Protein Alignment cac and Scn11a

DIOPT Version :10

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: XP_017168851.1
• Gene: Scn11a / 24046
• MGIID: 1345149
• Length: 1782
• Species: Mus musculus
• Alignment Length: 1750
• Identity: 454/1750 - (25%)
• Similarity: 775/1750 - (44%)
• Gaps: 405/1750 - (23%)

  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY-F 80
            :||||...||||.:...|.....|...::.|:|.||:.:|       .:.:|.::.......| |
Mouse   125 ALFILGPFNPIRSFMIRISVHSVFSMFIICTVIINCMFMA-------NNSSVDSRPSSNIPEYVF 182

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEV-DLRTLRAIRVLR 144
            :.|:.:||.:||||.|.::.:.||||:.||.:||.|:.|.....:  :|.:| :|.|||..||||
Mouse   183 IGIYVLEAVIKILARGFIVDEFSYLRDPWNWLDFIVIGTAIAPCF--LGNKVNNLSTLRTFRVLR 245

  Fly   145 PLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLED---PN 206
            .||.:|.|..|:|::.::::::..|:.:.:|.||.:.|||::|.:.:.|.|.:.|  ::|   ||
Mouse   246 ALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILSQKC--IKDDCGPN 308

  Fly   207 K------LVKEGESETPCNTDNILEKAT---GSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAML 262
            .      .|||.:||......|.|.:.:   || .||.||.       .|:...|:||:.|::.|
Mouse   309 AFSNKDCFVKENDSEDFIMCGNWLGRRSCPDGS-TCNKTTF-------NPDYNYTNFDSFGWSFL 365

  Fly   263 TVFQCITMEGW---------TAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAK 318
            .:|:.:|.:.|         |:.:|:.          .:||.:|.:|||::|||.|.|::..:.:
Mouse   366 AMFRVMTQDSWEKLYRQILRTSGIYFV----------FFFVVVIFLGSFYLLNLTLAVVTMAYEE 420

  Fly   319 EREKV--ENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKR 381
            :...|  |...:....:..|||.||.        |...|.:..:||:    ::.::|...:..||
Mouse   421 QNRNVAAETEAKEKMFQEAQQLLREE--------KEALVAMGIDRTS----LNSLQASSFSPKKR 473

  Fly   382 KKLKS-------LGKSKSTDTEEEEAEEDYGDDGYLKTRSK------------------------ 415
            |...|       :..||:......::|:|...:..|..::|
Mouse   474 KFFGSKTRKSFFMRGSKTARASASDSEDDASKNPQLLEQTKRLSQNLPVELFDEHVDPLHRQRAL 538

  Fly   416 ---------------------PQG----------SCTGFWRAEKRFRFWIRHTVKTQWFYWFVI- 448
                                 |.|          .|:..|...|:    :..|:.|..|....|
Mouse   539 SAVSILTITMQEQEKSQEPCFPCGKNLASKYLVWECSPPWLCIKK----VLQTIMTDPFTELAIT 599

  Fly   449 VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVI 513
            :.:.:|||.:|:||:...:.|.:.|....::|.|:|::||.:|:.||.|..||...:|.||.:|.
Mouse   600 ICIIVNTVFLAMEHHNMDNSLKDILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNIFDSIVA 664

  Fly   514 SGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFI 578
            ..|:.:|::.::   |..||.|.:||:||:||:.|.|.:|..|:..:.:|:.::.:|..:|.:.:
Mouse   665 LVSLADVLFHKL---SKNLSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVV 726

  Fly   579 LIFALLGMQLFGGQFNLPGGT-PET----NFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQ 638
            .||:::||:|||.:||....| ||:    :...|..:.|.||:||.|| |.|.|::.:....|:.
Mouse   727 FIFSVVGMRLFGAKFNKTCSTSPESLRRWHMGDFYHSFLVVFRILCGE-WIENMWECMQEMEGSP 790

  Fly   639 KGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLAN------------------------------- 672
               :..|.|:::::.|...:||:|:|:.:::.:|
Mouse   791 ---LCVIVFVLIMVVGKLVVLNLFIALLLNSFSNEEKDGNPEGETRKTKVQLALDRFSRAFYFMA 852

  Fly   673 ---------------------AQELTAAEEEQV---------EEDKE---------KQLQELEKE 698
                                 |.|..|.|....         |.|.|         ..|..|.||
Mouse   853 RALQNFCCKRCRRQNSPKPNEATESFAGESRDTATLDTRSWKEYDSEMTLYTGQAGAPLAPLAKE 917

  Fly   699 MEALQADG--------VHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSS------- 748
            .:.::..|        ...|.......|.|:|.....::...|.||.....|.|...|
Mouse   918 EDDMECCGECDASPTSQPSEEAQACDLPLKTKRLPSPDDHGVEMEVFSEEDPNLTIQSARKKSDA 982

  Fly   749 ---------------------------------------MFILSPTNPIRRGAHWVV--NL---- 768
                                                   :|:...|  |::.:.||:  ||
Mouse   983 ASMLSECSTIDLNDIFRNLQKTVSPQKQPDRCFPKGLSCIFLCCKT--IKKKSPWVLWWNLRKTC 1045

  Fly   769 ------PYFDFFIMVVISMSSIALAAED---PVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDL 824
                  .:|:.||:.||.:||.||..||   |.|  .:..|:|...|..||.:|.:||:||.|..
Mouse  1046 YQIVKHSWFESFIIFVILLSSGALIFEDVNLPSR--PQVEKLLKCTDNIFTFIFLLEMILKWVAF 1108

  Fly   825 GVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPK 889
            |.    ..|....|..:|.::|:.:.:|.          .||..:||.|.||.||||:.:.:...
Mouse  1109 GF----RKYFTSAWCWLDFLIVVVSGLSL----------TNLPNLKSFRNLRALRPLRALSQFEG 1159

  Fly   890 LKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---TDESKHTSA-------EC 944
            :|.|.:.:::::..::|:|:|.::|..||.::||..|:|||..|   ||.:|:.:|       :|
Mouse  1160 MKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNVPNQSQC 1224

  Fly   945 QGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPI 1009
            ..|.:              .||....::|||..|.|.|..|.|.:||..:    |.|..:.||..
Mouse  1225 LVSNY--------------TWKVPNVNFDNVGNAYLALLQVATYKGWLDI----MNAAVDSRGKD 1271

  Fly  1010 QNFRIEMSIFYIVYFIVF----PFFFVNIFVALIIITF-QEQGEAELQDGEIDKNQKSCIDF--T 1067
            :....|.:::..:||:||    .||.:|:|:.:||..| |:|.:...||..:.:.||...:.  .
Mouse  1272 EQPAFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKISGQDIFMTEEQKKYYNAMKK 1336

  Fly  1068 IGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINM 1132
            :|.:..::.:|:..|..:..|:.:|.|..|:..|:.|||.|.:::|.:...|.:..:|....:|:
Mouse  1337 LGTKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVTNMIIMMAESEGQPNEVKKIFDILNI 1401

  Fly  1133 GFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNSINV------GFLRL 1191
            .|..:|:||.::|:.... :::|.:.||:||.:.|:.||:..|  ..|..:.||      ..:||
Mouse  1402 VFVVIFTVECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTL--VSGLENSNVFPPTLFRIVRL 1463

  Fly  1192 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSIT 1256
            .|..|:::|:|....||.||:..:.|..:|..:.||:.::.|||||.||..|..:|.|:..:.|.
Mouse  1464 ARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMNWFSKVKRGSGIDDIF 1528

  Fly  1257 RHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKA-CDDDAEKAPGEYCGS-TLAYAYFVSFIF 1319
               ||.:|...::.||:..|...|..::...|:.|| |:..::    |.|.. .:|..||||:|.
Mouse  1529 ---NFDTFSGSMLCLFQITTSAGWDALLNPMLESKASCNSSSQ----ESCQQPQIAIVYFVSYII 1586

  Fly  1320 FCSFLMLNLFVAVIMDNFDYLTRDS-SILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMD 1383
            ....:::|:::|||::||:..|.:| ..||....:.|..||.::||.||..|.|:.:.|....:.
Mouse  1587 ISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEIWEKFDPEATQFIQYSSLSDFADALP 1651

  Fly  1384 PPLGFGNKCPNRLAYKKLIRMNMP--LDDELRVQ-----FTT----------TLFALIREN---- 1427
            .||....  |||..:   :.|::|  :.|.|...     |||          |:.|::.|.
Mouse  1652 EPLRVAK--PNRFQF---LMMDLPMVMGDRLHCMDVLFAFTTRVLGNSSGLDTMKAMMEEKFMEA 1711

  Fly  1428 ----------LSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLS 1477
                      ::...|..||      |....|...:....:||:.|.:       ||:.|
Mouse  1712 NPFKKLYEPIVTTTKRKEEE------ECAAVIQRAYRRHMEKMIKLKL-------KGRSS 1758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	93/311 (30%)
		Ion_trans	441..677	CDD:459842	78/293 (27%)
		Ion_trans	769..1050	CDD:459842	92/298 (31%)
		Ion_trans	1094..1345	CDD:459842	80/259 (31%)
		GPHH	1354..1407	CDD:465306	16/52 (31%)
		Ca_chan_IQ	1417..1496	CDD:462591	15/84 (18%)
		AF-4	<1512..>1704	CDD:461550
Scn11a	XP_017168851.1	Ion_trans	145..424	CDD:459842	92/307 (30%)
		Ion_trans	591..825	CDD:459842	76/240 (32%)
		Na_trans_assoc	829..1047	CDD:461936	29/219 (13%)
		Ion_trans	1051..1315	CDD:459842	92/297 (31%)
		Na_channel_gate	1307..1359	CDD:240441	11/51 (22%)
		Ion_trans	1363..1612	CDD:459842	79/258 (31%)
		GPHH	1623..1670	CDD:465306	16/51 (31%)