DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and Catsper1

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_647462.1	Gene:	Catsper1 / 225865	MGIID:	2179947	Length:	686	Species:	Mus musculus

Alignment Length:	358	Identity:	87/358 - (24%)
Similarity:	161/358 - (44%)	Gaps:	56/358 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 GKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFR-------FW--IRHTV----- 438
            ||::|.::..|.|....|:| :::.|.|.|       ||.|:..       .|  |.|.:
Mouse   286 GKAQSRESLRESASLSEGED-HVQKRKKAQ-------RAHKKAHTGNIFQLLWEKISHLLLGLQQ 342

  Fly   439 ------KTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYA-EFIFLGLFMSEMFIKMYALG 496
                  ::..|..|:.::|.||||.:..:.:.:.....|:.:.. :.|||.:::.|..:|:.|||
Mouse   343 MILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALG 407

  Fly   497 PRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFG---------LSV---LRALRLLRIFKVTKY 549
            .. ||...:|..|..::..::.:.:..::...|:.         |.|   :||||.:|:.:....
Mouse   408 LE-YFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSI 471

  Fly   550 WSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTV 614
            .:||..:..:|..|:.||.::|.|:|..:.:|:::...||      ....|:...|.| ..|.|:
Mouse   472 LTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALF------QDSDPKRFQNIF-TTLFTL 529

  Fly   615 FQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDN--LANAQELT 677
            |.:||.:||: ::|....:||......|..||.::..    :..||:.:|:.|||  :|..:.|.
Mouse   530 FTMLTLDDWS-LIYIDNRAQGAWYIIPILMIYIVIQY----FIFLNLVIAVLVDNFQMALLKGLE 589

  Fly   678 AAEEEQVEEDKEKQLQELEKEMEALQADGVHVE 710
            ..:.||.....||.|.:...::....|:....|
Mouse   590 KVKLEQAARVHEKLLDDSLTDLNKADANAQMTE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124	63/250 (25%)
		Ion_trans	769..1050	CDD:334124
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
Catsper1	NP_647462.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..177
		MPLKIP	99..>201	CDD:292140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..318		10/36 (28%)
		Ion_trans	386..581	CDD:278921	54/207 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810