DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and Tpcn2

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_006508676.1	Gene:	Tpcn2 / 233979	MGIID:	2385297	Length:	769	Species:	Mus musculus

Alignment Length:	743	Identity:	160/743 - (21%)
Similarity:	295/743 - (39%)	Gaps:	197/743 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 QWFY------------WFVIVLVFLN-----TVCVAVEHYGQ----PSFLTEFLYYAEFIFLGLF 484
            :|:|            :.:::|.|:.     |....|.:..|    |..|||.:   |...|..|
Mouse    59 RWYYSNVCQRVLGFIIFLILILAFVEVPSSFTKTADVRYRSQPWQPPCGLTETI---EAFCLLAF 120

  Fly   485 MSEMFIKMYALGPR---------IYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSV-----L 535
            :.::.:|.|.:|..         .||         :|:..|:.:.|.|        ||:     |
Mouse   121 LVDLSVKGYLVGQAQLQQNLWLLAYF---------MVLVVSVVDWIVS--------LSLACEEPL 168

  Fly   536 RALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLF--GGQFNLPGG 598
            |..||||.|.:.:..|.::..:..:..|:..:.|:..||.:.:.:|.::||.||  |.:......
Mouse   169 RMRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTIIGMLLFTIGEKDEAQDQ 233

  Fly   599 TPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFL 663
            .....|...|.||.::..:||..:..:||... .:|..|     ::::|||..|.|:..|:|:..
Mouse   234 ERLAYFRNLPEALTSLLVLLTTSNNPDVMIPA-YTQNRA-----FALFFIVFTLIGSLFLMNLLT 292

  Fly   664 AI--------------------------AVDNLANA---------------------QELTAAEE 681
            ||                          |.:.||:.                     :||.....
Mouse   293 AIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLASRAGPAGTTPEFPCWPAPDWIFHRELYGLPS 357

  Fly   682 EQ-----------------VEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEE 729
            .|                 |..:.|..|..|:|    .|.:..|.:.....|...:.:....:|.
Mouse   358 PQCFHYPVCSFLLAHLCLRVGVNPETFLPVLQK----TQLNKTHKQAIMQKVQSYEGRPMLADEF 418

  Fly   730 KKEEEEVTEG---PKPMLP-YSSMFILSPTNPIRRGAHWVVNLPYFDFF--IMVVISMSSIA--L 786
            :|..:||.:|   .:|:.| |.|.|:        :.|.::.:..|||:.  ::.:.::.||.  |
Mouse   419 QKLFDEVDKGLAKERPLKPQYQSPFL--------QTAQFIFSHHYFDYLGNLVALGNLLSICVFL 475

  Fly   787 AAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVV----- 846
            ..:..:....|.:.:|...||.|...:.:|:|.|:..||:   || ||....|:.|.::.
Mouse   476 VLDSDLLPGERDDFVLGILDYIFILYYLLELLFKVFALGL---PG-YLSYHSNVFDGLLTIILLV 536

  Fly   847 --ICAAVSFGFDMSGSSAGQ--NLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNI 907
              ||....:....||....|  .||.....|::..|...:.::.:|.:|.:.: |.|::..::..
Mouse   537 SEICTLAVYRLPHSGWKPEQYGPLSLWDMTRLMNTLIVFRFLRIIPNIKPMAE-VANTILGLIPN 600

  Fly   908 LIVY----ILFQFIFSVIGVQLFNGKFFYCTDES---KHTSAECQGSYFKYEEDELLPKQELRVW 965
            |..:    ::..::|::||:.||.|......:.|   .:.||.| ||:           ::|..|
Mouse   601 LRAFGGILVVAYYVFAMIGINLFRGVIVPPGNSSLVPDNNSAVC-GSF-----------EQLGYW 653

  Fly   966 KPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFF 1030
             |.  ::|:.|||::||:.|.....|..:|:    |.....||..      .::::::::|....
Mouse   654 -PN--NFDDFAAALITLWNVMVVNNWQVILE----AYKRYAGPWS------MVYFVLWWLVSSVI 705

  Fly  1031 FVNIFVALIIITF----QEQGEAELQDG 1054
            ::|:|:||::..|    ..||..:|..|
Mouse   706 WINLFLALLLENFLHRWDPQGHKQLLVG 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124	66/319 (21%)
		Ion_trans	769..1050	CDD:334124	71/304 (23%)
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
Tpcn2	XP_006508676.1	Ion_trans	68..299	CDD:366146	60/256 (23%)
Tpcn2	XP_006508676.1	Ion_trans	453..718	CDD:366146	68/294 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810