DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn7a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_033161.2 Gene:Scn7a / 20272 MGIID:102965 Length:1681 Species:Mus musculus


Alignment Length:1712 Identity:413/1712 - (24%)
Similarity:760/1712 - (44%) Gaps:337/1712 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLF-ILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
            |:| .|:..|.:|:.....:..|.|...:|::::.:.:::.: .:||   :.:||  :|.|   .
Mouse    97 SIFCTLSPLNSLRRAAIKALVHPLFRLLILISVLTDSILMCM-SNLP---EWILA--IENT---L 152

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRP 145
            |.|:..|..:|::|.|:.....|:|.::||.:||.|.:...:|::..:...:.|:|:|..|:|:.
Mouse   153 LGIYAFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRFSPLSSFLMLKTIRTFRILKI 217

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK 210
            :.|..|:.|:.:.|...:|.:...:   .|.||.:.:|:::|:..:.|.|...|  |..|    :
Mouse   218 IPLNHGLQSIVMTLAQCLKKLFGAI---ALALFFLAVFSLLGMGLFMGNLKHKC--LRWP----E 273

  Fly   211 EGESETPCNTDNIL------------EKATGSFVCNNTTS--------MCLEKWEGPNSGITSFD 255
            |.|:||..|....|            |.|..:.:|.|.|.        :|:::...|::|.||||
Mouse   274 ENENETLHNRTGSLNYSPERINFYYMEGAKYALLCGNRTDAGQCPEGYVCVKEGTNPDNGFTSFD 338

  Fly   256 NIGFAMLTVFQCITMEG----WTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEF 316
            |.|:::|.:|:.:|.:.    :..|||    |.|..: .|:||.:....:|::.:|.||:|:..:
Mouse   339 NFGWSLLAMFRLMTQDYPELLYHQILY----ASGKVY-MIFFVMISFWFAFYLTSLFLGILTMTY 398

  Fly   317 AKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKR 381
            .||:::.......|..:.||.: :||:         ||...||..||:.|            .|:
Mouse   399 EKEKQRACEESGGLDPKCQQTV-KELD---------EENDAAEMETTQIE------------MKK 441

  Fly   382 KKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGS---CTGFWRAEKRFRFWIRHTVKTQWF 443
            :...|:..:.           |..:|..|..|.:|:.|   |...|.     :|     :|| .|
Mouse   442 RSPTSINTTL-----------DILEDTTLGHREEPETSRKKCPICWH-----KF-----IKT-CF 484

  Fly   444 YW------------------------FVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLF 484
            .|                        |:::.:.||...:|:||:.....|...|:....:|:|::
Mouse   485 IWKCSPCWVKLNEFADRVITHPLADLFLVICIVLNICFLALEHFPMSEELRSLLHVGNLVFIGIY 549

  Fly   485 MSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKY 549
            ..||.:|:.|:.|..||:.|:|.||.:::...:.|::.::|:    ||:||..:.|:.| |:.||
Mouse   550 TIEMILKIIAMHPYGYFQISWNIFDSILVVLELTEILLADVE----GLAVLITVPLIFI-KLGKY 609

  Fly   550 WSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFN------LPGGTPET-NFNTF 607
            ....::|:..|.:|:.::..|:.||.:|:...|:.||:|||..:.      .....|:. :.:.|
Mouse   610 GPPFKSLMRILGSSLMALKDLVLLLCIFVYFSAVFGMKLFGRSYKDCVCHIKEDCQPQRWHMSDF 674

  Fly   608 PIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSI-YFIVLVLFGNYTLLNVF--------- 662
            ..|.:|||:||.|| |.|.:::.:...|.|     :.| ::::::|.||..:|.:|         
Mouse   675 LHAYMTVFRILCGE-WIETLWECMEVAGQA-----WCIPFYMMVILIGNLLILYLFVTLVSSFSY 733

  Fly   663 ---------------LAIA-----------------------------------------VDNLA 671
                           ||:|                                         :..|:
Mouse   734 YDATSEVNKEAKNLQLAMARIKSGINSMLLKLMCTERSVPTEATDQICDPSVKENISGHTLSELS 798

  Fly   672 NAQELTAAEEEQVEEDK----EKQLQEL---------------EKEMEALQADGVHVENGDGAVA 717
            |.|.....:::....:|    |.:.|.|               |.::|.|.......::|:|.  
Mouse   799 NTQTFLRYKDQSSSTEKTPVTESESQSLIASPSASETVPIASGESDIENLDNKETRSKSGNGG-- 861

  Fly   718 PSKSKGKKKEEEK---------KEEEEVTEGPKPMLPYSSMFILSPTNPI----RRGAHW----- 764
             ||.|.|:....:         :|||.|.|..|..|..:.....|.|..|    |.|..|     
Mouse   862 -SKEKMKQSSSSECSTVDIAISEEEEMVYEHEKSKLHKNGYERKSSTGQISRESRNGKIWKNIRK 925

  Fly   765 ----VVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKI-LNYFDYAFTGVFTIEMLLKIVDL 824
                :|...:|:.||.:|..:.:..||.||...:..:..|| |.|.|..|..:|.:|||||.|..
Mouse   926 TCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTTKILLEYADMIFAYIFILEMLLKWVAY 990

  Fly   825 GVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPK 889
            |.    .::....|..:|.:|||.    |...:.|.:. ::|:.:.|::.||.||.|...:|   
Mouse   991 GF----KAFFSNNWYKLDFMVVIV----FCLSLIGKTR-EDLNPLTSIKFLRALRVLSQFER--- 1043

  Fly   890 LKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESK---------HTSAECQ 945
            :|.|...::.:....|::.:|.::...:|||||||||.|||:.|.|.:|         ...::|:
Mouse  1044 MKVVLRALIKTTLPTVSVFLVCLMIWLLFSVIGVQLFAGKFYECIDPTKGERFPVFEVMNKSQCE 1108

  Fly   946 GSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQ 1010
            ...|    :|.:|      |:....::|||....|:|..|.|..||..::..::.:...:..|..
Mouse  1109 KLLF----NESMP------WENAKLNFDNVGNGFLSLLQVATFNGWISIMNSAIDSVGVNMQPSF 1163

  Fly  1011 NFRIEMSIFYIVYFIVFPFFF-VNIFVALIIITFQEQGEAELQDGEID-------KNQKSCIDFT 1067
            .:.:.|..::|: |::|..|. :.:.:.:||..|.:|   :::.|..:       |.|...:...
Mouse  1164 EYNLYMYSYFII-FVIFGLFLPLCMLIGVIIRNFNKQ---KIKQGGSNIFITVKQKKQYRALKKL 1224

  Fly  1068 IGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINM 1132
            :.| .:::..|:.||.|:..::.:|....|...|::||.|....:|::...|....|.::.::|.
Mouse  1225 LYA-DVQKPTPRPRNKFQGFLFDLVTHRVFNVIIILLICFQATTIMIQKDEQSPQMETAIFWMNS 1288

  Fly  1133 GFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALW-MEFGSNSINVGFLRLFRAAR 1196
            .|..:|::|.:||:..|.. ::|...||:.|.:.|:.||...|. :..|...:....::|...:|
Mouse  1289 IFVMLFTLECILKLTAFRC-HYFTSAWNVHDFMVVIFSITGLLLPLTIGQYFVPPSLVQLILLSR 1352

  Fly  1197 LIKLLRQGYTIRI---LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRH 1258
            :|.:||.|...::   |:...:.:..||..:.|||.::.|||||.||..|..:|   .|..|...
Mouse  1353 VIHILRPGKGPKVFHDLMLPLILALPALLNISLLIFLVMFIYAIFGMYNFAYVK---KEAGINDV 1414

  Fly  1259 NNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKA-PGEY----CGS-TLAYAYFVSF 1317
            :||::|...::.||:..|...|..::.|....:..|.|.:|. ||..    ||| ::..:||||:
Mouse  1415 SNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVKGDCGSPSVGISYFVSY 1479

  Fly  1318 IFFCSFLMLNLFVAVIMDNFDYLT----RDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDM 1378
            |.....:::|:::.:||   ::|:    :.|..|.......|.|:|..:||:.|..|..:::.|.
Mouse  1480 ILISWLIIVNMYIVLIM---EFLSIPSQKKSRTLSEDDFRRFFRVWNRFDPDRTQYIDSSKLSDF 1541

  Fly  1379 LKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADM 1443
            ...:||||....  ||:   .:|:.|::|:....|:.....|.|..:..:....|.  |...:::
Mouse  1542 AAALDPPLFMAK--PNK---GQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERV--EKILSEI 1599

  Fly  1444 ELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLEL 1508
            |....:.|.:.:..:       |.:..|.:.:.:|    :..:|..:::|.|..|.|..:.....
Mouse  1600 ESGFMLANPFKITYE-------PITTTLKRKQEAV----SATIIQRAYKSYRLRQNDKNVSDTPA 1653

  Fly  1509 QDASRHPSQESLT--GADAGHL 1528
            .|..|    :.||  ||.:|.:
Mouse  1654 IDDRR----DDLTSKGAHSGKI 1671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 81/310 (26%)
Ion_trans 441..677 CDD:334124 73/332 (22%)
Ion_trans 769..1050 CDD:334124 80/291 (27%)
Ion_trans 1094..1345 CDD:334124 72/264 (27%)
GPHH 1346..1416 CDD:339854 19/69 (28%)
Ca_chan_IQ 1418..1492 CDD:337190 10/73 (14%)
Scn7aNP_033161.2 Ion_trans 140..405 CDD:278921 78/286 (27%)
Ion_trans 523..739 CDD:278921 62/226 (27%)
Na_trans_assoc 743..927 CDD:284034 32/186 (17%)
Ion_trans 951..1204 CDD:278921 76/278 (27%)
Na_channel_gate 1195..1246 CDD:240441 10/54 (19%)
Ion_trans 1275..1497 CDD:278921 65/228 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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