DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cch1

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_593894.1 Gene:cch1 / 2542812 PomBaseID:SPAC6F6.01 Length:1854 Species:Schizosaccharomyces pombe


Alignment Length:1936 Identity:399/1936 - (20%)
Similarity:709/1936 - (36%) Gaps:575/1936 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GPKKEENPPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKT 67
            ||.:....||          .:.|.....|.|...|.:...:.:.|:.:.|:|.:....| .||:
pombe   160 GPPRANETPG----------RNLPFSPILRQIYNHPLYNIFIFVVIVLHAVLLMIRSDDP-HDKS 213

  Fly    68 VLAQKLEKTEAYFLCI----FCVEASLKILALGLVL------------------HKHSYLRNIWN 110
                   :|..|.:.:    :.:|..|||...|.:.                  ...||||:.||
pombe   214 -------QTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWN 271

  Fly   111 IMDFFVVVTGFMTQYPQIGPEVD--LRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIG 173
            .:||..:|..:::   .||.:..  .|....|..||..:|::.....:.:|||:.::..||:|:.
pombe   272 RVDFVAIVALWIS---VIGKKQQGIFRLFSMIACLRLTRLLNITRKTETILKSLKESSTPLVQVV 333

  Fly   174 LLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETP----C--NTDNILEKA----- 227
            ....|..|:.||:|::|:..:|::.|..|.|      .|:...|    |  :.:|.:::|     
pombe   334 SFNAFFGVMIAILGVQFFKASLNRQCVWLGD------YGDQYLPTGQFCGGHWENGIKRAYLDKN 392

  Fly   228 -------TGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALG 285
                   ...|:|.. .|:| ...|.|.|...||||...::..:|..::..|:|.|:|...||  
pombe   393 GFPSNVNPRGFICAE-KSVC-RVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDA-- 453

  Fly   286 SAFNWIYFVP--LIVIGSFF----MLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNG 344
                 .|||.  |.:|.::|    :::||:.|::..|...:...:|::|      |:.:::    
pombe   454 -----EYFVSCLLFIISAYFLTLWLMSLVIAVVTSSFIDLQHSGKNQKE------QKSVDK---- 503

  Fly   345 YVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGY 409
                                    |::         |.||                         
pombe   504 ------------------------HLI---------RNKL------------------------- 510

  Fly   410 LKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTE--F 472
                      |       :::.|:..       |.|...::....|:|  .:.|.|.|....  .
pombe   511 ----------C-------EKYLFYSN-------FIWISFIVAQFVTLC--TQTYDQTSSTANRYL 549

  Fly   473 LYYAEFIFLGLFMSEMFIKMYALGP--RIYFESSFNRFDCVVISGSIFEVIWSEVKGG-SFG-LS 533
            ::||...|  |..:|:.::.:|..|  |::|....|..|.|:...::..::.|..|.. :|| ||
pombe   550 IFYACVDF--LLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTLLPSIRKNPVAFGWLS 612

  Fly   534 VLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLP-- 596
            :....|:.|...:..|...:..|   |.::.:.:::|:..|.:.:.|.:|..::||.   :||  
pombe   613 IFAIARIYRCILLIPYTRKIAKL---LFSNFKQLLNLMLFLVIVLFIASLCAVRLFQ---DLPND 671

  Fly   597 GGTPE--TNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLL 659
            |.:.:  .:|.|...:.|.::||||.|:|.:||:.............|...:|.:..||.|..:|
pombe   672 GDSDDDAISFATTYESFLYMYQILTSENWTDVMFAIQARLAHLHLSWIPGAFFTLWFLFSNNVVL 736

  Fly   660 NVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGK 724
            ::|:|:...|.|.::  :..:.||::....:.|:.......:|..:.:...||       ..|||
pombe   737 SMFIAVIQVNFAPSE--SDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNG-------SRKGK 792

  Fly   725 KKEEEKKE---EEEVTEG--------PK-PMLP-------------------------------- 745
            ..:|...|   |:.:.:|        || |:.|                                
pombe   793 TVDESHYEWLYEDNIIKGFLRVTNIPPKEPLKPSLDTSPELSKYSLAKLSNNFKRFVMRDDPFSQ 857

  Fly   746 --------------------------------------------YSSMF-ILSPTNPIRR----- 760
                                                        |:.:| ::.|:|.|||     
pombe   858 AYFKRVIGIRWEKDMNLKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPSNRIRRFCQRL 922

  Fly   761 ---GAH----------WVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILN--------Y 804
               |.:          ||..:  ...||...|..:.|......|:.|   |:.:||        :
pombe   923 VMPGVNERYGGVEPYQWVYRV--IQVFIYACILTAVIIECIATPIYE---RDHLLNDKQHAWFVW 982

  Fly   805 FDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVS-FGFDMSGSSAGQNLST 868
            .:.||..:||||..:||:..|..:.|.:|||..||.:|..|::...:: :....|.:...:....
pombe   983 TEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHALLSRAFRA 1047

  Fly   869 IKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC 933
            .|:|||||::...:|.:|:     ..|.:::....:.:..:|.......|::....:|.|..:.|
pombe  1048 FKALRVLRLINLTQTSQRM-----FHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSC 1107

  Fly   934 TDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRA------FHYDNVAAAMLTLFAVQTGEGWP 992
            .|::..::::|...|..       ......||.||.      :.:|....|:|.||.:.:.|||.
pombe  1108 NDDNVLSASQCVLEYAS-------TPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEIASIEGWV 1165

  Fly   993 QVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEID 1057
            .:::..|..|..:..|..|.....::|::::.:|...:.:.:|:|:||..:.|:..:.....|  
pombe  1166 DIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERTGSAFFTAE-- 1228

  Fly  1058 KNQKSCIDFTIGARPLERYMPKNRNTF---------------KYKVWRIVVSTPF-EYFIMMLIV 1106
              |::.::.   .|.::...|..|...               |:.:||...:..: .:.:.:|.:
pombe  1229 --QRAWLEL---RRKIKSMRPSKRPAIRPLGLRGLCYDFAVQKHGIWRRTFTGLYIVHLLFLLTI 1288

  Fly  1107 FNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSI 1171
            |....:...|.........|:.|         ::...:|:.|.....||...||:||::..|||:
pombe  1289 FYPCPIAYTYVRNSIFLILSICY---------TINICVKVYGLSFYYFFHSFWNMFDVVVTLGSL 1344

  Fly  1172 VDALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLW--------TFVQSFK----ALPYV 1224
                       :.|:..|..|. .|.:.||:.  |:.:|:.        .|.|..|    :||.:
pombe  1345 -----------TCNIAILAKFE-NRSLTLLQT--TLLVLVTVHLIPKFDNFDQLSKTVVASLPSI 1395

  Fly  1225 CLLIA---MLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIM-- 1284
            ..|||   :|:..:||...|:||..|||.....   :.||:|....::|||....||.|.::|  
pombe  1396 FSLIATWIVLYITFAIAFNQIFGLTKLGLNGGP---NKNFRSIRNALVLLFTMTFGEGWNDVMHD 1457

  Fly  1285 -----LACLKGKACDDDAEKAPGEYCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYL-TR 1342
                 ..|:.|    ||...:.   ||: ..||..|:::.....::.:|:|:.|:.|||.|: |:
pombe  1458 YTISYPNCVNG----DDFYNSD---CGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTK 1515

  Fly  1343 DSSILGAHHLD--EFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMN 1405
            .||.......|  :|...||.:||..||.|                      |.|.|.|.::.:.
pombe  1516 SSSFTNLQRNDFRQFKDSWAPFDPMVTGYI----------------------PKRNAVKFVLSLR 1558

  Fly  1406 MPLD-----DE-------LRVQFTTTLFAL-IREN----LSIKMRAPEE-MDQADME-------- 1444
            ...|     ||       .:||..|...:: :.||    ..|.:.|.:: :|..|:.        
pombe  1559 GVYDFRIYRDEHTLRSIISKVQSKTGQQSVPMLENPLMGSEINLEALDQIIDTIDVNVVKERRNV 1623

  Fly  1445 LRETITNIWPLQA-----KKMLNLLV-----------PPSDQLNKGKLSVGKIYAGFLILESWRS 1493
            |....|.|..|..     ..:|.|:|           |.||.:.:          .:::.|..:|
pombe  1624 LNSLCTEIMTLPGNVISFSNILMLVVLHKIVDHREAFPISDYIRR----------AYVLSELEKS 1678

  Fly  1494 TR----FGQLDSGM------------------PMLELQDAS----RHPSQESLTGADAGHLHPGH 1532
            .|    .|.:::.:                  |.:.|.:.|    ..|.||.|.           
pombe  1679 IRMEKLLGLVETSIIRKTFLQHMEEKKKALENPFILLSEVSEILPETPIQEVLR----------- 1732

  Fly  1533 SYMNGHRRSPSLRHNGSP-----LARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHG- 1591
                        :||..|     ..|:||.         .|..||...|.|..:........|. 
pombe  1733 ------------QHNADPEQLLMSTRTPSV---------SDRSFSIVESTVPTIASGEGDDNHSV 1776

  Fly  1592 NSHPRYPRGSWSASTSPARSPSPSRY---GGHL--SRSKRTQLPYPT-YGT 1636
            ..|.:.|     ....|.||||....   |.|.  |.:.||...... :||
pombe  1777 EDHLKVP-----TDNEPRRSPSLKEVLLRGSHSLHSNNDRTSFDIEAGFGT 1822

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 79/334 (24%)
Ion_trans 441..677 CDD:334124 60/245 (24%)
Ion_trans 769..1050 CDD:334124 67/295 (23%)
Ion_trans 1094..1345 CDD:334124 68/275 (25%)
GPHH 1346..1416 CDD:339854 17/83 (20%)
Ca_chan_IQ 1418..1492 CDD:337190 18/103 (17%)
cch1NP_593894.1 Ion_trans 201..485 CDD:278921 75/309 (24%)
Ion_trans 533..748 CDD:278921 56/224 (25%)
Ion_trans 968..1220 CDD:278921 61/263 (23%)
Ion_trans 1289..1517 CDD:278921 67/260 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 114 1.000 Domainoid score I1537
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45628
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.940

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