Protein Alignment cac and NALCN

DIOPT Version :10

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: XP_024305104.1
• Gene: NALCN / 259232
• HGNCID: 19082
• Length: 1786
• Species: Homo sapiens
• Alignment Length: 1868
• Identity: 410/1868 - (21%)
• Similarity: 737/1868 - (39%)
• Gaps: 491/1868 - (26%)

  Fly    35 IEW--PPFEYAVL-----LTIIANCVVLALE-EHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLK 91
            |.|  .|:.:::|     :::|:.|:...:. ||.|     .|.......:...:.::..|...|
Human    49 ILWINKPWVHSLLRICAIISVISVCMNTPMTFEHYP-----PLQYVTFTLDTLLMFLYTAEMIAK 108

  Fly    92 ILALGLVLHKHSYLRNIWNIMDFFVVV---TGFMTQYPQIGPEVD-LRTLRAIRVLRPLKLVSG- 151
            :...|:|....||:::.|.:.|.|:|.   ...:.|..:|...|| :.....:|:.|||.::..
Human   109 MHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAF 173

  Fly   152 -------IPSLQV--VLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNK 207
                   :|..::  :||   ::...:..:.:.:||.::::.|:|::.:....:....:...|..
Human   174 RIYFRFELPRTRITNILK---RSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGN 235

  Fly   208 LVKEGES--ETPCNTDNILE---KATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQC 267
            :.....:  :|.|:.:  ||   :....|.|.:...:.|.:.|   .|.:.|:.||.::.||::.
Human   236 VTWNSLAIPDTHCSPE--LEEGYQCPPGFKCMDLEDLGLSRQE---LGYSGFNEIGTSIFTVYEA 295

  Fly   268 ITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKL 332
            .:.|||..::|...|:.....::.||:.||...::.:.|:.:.|:...||      |.|.:|
Human   296 ASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFA------EIRVQF--- 351

  Fly   333 RRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEE 397
               ||:         |                                    .|...:.||.|.:
Human   352 ---QQM---------W------------------------------------GSRSSTTSTATTQ 368

  Fly   398 EEAEEDYGDDGYLKTR---SKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVA 459
            ...|:..|  |:....   :||||      ||....:..:|.:|    |:.|::.:|.::.:..|
Human   369 MFHEDAAG--GWQLVAVDVNKPQG------RAPACLQKMMRSSV----FHMFILSMVTVDVIVAA 421

  Fly   460 VEHYGQPSFLTEF--LYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIW 522
            ..:|...:|..::  .|.||..|..||..|..:|::.||...|..||.::|:.:::.|:...| :
Human   422 SNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHV-Y 485

  Fly   523 SEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQ 587
            .::....|  :..:.||::|:.|::   .:|.:.|..:....:.:.||:......:::.:.:.:|
Human   486 PDLYHSQF--TYFQVLRVVRLIKIS---PALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQ 545

  Fly   588 LFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVL 652
            :|.....|      ..|.|||.|.:::|||||.|.|.:||.| .::..|.....:.:||||:..|
Human   546 MFCFVEEL------DRFTTFPRAFMSMFQILTQEGWVDVMDQ-TLNAVGHMWAPVVAIYFILYHL 603

  Fly   653 FGNYTLLNVFLAIAVDNL---ANAQELTAAEEEQVEEDKEKQL---------------------- 692
            |....||::|:|:.:|||   .:.::|...::.:...|.:::|
Human   604 FATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKL 668

  Fly   693 -------------------------------------------------------QELEKEMEAL 702
                                                                   |:|.|.:.::
Human   669 PSDFTVPKIRESFMKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSI 733

  Fly   703 QA----------------------------------------DGV------HVENGDGAVAPSK- 720
            :|                                        .||      .:.:|.....|:|
Human   734 RARNLLEKETAVTKILSKRPLPTSSPISIRCCLYLGRSHCHSSGVRACTRQRMLSGSFEGQPAKE 798

  Fly   721 --------------------------SKGKKKE-------------------------EEKKE-- 732
                                      |:||..|                         :||||
Human   799 RSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQA 863

  Fly   733 -------EEEVTEG----PKPM--------------LPYSSMFILSPTNPIRRGA------HWVV 766
                   |||:.|.    .||:              :...:.|..|.|:|: .||      |.:.
Human   864 EMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARFNASKTDPV-TGAVKNTKYHQLY 927

  Fly   767 NL----PYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVI 827
            :|    .|.|:.:::|...|.|::..|.|.| .......|...:|.|....:||:.|||:..|:.
Human   928 DLLGLVTYLDWVMIIVTICSCISMMFESPFR-RVMHAPTLQIAEYVFVIFMSIELNLKIMADGLF 991

  Fly   828 LHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNL---STIKSLRVLRVLRPLKTIKRVPK 889
            ..|.:.:|:|..:||..:.:.:.:...:      ..||:   |..:.|.|||.||||:..|.||:
Human   992 FTPTAVIRDFGGVMDIFIYLVSLIFLCW------MPQNVPAESGAQLLMVLRCLRPLRIFKLVPQ 1050

  Fly   890 LKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQG------SY 948
            ::.|...:.:..|.:..:.|:.:....:|:..|||||.||...|.|.:.....:|.|      |.
Human  1051 MRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSV 1115

  Fly   949 FKYEEDELLPKQEL------RVW-KPRAFHYDNVAAAMLTLFAVQTGEGWPQ---VLQHSMAATY 1003
            .|....:|.|.::.      ||| .||.|::|||..|||.||.|.:.:||.:   |:.|.:
Human  1116 SKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRV---- 1176

  Fly  1004 EDRGPIQNFRIEMSIFYIVYFIVFPF----FFVNIFVALIIITFQE-QGEAELQDGEIDKNQ--- 1060
               |||..          :|..||.|    ..:.:||.::|..|.| :|.|.|   .:|:.:
Human  1177 ---GPIHG----------IYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALL---TVDQRRWED 1225

  Fly  1061 -KSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYE 1124
             ||.:..   |:||......:.:.|:.|::.|.....|:..|.:|::..::||.:|:..: |...
Human  1226 LKSRLKI---AQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVE-DPVT 1286

  Fly  1125 KSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFD-LITVLGSIVDALWMEFGSNSINVGF 1188
            ..|..:::.||.:|.:|..:|||......|::...|.:| |:|.||    .:|:......:| .:
Human  1287 VPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLG----VVWVVLHFALLN-AY 1346

  Fly  1189 LRLFRAA----RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLG 1249
            ..:..|.    |...:..:..|:::||.|.|.|.....::.:.:.:|...||..|:.:||.:|.|
Human  1347 TYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYG 1411

  Fly  1250 TVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACL-KGKACDDDA----EKAPGEYCGSTL 1309
              || |.||.||.|..:.:.:|||..|||.|..||..|: :...|..|.    ....|.|.|
Human  1412 --EN-INRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAG--- 1470

  Fly  1310 AYAYFVSFIFFCSFLMLNLFVAVIMDNFD--YLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHY 1372
            |..||.||....:::||||.||:|::||.  |.|.:..:|..:.|..|..||...|....|.|..
Human  1471 ALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPT 1535

  Fly  1373 TEMYDMLK--------NMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFAL------ 1423
            ..:..:|:        ::|         .::|.:|.:......|.:...|.|...|..|
Human  1536 FRVKFLLRLLRGRLEVDLD---------KDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVD 1591

  Fly  1424 IRENLSI-KMRAPEEMDQA-DMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFL 1486
            ||::|.: ::.|.|:::.. :.|:.:....:|   .||.|..:.....|             ...
Human  1592 IRKSLQLEELLAREQLEYTIEEEVAKQTIRMW---LKKCLKRIRAKQQQ-------------SCS 1640

  Fly  1487 ILESWRSTRFGQLDSGM--PMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNG- 1548
            |:.|.|.::..:|...:  |.:|    :..||:::...:....:.|..|... ...||:|...|
Human  1641 IIHSLRESQQQELSRFLNPPSIE----TTQPSEDTNANSQDNSMQPETSSQQ-QLLSPTLSDRGG 1700

  Fly  1549 --SPLARSPSPRRRGHQY--------IHHDI-------GFSDTVSNVV 1579
              ...|.:..|:|:..|:        |.|.:       |...|:.:||
Human  1701 SRQDAADAGKPQRKFGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVV 1748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	62/313 (20%)
		Ion_trans	441..677	CDD:459842	63/240 (26%)
		Ion_trans	769..1050	CDD:459842	87/304 (29%)
		Ion_trans	1094..1345	CDD:459842	79/262 (30%)
		GPHH	1354..1407	CDD:465306	10/60 (17%)
		Ca_chan_IQ	1417..1496	CDD:462591	16/86 (19%)
		AF-4	<1512..>1704	CDD:461550	18/86 (21%)
NALCN	XP_024305104.1	Ion_trans	55..350	CDD:459842	63/313 (20%)
		Ion_trans	402..622	CDD:459842	63/236 (27%)
		Ion_trans	935..1209	CDD:459842	85/297 (29%)
		Ion_trans	1257..1506	CDD:459842	79/260 (30%)