DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and TPCN2

DIOPT Version :10

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_620714.2 Gene:TPCN2 / 219931 HGNCID:20820 Length:752 Species:Homo sapiens


Alignment Length:701 Identity:160/701 - (22%)
Similarity:282/701 - (40%) Gaps:156/701 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   434 IRHTV--KTQWFY----------------WFVIVLVFLNT---------VCVAVEHYGQPSFLTE 471
            |.|.|  .:.|.|                :.::.|.|:.|         |......:..|..|||
Human    62 INHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTE 126

  Fly   472 FLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSV-- 534
            .:   |.:.|.:|.:::.:|.|..|...:.::.:.....||:..|:  |.|      :..||:  
Human   127 SV---EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSL--VDW------TVSLSLVC 180

  Fly   535 ---LRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLP 596
               ||..||||.|.:.:..|.::..:..:..|:..:.|:..||.:.:.:|.:.||.||.|.....
Human   181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245

  Fly   597 GGTPE--TNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLL 659
            |...|  |.|...|.:|.::..:||..:..:||....      .|...|:|:|||..:.|:..|:
Human   246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY------SKNRAYAIFFIVFTVIGSLFLM 304

  Fly   660 NVFLAI--------------------------AVDNLANAQELTAAEEEQVEEDKEKQLQELEKE 698
            |:..||                          |.:.|::......|..:.|....:..||.|:| 
Human   305 NLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQK- 368

  Fly   699 MEALQADGVHVE------NGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNP 757
               :|.|..|.:      ...|:|..|..:.:|...| .:...|.|.| |...|.|.|:.|    
Human   369 ---VQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNE-LDRSVVKEHP-PRPEYQSPFLQS---- 424

  Fly   758 IRRGAHWVVNLPYFDFF--IMVVISMSSIA--LAAEDPVRENSRRNKILNYFDYAFTGVFTIEML 818
                |.::....|||:.  ::.:.::.||.  |..:..|....|.:.||...:..|...:.:|||
Human   425 ----AQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485

  Fly   819 LKIVDLGVILHPGSYLREFWNIMDAVVVICAAV--------------SFGFDMSGSSAGQNLSTI 869
            ||:..||:    ..||....|:.|.::.:...|              .:..:|.|.     ||..
Human   486 LKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL-----LSLW 541

  Fly   870 KSLRVLRVLRPLKTIKRVPKLK---AVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFF 931
            ...|:|.:|...:.::.:|.:|   .|...|:..::|:.....:.::..::|::||:.||.|...
Human   542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606

  Fly   932 YCTDESK----HTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWP 992
            .....|.    :.||.| ||:           ::|..|   |.::|:.|||::||:.:.....| 
Human   607 ALPGNSSLAPANGSAPC-GSF-----------EQLEYW---ANNFDDFAAALVTLWNLMVVNNW- 655

  Fly   993 QVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITF 1043
               |..:.|.....||..      .|:::::::|....:||:|:|||:..|
Human   656 ---QVFLDAYRRYSGPWS------KIYFVLWWLVSSVIWVNLFLALILENF 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:459842
Ion_trans 441..677 CDD:459842 64/293 (22%)
Ion_trans 769..1050 CDD:459842 70/300 (23%)
Ion_trans 1094..1345 CDD:459842
GPHH 1354..1407 CDD:465306
Ca_chan_IQ 1417..1496 CDD:462591
AF-4 <1512..>1704 CDD:461550
TPCN2NP_620714.2 Ion_trans <184..315 CDD:459842 39/136 (29%)
Interaction with phosphatidylinositol 3,5-bisphosphate. /evidence=ECO:0000269|PubMed:30860481 203..207 0/3 (0%)
Ion_trans 431..697 CDD:459842 69/299 (23%)
Blue background indicates that the domain is not in the aligned region.

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