DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn3a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001342095.1 Gene:Scn3a / 20269 MGIID:98249 Length:1996 Species:Mus musculus


Alignment Length:1965 Identity:487/1965 - (24%)
Similarity:819/1965 - (41%) Gaps:548/1965 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
            ::|:|||..||:||....|:....|...::.||:.|||.:.| .:.|...|.|        |..|
Mouse   106 SALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTL-SNPPDWTKNV--------EYTF 161

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRP 145
            ..|:..|:.:||||.|..|...::||:.||.:||.|:|..::|::..:|   ::..||..||||.
Mouse   162 TGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLG---NVSALRTFRVLRA 223

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK 210
            ||.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|  |:.|     
Mouse   224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC--LQWP----- 281

  Fly   211 EGESETPCNTDNILE---KATGSFV------------------------------CNNTTS---- 238
            ..:|....||.:...   .:.|:||                              |.|.:.    
Mouse   282 PSDSAFEINTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADDSHFYVLDGQKDPLLCGNGSDAGQC 346

  Fly   239 ----MCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVI 299
                :|::....||.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:
Mouse   347 PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY-MIFFVLVIFL 410

  Fly   300 GSFFMLNLVLGVLSGEFAK---------EREKVENRQEFLKLRRQQQ----------LERELNGY 345
            |||:::||:|.|::..:.:         |:::.|.:|...:|::||:          ..|:.:| 
Mouse   411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSG- 474

  Fly   346 VEWICKAEEVILAEERTTEEEKMHIMEARR-RNAAKRKKLKS------------LGKSKSTDT-- 395
               |....|::   |.::|..|:....|:. ||..|:::.:.            ..||:|.|:  
Mouse   475 ---IGGLGELL---ESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNHRPEGDRFPKSESEDSVK 533

  Fly   396 ---------------------------------------------------EEEEAEEDYGDDGY 409
                                                               ::..:|.|:.||.:
Mouse   534 RRSFLFSLDGNPLSGDKKLCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

  Fly   410 ---------------------------------------LKTRSK-------------------- 415
                                                   |....|                    
Mouse   599 STFEDSESRRDSLFVPHRPGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSAL 663

  Fly   416 --------PQGSCT-----------------------GFWRA---------------EKR----- 429
                    |:|:.|                       |..||               |.|     
Mouse   664 TSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAMSIASILTNTMEELEESRQKCPP 728

  Fly   430 --FRF------------W--IRHTVKTQWFYWFV----IVLVFLNTVCVAVEHYGQPSFLTEFLY 474
              :||            |  ::|.|.......||    .:.:.|||:.:|:|||......:..|.
Mouse   729 CWYRFANVFLIWDCCDSWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLT 793

  Fly   475 YAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALR 539
            ....:|.|:|.:||.:|:.|:.|..||:..:|.||.:::|.|:.|:..:.|:    ||||||:.|
Mouse   794 VGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANVE----GLSVLRSFR 854

  Fly   540 LLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-------NLPG 597
            |||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:       |...
Mouse   855 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINEDC 919

  Fly   598 GTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVF 662
            ..|..:.|.|..:.|.||::|.|| |.|.|:..:...|   :.|...::.:|:|: ||..:||:|
Mouse   920 KLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG---QTMCLIVFMLVMVI-GNLVVLNLF 979

  Fly   663 LAIAV-----DNLA---------NAQELTAAEEEQVEEDKEK----------------------- 690
            ||:.:     ||||         |.|......::.::..|.|                       
Mouse   980 LALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKIRECFRKAFFRKPKVIEIHEGNK 1044

  Fly   691 ---------QLQELEKEMEALQADGVHVENGDG------------------------------AV 716
                     .:.|:.||:..|: ||....:|.|                              ||
Mouse  1045 IDSCMSNNTGVVEISKELNYLK-DGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAV 1108

  Fly   717 ---------------------------APSKSKGK---------------KKEEEKKEEEEVTEG 739
                                       |.|.|:|.               :.||:.|.|...|||
Mouse  1109 GESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVAPPREGEQAEIEPEEDLKPEACFTEG 1173

  Fly   740 PKPMLPYSSMFILSPTNPI----RRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK 800
            .....|:..:........|    |:..:.:|...:|:.||:.:|.:||.|||.||...|..:..|
Mouse  1174 CIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIK 1238

  Fly   801 -ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQ 864
             :|.|.|..||.:|.:|||||.|..|.    .:|....|..:|.::|..:.||...:..|.|   
Mouse  1239 TMLEYADKVFTYIFILEMLLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANALGYS--- 1296

  Fly   865 NLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGK 929
            .|..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..|||::||.||.||
Mouse  1297 ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1361

  Fly   930 FFYCTDESKHTSAECQGSYF------KYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTG 988
            |::|.:.:       .||.|      .:.:.:.|.||..  ||....::|||.|..|.|..|.|.
Mouse  1362 FYHCVNMT-------TGSMFDMSEVNNFSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATF 1417

  Fly   989 EGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQ-----GE 1048
            :||..::..::.:......|:....:.|.::::::.|...||.:|:|:.:||..|.:|     | 
Mouse  1418 KGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG- 1481

  Fly  1049 AELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLL 1111
               ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:..|....|:..||:||..|.:.
Mouse  1482 ---QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1543

  Fly  1112 LMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALW 1176
            :|::..:|.......|..||:.|..:|:.|.:||:|.... .:|...|||||.:.|:.|||....
Mouse  1544 MMVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRY-YYFTIGWNIFDFVVVILSIVGMFL 1607

  Fly  1177 ME-----FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYA 1236
            .|     |.|.:: ...:||.|..|:::|::....||.||:..:.|..||..:.||:.::.||||
Mouse  1608 AELIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1671

  Fly  1237 IIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKA--CDDDAEK 1299
            |.||..|..:|   .|..|....||::|...::.||:..|...|..::...|....  ||.||..
Mouse  1672 IFGMSNFAYVK---KEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDAIH 1733

  Fly  1300 APGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRI 1358
             ||..    ||: ::...:|||:|.....:::|:::|||::||...|.:|: .|.....:.|..:
Mouse  1734 -PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEV 1797

  Fly  1359 WAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFAL 1423
            |.::||:||..|.:.::.|....:||||....  ||::   :||.|::|:....|:.....|||.
Mouse  1798 WEKFDPDATQFIEFCKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAF 1857

  Fly  1424 IR---------ENLSIKM----------------------RAPEEMDQADME-------LRETIT 1450
            .:         :.|.|:|                      |..||:..|.::       |::.:.
Mouse  1858 TKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLK 1922

  Fly  1451 NIWPLQAKKML--NLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASR 1513
            ||.....|:.:  .:::|     .||.:.:.|:                   :|....|..|.|.
Mouse  1923 NISNTYDKETIKGRIVLP-----IKGDMVIDKL-------------------NGNSTPEKTDGSS 1963

  Fly  1514 H----PSQESLTGAD 1524
            .    ||.:|:|..|
Mouse  1964 STTSPPSYDSVTKPD 1978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 92/336 (27%)
Ion_trans 441..677 CDD:334124 86/260 (33%)
Ion_trans 769..1050 CDD:334124 94/292 (32%)
Ion_trans 1094..1345 CDD:334124 82/262 (31%)
GPHH 1346..1416 CDD:339854 20/69 (29%)
Ca_chan_IQ 1418..1492 CDD:337190 18/113 (16%)
Scn3aNP_001342095.1 Ion_trans 127..434 CDD:306908 91/326 (28%)
Na_trans_cytopl 510..697 CDD:314757 13/186 (7%)
Ion_trans 759..972 CDD:306908 73/221 (33%)
Na_trans_assoc 998..1201 CDD:310839 28/203 (14%)
Ion_trans 1206..1478 CDD:306908 93/287 (32%)
Na_channel_gate 1470..1522 CDD:240441 12/55 (22%)
Ion_trans 1526..1782 CDD:306908 82/261 (31%)
GPHH 1786..1849 CDD:318993 20/67 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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