DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and Scn5a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_006512056.1 Gene:Scn5a / 20271 MGIID:98251 Length:2085 Species:Mus musculus


Alignment Length:1865 Identity:448/1865 - (24%)
Similarity:757/1865 - (40%) Gaps:528/1865 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::|:..:|:|:....|:....|...::.||:.|||.:|..:..|.         .:..|..|.
Mouse   175 ALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPW---------TKYVEYTFT 230

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||||.|..||..::||:.||.:||.|:|..:.|::..:|   ::..||..||||.|
Mouse   231 AIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLG---NVSALRTFRVLRAL 292

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS---------- 201
            |.:|.|..|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|..          
Mouse   293 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNG 357

  Fly   202 ---------------LEDP-NKLVKEGESETPCNTDNILEKATGSFVCNNTTS--------MCLE 242
                           |.|| |.|:|.|      .||.:|        |.|::.        .||:
Mouse   358 SVEADGIVWNSLDVYLNDPANYLLKNG------TTDVLL--------CGNSSDAGTCPEGYRCLK 408

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            ..|.|:.|.||||:..:|.|.:|:.:|.:.|..:...|..:.|..: .|:|:.:|.:|||:::||
Mouse   409 AGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIY-MIFFMLVIFLGSFYLVNL 472

  Fly   308 VLGVLS--------GEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTE 364
            :|.|::        ...|:..||.:..||.:::.:::.....:.| |:.:.::         :.|
Mouse   473 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRG-VDTVSRS---------SLE 527

  Fly   365 EEKMHIMEARRRNAAKRKKLKS---------LGKSKSTD-------------------------- 394
            ...:..:....|.:.:||:|.|         |.||.|.|                          
Mouse   528 MSPLAPVTNHERRSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRG 592

  Fly   395 ------TEEEEAEEDYGDD-------------------------------------GYLKTRSK- 415
                  ..::.:|.|:.||                                     |::....: 
Mouse   593 SIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVPWPLRRPSTQGQPGFGTSAPGHVLNGKRN 657

  Fly   416 ----------------------------------------------------PQGSCT-GF---- 423
                                                                ||..|. ||    
Mouse   658 STVDCNGVVSLLGAGDAEATSPGSHLLRPIVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPG 722

  Fly   424 -----------------------------W-RAEKRFRFW--------IRHTVKTQWFYWFVI-- 448
                                         | |..:.:..|        |:..||      ||:  
Mouse   723 ARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVK------FVVMD 781

  Fly   449 --------VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSF 505
                    :.:.|||:.:|:|||...:...|.|.....:|.|:|.:||..|:.||.|..||:..:
Mouse   782 PFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGW 846

  Fly   506 NRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISL 570
            |.||.:::..|:.|:..|.:.    .|||||:.||||:||:.|.|.:|..|:..:.||:.::.:|
Mouse   847 NIFDSIIVILSLMELGLSRMG----NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 907

  Fly   571 LFLLFLFILIFALLGMQLFGGQFNL-------PGGTPETNFNTFPIALLTVFQILTGEDWNEVMY 628
            ..:|.:.:.|||::||||||..::.       .|..|..:...|..|.|.:|:||.|| |.|.|:
Mouse   908 TLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMW 971

  Fly   629 QGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEE------------ 681
            ..:...|.:    :..:.|:::::.||..:||:|||:.:.:. :|..|||.:|            
Mouse   972 DCMEVSGQS----LCLLVFLLVMVIGNLVVLNLFLALLLSSF-SADNLTAPDEDGEMNNLQLALA 1031

  Fly   682 ----------------------------------------------------------------- 681
                                                                             
Mouse  1032 RIQRGLRFVKRTTWDFCCGLLRRRPKKPAALATHSQLPSCIAAPRSPPPPEVEKAPPARKETRFE 1096

  Fly   682 ---------------------------EQVEEDKEKQL----QELEKEMEALQADGVH------- 708
                                       :..|||:|..|    :|..|:.|:....|.|       
Mouse  1097 EDKRPGQGTPGDTEPVCVPIAVAESDTDDQEEDEENSLGTEEEESSKQQESQVVSGGHEPPQEPR 1161

  Fly   709 -----VENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNP----------- 757
                 .|........|.|:...::|.:.|......|..|...||.......||.           
Mouse  1162 AWSQVSETTSSEAEASTSQADWQQEREAEPRAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLG 1226

  Fly   758 --------------IRR------------GAHW---------VVNLPYFDFFIMVVISMSSIALA 787
                          :||            |..|         :|...:|:.||:.:|.:||.|||
Mouse  1227 EDVKDPEDCFTEGCVRRCPCCMVDTTQAPGKVWWRLRKTCYRIVEHSWFETFIIFMILLSSGALA 1291

  Fly   788 AEDPVRENSRRNKI-LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAV 851
            .||...|..:..|: |.|.|..||.||.:|||||.|..|.    ..|....|..:|.::|..:.|
Mouse  1292 FEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIVDVSLV 1352

  Fly   852 SFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQF 916
            |...:..|.:   .:..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..
Mouse  1353 SLVANTLGFA---EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWL 1414

  Fly   917 IFSVIGVQLFNGKFFYCTDESK----------HTSAECQ-----GSYFKYEEDELLPKQELRVWK 966
            |||::||.||.|||..|.::::          :..:||:     |..:               |.
Mouse  1415 IFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELY---------------WT 1464

  Fly   967 PRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF---- 1027
            ....::|||.|..|.|..|.|.:||..:    |.|..:.||..:..:.|.:::..:||:||    
Mouse  1465 KVKVNFDNVGAGYLALLQVATFKGWMDI----MYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFG 1525

  Fly  1028 PFFFVNIFVALIIITFQEQGEAEL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKV 1088
            .||.:|:|:.:||..|.:| :.:|  ||..:.:.||...:.  .:|::..::.:|:..|.::..:
Mouse  1526 SFFTLNLFIGVIIDNFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1589

  Fly  1089 WRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN 1153
            :.||....|:..||.||..|.:.:|::..:|.......|..||:.|..:|:.|.::|:.... ..
Mouse  1590 FDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALR-HY 1653

  Fly  1154 FFKDPWNIFDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWT 1213
            :|.:.|||||.:.|:.|||     |.:...|.|.:: ...:||.|..|:::|:|....||.||:.
Mouse  1654 YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTL-FRVIRLARIGRILRLIRGAKGIRTLLFA 1717

  Fly  1214 FVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGE 1278
            .:.|..||..:.||:.::.|||:|.||..|..:|.   |..|....|||:|...::.||:..|..
Mouse  1718 LMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKW---EAGIDDMFNFQTFANSMLCLFQITTSA 1779

  Fly  1279 AWPNIMLACLK--GKACDDDAEKAPGE--YCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFD 1338
            .|..::...|.  ...||.:...:.|.  .||| .:...:|.::|.....:::|:::|:|::||.
Mouse  1780 GWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFS 1844

  Fly  1339 YLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLI 1402
            ..|.:|: .|.....|.|..||.::||.||..|.|..:.|....:..||....  ||:::   ||
Mouse  1845 VATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAK--PNQIS---LI 1904

  Fly  1403 RMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRE 1447
            .|::|:....|:.....|||..:..|.    ...|||...:::.|
Mouse  1905 NMDLPMVSGDRIHCMDILFAFTKRVLG----ESGEMDALKIQMEE 1945

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 93/328 (28%)
Ion_trans 441..677 CDD:334124 79/252 (31%)
Ion_trans 769..1050 CDD:334124 94/300 (31%)
Ion_trans 1094..1345 CDD:334124 76/260 (29%)
GPHH 1346..1416 CDD:339854 21/69 (30%)
Ca_chan_IQ 1418..1492 CDD:337190 8/30 (27%)
Scn5aXP_006512056.1 Ion_trans 195..488 CDD:366146 90/319 (28%)
Na_trans_cytopl 550..732 CDD:371806 15/181 (8%)
Ion_trans 781..994 CDD:366146 69/221 (31%)
Na_trans_assoc 1020..1268 CDD:368948 25/247 (10%)
Ion_trans 1272..1547 CDD:366146 94/301 (31%)
Na_channel_gate 1539..1591 CDD:240441 10/52 (19%)
Ion_trans 1596..1850 CDD:366146 76/258 (29%)
GPHH 1862..1909 CDD:374878 17/51 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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