DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn11a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_017168851.1 Gene:Scn11a / 24046 MGIID:1345149 Length:1782 Species:Mus musculus


Alignment Length:1750 Identity:454/1750 - (25%)
Similarity:775/1750 - (44%) Gaps:405/1750 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY-F 80
            :||||...||||.:...|.....|...::.|:|.||:.:|       .:.:|.::.......| |
Mouse   125 ALFILGPFNPIRSFMIRISVHSVFSMFIICTVIINCMFMA-------NNSSVDSRPSSNIPEYVF 182

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEV-DLRTLRAIRVLR 144
            :.|:.:||.:||||.|.::.:.||||:.||.:||.|:.|.....:  :|.:| :|.|||..||||
Mouse   183 IGIYVLEAVIKILARGFIVDEFSYLRDPWNWLDFIVIGTAIAPCF--LGNKVNNLSTLRTFRVLR 245

  Fly   145 PLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLED---PN 206
            .||.:|.|..|:|::.::::::..|:.:.:|.||.:.|||::|.:.:.|.|.:.|  ::|   ||
Mouse   246 ALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILSQKC--IKDDCGPN 308

  Fly   207 K------LVKEGESETPCNTDNILEKAT---GSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAML 262
            .      .|||.:||......|.|.:.:   || .||.||.       .|:...|:||:.|::.|
Mouse   309 AFSNKDCFVKENDSEDFIMCGNWLGRRSCPDGS-TCNKTTF-------NPDYNYTNFDSFGWSFL 365

  Fly   263 TVFQCITMEGW---------TAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAK 318
            .:|:.:|.:.|         |:.:|:.          .:||.:|.:|||::|||.|.|::..:.:
Mouse   366 AMFRVMTQDSWEKLYRQILRTSGIYFV----------FFFVVVIFLGSFYLLNLTLAVVTMAYEE 420

  Fly   319 EREKV--ENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKR 381
            :...|  |...:....:..|||.||.        |...|.:..:||:    ::.::|...:..||
Mouse   421 QNRNVAAETEAKEKMFQEAQQLLREE--------KEALVAMGIDRTS----LNSLQASSFSPKKR 473

  Fly   382 KKLKS-------LGKSKSTDTEEEEAEEDYGDDGYLKTRSK------------------------ 415
            |...|       :..||:......::|:|...:..|..::|                        
Mouse   474 KFFGSKTRKSFFMRGSKTARASASDSEDDASKNPQLLEQTKRLSQNLPVELFDEHVDPLHRQRAL 538

  Fly   416 ---------------------PQG----------SCTGFWRAEKRFRFWIRHTVKTQWFYWFVI- 448
                                 |.|          .|:..|...|:    :..|:.|..|....| 
Mouse   539 SAVSILTITMQEQEKSQEPCFPCGKNLASKYLVWECSPPWLCIKK----VLQTIMTDPFTELAIT 599

  Fly   449 VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVI 513
            :.:.:|||.:|:||:...:.|.:.|....::|.|:|::||.:|:.||.|..||...:|.||.:|.
Mouse   600 ICIIVNTVFLAMEHHNMDNSLKDILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNIFDSIVA 664

  Fly   514 SGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFI 578
            ..|:.:|::.::   |..||.|.:||:||:||:.|.|.:|..|:..:.:|:.::.:|..:|.:.:
Mouse   665 LVSLADVLFHKL---SKNLSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVV 726

  Fly   579 LIFALLGMQLFGGQFNLPGGT-PET----NFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQ 638
            .||:::||:|||.:||....| ||:    :...|..:.|.||:||.|| |.|.|::.:....|:.
Mouse   727 FIFSVVGMRLFGAKFNKTCSTSPESLRRWHMGDFYHSFLVVFRILCGE-WIENMWECMQEMEGSP 790

  Fly   639 KGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLAN------------------------------- 672
               :..|.|:::::.|...:||:|:|:.:::.:|                               
Mouse   791 ---LCVIVFVLIMVVGKLVVLNLFIALLLNSFSNEEKDGNPEGETRKTKVQLALDRFSRAFYFMA 852

  Fly   673 ---------------------AQELTAAEEEQV---------EEDKE---------KQLQELEKE 698
                                 |.|..|.|....         |.|.|         ..|..|.||
Mouse   853 RALQNFCCKRCRRQNSPKPNEATESFAGESRDTATLDTRSWKEYDSEMTLYTGQAGAPLAPLAKE 917

  Fly   699 MEALQADG--------VHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSS------- 748
            .:.::..|        ...|.......|.|:|.....::...|.||.....|.|...|       
Mouse   918 EDDMECCGECDASPTSQPSEEAQACDLPLKTKRLPSPDDHGVEMEVFSEEDPNLTIQSARKKSDA 982

  Fly   749 ---------------------------------------MFILSPTNPIRRGAHWVV--NL---- 768
                                                   :|:...|  |::.:.||:  ||    
Mouse   983 ASMLSECSTIDLNDIFRNLQKTVSPQKQPDRCFPKGLSCIFLCCKT--IKKKSPWVLWWNLRKTC 1045

  Fly   769 ------PYFDFFIMVVISMSSIALAAED---PVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDL 824
                  .:|:.||:.||.:||.||..||   |.|  .:..|:|...|..||.:|.:||:||.|..
Mouse  1046 YQIVKHSWFESFIIFVILLSSGALIFEDVNLPSR--PQVEKLLKCTDNIFTFIFLLEMILKWVAF 1108

  Fly   825 GVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPK 889
            |.    ..|....|..:|.::|:.:.:|.          .||..:||.|.||.||||:.:.:...
Mouse  1109 GF----RKYFTSAWCWLDFLIVVVSGLSL----------TNLPNLKSFRNLRALRPLRALSQFEG 1159

  Fly   890 LKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---TDESKHTSA-------EC 944
            :|.|.:.:::::..::|:|:|.::|..||.::||..|:|||..|   ||.:|:.:|       :|
Mouse  1160 MKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNVPNQSQC 1224

  Fly   945 QGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPI 1009
            ..|.:              .||....::|||..|.|.|..|.|.:||..:    |.|..:.||..
Mouse  1225 LVSNY--------------TWKVPNVNFDNVGNAYLALLQVATYKGWLDI----MNAAVDSRGKD 1271

  Fly  1010 QNFRIEMSIFYIVYFIVF----PFFFVNIFVALIIITF-QEQGEAELQDGEIDKNQKSCIDF--T 1067
            :....|.:::..:||:||    .||.:|:|:.:||..| |:|.:...||..:.:.||...:.  .
Mouse  1272 EQPAFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKISGQDIFMTEEQKKYYNAMKK 1336

  Fly  1068 IGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINM 1132
            :|.:..::.:|:..|..:..|:.:|.|..|:..|:.|||.|.:::|.:...|.:..:|....:|:
Mouse  1337 LGTKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVTNMIIMMAESEGQPNEVKKIFDILNI 1401

  Fly  1133 GFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNSINV------GFLRL 1191
            .|..:|:||.::|:.... :::|.:.||:||.:.|:.||:..|  ..|..:.||      ..:||
Mouse  1402 VFVVIFTVECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTL--VSGLENSNVFPPTLFRIVRL 1463

  Fly  1192 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSIT 1256
            .|..|:::|:|....||.||:..:.|..:|..:.||:.::.|||||.||..|..:|.|:..:.|.
Mouse  1464 ARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMNWFSKVKRGSGIDDIF 1528

  Fly  1257 RHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKA-CDDDAEKAPGEYCGS-TLAYAYFVSFIF 1319
               ||.:|...::.||:..|...|..::...|:.|| |:..::    |.|.. .:|..||||:|.
Mouse  1529 ---NFDTFSGSMLCLFQITTSAGWDALLNPMLESKASCNSSSQ----ESCQQPQIAIVYFVSYII 1586

  Fly  1320 FCSFLMLNLFVAVIMDNFDYLTRDS-SILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMD 1383
            ....:::|:::|||::||:..|.:| ..||....:.|..||.::||.||..|.|:.:.|....:.
Mouse  1587 ISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEIWEKFDPEATQFIQYSSLSDFADALP 1651

  Fly  1384 PPLGFGNKCPNRLAYKKLIRMNMP--LDDELRVQ-----FTT----------TLFALIREN---- 1427
            .||....  |||..:   :.|::|  :.|.|...     |||          |:.|::.|.    
Mouse  1652 EPLRVAK--PNRFQF---LMMDLPMVMGDRLHCMDVLFAFTTRVLGNSSGLDTMKAMMEEKFMEA 1711

  Fly  1428 ----------LSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLS 1477
                      ::...|..||      |....|...:....:||:.|.:       ||:.|
Mouse  1712 NPFKKLYEPIVTTTKRKEEE------ECAAVIQRAYRRHMEKMIKLKL-------KGRSS 1758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 93/311 (30%)
Ion_trans 441..677 CDD:334124 78/293 (27%)
Ion_trans 769..1050 CDD:334124 92/298 (31%)
Ion_trans 1094..1345 CDD:334124 80/259 (31%)
GPHH 1346..1416 CDD:339854 21/76 (28%)
Ca_chan_IQ 1418..1492 CDD:337190 14/83 (17%)
Scn11aXP_017168851.1 Ion_trans 145..424 CDD:366146 92/307 (30%)
Ion_trans 591..825 CDD:366146 76/240 (32%)
Na_trans_assoc 830..1047 CDD:368948 29/218 (13%)
Ion_trans 1051..1315 CDD:366146 92/297 (31%)
Na_channel_gate 1307..1359 CDD:240441 11/51 (22%)
Ion_trans 1363..1612 CDD:366146 79/258 (31%)
GPHH 1623..1670 CDD:374878 16/51 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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