DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and Cacna1b

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_006233631.1	Gene:	Cacna1b / 257648	RGDID:	628852	Length:	2359	Species:	Rattus norvegicus

Alignment Length:	2400	Identity:	1052/2400 - (43%)
Similarity:	1289/2400 - (53%)	Gaps:	623/2400 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GGPKKEENPPGG------------------GP-----------TSLFILTEDNPIRKYTRFIIEW 37
            |||.:...|||.                  .|           .|||:.:|||.:|||.:.|.||
  Rat    30 GGPGQGGLPPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEW 94

  Fly    38 PPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKH 102
            |||||.:|.||||||:|||||:|||.||||.::::|:.||.||:.|||.||.:||:|||.|.||.
  Rat    95 PPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKG 159

  Fly   103 SYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMA 167
            |||||.||:|||.||:||.:.   ..|.:.|||||||:||||||||||||||||||||||:|||.
  Rat   160 SYLRNGWNVMDFVVVLTGILA---TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMV 221

  Fly   168 PLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFV 232
            ||||||||:.|||::|||||||||.|..||.|:    ||....|...:.||.      |...:.:
  Rat   222 PLLQIGLLLFFAILMFAIIGLEFYMGKFHKACF----PNSTDAEPVGDFPCG------KEAPARL 276

  Fly   233 CNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLI 297
            |::.|. |.|.|.|||.|||:||||.||:|||||||||||||.|||.||||.|:.:||:||:|||
  Rat   277 CDSDTE-CREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLI 340

  Fly   298 VIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERT 362
            :|||||||||||||||||||||||:||||:.|||||||||:|||||||:|||.|||||:||||..
  Rat   341 IIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDK 405

  Fly   363 TEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGD-------DGYLKTRSKPQGSC 420
            ..|||..:....:|.|.|        ||::.....||.|:.:.|       ......:|....|.
  Rat   406 NAEEKSPLDAVLKRAATK--------KSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESS 462

  Fly   421 TGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFM 485
            :.|.|.||.|||.||..||.|.|||.|:.:|.|||:|||:.||.||..||..||:|||:|||||:
  Rat   463 SYFRRKEKMFRFLIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFL 527

  Fly   486 SEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GGSFGLSVLRALRLLRIFKVTKY 549
            :||.:|||.||||.||.||||.||..||.||||||:|:.:| |.|||:|||||||||||||||||
  Rat   528 TEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKY 592

  Fly   550 WSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTV 614
            |:||||||:||||||:|||||||||||||::||||||||||||||....||.|||:|||.|:|||
  Rat   593 WNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTV 657

  Fly   615 FQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAA 679
            ||||||||||.|||.||.||||..|||..|.|||||.||||||||||||||||||||||||||..
  Rat   658 FQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 722

  Fly   680 EEEQVEEDKEK------------------------------------------------------ 690
            |||..|...:|
  Rat   723 EEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAFVKQTRGTVSRSSSVSSVNSPRQQNSAKAR 787

  Fly   691 ----------QLQELEKEMEALQA----------------------------------DG----- 706
                      :||.|....|||.:                                  ||
  Rat   788 SVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVVEPGRDGLRGPA 852

  Fly   707 ----------------------------------------------------------------- 706

  Rat   853 GNKSKPEGTEATEGADPPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAESTETGAREERARPRRS 917

  Fly   707 ----------------------------------------------------------------- 706

  Rat   918 HSKEAPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGKEGTAPVLVPKGERR 982

  Fly   707 ----------------------------------------------------------------- 706

  Rat   983 ARHRGPRTGPRETENSEEPTRRHRAKHKVPPTLEPPEREVAEKESNVVEGDKETRNHQPKEPRCD 1047

  Fly   707 -------------------------------------------------VHV------ENGDGAV 716
                                                             |||      ..|:..|
  Rat  1048 LEAIAVTGVGSLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTGPPGEATV 1112

  Fly   717 APSKSKGKKKEEEKKEEEEVTE----GPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMV 777
            .||.:...:.:.|.|:|.|..:    ||:|::||||||.|||||.:||..|::|.:.||:..|:|
  Rat  1113 VPSANTDLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILV 1177

  Fly   778 VISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMD 842
            ||::||||||||||||.:|.||..|.|.||.||||||.||::|::|||::||||:|.|:.|||:|
  Rat  1178 VIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILD 1242

  Fly   843 AVVVICAAVSFGF-DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVN 906
            .:||..|.|:|.| ...|.|.|::::|||||||||||||||||||:|||||||||||||||||:|
  Rat  1243 FIVVSGALVAFAFSSFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLN 1307

  Fly   907 ILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFH 971
            |||||:||.|||:||.||||.|||||||||||....:|:|.|..||::|:  :.:.|.||...||
  Rat  1308 ILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEV--EAQPRQWKKYDFH 1370

  Fly   972 YDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFV 1036
            ||||..|:||||.|.||||||.||:||:.||||::||...||:|:||||:|||:|||||||||||
  Rat  1371 YDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFV 1435

  Fly  1037 ALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFI 1101
            |||||||||||:..:.:..::||:::||||.|.|:||.||||:|:.:|:||.|..|||.||||||
  Rat  1436 ALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFI 1500

  Fly  1102 MMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLIT 1166
            |.:|..||::||||:::....||..||.:|:.||.|||:|.:||||.|||.|:|:|.||:||.:|
  Rat  1501 MAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVT 1565

  Fly  1167 VLGSIVDALWMEFG--SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1229
            |||||.|.|..|..  :|.||:.||||||||||||||||||||||||||||||||||||||||||
  Rat  1566 VLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1630

  Fly  1230 MLFFIYAIIGMQVFGNIKL--GTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKA 1292
            |||||||||||||||||.|  ||   ||.|||||::|:|.:|||||.||||||..|||:||..:|
  Rat  1631 MLFFIYAIIGMQVFGNIALDDGT---SINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRA 1692

  Fly  1293 CDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVR 1357
            ||..|..:.   |||..||.|||||||.|||||||||||||||||:||||||||||.||||||:|
  Rat  1693 CDPHANASE---CGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIR 1754

  Fly  1358 IWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDE-LRVQFTTTLF 1421
            :||||||.|.|:|.|.:|::|||:|.||||.|.|||.|:|||:|:|||||:.:| :.|.||:||.
  Rat  1755 VWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLM 1819

  Fly  1422 ALIRENLSIKMR-APEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGF 1485
            ||||..|.||:. |..:..|.|.|||:.|:::|....:|.|:|||||.   ...:::|||:||..
  Rat  1820 ALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVPPH---KPDEMTVGKVYAAL 1881

  Fly  1486 LILESWRSTRF---------GQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRS 1541
            :|.:.::..:.         |.|....|:     :..||.:.:|.......|.....::. .:.:
  Rat  1882 MIFDFYKQNKTTRDQTHQAPGGLSQMGPV-----SLFHPLKATLEQTQPAVLRGARVFLR-QKSA 1940

  Fly  1542 PSLRHNGS---------------------PLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKET 1585
            .||.:.|:                     .|..:.:|..|||. ....:|....::..|:|...|
  Rat  1941 TSLSNGGAIQTQESGIKESLSWGTQRTQDVLYEARAPLERGHS-AEIPVGQPGALAVDVQMQNMT 2004

  Fly  1586 RHPRHGNSHP---------RYPRGSWSASTSPA-------RS--------------------PSP 1614
            .....|...|         ..||  .:|.|.||       ||                    |.|
  Rat  2005 LRGPDGEPQPGLESQGRAASMPR--LAAETQPAPNASPMKRSISTLAPRPHGTQLCNTVLDRPPP 2067

  Fly  1615 SRYGGH-------------LSRSKRTQLPYPTYGTTSL--------------CQRSRSPSPARLQ 1652
            |:...|             .|..|...|...|.|..|.              |:|.|.....|.|
  Rat  2068 SQVSHHHHHRCHRRRDKKQRSLEKGPSLSVDTEGAPSTAAGSGLPHGEGSTGCRRERKQERGRSQ 2132

  Fly  1653 EMR-------ERDRLGYGID-MGVTHVQHSYPTLASR---------------------------- 1681
            |.|       |:.|. |..| .|........|:|:|.
  Rat  2133 ERRQPSSSSSEKQRF-YSCDRFGSREPPQPKPSLSSHPISPTAALEPGPHPQGSGSVNGSPLMST 2196

  Fly  1682 -------RAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTH--------THHSTPHSVHSLPH 1731
                   |.| .|:||.||..|     :| :|.:...|:||.|        ...|.......|..
  Rat  2197 SGASTPGRGG-RRQLPQTPLTP-----RP-SITYKTANSSPVHFAEGQSGLPAFSPGRLSRGLSE 2254

  Fly  1732 HRDLL-RDPRDMYYSSRERERDRERLRDR-DRDRDRDRLHEYDLRYEYRDRERELYERERDRERE 1794
            |..|| ::|.....:|..|......|..| |.:.....|.|..|.:|           |......
  Rat  2255 HNALLQKEPLSQPLASGSRIGSDPYLGQRLDSEASAHNLPEDTLTFE-----------EAVATNS 2308

  Fly  1795 VERERLEYIAPLSFEQALAMGRTGRVLPSPVLNGFK----PKSGLNPRHS--DSDEEDWC 1848
            ....|..|::.|: .|:..:.|        |.||:.    ..:|:..|||  ..|::.||
  Rat  2309 GRSSRTSYVSSLT-SQSHPLRR--------VPNGYHCTLGLSTGVRARHSYHHPDQDHWC 2359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	188/286 (66%)
		Ion_trans	441..677	CDD:334124	180/236 (76%)
		Ion_trans	769..1050	CDD:334124	189/281 (67%)
		Ion_trans	1094..1345	CDD:334124	177/254 (70%)
		GPHH	1346..1416	CDD:339854	45/70 (64%)
		Ca_chan_IQ	1418..1492	CDD:337190	30/74 (41%)
Cacna1b	XP_006233631.1	Ion_trans	112..367	CDD:278921	174/268 (65%)
		Ion_trans	500..721	CDD:278921	171/220 (78%)
		Ion_trans	1186..1448	CDD:278921	179/263 (68%)
		Ion_trans	1511..1742	CDD:278921	166/236 (70%)
		GPHH	1750..1814	CDD:293510	39/63 (62%)
		Ca_chan_IQ	1816..1890	CDD:285917	30/76 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I760
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20184
Inparanoid	1	1.050	1808	1.000	Inparanoid score	I58
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	LDO	PTHR45628
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X841
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870