DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and Tpcn1

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_665852.1	Gene:	Tpcn1 / 252972	MGIID:	2182472	Length:	817	Species:	Mus musculus

Alignment Length:	801	Identity:	155/801 - (19%)
Similarity:	299/801 - (37%)	Gaps:	242/801 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 AVLLTIIANC---VVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALG---LVLHK 101
            |:||.:::.|   .|..|:.|      |.:...|   |.:.|.:...|..:|:..||   .|.||
Mouse   117 ALLLLLLSLCESPAVPVLKLH------TYVHATL---ELFALMVVVFELCMKLRWLGFHTFVRHK 172

  Fly   102 HSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLV-----SGIPSLQVVLKS 161
            .:.::....::.|...:...:.|...:         |..|.||.:.||     .|:   :..|:.
Mouse   173 RTMVKTSVLVVQFIEAIVVLVRQTSHV---------RVTRALRCIFLVDCRYCGGV---RRNLRQ 225

  Fly   162 IIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEK 226
            |.:::.|.:.|.||:||.::||||:|...:|
Mouse   226 IFQSLPPFMDILLLLLFFMIIFAILGFYLFS---------------------------------- 256

  Fly   227 ATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAIL---YWTNDALGSAF 288
                                .|.....|..:..:::.:|..:|...:..::   |..|     .:
Mouse   257 --------------------TNPSDPYFSTLENSIVNLFVLLTTANFPDVMMPSYSRN-----PW 296

  Fly   289 NWIYFVPLIVIGSFFMLNLVLGVLSGEFAK-EREKVENRQEFLKLRRQQQLERELNGYVEWICKA 352
            :.::|:..:.|..:|::||:|.|:...|.. |:.|.::
Mouse   297 SCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKHKFKS--------------------------- 334

  Fly   353 EEVILAEERTTEEEKMHIMEARRRNAA----KRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTR 413
               :|..:||..:....::.::||.|.    :.:.|....|.:.:      |.|.:.....|...
Mouse   335 ---LLLHKRTAIQHAYGLLASQRRPAGISYRQFEGLMRFYKPRMS------ARERFLTFKALNQS 390

  Fly   414 SKPQGSCTGF----------WRAEKRFRFW--------------IRHTVKTQWFYWFVIVLVFLN 454
            :.|..|...|          |:|::..:.|              |...|.::.|.:|:.::|.:|
Mouse   391 NTPLLSLKDFYDIYEVAALQWKAKRNRQHWFDELPRTAFLIFKGINILVNSKAFQYFMYLVVAVN 455

  Fly   455 TVCVAVEHY----GQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISG 515
            .|.:.||.:    |  :|.::.:.::..:||.::..|:|:|:..|||..|..|.:|.||..|.:.
Mouse   456 GVWILVETFMLKGG--NFTSKHVPWSYLVFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAF 518

  Fly   516 SIFEVIWSEVKGGSF-GLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFIL 579
            :...::...:....| .:.|||.|:|||:||:.|.:   ||::.::...:..:.||...|..|..
Mouse   519 AFLGLLALTLNMEPFYFIVVLRPLQLLRLFKLKKRY---RNVLDTMFELLPRMASLGLTLLTFYY 580

  Fly   580 IFALLGMQLFGGQFNLPGGTPE-------------------------------TNFNTFPIALLT 613
            .||::||:.|.|:.     ||.                               .||:....:.:|
Mouse   581 SFAIVGMEFFNGRL-----TPNCCNTSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSFVT 640

  Fly   614 VFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFL--------------- 663
            :|::....:|..:| :|:.||......:.:..::||.::.  .|::..|:
Mouse   641 LFELTVVNNWYIIM-EGVTSQTSHWSRLYFMTFYIVTMVV--MTIIVAFILEAFVFRMNYSRKSQ 702

  Fly   664 ------AIAVDNLANAQELTAA-----EEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVA 717
                  .|.::...:.:||.|.     ||.....|..:.|..| .:||..|.:.:       ...
Mouse   703 DSEVDSGIVIEKEMSKEELMAVLELYREERGTSSDVTRLLDTL-SQMEKYQQNSM-------VFL 759

  Fly   718 PSKSKGKKKEEEKKEEEEVTE 738
            ..:|:.|.....|..:||:.|
Mouse   760 GRRSRTKSDLSLKMYQEEIQE 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	57/295 (19%)
		Ion_trans	441..677	CDD:334124	63/292 (22%)
		Ion_trans	769..1050	CDD:334124
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
Tpcn1	NP_665852.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..65
		Ion_trans	137..331	CDD:366146	50/273 (18%)
		Ion_trans	441..691	CDD:366146	61/262 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	785..817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810