DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and Nalcn

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001380622.1 Gene:Nalcn / 266760 RGDID:628710 Length:1770 Species:Rattus norvegicus


Alignment Length:1903 Identity:417/1903 - (21%)
Similarity:758/1903 - (39%) Gaps:478/1903 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 IEW--PPFEYAVL-----LTIIANCVVLALE-EHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLK 91
            |.|  .|:.:::|     :::|:.|:...:. ||.|     .|.......:...:.::..|...|
  Rat    30 ILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYP-----PLQYVTFTLDTLLMFLYTAEMIAK 89

  Fly    92 ILALGLVLHKHSYLRNIWNIMDFFVVV---TGFMTQYPQIGPEVD-LRTLRAIRVLRPLKLVSG- 151
            :...|:|....||:::.|.:.|.|:|.   ...:.|..:|...|| :.....:|:.|||.::.. 
  Rat    90 MHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAF 154

  Fly   152 -------IPSLQV--VLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNK 207
                   :|..::  :||   ::...:..:.:.:||.::::.|:|::.:....:....:...|..
  Rat   155 RIYFRFELPRTRITNILK---RSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGN 216

  Fly   208 LVKEGES--ETPCNTDNILE---KATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQC 267
            :.....:  :|.|:.:  ||   :....|.|.:...:.|.:.|   .|.:.|:.||.::.||::.
  Rat   217 VTWNSLAIPDTHCSPE--LEEGYQCPPGFKCMDLEDLGLSRQE---LGYSGFNEIGTSIFTVYEA 276

  Fly   268 ITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKL 332
            .:.|||..::|...|:.....::.||:.||...::.:.|:.:.|:...||      |.|.:|   
  Rat   277 SSQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFA------EIRVQF--- 332

  Fly   333 RRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEE 397
               ||:         |..::.        ||                            ||.|.:
  Rat   333 ---QQM---------WGTRSS--------TT----------------------------STATTQ 349

  Fly   398 EEAEEDYGDDGYLKTR---SKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVA 459
            ...|:..|  |:....   :||||      ||....:..:|.:|    |:.|::.:|.::.:..|
  Rat   350 MFHEDAAG--GWQLVAVDVNKPQG------RAPACLQKMMRSSV----FHMFILSMVTVDVIVAA 402

  Fly   460 VEHYGQPSFLTEF--LYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIW 522
            ..:|...:|..::  .|.||..|..||..|..:|::.||...|..||.::|:.:::.|:...| :
  Rat   403 SNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHV-Y 466

  Fly   523 SEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQ 587
            .::....|  :..:.||::|:.|::   .:|.:.|..:....:.:.||:......:::.:.:.:|
  Rat   467 PDLYHSQF--TYFQVLRVVRLIKIS---PALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQ 526

  Fly   588 LFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVL 652
            :|.....|      ..|.|||.|.:::|||||.|.|.:||.|.:.:.|.....:: :||||:..|
  Rat   527 MFCFVEEL------DRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPLV-AIYFILYHL 584

  Fly   653 FGNYTLLNVFLAIAVDNL---ANAQELTAAEEEQVEEDKEKQL---------------------- 692
            |....||::|:|:.:|||   .:.::|...::.:...|.:::|                      
  Rat   585 FATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKL 649

  Fly   693 -------------------------------------------------------QELEKEMEAL 702
                                                                   |:|.|.:.::
  Rat   650 PSDFTVPKIRESFMKQFIDRQQQDTCCLFRILPSTSSSSCDNPKRPTVEDNKYIDQKLRKSVFSI 714

  Fly   703 QADGV-----------------HVENGDGAVAPSK---------------------------SKG 723
            :|..:                 .:.:|.....|:|                           |:|
  Rat   715 RARNLLEKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRG 779

  Fly   724 KKKE-------------------------EEKKE---------EEEVTEG----PKPM------- 743
            |..|                         :||||         |||:.|.    .||:       
  Rat   780 KSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREH 844

  Fly   744 -------LPYSSMFILSPTNPIRRGA------HWVVNL----PYFDFFIMVVISMSSIALAAEDP 791
                   :...:.|..|.|:|: .||      |.:.:|    .|.|:.::.|...|.|::..|.|
  Rat   845 RFRNFCRVVVRARFNASKTDPV-TGAVKNTKYHQLYDLLGLVTYLDWVMITVTICSCISMMFESP 908

  Fly   792 VRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFD 856
            .| .......|...:|.|....:||:.|||:..|:...|.:.:|:|..:||..:.:.:.:...: 
  Rat   909 FR-RVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCW- 971

  Fly   857 MSGSSAGQNL---STIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIF 918
                 ..||:   |..:.|.|||.||||:..|.||:::.|...:.:..|.:..:.|:.:....:|
  Rat   972 -----MPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVF 1031

  Fly   919 SVIGVQLFNGKFFYCTDESKHTSAECQG------SYFKYEEDELLPKQEL------RVW-KPRAF 970
            :..|||||.||...|.|.:.....:|.|      |..|....:|.|.::.      ||| .||.|
  Rat  1032 ASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNF 1096

  Fly   971 HYDNVAAAMLTLFAVQTGEGWPQ---VLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPF--- 1029
            ::|||..|||.||.|.:.:||.:   |:.|.:       |||..          :|..||.|   
  Rat  1097 NFDNVGNAMLALFEVLSLKGWVEVRDVIIHRV-------GPIHG----------IYIHVFVFLGC 1144

  Fly  1030 -FFVNIFVALIIITFQE-QGEAELQDGEIDKNQ----KSCIDFTIGARPLERYMPKNRNTFKYKV 1088
             ..:.:||.::|..|.| :|.|.|   .:|:.:    ||.:..   |:||......:.:.|:.|:
  Rat  1145 MIGLTLFVGVVIANFNENKGTALL---TVDQRRWEDLKSRLKI---AQPLHLPPRPDNDGFRAKM 1203

  Fly  1089 WRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN 1153
            :.|.....|:..|.:|::..::||.:|:..: |.....|..:::.||.:|.:|..:|||......
  Rat  1204 YDITQHPFFKRTIALLVLAQSVLLSVKWDVE-DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAG 1267

  Fly  1154 FFKDPWNIFD-LITVLGSIVDALWMEFGSNSINVGFLRLFRAA----RLIKLLRQGYTIRILLWT 1213
            |::...|.:| |:|.||    .:|:......:| .:..:..|.    |...:..:..|:::||.|
  Rat  1268 FWQSRRNRYDLLVTSLG----VVWVVLHFALLN-AYTYMMGACVIVFRFFSICGKHVTLKMLLLT 1327

  Fly  1214 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGE 1278
            .|.|.....::.:.:.:|...||..|:.:||.:|.|  || |.||.||.|..:.:.:|||..|||
  Rat  1328 VVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYG--EN-INRHANFSSAGKAITVLFRIVTGE 1389

  Fly  1279 AWPNIMLACL-KGKACDDDA----EKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFD 1338
            .|..||..|: :...|..|.    ....|.|.|   |..||.||....:::||||.||:|::||.
  Rat  1390 DWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAG---ALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451

  Fly  1339 --YLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLK--------NMDPPLGFGNKCP 1393
              |.|.:..:|..:.|..|..||...|....|.|....:..:|:        ::|         .
  Rat  1452 LFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLD---------K 1507

  Fly  1394 NRLAYKKLIRMNMPLDDELRVQFTTTLFAL------IRENLSI-KMRAPEEMDQA-DMELRETIT 1450
            ::|.:|.:......|.:...|.|...|..|      ||::|.: ::.|.|:::.. :.|:.:...
  Rat  1508 DKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTI 1572

  Fly  1451 NIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGM--PMLELQDASR 1513
            .:|   .||.|..:.....|             ...|:.|.|.::..:|...:  |.:|    :.
  Rat  1573 RMW---LKKCLKRIRAKQQQ-------------SCSIIHSLRESQQQELSRFLNPPSIE----TT 1617

  Fly  1514 HPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNG---SPLARSPSPRRRGHQYIHHDIGFSDTV 1575
            .||:::...:...:..| .|.......||:|...|   ...|.:..|:|:..|:.......::..
  Rat  1618 QPSEDTNANSQDHNTQP-ESSSQQQLLSPTLSDRGGSRQDAADTGKPQRKIGQWRLPSAAIAEKT 1681

  Fly  1576 SNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSP---------SRYGGHLSRSKRTQLPY 1631
            :.|.:|          :|:.:.|.......:....:|.|         .|:||      ||.:  
  Rat  1682 APVNKM----------SSYSQDPEREEEEVSKGFLAPKPISHSVSSVNLRFGG------RTTM-- 1728

  Fly  1632 PTYGTTSLCQRSRSPSPA 1649
                .:.:|:.:..|..|
  Rat  1729 ----KSVVCKMNPMPDTA 1742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 62/313 (20%)
Ion_trans 441..677 CDD:334124 63/240 (26%)
Ion_trans 769..1050 CDD:334124 87/304 (29%)
Ion_trans 1094..1345 CDD:334124 79/262 (30%)
GPHH 1346..1416 CDD:339854 14/77 (18%)
Ca_chan_IQ 1418..1492 CDD:337190 15/81 (19%)
NalcnNP_001380622.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..789 4/26 (15%)
PLN03223 <1336..1451 CDD:215637 44/120 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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