DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and PKD2L2

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_001287850.1	Gene:	PKD2L2 / 27039	HGNCID:	9012	Length:	624	Species:	Homo sapiens

Alignment Length:	793	Identity:	154/793 - (19%)
Similarity:	254/793 - (32%)	Gaps:	321/793 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 HLPGGDKTVLAQK--------LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFV 116
            |..|..|..|..:        |::...||  ||.:  :|.||..|:| :.|.|..|  .:|....
Human     8 HRGGASKHKLHYRKEVEITTTLQELLLYF--IFLI--NLCILTFGMV-NPHMYYLN--KVMSSLF 65

  Fly   117 VVTGFMTQYPQIGPEVDLRTLRAIRVLRPL-KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAI 180
            :.|..        |..:....::||.:... |.:.|                |||:
Human    66 LDTSV--------PGEERTNFKSIRSITDFWKFMEG----------------PLLE--------- 97

  Fly   181 VIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNIL---EKATGSFVCNNT------ 236
                  ||.:.|...::..|:|::.:::..|          |||   .:.....|.|||
Human    98 ------GLYWDSWYNNQQLYNLKNSSRIYYE----------NILLGVPRVRQLKVRNNTCKVYSS 146

  Fly   237 ----TSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLI 297
                .|.|..|:...|..:::|   |..:.|.::           |.|::. .|.::|.:
Human   147 FQSLMSECYGKYTSANEDLSNF---GLQINTEWR-----------YSTSNT-NSPWHWGF----- 191

  Fly   298 VIGSFFMLNLVLGVLSGE---FAKEREKVENRQEFLKLRRQQQLER------------------- 340
                       |||....   |...:.|.|.:.:|:.||....:.|
Human   192 -----------LGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLF 245

  Fly   341 ------------------------ELNGYVEWI------CKAEEVILAEERTTEEEKMHIMEARR 375
                                    :|..||.:.      |:....|.....||:|.|
Human   246 CIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVK-------- 302

  Fly   376 RNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKT 440
                |.|:.||                     .|.|:          .|.
Human   303 ----KIKEFKS---------------------AYFKS----------IWN--------------- 317

  Fly   441 QWFYWFVIVLVFLNTVCVAVEHY---------GQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALG 496
                |..::|:.|..|.|:...|         ||....||  .|::|.||..:
Human   318 ----WLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTE--KYSDFYFLACW------------ 364

  Fly   497 PRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLL 561
             .||:.:        :|:.:|| ..|                  ::|||...:..::..|..:|.
Human   365 -HIYYNN--------IIAITIF-FAW------------------IKIFKFISFNKTMSQLSSTLS 401

  Fly   562 NSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEV 626
            ..::.|:....:.|:....:|.||..:||.|.:        :|:||..::...|:|:.| |:|
Human   402 RCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVD--------DFSTFQNSIFAQFRIVLG-DFN-- 455

  Fly   627 MYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLA-------------------- 671
             :.| |.|.....|.||.|.||..|.|   .|||:||||..|..:
Human   456 -FAG-IQQANPILGPIYFITFIFFVFF---VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMI 515

  Fly   672 -----NAQELTAAEEEQVEEDKE-KQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEK 730
                 |..|....::.|.:|||: |...:|.::......|...::|     |....|.|::.|:|
Human   516 KQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQN-----AEQMKKWKERLEKK 575

  Fly   731 KEEEEVTEGPKPM 743
            ....|:.:..:|:
Human   576 YYSMEIQDDYQPV 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	56/288 (19%)
		Ion_trans	441..677	CDD:334124	62/269 (23%)
		Ion_trans	769..1050	CDD:334124
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
PKD2L2	NP_001287850.1	PKD_channel	76..497	CDD:332708	117/612 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910