DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn5a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_038936827.1 Gene:Scn5a / 25665 RGDID:3637 Length:2020 Species:Rattus norvegicus


Alignment Length:2078 Identity:491/2078 - (23%)
Similarity:815/2078 - (39%) Gaps:607/2078 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::|:..:|:|:....|:....|...::.||:.|||.:|..:..|.         .:..|..|.
  Rat   111 ALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPW---------TKYVEYTFT 166

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||||.|..||..::||:.||.:||.|:|..:.|::..:|   ::..||..||||.|
  Rat   167 AIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLG---NVSALRTFRVLRAL 228

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS---------- 201
            |.:|.|..|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|..          
  Rat   229 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNG 293

  Fly   202 ---------------LEDP-NKLVKEGESETPCNTDNILEKATGSFVCNNTTS--------MCLE 242
                           |.|| |.|:|.|      .||.:|        |.|::.        .||:
  Rat   294 SVEADGLVWNSLDVYLNDPANYLLKNG------TTDVLL--------CGNSSDAGTCPEGYRCLK 344

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            ..|.|:.|.||||:..:|.|.:|:.:|.:.|..:...|..:.|..: .|:|:.:|.:|||:::||
  Rat   345 AGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIY-MIFFMLVIFLGSFYLVNL 408

  Fly   308 VLGVLS--------GEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTE 364
            :|.|::        ...|:..||.:..||.:::.:::.....:.|          |......:.|
  Rat   409 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRG----------VDTVSHSSLE 463

  Fly   365 EEKMHIMEARRRNAAKRKKLKS---------LGKSKSTD-------------------------- 394
            ...:..:....|.:.:||:|.|         |.||.|.|                          
  Rat   464 MSPLAPVTNHERKSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRG 528

  Fly   395 ------TEEEEAEEDYGDD-------------------------------------GYLKTRSK- 415
                  ..::.:|.|:.||                                     ||:....: 
  Rat   529 SIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVPWPLRHPSAQGQPGPGASAPGYVLNGKRN 593

  Fly   416 ----------------------------------------------------PQGSCT-GF---- 423
                                                                ||..|. ||    
  Rat   594 STVDCNGVVSLLGAGDAEATSPGSYLLRPMVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPG 658

  Fly   424 -----------------------------W-RAEKRFRFW--------IRHTVKTQWFYWFVI-- 448
                                         | |..:.:..|        |:..||      ||:  
  Rat   659 ARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVK------FVVMD 717

  Fly   449 --------VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSF 505
                    :.:.|||:.:|:|||...:...|.|.....:|.|:|.:||..|:.||.|..||:..:
  Rat   718 PFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGW 782

  Fly   506 NRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISL 570
            |.||.:::..|:.|:..|.:.    .|||||:.||||:||:.|.|.:|..|:..:.||:.::.:|
  Rat   783 NIFDSIIVILSLMELGLSRMG----NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 843

  Fly   571 LFLLFLFILIFALLGMQLFGGQFNL-------PGGTPETNFNTFPIALLTVFQILTGEDWNEVMY 628
            ..:|.:.:.|||::||||||..::.       .|..|..:...|..|.|.:|:||.|| |.|.|:
  Rat   844 TLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMW 907

  Fly   629 QGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEE------------ 681
            ..:...|.:    :..:.|:::::.||..:||:|||:.:.:. :|..|||.:|            
  Rat   908 DCMEVSGQS----LCLLVFLLVMVIGNLVVLNLFLALLLSSF-SADNLTAPDEDGEMNNLQLALA 967

  Fly   682 ----------------------------------------------------------------- 681
                                                                             
  Rat   968 RIQRGLRFVKRTTWDFCCGILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETRFE 1032

  Fly   682 ---------------------------EQVEEDKEKQL---QELEKEMEALQADGVH-------- 708
                                       |..|||:|..|   :|..|:.|:....|.|        
  Rat  1033 EDKRPGQGTPGDSEPVCVPIAVAESDTEDQEEDEENSLGTEEESSKQQESQVVSGGHEPYQEPRA 1097

  Fly   709 ----VENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNP------------ 757
                .|........|.|:...::|:|.|.:....|..|...||.......||.            
  Rat  1098 WSQVSETTSSEAGASTSQADWQQEQKTEPQAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGE 1162

  Fly   758 -------------IRR------------GAHW---------VVNLPYFDFFIMVVISMSSIALAA 788
                         :||            |..|         :|...:|:.||:.:|.:||.|||.
  Rat  1163 DVKDPEDCFTEGCVRRCPCCMVDTTQSPGKVWWRLRKTCYRIVEHSWFETFIIFMILLSSGALAF 1227

  Fly   789 EDPVRENSRRNKI-LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVS 852
            ||...|..:..|: |.|.|..||.||.:|||||.|..|.    ..|....|..:|.::|..:.||
  Rat  1228 EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIVDVSLVS 1288

  Fly   853 FGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFI 917
            ...:..|.:   .:..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..|
  Rat  1289 LVANTLGFA---EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 1350

  Fly   918 FSVIGVQLFNGKFFYCTDESK----------HTSAECQ-----GSYFKYEEDELLPKQELRVWKP 967
            ||::||.||.|||..|.::::          :..:||:     |..:               |..
  Rat  1351 FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELY---------------WTK 1400

  Fly   968 RAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF----P 1028
            ...::|||.|..|.|..|.|.:||..:    |.|..:.||..:..:.|.:::..:||:||    .
  Rat  1401 VKVNFDNVGAGYLALLQVATFKGWMDI----MYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGS 1461

  Fly  1029 FFFVNIFVALIIITFQEQGEAEL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVW 1089
            ||.:|:|:.:||..|.:| :.:|  ||..:.:.||...:.  .:|::..::.:|:..|.::..::
  Rat  1462 FFTLNLFIGVIIDNFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIF 1525

  Fly  1090 RIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNF 1154
            .||....|:..||.||..|.:.:|::..:|.......|..||:.|..:|:.|.::|:.... ..:
  Rat  1526 DIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALR-HYY 1589

  Fly  1155 FKDPWNIFDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTF 1214
            |.:.|||||.:.|:.|||     |.:...|.|.:: ...:||.|..|:::|:|....||.||:..
  Rat  1590 FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTL-FRVIRLARIGRILRLIRGAKGIRTLLFAL 1653

  Fly  1215 VQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEA 1279
            :.|..||..:.||:.::.|||:|.||..|..:|.   |..|....|||:|...::.||:..|...
  Rat  1654 MMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKW---EAGIDDMFNFQTFANSMLCLFQITTSAG 1715

  Fly  1280 WPNIMLACLK--GKACDDDAEKAPGE--YCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDY 1339
            |..::...|.  ...||.:...:.|.  .||| .:...:|.::|.....:::|:::|:|::||..
  Rat  1716 WDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSV 1780

  Fly  1340 LTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIR 1403
            .|.:|: .|.....|.|..||.::||.||..|.|..:.|....:..||....  ||:::   ||.
  Rat  1781 ATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAK--PNQIS---LIN 1840

  Fly  1404 MNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPS 1468
            |::|:....|:.....|||..:..|.    ...|||...:::.|...                  
  Rat  1841 MDLPMVSGDRIHCMDILFAFTKRVLG----ESGEMDALKIQMEEKFM------------------ 1883

  Fly  1469 DQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDA-SRHPSQESLTGADAGHLHPGH 1532
             ..|..|:|...|           :|...:....:....:|.| .||..|.|:..|         
  Rat  1884 -AANPSKISYEPI-----------TTTLRRKHEEVSATVIQRAFRRHLLQRSVKHA--------- 1927

  Fly  1533 SYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRY 1597
            |::...:.      .||.|:...:|.|.|               .:..|:       :||    :
  Rat  1928 SFLFRQQA------GGSGLSDEDAPEREG---------------LIAYMM-------NGN----F 1960

  Fly  1598 PRGSWSASTSPARSPS-PSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDR 1659
            .|.|...|:|...|.| |..|.. ::|:....||      ......|||...|......:|||
  Rat  1961 SRRSAPLSSSSISSTSFPPSYDS-VTRATSDNLP------VRASDYSRSEDLADFPPSPDRDR 2016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 93/328 (28%)
Ion_trans 441..677 CDD:334124 79/252 (31%)
Ion_trans 769..1050 CDD:334124 94/300 (31%)
Ion_trans 1094..1345 CDD:334124 76/260 (29%)
GPHH 1346..1416 CDD:339854 21/69 (30%)
Ca_chan_IQ 1418..1492 CDD:337190 12/73 (16%)
Scn5aXP_038936827.1 Ion_trans 131..424 CDD:395416 90/319 (28%)
Na_trans_cytopl 484..668 CDD:403218 17/183 (9%)
Ion_trans 717..930 CDD:395416 69/221 (31%)
Na_trans_assoc 956..1203 CDD:399489 27/246 (11%)
Ion_trans 1207..1482 CDD:395416 94/301 (31%)
Na_channel_gate 1474..1526 CDD:240441 10/52 (19%)
Ion_trans 1531..1785 CDD:395416 76/258 (29%)
GPHH 1797..1844 CDD:407139 17/51 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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