|.|:  
  Rat  1501 VKKGSGIDDIF---NFETFTGSMLCLFQITTSAGWDTLLNPMLEAK-----------EHCNSSSQ 1551

  Fly  1309 -------LAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDS-SILGAHHLDEFVRIWAEYDPN 1365
                   :|..||||:|.....:::|:::|||::||:..|.:| ..||....:.|..:|.::||.
  Rat  1552 DSCQQPQIAVVYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEVWEKFDPE 1616

  Fly  1366 ATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSI 1430
            |:..|.|:.:.|....:..||....  ||:..:   :.|::|:....|:.....|||.....|. 
  Rat  1617 ASQFIQYSALSDFADALPEPLRVAK--PNKFQF---LVMDLPMVMGDRLHCMDVLFAFTTRVLG- 1675

  Fly  1431 KMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVP 1466
                    |.:.::..:|:.....::|.....|..|
  Rat  1676 --------DSSGLDTMKTMMEEKFMEANPFKKLYEP 1703

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 87/315 (28%)
Ion_trans 441..677 CDD:334124 74/242 (31%)
Ion_trans 769..1050 CDD:334124 88/298 (30%)
Ion_trans 1094..1345 CDD:334124 76/265 (29%)
GPHH 1346..1416 CDD:339854 17/69 (25%)
Ca_chan_IQ 1418..1492 CDD:337190 9/49 (18%)
Scn11aNP_062138.1 I. /evidence=ECO:0000305 115..403 90/323 (28%)
Ion_trans 160..404 CDD:278921 79/265 (30%)
II. /evidence=ECO:0000305 554..820 81/275 (29%)
Ion_trans 589..807 CDD:278921 69/223 (31%)
Na_trans_assoc 812..1029 CDD:284034 24/225 (11%)
III. /evidence=ECO:0000305 1022..1319 95/330 (29%)
Ion_trans 1051..1297 CDD:278921 80/279 (29%)
Na_channel_gate 1289..1341 CDD:240441 11/51 (22%)
IV. /evidence=ECO:0000305 1328..1619 87/305 (29%)
Ion_trans 1363..1595 CDD:278921 68/246 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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