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Protein Alignment cac and Scn2a

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_036779.2	Gene:	Scn2a / 24766	RGDID:	3632	Length:	2005	Species:	Rattus norvegicus

Alignment Length:	1914	Identity:	471/1914 - (24%)
Similarity:	810/1914 - (42%)	Gaps:	495/1914 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
            ::|:|||..|||||....|:....|...::.||:.|||.:.: .:.|...|.|        |..|
  Rat   107 SALYILTPFNPIRKLAIKILVHSLFNVLIMCTILTNCVFMTM-SNPPDWTKNV--------EYTF 162

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRP 145
            ..|:..|:.:||||.|..|...::||:.||.:||.|:...::|::..:|   ::..||..||||.
  Rat   163 TGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLG---NVSALRTFRVLRA 224

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDP----- 205
            ||.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|  |:.|
  Rat   225 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC--LQWPPDNST 287

  Fly   206 ----------NKLVKEG----ESETPCNTDN---------ILEKATGSFVCNNTTS--------M 239
                      |.|...|    .:....|.|.         .||....:.:|.|::.        :
  Rat   288 FEINITSFFNNSLDWNGTAFNRTVNMFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYI 352

  Fly   240 CLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFM 304
            |::....||.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||::
  Rat   353 CVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYL 416

  Fly   305 LNLVLGVLSGEFAK---------EREKVENRQEFLKLRRQQQ-----------LERELNGYVEWI 349
            :||:|.|::..:.:         |:::.|.:|...:|::||:           ..|:.:|.....
  Rat   417 INLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIG 481

  Fly   350 CKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLK----------SLGKSKSTDTEEEE----- 399
            ..:|...:|.:.:::.||      ..:|..|:||.|          ::.||.|.|:..::
  Rat   482 VFSESSSVASKLSSKSEK------ELKNRRKKKKQKEQAGEEEKEDAVRKSASEDSIRKKGFRFS 540

  Fly   400 ------------------------------------------------AEEDYGDDGY------- 409
                                                            :|.|:.||.:
  Rat   541 LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFKGRVKDIGSENDFADDEHSTFEDND 605

  Fly   410 --------------------------------LKTRSK--------------------------- 415
                                            |....|
  Rat   606 SRRDSLFVPHRHGERRPSNVSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQL 670

  Fly   416 -PQGSCTGFWRAEKR--------------------------------------------FRF--- 432
             |:|:.|.....::|                                            ::|
  Rat   671 LPEGTTTETEIRKRRSSSYHVSMDLLEDPSRQRAMSMASILTNTMEELEESRQKCPPCWYKFANM 735

  Fly   433 ---------W--IRHTVKTQWFYWFV----IVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLG 482
                     |  ::|.|.......||    .:.:.|||:.:|:|||......:..|.....:|.|
  Rat   736 CLIWDCCKPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTG 800

  Fly   483 LFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVT 547
            :|.:|||:|:.|:.|..||:..:|.||..::|.|:.|:..:.|:    ||||||:.||||:||:.
  Rat   801 IFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVE----GLSVLRSFRLLRVFKLA 861

  Fly   548 KYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-----------NLPGGTPE 601
            |.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:           .||.....
  Rat   862 KSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMH 926

  Fly   602 TNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIA 666
            ..|::|    |.||::|.|| |.|.|:..:...|   :.|..:::.:|:|: ||..:||:|||:.
  Rat   927 DFFHSF----LIVFRVLCGE-WIETMWDCMEVAG---QTMCLTVFMMVMVI-GNLVVLNLFLALL 982

  Fly   667 V-----DNLANAQE-----------------------------LTAAEEEQVEEDKEKQLQELEK 697
            :     ||||...:                             ..|...:|...|:.|.|::|..
  Rat   983 LSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNN 1047

  Fly   698 EMEA---------LQADGVHVENGDGAVA----------------------PS------------ 719
            :.::         :..|..::::|:|..:                      ||
  Rat  1048 KKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIALGES 1112

  Fly   720 --------KSKGKKKEEEKKEEEEVT--------------EGPKPML-PYSSMFILSPTN----- 756
                    :...:...||.||:...|              ||.:|.. |..|   |.|..
  Rat  1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEAEPEES---LEPEACFTED 1174

  Fly   757 ---------------------PIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK 800
                                 .:|:..:.:|...:|:.||:.:|.:||.|||.||...|..:..|
  Rat  1175 CVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIK 1239

  Fly   801 -ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQ 864
             :|.|.|..||.:|.:|||||.|..|..:    |....|..:|.::|..:.||...:..|.|
  Rat  1240 TMLEYADKVFTYIFILEMLLKWVAYGFQM----YFTNAWCWLDFLIVDVSLVSLTANALGYS--- 1297

  Fly   865 NLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGK 929
            .|..|||||.||.||||:.:.|...::.|.:.::.::.:::|:|:|.::|..|||::||.||.||
  Rat  1298 ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362

  Fly   930 FFYC----TDESKHTS-----AECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAV 985
            |::|    |.|....|     :|||.         |:...:...||....::|||....|:|..|
  Rat  1363 FYHCINYTTGEMFDVSVVNNYSECQA---------LIESNQTARWKNVKVNFDNVGLGYLSLLQV 1418

  Fly   986 QTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQ---- 1046
            .|.:||..::..::.:...:..|.....:.|.::::::.|...||.:|:|:.:||..|.:|
  Rat  1419 ATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483

  Fly  1047 -GEAELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFN 1108
             |    ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:..|....|:..||:||..|
  Rat  1484 GG----QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544

  Fly  1109 TLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVD 1173
            .:.:|::..:|.......|.:||:.|..:|:.|.|||:|... ..:|...|||||.:.|:.|||.
  Rat  1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDFVVVILSIVG 1608

  Fly  1174 ALWME-----FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1233
            ....|     |.|.:: ...:||.|..|:::|::....||.||:..:.|..||..:.||:.::.|
  Rat  1609 MFLAELIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1672

  Fly  1234 IYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAE 1298
            ||||.||..|..:|.   |..|....||::|...::.||:..|...|..::...|.....|.|.|
  Rat  1673 IYAIFGMSNFAYVKR---EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPE 1734

  Fly  1299 K-APGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFV 1356
            | .||..    ||: ::...:|||:|.....:::|:::|||::||...|.:|: .|.....:.|.
  Rat  1735 KDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFY 1799

  Fly  1357 RIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLF 1421
            .:|.::||:||..|.:.::.|....:||||....  ||::   :||.|::|:....|:.....||
  Rat  1800 EVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILF 1859

  Fly  1422 ALIRENLSIKMRAPEEMD--QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAG 1484
            |..:..|.    ...|||  :..||.|...:|...:..:.:...|....::::  .:.:.:.|..
  Rat  1860 AFTKRVLG----ESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVS--AIVIQRAYRR 1918

  Fly  1485 FLILESWRSTRF------GQLDSGMPMLE 1507
            :|:.:..:....      |:.|.|.|:.|
  Rat  1919 YLLKQKVKKVSSIYKKDKGKEDEGTPIKE 1947

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.