DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_038953406.1 Gene:Cacna1a / 25398 RGDID:2244 Length:2463 Species:Rattus norvegicus


Alignment Length:2501 Identity:1077/2501 - (43%)
Similarity:1332/2501 - (53%) Gaps:680/2501 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            |||:.:|||.:|||.:.|.|||||||.:|.||||||:|||||:|||..|||.::::|:.||.||:
  Rat   168 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFI 232

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|||.||.:||:|||...||.|||||.||:|||.||:||.:.   .:|.|.|||||||:||||||
  Rat   233 GIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILA---TVGTEFDLRTLRAVRVLRPL 294

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            ||||||||||||||||:|||.||||||||:.|||:||||||||||.|..|.||:. |..:.:  :
  Rat   295 KLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE-EGTDDI--Q 356

  Fly   212 GESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAI 276
            |||..||.|:   |.|.   .|.|.|. |...|||||:|||.||||.||:|||||||||||||.:
  Rat   357 GESPAPCGTE---EPAR---TCPNGTK-CQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDL 414

  Fly   277 LYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERE 341
            ||.:|||.|:.:||:||:|||:|||||||||||||||||||||||:||||:.|||||||||:|||
  Rat   415 LYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 479

  Fly   342 LNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGD 406
            ||||:|||.|||||||||:.|..|:: |..:...|.|       :|.|||:.....||||:...|
  Rat   480 LNGYMEWISKAEEVILAEDETDVEQR-HPFDGALRRA-------TLKKSKTDLLNPEEAEDQLAD 536

  Fly   407 DGYL-------KTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYG 464
            ...:       ..:|....:.|.|.:.|:|.||:||..||||.|||.|:.||.|||:|||:.||.
  Rat   537 IASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYN 601

  Fly   465 QPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GG 528
            ||.:|::||||||||||||||||||||||.||.|.||.||||.|||.||.||||||||:.:| |.
  Rat   602 QPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGT 666

  Fly   529 SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF 593
            |||:||||||||||||||||||:||||||:||||||:|||||||||||||::|||||||||||||
  Rat   667 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF 731

  Fly   594 NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658
            |...|||.|||:|||.|::||||||||||||||||.||.||||.|.||::|||||||.|||||||
  Rat   732 NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTL 796

  Fly   659 LNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEM------------------------ 699
            |||||||||||||||||||..|:|:.|...:|...:..||:                        
  Rat   797 LNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKP 861

  Fly   700 ---------------------EALQADGV------------------------------------ 707
                                 |||..|..                                    
  Rat   862 AKSVWEQRTSEMRKQNLLASREALYGDAAERWPTTYARPLRPDVKTHLDRPLVVDPQENRNNNTN 926

  Fly   708 ---------------------------------------------------------HV------ 709
                                                                     ||      
  Rat   927 KSRAPEALRQTARPRESARDPDARRAWPSSPERAPGREGPYGRESEPQQREHAPPREHVPWDADP 991

  Fly   710 ---------------------------------------------------------ENGDG--- 714
                                                                     |..||   
  Rat   992 ERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERK 1056

  Fly   715 ----------------------------------------------------------------- 714
                                                                             
  Rat  1057 RRHRHGPPAHDDRERRHRRRKESQGSGVPMSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLA 1121

  Fly   715 --------------AVAPSKSK---------------------------GK-------------- 724
                          .:.||.:|                           |.              
  Rat  1122 TGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSL 1186

  Fly   725 --------------------------------------------------KKEEEKKEEEEV--- 736
                                                              |||||||||||.   
  Rat  1187 IVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPG 1251

  Fly   737 TEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKI 801
            .:|||||.|||||||||.|||:||..|:::||.||:..|::||:||||||||||||:.|:.||.:
  Rat  1252 EDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNV 1316

  Fly   802 LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMS--GSSAGQ 864
            |.||||.||||||.||::|::|||::||.|:|.|:.|||:|.:||..|.|:|.|..|  |:|.|:
  Rat  1317 LRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTSSTRGNSKGK 1381

  Fly   865 NLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGK 929
            :::|||||||||||||||||||:|||||||||||||||||.||||||:||.|||:|:.||||.||
  Rat  1382 DINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK 1446

  Fly   930 FFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQV 994
            ||:||||||....:|:|.|..||::|:  |...|.||...||||||..|:||||.|.||||||||
  Rat  1447 FFHCTDESKEFERDCRGKYLLYEKNEV--KARDREWKKYDFHYDNVLWALLTLFTVSTGEGWPQV 1509

  Fly   995 LQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKN 1059
            |:||:.||:|::||...:|:||||||:|||:||||||||||||||||||||||:..:::..::||
  Rat  1510 LKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKN 1574

  Fly  1060 QKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYE 1124
            :::||||.|.|:||.|:||:|:.:|:|::|:.|||.||||.||.:|..||::||||::.....||
  Rat  1575 ERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYE 1639

  Fly  1125 KSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFG--SNSINVG 1187
            .:|:..|:.||.:||:|.|||::.||:.|:|:|.|||||.:||||||.|.|..|||  :|.||:.
  Rat  1640 NALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNPNNFINLS 1704

  Fly  1188 FLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL-GTV 1251
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.: |..
  Rat  1705 FLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGED 1769

  Fly  1252 ENS------ITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLA 1310
            |:|      ||.||||::|.|.:|||||.||||||.||||:||.||.||.::.....| ||:..|
  Rat  1770 EDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGIQKPE-CGNEFA 1833

  Fly  1311 YAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEM 1375
            |.|||||||.|||||||||||||||||:||||||||||.|||||:||:||||||.|.|::.|.:|
  Rat  1834 YFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYPDM 1898

  Fly  1376 YDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKM-RAPEEMD 1439
            |.||::|.||||.|.|||.|:|||:|:||::|:.|:..|.|.:||.||||..|.||: :...:..
  Rat  1899 YQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQ 1963

  Fly  1440 QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQL----- 1499
            |.|.|||:.:..|||..::|.|:|||.|....:   |:||||||..:|:|.:|.::..:|     
  Rat  1964 QMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTD---LTVGKIYAAMMIMEYYRQSKAKKLQAMRE 2025

  Fly  1500 -DSGMPMLELQDASRHPSQE---SLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRR 1560
             .:..|::..:.....|:||   |.....:..|.||...|          ...|.:..||     
  Rat  2026 EQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLM----------AQESSMKESP----- 2075

  Fly  1561 GHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSK 1625
                       |.......||.::|              |:|    ||.|.|.            
  Rat  2076 -----------SWVTQRAQEMFQKT--------------GTW----SPERGPP------------ 2099

  Fly  1626 RTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLP 1690
             ..:|             .|...::..||||....||      :..:|..|.....||.   .:|
  Rat  2100 -IDMP-------------NSQPNSQSVEMREMGTDGY------SDSEHYLPMEGQTRAA---SMP 2141

  Fly  1691 PTPSKPSTLQLKPTNINFPKL-NASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRE 1754
            ..|::....:.:|...|...: :.||                                 .:|...
  Rat  2142 RLPAENQRRRGRPRGNNLSTISDTSP---------------------------------MKRSAS 2173

  Fly  1755 RLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDR-EREVERERLEYI-APLSFEQALAMGRT 1817
            .|..:.|     ||.:|.|.....:..:..::|.||| .|..||....|. ........|:|...
  Rat  2174 VLGPKAR-----RLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQ 2233

  Fly  1818 GRVLPSPVLNGFKPKSGLNPRHSDSDEEDWCXQRLXLRSRNRKDQIWVXHQAICSSLSAPNLDHN 1882
            ...|||                .|.|::..       |.::||.:                    
  Rat  2234 SGDLPS----------------KDRDQDRG-------RPKDRKHR-------------------- 2255

  Fly  1883 FDTIRHSYQIPEHLQNLPYLCPPVHQHQHQHQTQTQNQRQHQDQHLYQRYGTNVSTPKLGTTISD 1947
                      |.|          .|.|.|.|......:|..|::            |..|.    
  Rat  2256 ----------PHH----------HHHHHHHHPPAPDRERYAQER------------PDTGR---- 2284

  Fly  1948 IKLAGVSLQELSPNRQPQSQQKQEQQLHQDGWLRWYRQSGPYGSPVMASLPETRATS-PHSDIEF 2011
                 ...:|...:|.|  .:.:|...|:.|      .|...|||.    |.|..|| |...   
  Rat  2285 -----ARAREQRWSRSP--SEGREHATHRQG------SSSVSGSPA----PSTSGTSTPRRG--- 2329

  Fly  2012 IRTMKRSETGTTAITPRTTKTEAMILSVPITITSPL----AIKKIYSDNDINYNTERGTDNDRVD 2072
                 |.:...|..|||           |:...||.    |.:::.........:.||.  .|..
  Rat  2330 -----RRQLPQTPCTPR-----------PLVSYSPAPRRPAARRMAGPPAPPGGSPRGC--RRAP 2376

  Fly  2073 DAPAHHYHQP-----ELTTPDLQDEPPLQQH 2098
            ..|||....|     :.|.||...|||...|
  Rat  2377 RWPAHAPEGPRPRGADYTEPDSPREPPGGAH 2407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 190/286 (66%)
Ion_trans 441..677 CDD:334124 190/236 (81%)
Ion_trans 769..1050 CDD:334124 188/282 (67%)
Ion_trans 1094..1345 CDD:334124 175/259 (68%)
GPHH 1346..1416 CDD:339854 42/69 (61%)
Ca_chan_IQ 1418..1492 CDD:337190 32/74 (43%)
Cacna1aXP_038953406.1 Ion_trans 188..462 CDD:395416 190/286 (66%)
Ion_trans 578..816 CDD:395416 191/237 (81%)
PHA03247 <879..1260 CDD:223021 29/380 (8%)
Ion_trans 1284..1564 CDD:395416 188/281 (67%)
Ion_trans 1609..1868 CDD:395416 175/259 (68%)
GPHH 1877..1930 CDD:407139 32/52 (62%)
Ca_chan_IQ 1941..2014 CDD:400901 32/75 (43%)
PHA03307 2040..>2444 CDD:223039 112/602 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 389 1.000 Domainoid score I760
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1808 1.000 Inparanoid score I58
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X841
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.970

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