DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1i

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_006521012.1 Gene:Cacna1i / 239556 MGIID:2178051 Length:2226 Species:Mus musculus


Alignment Length:2270 Identity:554/2270 - (24%)
Similarity:902/2270 - (39%) Gaps:659/2270 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PKKEENP----PGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGG 64
            |....||    |...|.:.|.|.:....|.:...::..|.||...:|.|:.|||.|.:  :.|..
Mouse    39 PLDGTNPDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCD 101

  Fly    65 DKTVLAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYP 126
            |...|:.:   |:..:.:....|.:|..||::||| :..|..||.:.||.:|||:|:.| |.:|.
Mouse   102 DMECLSDRCKILQVFDDFIFIFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAG-MVEYS 164

  Fly   127 QIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFY 191
            .....::|..:|.:|||||||.::.:||:::::..::..:..|..:.||..|...||.|||::.:
Mouse   165 LDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 229

  Fly   192 SGALHKTCY-----------------------------SLEDPNKL--------VKEGESETPCN 219
            :|.|...|:                             ||...|.:        :||...|...:
Mouse   230 AGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 294

  Fly   220 TDNILEKATG------SFVC---NNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTA 275
            .|::.:...|      |.:|   |...::|......|:.|..:|||||:|.:.:||.||:|||..
Mouse   295 KDDMYDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVE 359

  Fly   276 ILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KERE---KVENRQEFLKLRRQ 335
            |:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:  |:||   .:|.||.:|.....
Mouse   360 IMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTV 423

  Fly   336 QQLERELNGYVE---WIC----KAE---------------------------------------- 353
            .......:.|.|   ::|    ||:                                        
Mouse   424 ASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQATGPGTPAPAKPGPHAKEPSHCKLC 488

  Fly   354 -----------------EVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEE--- 398
                             ..|||.:.::.....|  ||.||.:       .||   |||:.:|   
Mouse   489 PRHSPLDTTPHTLVQPISAILASDPSSCPRCQH--EAGRRPS-------GLG---STDSGQEGSG 541

  Fly   399 -----EAE---------EDYGDDGYLKTRSKPQGS---CTGFWRAEKRFRFWIRHTVKTQWFYWF 446
                 |||         ||....|..|...:..|:   |...|| |.|.:  :|..|.:::|...
Mouse   542 SGGSAEAEANGDGPQSSEDGVSSGLGKEEEQEDGAARLCGDVWR-ETRAK--LRGIVDSKYFNRG 603

  Fly   447 VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCV 511
            :::.:.:|||.:.:||:.||..||..|.....:|..:|..||.:|:.|.|...|..:.:|.||.:
Mouse   604 IMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSI 668

  Fly   512 VISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFL 576
            ::..||:|:: .:..|   ||||||..||||:.|:.::..:||..::.|:.:|.::.:...||.|
Mouse   669 IVIISIWEIV-GQADG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLML 729

  Fly   577 FILIFALLGMQLFGGQFNLPGGTPET-----NFNTFPIALLTVFQILTGEDWNEVMYQGIISQGG 636
            ||.||::|||.:||.:|:|...|.:|     ||::...|::|||||||.||||.|:|.|:     
Mouse   730 FIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM----- 789

  Fly   637 AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEME- 700
            |......|:||:.|:.||||.|.|:.:||.|:..  ..|..|......|:.....|:||:|..| 
Mouse   790 ASTTPWASLYFVALMTFGNYVLFNLLVAILVEGF--QAEGDANRSYSDEDQSSSNLEELDKLPEG 852

  Fly   701 ------------------------------------------ALQADGVHV-------------- 709
                                                      :||.|.|.|              
Mouse   853 LDSSRDLKLCPIPMTPNGHLDPSLPLGGHLGPAGAMGAAPRLSLQPDPVLVALESRKSSVMSLGR 917

  Fly   710 --------------------------------------------------ENGDGAV-------- 716
                                                              |.|...|        
Mouse   918 MSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHESLLSGERGGSCVRACEGARE 982

  Fly   717 -APSK------------------------------------------------------------ 720
             ||.:                                                            
Mouse   983 DAPPRAAPLHAPHTHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLAELVPVVGAHSRAAWRAAGQA 1047

  Fly   721 ------------------SKGKKKEEEKKEEEEV-----------TEGPKP----MLPYSSMFIL 752
                              :|...:.:..::|||:           .:..||    :....|:::.
Mouse  1048 PGHEDCNGRMPNIAKDVFTKMDDRRDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLF 1112

  Fly   753 SPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNKILNYFDYAFTGVFTIE 816
            ||.|..|.....::....||:.::..|.::.|.:|.|.| :...|.....|...:|.||.:|..|
Mouse  1113 SPENKFRILCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGE 1177

  Fly   817 MLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPL 881
            |.||:|.||:.....:|||..||::|..:|..:.:.....::.:...:.|..::.||:||.||||
Mouse  1178 MTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPL 1242

  Fly   882 KTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC--TDESKHTS-AE 943
            :.|.|.|.||.|.:.:::|||.:.||:::...|..||.::|||||.|||::|  .|....|: ::
Mouse  1243 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSD 1307

  Fly   944 CQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGP 1008
            |..:.::              |....:::||:..|:::||.:.:.:||..::.:.:.|...|:.|
Mouse  1308 CVAANYR--------------WVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQP 1358

  Fly  1009 IQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITF---QEQGEAELQDGEIDKNQKSCIDFTIGA 1070
            :.|....|.:::|.:.::..||.:|:||.:::..|   ::..|||    |..:.::..:      
Mouse  1359 VTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE----EARRREEKRL------ 1413

  Fly  1071 RPLERYMPKNRNTFKYKVW---RIVV-----STPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSL 1127
            |.||:...|.:....|..:   |:::     |...:.||..:|..|.:.:.::::||....|.:|
Mouse  1414 RRLEKKRRKAQRLPYYATYCPTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETAL 1478

  Fly  1128 KYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS---IN---V 1186
            ||.|..||.:|.:|.|||::.||::.||||.||..||..||.|::.....|...|:   ||   :
Mouse  1479 KYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTII 1543

  Fly  1187 GFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTV 1251
            ..:|:.|.||::|||:....:|.||.|.||:...:..:.||..:||||||.:|:::||.:.... 
Mouse  1544 RIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCND- 1607

  Fly  1252 EN---SITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYA- 1312
            ||   .::||..|::|....:.||:.:||:.|..||...|:.  |..|...     |.|:|.:. 
Mouse  1608 ENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRD--CTHDERS-----CLSSLQFVS 1665

  Fly  1313 --YFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEM 1375
              |||||:....|:::|:.|||:|.:.|...::                |:.|.....:|.    
Mouse  1666 PLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE----------------AQEDAEMDAEIE---- 1710

  Fly  1376 YDMLKNMDP---------PLGFGNKCPN-----------------------------RLAYKK-- 1400
            .:|...:.|         |......||.                             |..|..  
Mouse  1711 LEMAHGLGPGPGPCPCPCPCPCPCPCPGPRMPTSSPGAPGRGSGGAGVGGDTESHLCRHCYSPAQ 1775

  Fly  1401 ----LIRMNMPLDDELRVQFTTTLFALIRENLSIKM----RAPEEMDQADMELRETITNIWPLQA 1457
                |..:::.:.|.|..:.|      |.:|||..:    .:|...|:...:.:|     .|: |
Mouse  1776 ETLWLDSVSLIIKDSLEGELT------IIDNLSGSIFHHYSSPAGCDKCHHDKQE-----GPV-A 1828

  Fly  1458 KKMLNLLVPPSDQLNKG-------KLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHP 1515
            ::....|..||.::.:|       :|:..:.::    |.|.||:.....|.    |.|:|.:..|
Mouse  1829 QRSRPRLPHPSPRVTRGHHLPPQVQLAETEAFS----LNSDRSSSVLLGDD----LSLEDPTACP 1885

  Fly  1516 S--QESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPS---------PRRRGHQYIHHDI 1569
            .  :||     .|.|.|......|..........|.|::..|.         |......::.|:.
Mouse  1886 QGPKES-----KGELEPPEPMQAGDLDECFFPFAGEPVSAGPESLLCEMGAIPFNPVQSWLKHES 1945

  Fly  1570 G------FS-DTVSNVVEMVKETRHP---------RHGNSHPRYPR----GSWSASTSP------ 1608
            .      || |..|.:::|..|..||         ..|.|....|:    |||::..||      
Mouse  1946 NQAPPSPFSPDGSSPLLQMPAEFFHPAVSASQKGQEPGMSSGTLPKIALQGSWASLRSPSVNCTL 2010

  Fly  1609 ---------ARSPSPSRYGGH----------LSRSKR------TQLPYPTYGTTSLCQRSRSPSP 1648
                     :...|||...|.          ||.|.|      .|:|.|        :.|.||:.
Mouse  2011 LRQATVSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPVQVPGP--------RASLSPAT 2067

  Fly  1649 ARLQEMRERDRL--------------GYGIDMGVTHVQHSYPTLASRRAGIGRR----------- 1688
            .|...:|.|...              |.....|.|:.....|:....|.|.|..           
Mouse  2068 RRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTYHDSMDPSDEEGRGGAGGGGAGSEHSETLS 2132

  Fly  1689 ---------LPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDP 1739
                     ||||        |.|..:. |....|.|.:..:.|....:....|.|.|.|
Mouse  2133 SLSLTSLFCLPPT--------LPPPGLT-PARKFSSTSSLAAGPGRPGATVSVRGLARSP 2183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 106/340 (31%)
Ion_trans 441..677 CDD:334124 89/240 (37%)
Ion_trans 769..1050 CDD:334124 83/287 (29%)
Ion_trans 1094..1345 CDD:334124 91/262 (35%)
GPHH 1346..1416 CDD:339854 13/113 (12%)
Ca_chan_IQ 1418..1492 CDD:337190 16/84 (19%)
Cacna1iXP_006521012.1 Ion_trans 76..407 CDD:366146 105/335 (31%)
Ion_trans 597..824 CDD:366146 88/237 (37%)
Ion_trans 1128..1400 CDD:366146 82/285 (29%)
Ion_trans 1445..1700 CDD:366146 91/278 (33%)
PHA03307 1867..>2226 CDD:223039 71/343 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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