DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and Scn9a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001277603.1 Gene:Scn9a / 20274 MGIID:107636 Length:1984 Species:Mus musculus


Alignment Length:1906 Identity:472/1906 - (24%)
Similarity:822/1906 - (43%) Gaps:449/1906 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::|:..:|:|:.:..|:....|...::.||:.||:.:.: .:.|...|.|        |..|.
Mouse   105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTM-SNPPDWTKNV--------EYTFT 160

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||||.|..:.:.::||:.||.:||.|:|..::|::..:|   ::..||..||||.|
Mouse   161 GIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLG---NVSALRTFRVLRAL 222

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCY--SLEDPNKL- 208
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|:  .||....| 
Mouse   223 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKDLEQNETLE 287

  Fly   209 --VKEGESETPCNT-DNILEKATGSFVCNNTT--SMCLEKWE------GPNSGITSFDNIGFAML 262
              :...|||..... ...||.:..:.:|..:|  ..|.|.:|      .|:.|.||||..|:|.|
Mouse   288 SIMSTAESEEELKRYFYYLEGSKDALLCGFSTDSGQCPEGYECVTAGRNPDYGYTSFDTFGWAFL 352

  Fly   263 TVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSG----------EFA 317
            .:|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:|.|::.          |.|
Mouse   353 ALFRLMTQDYWENLYQQTLRAAGKTY-MIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEA 416

  Fly   318 KEREKVENRQEFLKLRR-QQQLERELNGYVEWICKAEEVILA-EERTTEEEKMHIMEAR-RRNAA 379
            |::| :|.:|...:|:: |::.|.......|:.......|:. .|.::|..::....|: |||..
Mouse   417 KQKE-LEFQQMLDRLKKEQEEAEAIAAAAAEYTSLGRSRIMGLSESSSETSRLSSKSAKERRNRR 480

  Fly   380 KRKKLK-SLGKSKSTD------------------------------------------------- 394
            |:||.| |.|:.|..|                                                 
Mouse   481 KKKKQKLSSGEEKGDDEKLSKSGSEESIRKKSFHLGVEGHHRAREKRLSTPNQSPLSIRGSLFSA 545

  Fly   395 -------------------TEEEEAEED---YGD------------------------------- 406
                               :|.|.|:::   :||                               
Mouse   546 RRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSPPV 610

  Fly   407 ----------------------------------------------------------------- 406
                                                                             
Mouse   611 LPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLS 675

  Fly   407 -----DGYLKTRSKPQGS---------------CTGFW-RAEKRFRFW--IRHTVKTQWFYWFVI 448
                 |.:|:.|:..:.|               |..:| |....|..|  ..:.:|.:.|.:|::
Mouse   676 EDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHTFLIWNCSPYWIKFKKFIYFIV 740

  Fly   449 ----------VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFES 503
                      :.:.|||:.:|:||:.........|.....:|.|:|.:||.:|:.|:.|..||:.
Mouse   741 MDPFVDLAITICIVLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFAAEMVLKLIAMDPYEYFQV 805

  Fly   504 SFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSII 568
            .:|.||.::::.|:.|:..::|:    ||||||:.||||:||:.|.|.:|..|:..:.||:.::.
Mouse   806 GWNIFDSLIVTLSLVELFLADVE----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 866

  Fly   569 SLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEV 626
            :|..:|.:.:.|||::||||||..:       |.....|..:.|.|..:.|.||::|.|| |.|.
Mouse   867 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINENCKLPRWHMNDFFHSFLIVFRVLCGE-WIET 930

  Fly   627 MYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAV-----DNLANAQELTAAEEEQV-- 684
            |:..:...|   :.|...:|.:|:|: ||..:||:|||:.:     |||...:|.|.|...|:  
Mouse   931 MWDCMEVAG---QTMCLIVYMMVMVI-GNLVVLNLFLALLLSSFSSDNLTAIEEDTDANNLQIAV 991

  Fly   685 --------------------------------------------------------------EED 687
                                                                          |:|
Mouse   992 ARIKRGINYVKQTLREFILKSFSKKPKGSKDTKRTADPNNKRENYISNRTLAEISKDHNFLKEKD 1056

  Fly   688 K--------------EKQLQEL---------------EKEMEALQADGVHVENGDGAVAPSKSKG 723
            |              |...|..               |.::|.:..:.:..::........:::.
Mouse  1057 KISGFSSSLDKSFMDENDYQSFIHNPSLTVTVPIAPGESDLENMNTEELSSDSDSDYSKERRNRS 1121

  Fly   724 KKKE----------EEKKEEEEV---------TEGPKPMLPYSSMFILSPTN----PIRRGAHWV 765
            ...|          ||:.|.|.:         |:|.....|...:.|.|...    .||:..:.:
Mouse  1122 SSSECSTVDNPLPGEEEAEAEPINADEPEACFTDGCVRRFPCCQVNIDSGKGKVWWTIRKTCYRI 1186

  Fly   766 VNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILNYFDYAFTGVFTIEMLLKIVDLGVILH 829
            |...:|:.||:::|.:||.|||.||...|..:..| ||.|.|..||.:|.:|||||.|..|.   
Mouse  1187 VEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVAYGY--- 1248

  Fly   830 PGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVF 894
             .:|....|..:|.::|..:.|:...:..|.|   :|..|||||.||.||||:.:.|...::.|.
Mouse  1249 -KTYFTNAWCWLDFLIVDVSLVTLVANTLGYS---DLGPIKSLRTLRALRPLRALSRFEGMRVVV 1309

  Fly   895 DCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---TDESKHTSAECQGSYFKYEEDEL 956
            :.::.::.:::|:|:|.::|..|||::||.||.|||:.|   ||.|:.:.::...   :.|...|
Mouse  1310 NALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTDGSRFSVSQVAN---RSECFAL 1371

  Fly   957 LPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
            :.......||....::|||....|:|..|.|.:||..::..::.:...:..||..:.:.|.|:::
Mouse  1372 MNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFV 1436

  Fly  1022 VYFIVFPFFFVNIFVALIIITFQEQGEAEL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRN 1082
            ::.|...||.:|:|:.:||..|.:| :.:|  ||..:.:.||...:.  .:|::..::.:|:..|
Mouse  1437 IFIIFGSFFTLNLFIGVIIDNFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGN 1500

  Fly  1083 TFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKII 1147
            .|:..::.:|.:..|:..||:||..|.:.:|::...|.|.....|.:||:.|..:|:.|.|||:|
Mouse  1501 KFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTDYMSFVLYWINVVFIILFTGECVLKLI 1565

  Fly  1148 GFGVKNFFKDPWNIFDLITVLGSIVDALWME-----FGSNSINVGFLRLFRAARLIKLLRQGYTI 1207
            ... ..:|...|||||.:.|:.|||.....|     |.|.:: ...:||.|..|:::|::....|
Mouse  1566 SLR-HYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGI 1628

  Fly  1208 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLF 1272
            |.||:..:.|..||..:.||:.::.|||||.||..|..:|   .|..|....||::|...::.||
Mouse  1629 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK---KEAGINDMFNFETFGNSMICLF 1690

  Fly  1273 RCATGEAWPNIMLACLKGKACDDDAEKA-PGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVA 1331
            :..|...|..::...|.....|.|.:|. ||..    ||: ::...||||:|.....:::|:::|
Mouse  1691 QITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIA 1755

  Fly  1332 VIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNR 1395
            ||::||...|.:|: .|.....:.|..:|.::||:||..|.:.::.|....:||||....  ||:
Mouse  1756 VILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAK--PNK 1818

  Fly  1396 LAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKM 1460
            :   :||.|::|:....|:.....|||..:..|.    ...|||....::.|...:..|.:..  
Mouse  1819 V---QLIAMDLPMVSGDRIHCLDILFAFTKRVLG----ESGEMDSLRSQMEERFMSANPSKVS-- 1874

  Fly  1461 LNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRH---PSQESL-- 1520
               ..|.:..|.:.:..|    :..:|..::|..|..|....:..:.::|..|.   |::|.:  
Mouse  1875 ---YEPITTTLKRKQEDV----SATIIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLPNKEDIVF 1932

  Fly  1521 -----------TGADAGHLHP 1530
                       |.|.|..:.|
Mouse  1933 DNVNENSSPEKTDATASTISP 1953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 94/310 (30%)
Ion_trans 441..677 CDD:334124 83/257 (32%)
Ion_trans 769..1050 CDD:334124 92/284 (32%)
Ion_trans 1094..1345 CDD:334124 84/261 (32%)
GPHH 1346..1416 CDD:339854 20/69 (29%)
Ca_chan_IQ 1418..1492 CDD:337190 13/73 (18%)
Scn9aNP_001277603.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55
I. /evidence=ECO:0000305 112..410 93/310 (30%)
Ion_trans 147..410 CDD:278921 85/274 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..540 14/81 (17%)
Na_trans_cytopl 487..606 CDD:288761 9/118 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..609 2/34 (6%)
II. /evidence=ECO:0000305 725..988 86/271 (32%)
Ion_trans 760..955 CDD:278921 67/203 (33%)
Na_trans_assoc 981..1185 CDD:284034 22/203 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1039 0/23 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1089..1145 7/55 (13%)
III. /evidence=ECO:0000305 1178..1486 100/318 (31%)
Ion_trans 1224..1464 CDD:278921 78/250 (31%)
Na_channel_gate 1456..1508 CDD:240441 11/52 (21%)
IV. /evidence=ECO:0000305 1495..1793 95/302 (31%)
Ion_trans 1530..1768 CDD:278921 78/242 (32%)
GPHH 1780..1835 CDD:293510 19/59 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1933..1984 4/21 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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