DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and Catsper2

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_694715.2	Gene:	Catsper2 / 212670	MGIID:	2387404	Length:	588	Species:	Mus musculus

Alignment Length:	432	Identity:	88/432 - (20%)
Similarity:	172/432 - (39%)	Gaps:	95/432 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVL---AQKLEKTEAYFLCIFCVE 87
            |:..:..::::...|...::..|..|..||.:|..|.....|.|   ...||..:.:.|..|.||
Mouse    94 PLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVE 158

  Fly    88 ASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQI-------GPEVDLRTLRAIRVLRP 145
            ..|..||...:     :.::.||:.||||.:...:   |::       ...|.|:.||..||||.
Mouse   159 ILLMWLASFSL-----FWKDAWNVFDFFVTLLSLL---PELVVLLGVPAHSVWLQLLRVCRVLRS 215

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK 210
            |||.:....::|:|.::::|:..:..:.:|:|....|||:.|:.|:......|...||
Mouse   216 LKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLE------- 273

  Fly   211 EGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTA 275
                      .|:.                             |.::..:::|||...|::.|.|
Mouse   274 ----------YNMF-----------------------------FSDLLNSLVTVFILFTLDHWYA 299

  Fly   276 IL--YWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLR----- 333
            :|  .|........|:.||.:..:::||....|:::.::...|...|.::......|:::
Mouse   300 VLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADM 364

  Fly   334 -RQQQLER-----ELNGYVEWICKAEEVILA---------------EERTTEEEKMHIMEARRRN 377
             :||.::|     .|.|  ..:.|..|.|:.               ::...:::|....|:....
Mouse   365 FKQQIIQRRQHSESLRG--TSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDKSDATESDGEK 427

  Fly   378 AAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGS 419
            ....:......:|:::::|:.:.|:||....| ..:|.|:.|
Mouse   428 NENEESDSENSESENSESEKIDPEKDYAKKSY-PEKSHPEKS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	67/298 (22%)
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
Catsper2	NP_694715.2	Ion_trans	105..350	CDD:366146	67/298 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900