DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn10a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_058943.2 Gene:Scn10a / 29571 RGDID:3629 Length:1956 Species:Rattus norvegicus


Alignment Length:1969 Identity:466/1969 - (23%)
Similarity:793/1969 - (40%) Gaps:535/1969 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGGPKKEENPPGGGPTSLFILTEDNPIRKYTRFIIEW-----PPFEYA----------------V 44
            :|.|.::.:|......:..:|   |..|..:||...|     .||...                :
  Rat    75 VGEPLEDLDPFYSTHRTFMVL---NKSRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFI 136

  Fly    45 LLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIW 109
            .:||:.|||.:...: ||           ||.|..|..|:..||.:||||.|..|::.:|||:.|
  Rat   137 TITILVNCVCMTRTD-LP-----------EKVEYVFTVIYTFEALIKILARGFCLNEFTYLRDPW 189

  Fly   110 NIMDFFVVVTGFMTQYPQIGPEVDLR---TLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQ 171
            |.:||.|:...:      :|..:|||   .||..||||.||.||.||.|:|::.::|.::..|..
  Rat   190 NWLDFSVITLAY------VGAAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLAD 248

  Fly   172 IGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEK---------- 226
            :.:|.:|.:.:||::||:.:.|.|         .||.::.|..  |...||:..:          
  Rat   249 VTILTVFCLSVFALVGLQLFKGNL---------KNKCIRNGTD--PHKADNLSSEMAEYIFIKPG 302

  Fly   227 ATGSFVCNNTTS--------MCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDA 283
            .|...:|.|.:.        :||:..:.|:...||||:..:|.|::|:.:|.:.|..:...|..|
  Rat   303 TTDPLLCGNGSDAGHCPGGYVCLKTPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRA 367

  Fly   284 LGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEW 348
            .|..: .::||.:|.:|||:::||:|.|::..:.::.:..        :...:..|::....:|.
  Rat   368 SGKMY-MVFFVLVIFLGSFYLVNLILAVVTMAYEEQSQAT--------IAEIEAKEKKFQEALEV 423

  Fly   349 ICKAEEVILAEERTTEEEKMHI---MEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDY------ 404
            :.|.:||:.|....|...:.|.   :.::..| .:|.::||.....|||.......:.|      
  Rat   424 LQKEQEVLAALGIDTTSLQSHSGSPLASKNAN-ERRPRVKSRVSEGSTDDNRSPQSDPYNQRRMS 487

  Fly   405 ----------------------------------------------------------------- 404
                                                                             
  Rat   488 FLGLSSGRRRASHGSVFHFRAPSQDISFPDGITDDGVFHGDQESRRGSILLGRGAGQTGPLPRSP 552

  Fly   405 -----------GDDGYL------KTRSKPQG---------------------------------- 418
                       |::|.|      .|...|:|                                  
  Rat   553 LPQSPNPGRRHGEEGQLGVPTGELTAGAPEGPALDTTGQKSFLSAGYLNEPFRAQRAMSVVSIMT 617

  Fly   419 ---------------------------SCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTV 456
                                       .|...||   :|:..:...|...:....:.:.:.:|||
  Rat   618 SVIEELEESKLKCPPCLISFAQKYLIWECCPKWR---KFKMALFELVTDPFAELTITLCIVVNTV 679

  Fly   457 CVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVI 521
            .:|:|||.........|.....:|...|..||..|:.|..|..||:..:|.||||:::.|:.|: 
  Rat   680 FMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLEL- 743

  Fly   522 WSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGM 586
             |..|.||  |||||..||||:||:.|.|.:|..|:..:.||:.::.:|.|:|.:.:.||||:|.
  Rat   744 -SASKKGS--LSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGK 805

  Fly   587 QLFGGQFNL-PGGTPETN-----------FNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQK 639
            ||....:.. ..|....|           |::|    |.||:||.|| |.|.|:   :....:||
  Rat   806 QLLSEDYGCRKDGVSVWNGEKLRWHMCDFFHSF----LVVFRILCGE-WIENMW---VCMEVSQK 862

  Fly   640 GMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEE---------------------- 682
            .:...::..|:|| ||..:||:|:|:.: |..:|..|||.|::                      
  Rat   863 SICLILFLTVMVL-GNLVVLNLFIALLL-NSFSADNLTAPEDDGEVNNLQLALARIQVLGHRASR 925

  Fly   683 ---------------QVE----------------------------------------------- 685
                           :||                                               
  Rat   926 AIASYISSHCRFRWPKVETQLGMKPPLTSSEAKNHIATDAVSAAVGNLTKPALSSPKENHGDFIT 990

  Fly   686 ----------EDKEKQLQELEKEMEALQADGVHVENGDGA------------------------- 715
                      .:.|..|.|||::||.........|:..|.                         
  Rat   991 DPNVWVSVPIAEGESDLDELEEDMEQASQSSWQEEDPKGQQEQLPQVQKCENHQAARSPASMMSS 1055

  Fly   716 --VAPSKSKGKKKEEEKK--------------------EEEEV------------------TEGP 740
              :||...:..|:::..:                    :.||:                  |||.
  Rat  1056 EDLAPYLGESWKRKDSPQVPAEGVDDTSSSEGSTVDCPDPEEILRKIPELADDLDEPDDCFTEGC 1120

  Fly   741 KPMLPYSSMFILSPTNP------IRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRR 798
            ....|..:  :.:..:|      :|:..:.:|...:|:.||:.:|.:||.|||.||. :.|..|.
  Rat  1121 TRRCPCCN--VNTSKSPWATGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRV 1183

  Fly   799 NKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAG 863
            ..:|.|.|..||.:|..|||||.|..|.    ..|....|..:|.::|..:..|.   ::.....
  Rat  1184 KSVLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWLDFLIVNISLTSL---IAKILEY 1241

  Fly   864 QNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNG 928
            .::::||:||.||.||||:.:.|...::.|.|.:|.::.:::|:|:|.::|..|||::||.||.|
  Rat  1242 SDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1306

  Fly   929 KFFYCTDESK-----------HTSAECQ-----GSYFKYEEDELLPKQELRVWKPRAFHYDNVAA 977
            ||..|.|...           :..:||.     |.:|               |.....::||||.
  Rat  1307 KFSKCVDTRNNPFSNVNSTMVNNKSECHNQNSTGHFF---------------WVNVKVNFDNVAM 1356

  Fly   978 AMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIIT 1042
            ..|.|..|.|.:||..::..::.:...:..|.....:.|.::::|:.|...||.:|:||.:||..
  Rat  1357 GYLALLQVATFKGWMDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDN 1421

  Fly  1043 FQEQGEAEL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMM 1103
            |.:| :.:|  ||..:.:.||...:.  .:|::..::.:|:..|.::..|:.||....|:..||:
  Rat  1422 FNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMV 1485

  Fly  1104 LIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN-FFKDPWNIFDLITV 1167
            ||..|.:.:|::...||:...|.|..||..|..:|:.|.|:|:  |.::. :|.:.||:||.|.|
  Rat  1486 LICLNMITMMVETDEQGEEKTKVLGRINQFFVAVFTGECVMKM--FALRQYYFTNGWNVFDFIVV 1548

  Fly  1168 L--------GSIVDALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1224
            :        .:|:.:|...|......|  :||.|..|:::|:|....||.||:..:.|..||..:
  Rat  1549 ILSIGSLLFSAILKSLENYFSPTLFRV--IRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNI 1611

  Fly  1225 CLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLK 1289
            .||:.::.|||:|.||..|.|:   ..|..|....||::|...::.||:..|...|..::...|.
  Rat  1612 GLLLFLVMFIYSIFGMASFANV---VDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILN 1673

  Fly  1290 --GKACDDDAEKAPGE--YCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILG 1348
              ...||.:...:.|.  .||| .:...:|.::|.....:::|:::|||::||:..|.:|: .|.
  Rat  1674 TGPPYCDPNLPNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLS 1738

  Fly  1349 AHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELR 1413
            ....|.|...|.::||.||..|.::.:.|....:..||....  ||:   ..||:|::||....:
  Rat  1739 EDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPK--PNQ---NILIQMDLPLVPGDK 1798

  Fly  1414 VQFTTTLFALIRENLSIKMRAPEEMD--QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKL 1476
            :.....|||..:..|.    ...|:|  :.:||.:...||:.....:.:...|....:.|:  ..
  Rat  1799 IHCLDILFAFTKNVLG----ESGELDSLKTNMEEKFMATNLSKASYEPIATTLRWKQEDLS--AT 1857

  Fly  1477 SVGKIYAGFLILESW---------RSTRFG-----------QLDSGMP-MLELQDA-SRHPSQES 1519
            .:.|.|..:::..|.         |:...|           ..:||:| ..|...| |..||.:|
  Rat  1858 VIQKAYRSYMLHRSLTLSNTLHVPRAEEDGVSLPGEGYVTFMANSGLPDKSETASATSFPPSYDS 1922

  Fly  1520 LTG--ADAGHLHPGHSYMN 1536
            :|.  :|..:::|..|..|
  Rat  1923 VTRGLSDRANINPSSSMQN 1941

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 93/328 (28%)
Ion_trans 441..677 CDD:334124 82/247 (33%)
Ion_trans 769..1050 CDD:334124 89/297 (30%)
Ion_trans 1094..1345 CDD:334124 78/264 (30%)
GPHH 1346..1416 CDD:339854 19/69 (28%)
Ca_chan_IQ 1418..1492 CDD:337190 15/84 (18%)
Scn10aNP_058943.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..54
I. /evidence=ECO:0000305 116..404 91/317 (29%)
Ion_trans 129..406 CDD:395416 90/306 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..484 9/43 (21%)
Na_trans_cytopl <482..614 CDD:403218 6/131 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..581 4/43 (9%)
II. /evidence=ECO:0000305 646..910 91/280 (33%)
Ion_trans 663..893 CDD:395416 81/243 (33%)
Na_trans_assoc 903..1148 CDD:399489 22/246 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1008..1094 10/85 (12%)
III. /evidence=ECO:0000305 1141..1450 96/331 (29%)
Ion_trans 1152..1428 CDD:395416 89/298 (30%)
Na_channel_gate 1420..1472 CDD:240441 11/52 (21%)
IV. /evidence=ECO:0000305 1459..1758 91/305 (30%)
Ion_trans 1476..1733 CDD:395416 78/263 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1906..1956 11/36 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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