DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and Catsper3

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_006253634.1	Gene:	Catsper3 / 290989	RGDID:	1305700	Length:	395	Species:	Rattus norvegicus

Alignment Length:	395	Identity:	85/395 - (21%)
Similarity:	169/395 - (42%)	Gaps:	62/395 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 RAEKRFRFWIRHTVKTQWFYWFVIVLVFLNT-VCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
            |.:|:.:.:.|...|:..|...:|..|..|: :.|...:|.....:......:|..|:.::..|.
  Rat    34 RRDKQCQAFFRKVTKSTLFQILMITTVTANSFLLVLGTNYDIHFRMFRVFEISELFFVSIYACEF 98

  Fly   489 FIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFG-LSVLRALRLLRIFKVTKYWSS 552
            .:|:| :.|..|::..:|..|.|::..........::||..|. |.....::.||:.|:..|...
  Rat    99 LMKVY-VDPITYWKDGYNILDVVILVIITIPYFLRKIKGNHFEYLHFADGIQSLRVLKLISYSRG 162

  Fly   553 LRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQI 617
            :|.|:|::..::.::.|:|.||||.:.:||:||..|||   |...| ..||:.....|..|:|.:
  Rat   163 IRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFG---NADRG-DLTNWGNLAAAFFTLFSL 223

  Fly   618 LTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANA-----QELT 677
            .|.:.|..:.     .:...:|..:...:.|:.:|..::..||:|:.:.:.:..::     :|:|
  Rat   224 ATVDGWTNLQ-----EELDKRKFTVSRAFTILFILLASFIFLNMFVGVMIMHTEDSIKKFEREMT 283

  Fly   678 AAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKP 742
            ......:.|:|:..|:..:.|:..|    ::.:...|                |...|:.||.|.
  Rat   284 LERNLALMEEKQMILRRQQDEVNRL----MNTQKVGG----------------KSFVEMVEGFKR 328

  Fly   743 MLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFI------MVVIS---------MSSIALAAED-P 791
            .|.::...:|.         .:..:|.:.|.::      .|::|         .:.:.|..|| |
  Rat   329 TLRHTDPMVLD---------EFCTSLSFIDIYLDTLDNQDVIVSKLQELYYEIANVLNLMLEDMP 384

  Fly   792 VRENS 796
            .||.|
  Rat   385 PREKS 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124	56/242 (23%)
		Ion_trans	769..1050	CDD:334124	10/44 (23%)
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
Catsper3	XP_006253634.1	Ion_trans	73..269	CDD:278921	50/205 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900